A Unique, Highly Exposed Community Followed for 45 Years and Three Generations
Michele Marcus, Emory University
The Michigan PBB study is a multi-generational cohort of individuals from Michigan, their children, and grandchildren, followed over 40 years after a widespread polybrominated biphenyl (PBB) exposure in 1973. For more information about this cohort, visit the NIEHS Epidemiology Resources webpage for Michigan PBB.
Cohort Maintenance & Enrichment Activities:
Updating the vital status of the entire cohort. Partnering with the affected Michigan community to support the continuation of the PBB research efforts. Maintaining community engagement through partner and community meetings, responding to inquiries from the community and clinicians, and regularly updating the website and social media.
Data Management & Sharing Activities:
Building a data management, analytic, and visualization platform to enable linking over 40 years of follow-up data and thousands of biospecimens. The platform will curate diverse formats of data into a consistent, aggregate database to facilitate longitudinal analyses of data. Developing web portals to enable broad sharing of the cohort resources with important stakeholder groups, including the scientific community, cohort members, and local public health agencies.
Historical data collected over 40 years (which is linked to banked biological samples, such as blood, urine, and semen) can be made available upon request to the principal investigator, Michele Marcus. De-identified data will be publicly available by 2024.
Please see NIH RePORTER for publications associated with this R24 grant.