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Your Environment. Your Health.

Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT)

Principal Investigator:
Hu, Howard; Peterson, Karen; Hernandez-Avila, Mauricio; Tellez-Rojo, Martha Maria
Institution:
University of Michigan
Location:
Mexico City, Mexico
Number of Participants:
753
Lifestage of Participants:
Prenatal, Infant (0-1 year), Youth (1-18 years)
Exposures:
Lead, Arsenic, Cadmium, Chromium, Copper, Manganese, Mercury/Methylmercury, Fluorinated Compounds, Nutrition/Diet, Bisphenol A (BPA), Phthalates, Psychosocial Stress, Environmental tobacco smoke, Air Pollution, Zinc
Health Outcomes:
Allergic response, Autoimmune outcomes, Birthweight, Metabolic syndrome, Neurobehavioral outcomes, Neurodevelopmental outcomes, Obesity/Body weight, Premature/Delayed puberty, Dental health
Brief Description:
This is a group of three sequentially-enrolled, on-going, epidemiologic birth cohort studies in Mexico City with an original aim to investigate the impact of lead on child development. The research aims have since expanded to include a wide range health outcomes and environmental, nutritional, behavioral, genetic, and epigenetic risk factors. Children enrolled in the study were born beginning in 1994 through 2011 and were evaluated every 3-6 months during the first 3 years of life.

Related NIEHS-Funded Projects

Projects listed supported initial development of the epidemiological resource, added study participants, collected additional information or samples from study participants, and/or used samples or datasets derived from the resource.

Project 1: Perinatal and Peripubertal Mixtures, Physical Growth and Sexual Matur

Grant Number:
Principal Investigator:
Meeker, John D (Contact); Padmanabhan, Vasantha
Institution:
University of Michigan
Most Recent Award Year:
2013
Additional Details

Project 2: Metabolic Consequences of In Utero and Peripubertal Toxicant-Diet Exposures

Grant Number:
Principal Investigator:
Peterson, Karen Eileen (Contact); Padmanabhan, Vasantha
Institution:
University of Michigan
Most Recent Award Year:
2013
Additional Details

Metal mixtures, children's cognition, and sensitive developmental windows

Grant Number:
Principal Investigator:
Henn, Claus; Gunhild, Birgit
Institution:
Harvard University
Most Recent Award Year:
2013
Additional Details

The Toxic Environment and the Epigenetics of Fetal Growth

Grant Number:
Principal Investigator:
Burris, Heather Herson
Institution:
Beth Israel Deaconess Medical Center
Most Recent Award Year:
2013
Additional Details

Stress-Lead Interactions and Child Development

Grant Number:
Principal Investigator:
Wright, Robert O
Institution:
Brigham And Women's Hospital
Most Recent Award Year:
2012
Additional Details

Prenatal and Childhood Exposure to Fluoride and Neurodevelopment

Grant Number:
Principal Investigator:
Hu, Howard
Institution:
University of Toronto
Most Recent Award Year:
2012
Additional Details

Early Life Environmental Toxicant Exposure and Oral Health

Grant Number:
Principal Investigator:
Arora, Manish
Institution:
Harvard University
Most Recent Award Year:
2011
Additional Details

Environment, Fetal Tissue DNA Methylation & Birthweight

Grant Number:
Principal Investigator:
Baccarelli, Andrea; Wright, Robert O (Contact)
Institution:
Mount Sinai School of Medicine
Most Recent Award Year:
2011
Additional Details

Immune dysfunction associated with early life heavy metal exposure

Grant Number:
Principal Investigator:
Somers, Emily Catherine
Institution:
University of Michigan
Most Recent Award Year:
2011
Additional Details

Project 1: Prenatal Lead Exposure, Early Childhood Growth, and Sexual Maturation

Grant Number:
Principal Investigator:
Peterson, Karen
Institution:
University of Michigan
Most Recent Award Year:
2010
Additional Details

Fetal Lead Exposure, Genes, and Neurodevelopment

Grant Number:
Principal Investigator:
Hu, Howard
Institution:
University of Michigan
Most Recent Award Year:
2006
Additional Details

Metal Mixtures and Neurodevelopment

Grant Number:
Principal Investigator:
Wright, Robert O
Institution:
Brigham And Women's Hospital
Most Recent Award Year:
2006
Additional Details