To advance our understanding of the effects of environmental exposures on child health and development, the National Institutes of Health has launched a new seven-year initiative called the Environmental Influences on Child Health Outcomes (ECHO) program. ECHO will focus on four high-impact public health outcomes: upper and lower airway disease, obesity, birth outcomes, and neurodevelopment. Environmental influences will be broadly defined to include physical, chemical, biological, social, behavioral, natural, and built environments. The studies will share standardized core data elements managed by a central coordinating center and an associated data analysis center. ECHO includes seven funding opportunities. Letters of Intent are due on March 15, and applications are due on April 15. An informational webinar on ECHO funding opportunities is scheduled for February 1, 2016 from 2:30 to 3:30 p.m. EST. In addition, the NIEHS-led Children's Health Exposure Analysis Resource will be expanded to support analysis of biological samples for ECHO.