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Your Environment. Your Health.

Prenatal PCE Exposure in New England

Principal Investigator:
Aschengrau, Ann
Boston University
Massachusetts; Rhode Island
Number of Participants:
Lifestage of Participants:
Prenatal, Infant (0-1 year)
Tetrachloroethylene (PCE)
Health Outcomes:
Oral clefts, Central nervous system defects, Male genital defects, Stillbirths due to placental dysfunction
Brief Description:
This is a population-based case-control study examining the connection between prenatal exposure to tetrachloroethylene (PCE) through drinking and the development of adverse pregnancy outcomes. It uses a source population of 268,339 livebirths and stillbirths whose public drinking water was contaminated with PCE between 1969 and 1995. The group has identified cases of oral clefts, central nervous system defects, male genital defects and stillbirths due to placental dysfunction and controls that were unaffected. Prenatal exposure to PCE is being assessed using a fate and transport model in a geographic information system (GIS) platform.

Related NIEHS-Funded Projects

Projects listed supported initial development of the epidemiological resource, added study participants, collected additional information or samples from study participants, and/or used samples or datasets derived from the resource.

Project 1: Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water

Grant Number:
Principal Investigator:
Aschengrau, Ann
Boston University
Most Recent Award Year:
Additional Details
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