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Your Environment. Your Health.

Michigan PBB Cohort

Principal Investigator:
Marcus, Michele
Institution:
Emory University
Location:
Michigan
Number of Participants:
4000
Lifestage of Participants:
Prenatal, Infant (0-1 year), Adult (18+ years), Transgenerational
Exposures:
Polybrominated biphenyls (PBBs), Polybrominated diphenyl ethers (PBDEs), Polychlorinated biphenyls (PCBs), Dichlorodiphenyltrichloroethane/Dichlorodiphenyldichloroethylene (DDT/DDE)
Health Outcomes:
Birth outcomes, Sex ratio, Fertility, Growth, Premature/Delayed puberty, Menstrual function, Thyroid function, Steroid hormones, Semen characteristics
Brief Description:
This is a multi-generational cohort study to assess the effects of polybrominated biphenyl (PBB) exposure on a number of outcomes in men and women and their offspring after a widespread exposure incident in 1973. The Michigan PBB Registry was established in 1976 and enrolled approximately 4,000 farmers, chemical workers, and others with PBB exposure risk; children and grandchildren of original registrants have also been enrolled.

Related NIEHS-Funded Projects

Projects listed supported initial development of the epidemiological resource, added study participants, collected additional information or samples from study participants, and/or used samples or datasets derived from the resource.

Collaborative Research and Action: Empowering an Exposed Community

Grant Number:
Principal Investigator:
Marcus, Michele
Institution:
Emory University
Most Recent Award Year:
2016
Additional Details

Genetic Biomarkers of Polybrominated Biphenyl (PBB) Exposure

Grant Number:
Principal Investigator:
Smith, Alicia K (contact); Conneely, Karen
Institution:
Emory University
Most Recent Award Year:
2015
Additional Details

Evaluation and Validation of Dried Blood Spots as Matrix for Exposure Assessment

Grant Number:
Principal Investigator:
Barr, Dana Boyd
Institution:
Emory University
Most Recent Award Year:
2014
Additional Details

Brominated Flame Retardants: Multigenerational Endocrine Disruption?

Grant Number:
Principal Investigator:
Marcus, Michele
Institution:
Emory University
Most Recent Award Year:
2010
Additional Details