Leonardo Trasande, M.D.
New York University School of Medicine
NIEHS Grant R01ES022972
Increased recognition of potential health risks related to di-2-ethylhexylphlatate (DEHP) is leading manufacturers to switch to chemically similar di-isononyl phthalate (DINP) and di-isodecyl phthalate (DIDP) in products such as furnishings, cookware, and plastic food packaging. However, these replacements may also pose health problems in children, according to new research from an NIEHS grantee and colleagues.
The researchers published two studies that examined the effects of DINP and DIDP on 2009-2012 participants in the National Health and Nutrition Examination Survey (NHANES), a biannual and nationally representative survey of the U.S. population administered by the Centers for Disease Control and Prevention. In one study, they examined study participants ages 6 to 19 and found a significant association between high blood pressure and the presence of DINP and DIDP urinary metabolites.
A second study examined 12- to 19-year-olds from the NHANES study and revealed a link between DINP and DIDP concentrations and increased insulin resistance. Specifically, 34.4 percent of the adolescents with the highest DINP metabolite urinary levels showed insulin resistance, compared to 23.4 percent of the adolescents with the lowest levels of DINP. Similarly for DEHP, 37.7 percent of study participants with the highest levels had insulin resistance, compared to 20.5 percent with the lowest DEHP levels.
Citation: Trasande L, Attina TM. 2015. Association of exposure to di-2-ethylhexylphthalate replacements with increased blood pressure in children and adolescents. Hypertension 66(2):301-308. Attina TM, Trasande L. 2015. Association of exposure to di-2-Ethylhexylphthalate replacements with increased insulin resistance in adolescents from NHANES 2009-2012. J Clin Endocrinol Metab 00(7):2640-2650.