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Your Environment. Your Health.

BPA Associated with IVF Implantation Failure

Russ Hauser, M.D., Sc.D.
Harvard School of Public Health
NIEHS Grants R01ES009718, P30ES000002


A study funded by NIEHS showed an association between bisphenol A (BPA) urinary concentrations and embryo implantation failure in women undergoing in vitro fertilization (IVF). The carefully synchronized hormonal signals and feedback loops involved in an embryo implanting to the uterus make this stage of prenatal development potentially vulnerable to endocrine disruptors such as BPA, which is found in many consumer products.

The researchers measured the urinary BPA levels of 137 women undergoing 180 IVF cycles at the Massachusetts General Hospital Fertility Center. Overall, 75 IVF cycles (42 percent) resulted in implantation failure. The investigators found that implantation failure was almost twice as likely for women with urinary BPA concentrations of 3.80 to 26.48 micrograms per liter than for women with the lowest concentration of less than 1.69 micrograms per liter.


Citation: Ehrlich S, Williams PL, Missmer SA, Flaws JA, Berry KF, Calafat AM, Ye X, Petrozza JC, Wright D, Hauser R. 2012. Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environ Health Perspect; doi:10.1289/ehp.1104307 [Online 6 April 2012].

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