Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Transposable Elements Contribute to Tumor Growth

Ting Wang, Ph.D.
Washington University School of Medicine in St. Louis
U24ES026699

An NIEHS-funded study revealed that transposable elements, which are sequences of DNA that move around in the genome, are important drivers of tumor growth. The study provides the first comprehensive look at the role transposable elements play in activating cancer genes.

Typical genome sequencing methods that look for genetic mutations that drive cancer do not detect transposable elements. So the researchers used more powerful sequencing techniques to analyze 7,769 tumor samples from 15 different types of cancer. They discovered 129 transposable elements that played a part in tumor growth by influencing 106 different cancer genes. The authors reported that transposable elements switch on cancer-related genes that are usually silent and keep them switched on.

At least one transposable element activated a cancer gene in about half of all the tumors studied. Although transposable elements were widespread, the pattern of transposable elements varied across cancer types. For example, 87% of tumor samples from a type of lung cancer called squamous cell carcinoma had at least one transposable element, but this was only 12% for glioma brain cancers.

According to the authors, a better understanding of transposable elements may provide more information about what leads to accelerated tumor growth in some cancers and new targets to study for future cancer therapies.

Citation: Jang HS, Shah NM, Du AY, Dailey ZZ, Pehrsson EC, Godoy PM, Zhang D, Li D, Xing X, Kim S, O'Donnell D, Gordon JI, Wang T. 2019. Transposable elements drive widespread expression of oncogenes in human cancers. Nat Genet 51(4):611–617.


Back
to Top