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Your Environment. Your Health.

Children with in utero Arsenic Exposure: Bangladesh

Principal Investigator:
Christiani, David
Institution:
Harvard University
Location:
Bangladesh
Number of Participants:
1,613 Pregnant women and 1,189 Mother-infant pairs
Lifestage of Participants:
Prenatal, Infant (0-1 year), Youth (1-18 years)
Exposures:
Arsenic, Lead, Manganese, Cadmium
Health Outcomes:
Birth outcomes, Immune function, Neurodevelopmental outcomes
Brief Description:
This is a prospective birth cohort study in Bangladesh examining the impact of chronic arsenic exposure on birth, neurodevelopmental, and respiratory outcomes. A total of 1,613 pregnant mothers were recruited from Sirajdikhan and Pabna Sadar Upazilas Districts of Bangladesh from 2008-2011. Women were eligible to participate if they were 18 years or older with an ultrasound confirmed singleton pregnancy of ≤16 weeks gestation, used a tube well as their primary source of drinking water and had been using the same drinking water source for at least six months, and intended to live in her current residence throughout pregnancy. At the end of follow-up, 1,189 livebirths, 259 preterm births, 72 stillbirths, and 132 miscarriages were recorded. The neurodevelopment study involves continued follow-up of 812 children.

Related NIEHS-Funded Projects

Projects listed supported initial development of the epidemiological resource, added study participants, collected additional information or samples from study participants, and/or used samples or datasets derived from the resource.

Developmental Exposure to Arsenic and Immune Function in Children

Grant Number:
Principal Investigator:
Kile, Molly L
Institution:
Oregon State University
Most Recent Award Year:
2014
Additional Details

Project 1: Epidemiology of Developmental Windows, Metal Mixtures

Grant Number:
Principal Investigator:
Wright, Robert O (Contact); Bellinger, David
Institution:
Harvard University
Most Recent Award Year:
2010
Additional Details

Project 2: Genetic Epidemiology of Neurodevelopmental Metal Toxicity

Grant Number:
Principal Investigator:
Christiani, David C (Contact); Bellinger, David
Institution:
Harvard University
Most Recent Award Year:
2010
Additional Details

Neurodevelopmental Effects of Early Life Arsenic Exposure

Grant Number:
Principal Investigator:
Mazumdar, Maitreyi
Institution:
Children's Hospital Boston
Most Recent Award Year:
2009
Additional Details

Arsenic Exposure and Birth Outcomes in Bangladesh

Grant Number:
Principal Investigator:
Christiani, David C
Institution:
Harvard University
Most Recent Award Year:
2007
Additional Details
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