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Your Environment. Your Health.

NIEHS-Funded Epidemiology Resources

The NIEHS has made substantial investment in environmental epidemiology research studies. This webpage provides general information for the public and grantees to exhibit the breadth of these resources and to facilitate collaborations. The data listed in the table below can be queried by entering a term into the search box at the top of the table. The displayed results will be limited to records that contain an exact match to the search term entered. Additional information about related NIEHS-funded projects is available by following the linked names in the Epidemiology Resource column. Examples of additional information include: number of participants, biosamples collected, environmental samples collected, genes and other DNA products studied, and more.

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Epidemiology Resource Principal Investigator Lifestage1 Outcomes

Exposures
Location
A Study to Understand the Mechanisms of Asthma Dietary Interventions to Protect Against Environmental Triggers (Asthma-DIET)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7325155)
Brief Description
This is a longitudinal study examining how diet may affect susceptibility to asthmatic triggers from in-home pollutants among 200 inner city Baltimore children. Previous NIEHS-funded studies from the same catchment area have addressed similar outcomes.
Diette, Gregory Youth, Adulthood Asthma, Airway inflammation/Hyperresponsiveness

Allergens, Nutrition/Diet, NO/NO2, Particulate matter, Environmental tobacco smoke
Baltimore, Maryland
Airborne Exposures to Persistent Organic Pollutants (AESOP)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7936633)
Brief Description
This is a study to examine sources, exposures, and body burden of congener-specific polychlorinated biphenyls (PCBs) and hydroxylated polychlorinated biphenyl (OH-PCB) exposures in children and their mothers residing in an urban area where dredging of PCB-contaminated sediment is occurring and a rural area without known industrial legacy contamination.
Thorne, Peter S Youth, Adulthood Exposomics, Metabolomics, Obesity

PCBs
East Chicago, Illinois; Columbus Junction and Louisa County, Iowa
Arsenic and Cancer Incidence in Northern Chile()
Brief Description
This is a case-control study designed to examine the impact of in utero arsenic exposure and the risk of cancer in young adults in Northern Chile. The study has recruited over 1,000 participants since 2007.
Steinmaus, Craig; Ferreccio, Catterina Prenatal, Infant, Youth, Adulthood Breast cancers, Lung cancer, Prostate cancer, Bladder cancer

Arsenic
Chile, Region I (including Arica) and Region II (including Antofagasta)
BCERP: Cohort Study of Young Girls' Nutrition, Environment, and Transitions (CYGNET)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8010777)
Brief Description
This is a children's cohort study examining the influence of environmental exposures, life-style factors, and genetics on the timing of puberty in the San Francisco area. The study enrolled approximately 400 girls 6-8 years of age and is one of three study sites of the Breast Cancer and the Environment Research Program (BCERP) Puberty Study initiated in 2003.
Kushi, Lawrence Youth Premature/Delayed puberty, Breast cancers

Hormonal mimics/Hormones
San Francisco, California
BCERP: Growing Up Female(http://projectreporter.nih.gov/project_info_description.cfm?aid=8011003)
Brief Description
This is a children's cohort study examining the influence of environmental exposures, life-style factors, and genetics on the timing of puberty among young girls residing in the greater Cincinnati area. The study enrolled approximately 400 girls 6-7 years of age and is one of three study sites of the Breast Cancer and the Environment Research Program (BCERP) Puberty Study initiated in 2003.
Biro, Frank Youth Metabolic syndrome, Obesity/Body weight, Premature/Delayed puberty, Breast cancers

Phytoestrogens, Psychosocial stress, PFOA, Perchlorates, Phthalates
Cincinnati, Ohio
BCERP: Growing Up Healthy (http://projectreporter.nih.gov/project_info_description.cfm?aid=8011122)
Brief Description
This is a children's cohort study examining the influence of environmental exposures, life-style factors, and genetics on the timing of puberty among girls residing in East Harlem, New York City. The Growing Up Healthy study enrolled approximately 400 girls 7-8 years of age and is one of three study sites of the Breast Cancer and the Environment Research Program (BCERP) Puberty Study initiated in 2003.
Wolff, Mary S Youth Obesity/Body weight, Growth, Premature/Delayed puberty

Hormonal mimics/Hormones, Nutrition/Diet, Psychosocial stress, Built environment
New York, New York
Biomarkers of Exposure to Arsenic (BEAR) (http://projectreporter.nih.gov/project_info_description.cfm?aid=7984435)
Brief Description
This is a birth cohort study designed to examine the association between inorganic arsenic exposure during pregnancy and outcomes in children in Gomez Palacio, Mexico. The study has recruited over 200 pregnant women since 2011.
Fry, Rebecca Prenatal, Infant Birth outcomes

Arsenic
Gomez Palacio, Mexico
COPD and Domestic Endotoxin (CODE)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8477814)
Brief Description
This was an observational study designed to understand whether indoor pollutant concentrations in homes of former smokers with chronic obstructive pulmonary disease (COPD) affect respiratory morbidity. The study enrolled 84 participants.
Hansel, Nadia Adulthood Chronic obstructive pulmonary disease (COPD), Morbidity/Mortality, Asthma

Extreme heat, Physical and non-chemical stress, NO/NO2, Particulate matter
Not Specified
Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7852911)
Brief Description
This is a pregnancy study examining the effects, including the cumulative effects, of chemicals and other factors in the environment on children’s health among pregnant women and children living in the Salinas Valley, California. This study has enrolled approximately 600 participants since 1999.
Eskenazi, Brenda Prenatal, Infant, Youth, Adulthood Asthma, Allergic response, Birthweight, Gestation length, Metabolic syndrome, Neurobehavioral outcomes, Neurodevelopmental outcomes, Obesity/Body weight, Premature/Delayed puberty, Respiratory outcomes, Thyroid dysfunction, Dental health

BPA, DDT/DDE, Manganese, Pesticides, Organophosphate flame retardants, PBDEs, Phthalates, Triclosan, Arsenic, Cadmium, Lead, Zinc
Salinas, California
Childhood Autism Risks from Genetics and Environment (CHARGE)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7189289)
Brief Description
This is a case-control study to examine children's autism risk factors in California. The study has recruited over 1,800 participants since 2003.
Hertz-Picciotto, Irva; Pessah, Isaac Pre-conception, Prenatal, Infant, Youth, Adulthood Autism spectrum disorder (ASD), Neurobehavioral outcomes, Neurodevelopmental outcomes, Immune function

Me/MeHg, Metals, PBDEs, PCBs, Pyrethroids, Fipronil, Phthalates, Triclosan, Triclocarban
California
Children with in utero Arsenic Exposure: Bangladesh(http://projectreporter.nih.gov/project_info_description.cfm?aid=7246286)
Brief Description
This is a prospective birth cohort study in Bangladesh examining the impact of chronic arsenic exposure on birth, neurodevelopmental, and respiratory outcomes. A total of 1,613 pregnant mothers were recruited from Sirajdikhan and Pabna Sadar Upazilas Districts of Bangladesh from 2008-2011. Women were eligible to participate if they were 18 years or older with an ultrasound confirmed singleton pregnancy of ≤16 weeks gestation, used a tube well as their primary source of drinking water and had been using the same drinking water source for at least six months, and intended to live in her current residence throughout pregnancy. At the end of follow-up, 1,189 livebirths, 259 preterm births, 72 stillbirths, and 132 miscarriages were recorded. The neurodevelopment study involves continued follow-up of 812 children.
Christiani, David Prenatal, Infant, Youth Birth outcomes, Immune function, Neurodevelopmental outcomes

Arsenic, Lead, Manganese, Cadmium
Bangladesh
Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8295885)
Brief Description
CCAAPS is a longitudinal cohort study of children born in the greater Cincinnati, Ohio region. CCAAPS seeks to estimate the association between traffic related air pollution, specifically diesel exhaust particles and: 1) the development of allergic disease and asthma, and 2) neurobehavioral outcomes in childhood. The study has recruited 762 participants from the Greater Cincinnati/Northern Kentucky area since 2001.
Ryan, Patrick (Lemasters, Grace) Youth Asthma, Atopy, Lung function, Neurological/Cognitive outcomes

Particulate matter, Traffic pollutants, Diesel exhaust, Allergens, Mold, Environmental tobacco smoke, Housing/Community characteristics
Ohio
Cincinnati Lead Study (CLS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7246949)
Brief Description
This is a birth cohort study designed to examine the relationship between perinatal lead and manganese exposure, genotypic variances, and neuroanatomical anomalies, with adult criminal behavior and attention deficit hyperactivity disorder (ADHD) in Cincinnati, Ohio. The study has recruited over 300 subjects since 1979.
Dietrich, Kim Prenatal, Infant, Youth, Adulthood Adult attention deficit hyperactivity disorder (ADHD), Neurobehavioral outcomes, Neurodevelopmental outcomes, Osteoporosis

Lead, Manganese
Cincinnati, Ohio
Composite and Urinary Bisphenol A Study()
Brief Description
The study is a follow-up investigation to the New England Children's Amalgam Trial (NECAT) study to examine the potential for bisphenol A (BPA)-related negative health effects of dental composites in children, including weight gain, behavioral problems, neuropsychological function, and immune function. The study will leverage follow-up of 534 children from two communities (one in rural Maine and one in urban Massachusetts) enrolled in the original NECAT trial as well as enroll approximately 100 new children to determine urinary BPA exposure effects of these dental materials.
Maserejian, Nancy Nairi Youth Neurobehavioral outcomes, Neurodevelopmental outcomes, Obesity/Body weight, Immune function

BPA
Boston/Cambridge, Massachusetts; Farmington, Maine
DNA Repair in Head and Neck Cancer(http://projectreporter.nih.gov/project_info_description.cfm?aid=7467113)
Brief Description
This is a case-control study examining the impact of alcohol, smoking, and genetic polymorphisms on risk of squamous cell carcinoma of the head and neck in Texas. The study has collected 3,200 DNA samples since 2001.
Wei, Qingyi Adulthood Cancer outcomes

Tobacco smoke, Alcohol
Texas
Deep Water Horizon: Gulf Resilience on Women's Health (http://projectreporter.nih.gov/project_info_description.cfm?aid=8239654)
Brief Description
This is a prospective study designed to assess the long-term health effects of the 2010 Gulf of Mexico oil spill in Mississippi, Louisiana, and Texas. The study includes 250 pregnant and non-pregnant women each, from two affected communities, and an additional 1,000 pregnant women will be recruited to allow examination of the effects of disasters and environmental exposures on birth outcomes.
Lichtveld, Maureen Adulthood Mental health outcomes, Low birthweight, Preterm birth, Fertility

Foodborne PAHs, Psychosocial stress, Lead, Cadmium, Mercury, VOCs, Environmental disaster
New Orleans, Louisiana
Deep Water Horizon: Women and Their Children's Health (WaTCH)()
Brief Description
This is a longitudinal study examining the short- and long-term health effects from the 2010 Deepwater Horizon oil spill in Louisiana. The study plans on enrolling 2,500 women and 800 children from 2012 to 2017.
Trapido, Edward Youth, Adulthood Neurological outcomes, Respiratory outcomes, Immunologic outcomes, Reproductive outcomes

Environmental disaster, Nutrition/Diet, Arsenic, Cadmium, Chromium, Nickel, Manganese, Lead, Resiliency
Southeast Louisiana
Early Autism Risk Longitudinal Investigation (EARLI)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7277515)
Brief Description
This was a multi-site prospective cohort study of pregnant mothers who already have an autistic child. The study enrolled 225 siblings of austism spectrum disorder (ASD) probands to examine possible environmental risk factors for autism and study whether there is any interplay between environmental factors and genetic susceptibility.
Newschaffer, Craig Prenatal, Infant, Youth Autism spectrum disorder (ASD), Neurodevelopmental outcomes

Brominated compounds, PCBs, Pesticides, PAHs, Parabens, Phenols, Phthalates, Metals, Traffic-related air pollutants, Particulate matter, NO/NO2, Ozone
Pennsylvania; Maryland; California
Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT)()
Brief Description
This is a group of three sequentially-enrolled, on-going, epidemiologic birth cohort studies in Mexico City with an original aim to investigate the impact of lead on child development. The research aims have since expanded to include a wide range health outcomes and environmental, nutritional, behavioral, genetic, and epigenetic risk factors. Children enrolled in the study were born beginning in 1994 through 2011 and were evaluated every 3-6 months during the first 3 years of life.
Hu, Howard; Peterson, Karen; Hernandez-Avila, Mauricio; Tellez-Rojo, Martha Maria Prenatal, Infant, Youth Allergic response, Autoimmune outcomes, Birthweight, Metabolic syndrome, Neurobehavioral outcomes, Neurodevelopmental outcomes, Obesity/Body weight, Premature/Delayed puberty, Dental health

Lead, Arsenic, Cadmium, Chromium, Copper, Manganese, Me/MeHg, Fluorinated Compounds, Nutrition/Diet, BPA, Phthalates, Psychosocial Stress, Environmental tobacco smoke, Air Pollution, Zinc
Mexico City, Mexico
Early Markers for Autism (EMA) Study (http://projectreporter.nih.gov/project_info_description.cfm?aid=7781279)
Brief Description
This is a nested case-control study to examine biological markers of susceptibility and exposure for autism in Orange, San Diego, and Imperial Counties, California. This study included around 1,200 mother-infant pairs.
Croen, Lisa Prenatal, Infant, Youth Autism spectrum disorder (ASD), Developmental delay

Organochlorine pesticides, PBDEs, PCBs, PFCs, Air pollutants
Oakland, California
Egyptian Agricultural Workers(http://projectreporter.nih.gov/project_info_description.cfm?aid=8411398)
Brief Description
This is a longitudinal study that examines biomarkers of pesticide exposure on neurological function in adolescent pesticide applicators in Egypt.
Rohlman, Diane Youth, Adulthood Neurobehavioral outcomes, Attention deficit hyperactivity disorder (ADHD), Lung function

Organophosphates, Pyrethroids, Chlorpyrifos
Egypt
Environment and Reproductive Health (EARTH) Study(http://projectreporter.nih.gov/project_info_description.cfm?aid=7584949)
Brief Description
This study is designed to determine the developmental and reproductive toxicity of phthalates and phenols in couples from a fertility clinic. Men and women were recruited at preconception and followed through treatment cycles for infertility and through pregnancy until delivery. Associations between environmental exposures and markers of male fertility and female fertility and pregnancy outcomes were investigated.
Hauser, Russ Pre-conception, Prenatal Birth outcomes, Reproductive outcomes, Fertility

BPA, PBDEs, Phthalates, Other EDCs
Massachusetts
Faroe Islands Birth Cohorts(http://projectreporter.nih.gov/project_info_description.cfm?aid=8437872)
Brief Description
This is a group of birth cohort studies recruited in the Faroe Islands at intervals between 1986 and 2008 and designed to examine the effects of environmental chemicals on postnatal development with a main focus on neurobehavioral functions, metabolic outcomes and immune system responses to vaccinations in the Faroe Islands. The initial cohort recruited over 1,000 participants born between 1986 and 1987 with follow-up examinations at ages 7, 14, 22 years, the most recent follow-up, at age 28, has just been completed. A smaller cohort has been followed up to age 10 years. The third cohort includes around 650 participants with follow-up completed through age 13 years. The youngest cohort of close to 500 births has so far been followed through to age 5.
Grandjean, Philippe; Weihe, Pál Prenatal, Infant, Youth, Adulthood Immune response, Allergic response, Diabetes, Metabolic syndrome, Obesity/Body weight, Cardiovascular outcomes, Neurobehavioral outcomes

PFASs, Me/MeHg, PCBs, HCB, Dioxins, DDT/DDE
Faroe Islands
Great Lakes Fish Consumption and PCB Exposure(http://projectreporter.nih.gov/project_info_description.cfm?aid=7782956)
Brief Description
This is a birth cohort study that examines developmental outcomes due to prenatal exposure to toxicants in Oswego, New York. The study recruited 202 children from 1990 to 1993.
Stewart, Paul Prenatal, Youth, Adulthood Diabetes, Obesity/Body weight, Neurodevelopmental outcomes

PCBs, Dioxins, DDT/DDE, PBDEs
Oswego, New York
Gulf Coast Health Alliance: Health Risks related to the Macondo Spill (GC-HARMS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8238772)
Brief Description
This is a prospective study designed to assess the long-term health effects of the 2010 Gulf of Mexico oil spill in Mississippi, Louisiana, and Texas. The study includes 100 participants from each of the three research sites and 100 from a comparison site.
Elferink, Cornelis Not Specified Not Specified

Foodborne PAHs, Smoking, Psychosocial stress
Gulfport, Mississippi; Biloxi Mississippi; Galveston, Texas; Southeast Louisiana
Health Effects of Arsenic Longitudinal Study (HEALS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8262904)
Brief Description
This large prospective cohort study is based on individual-level data from a population exposed to a wide range of inorganic arsenic from drinking water in Araihazar, Bangladesh. Since 2000, the study has recruited more than 35,000 men and women.
Ahsan, Habibul; Graziano, Joseph Youth, Adulthood Atherosclerosis, Cardiovascular disease, Coronary artery disease, Diabetes, Immune function, Lung function, Skin cancer, Skin lesions

Arsenic, Nutrition/Supplements
Araihazar, Bangladesh
Health Outcomes and Measures of the Environment (HOME) Study(http://projectreporter.nih.gov/project_info_description.cfm?aid=8159870)
Brief Description
This is a birth cohort study in Cincinnati to evaluate the impact of low-level fetal and early childhood chemical exposures on health, developmental, and behavioral outcomes. The study recruited over 400 pregnant women between 2003 to 2006. Offspring have been followed to age 8 years, and new follow-up at age 12 years is ongoing for 410 live-born children, all are eligible for continued follow-up.
Lanphear, Bruce; Yolton, Kimberly; Braun, Joseph; Chen, Aimin Prenatal, Infant, Youth Attention deficit hyperactivity disorder (ADHD), Asthma, Infectious disease/infection, Neurobehavioral outcomes, Obesity, Thyroid function, Physical injury, Growth

Phenols, BPA, Triclosan, Flame retardants, PFASs, Phthalates, Environmental tobacco smoke, PCBs, Lead, Me/MeHg, Pesticides, Built environment
Cincinnati, Ohio
Home Observation of Periconceptional Exposures (HOPE) Study (http://projectreporter.nih.gov/project_info_description.cfm?aid=8182055)
Brief Description
This is a peri-conceptional cohort of couples to examine the associations between bisphenol A (BPA) and disinfection by-product levels around the time of ovulation or conception on semen quality and time to pregnancy, and evaluate the degree of potential bias introduced by common retrospective exposure assessment methods.
Porucznik, Christina A Adulthood, In utero among couples that conceived Fertility

BPA, Disinfection by-products
Salt Lake City, Utah
Honduran Families Using Cook Stoves(http://projectreporter.nih.gov/project_info_description.cfm?aid=8501114)
Brief Description
This is a cross-sectional study designed to compare novel exposure measurements and health outcomes between women from households with cleaner-burning stoves and open-fire cook stoves in Rio Guacerique, Honduras. The study plans to enroll 150 households (75 of each stove type).
Peel, Jennifer Adulthood Blood pressure, Augmentation index, Metabolic syndrome, Blood lipids, HbA1c, Systemic inflammation, Exhaled nitric oxide, Self-reported symptoms, Telomere length

Particulate matter, Carbon monoxide (CO), Elemental carbon, Organic carbon, Endotoxin
Rio Guacerique, Honduras
Marietta Community Actively Researching Exposure Study (CARES)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7429169)
Brief Description
This is a cohort study designed to explore the health effects of long term manganese exposure in children living in Washington, Columbiana, and Guernsey Counties in Ohio, Hancock and Wood Counties in West Virginia and Beaver County in Pennsylvania. Participants were recruited from 2008 to 2014.
Haynes, Erin Youth Neurobehavioral outcomes, Neurodevelopmental outcomes

Manganese, Lead, Environmental tobacco smoke
Ohio; West Virginia; Pennsylvania
Markers of Autism Risk in Babies-Learning Early Signs (MARBLES)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8164089)
Brief Description
This is a longitudinal study investigating perinatal biological and environmental risk factors of autism among women who have a biological child with autism.
Hertz-Picciotto, Irva Prenatal, Infant, Youth Autism spectrum disorder (ASD), Neurodevelopmental outcomes, Neurobehavioral outcomes, Immune function

PBDEs, Pyrethroids, PCBs, Phthalates, Folic acid, Traffic-related air pollutants, Particulate matter, NO/NO2, Ozone, PAHs
Sacramento-Davis area, California
Mexico City Air Pollution and Birth Outcomes(http://projectreporter.nih.gov/project_info_description.cfm?aid=7539025)
Brief Description
This is a birth cohort study designed to examine whether air pollution and inflammation act together to influence pregnancy outcomes in Mexico City, Mexico. Critical time windows of exposure during pregnancy will also be examined. The study has recruited 800 participants since 2008.
O'Neill, Marie Sylvia Prenatal, Infant Birthweight, Birth length, Gestational age, Head circumference, Immunosuppression

Particulate matter, CO/CO2, NO/NO2, Ozone, PAHs, SOx, Nutrition/Diet
Mexico City, Mexico
Michigan PBB Cohort(http://projectreporter.nih.gov/project_info_description.cfm?aid=7887912)
Brief Description
This is a multi-generational cohort study to assess the effects of polybrominated biphenyl (PBB) exposure on a number of outcomes in men and women and their offspring after a widespread exposure incident in 1973. The Michigan PBB Registry was established in 1976 and enrolled approximately 4,000 farmers, chemical workers, and others with PBB exposure risk; children and grandchildren of original registrants have also been enrolled.
Marcus, Michele Prenatal, Infant, Adult, Transgenerational Birth outcomes, Sex ratio, Fertility, Growth, Premature/Delayed puberty, Menstrual function, Thyroid function, Steroid hormones, Semen characteristics

PBBs, PBDEs, PCBs, DDT/DDE
Michigan
Mother-Offspring Neurodevelopment in Rural China(http://projectreporter.nih.gov/project_info_description.cfm?aid=8433755)
Brief Description
This is a birth cohort study in Guangxi province, China designed to examine the association between prenatal exposure to methylmercury from rice consumption and child neurodevelopmental outcomes. The study enrolled subjects from 2013-2014.
Rothenberg, Sarah Prenatal, Infant, Youth Neurodevelopmental outcomes

Me/MeHg
Guangxi province, China
Navajo Uranium Assessment and Kidney Health Project (NUAKHP)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7068731)
Brief Description
This is a community-level survey to assess water quality and usage patterns and examine the influence of uranium exposure from mining and processing on tribal lands on chronic kidney disease in the Navajo Nation. Approximately 1,300 study participants were enrolled into the project.
Lewis, Johnnye Adulthood Kidney outcomes

Uranium
20 Navajo communities in northwestern New Mexico
New Bedford Cohort(http://projectreporter.nih.gov/project_info_description.cfm?aid=7132131)
Brief Description
This is a birth cohort study examining the association of perinatal polychlorinated biphenyl (PCBs), dichlorodiphenyldichloroethylene (DDE), and lead exposure on children's growth and development. The study recruited 790 mother-child pairs living near the New Bedford Superfund site between 1993 and 1998.
Korrick, Susan Prenatal, Youth Neurobehavioral outcomes

PCBs, DDT/DDE, Lead, Arsenic, Manganese, Me/MeHg, HCB, BPA, Phthalates
New Bedford, Massachusetts
New England Children's Amalgam Trial (NECAT)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8105865)
Brief Description
The study is a follow-up investigation to the New England Children's Amalgam Trial (NECAT) study to examine the potential for bisphenol A (BPA)-related negative health effects of dental composites in children, including weight gain, behavioral problems, neuropsychological function, and immune function. The study will leverage follow-up of 534 children from two communities (one in rural Maine and one in urban Massachusetts) enrolled in the original NECAT trial as well as enroll approximately 100 new children to determine urinary BPA exposure effects of these dental materials.
McKinlay, Sonja M Child, Adolescent Immune Outcomes, Metabolic Outcomes, Neurological and Cognitive Outcomes | Hormonal Mimics and Hormones Boston/Cambridge, MA; Farmington, ME
New York City Mothers and Newborns Study(http://projectreporter.nih.gov/project_info_description.cfm?aid=7209146)
Brief Description
This is a birth cohort study that examines the effects of early life exposures to air pollutants, pesticides, and environmental tobacco smoke on children's growth and development in New York City. The study has recruited approximately 725 pregnant mothers since 1998.
Perera, Frederica Prenatal, Infant, Youth Allergic response, Asthma, Birth weight/Length, Gestational age, Head circumference, Metabolic syndrome, Neurobehavioral outcomes, Neurodevelopmental outcomes, Obesity/Body weight, Thyroid dysfunction

Black carbon, BPA, Chlorpyrifos, Environmental tobacco smoke, Nickel, PAHs, PBDEs, Phthalates, Pyrethroids, Traffic pollutants, Vanadium
New York City, New York
Northern California Childhood Leukemia Study (NCCLS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7852178)
Brief Description
This is a population-based case-control study to examine the relationship between environmental exposures, gene susceptibility, and childhood leukemia. The study was initiated in 1995 and has undergone multiple phases of enrollment with the goal of including approximately 1,000 leukemia cases.
Metayer, Catherine Youth Childhood leukemia

Air pollutants, Brominated compounds, Chlorinated compounds
California
Pesticide Exposure and Childhood Autism(http://projectreporter.nih.gov/project_info_description.cfm?aid=8638824)
Brief Description
This is a retrospective cohort using existing data from the California Department of Developmental Services database designed to examine the association between pesticide exposure and autism risk in California. The study will include at least 20,000 cases and 200,000 controls using birth records of all California children born 1997-2009.
Von Ehrenstein, Ondine Pre-conception, Prenatal, Infant, Youth Autism spectrum disorder (ASD)

Agricultural pesticides, Organophosphates, Carbamates, Organochlorines
California
Prenatal Environmental Determinants of InterGenerational Risk (PEDIGREE)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8011387)
Brief Description
This is an ancillary study to the Child Health and Development Studies (CHDS) cohort to examine the influence of early life exposure to organochlorines and breast cancer risk. PEDIGREE enrolled approximately 400 adult daughters of CHDS mother-infant pairs originally enrolled in the 1960s.
Cohn, Barbara; Terry, Mary Beth Prenatal, Youth, Adulthood, Transgenerational Breast cancers

PCBs, Organochlorines, DDT/DDE
Oakland, California
Prenatal Exposure to BPA/Phthalates: Infant Physical and Behavioral Development(http://projectreporter.nih.gov/project_info_description.cfm?aid=8678914&icde=24615776)
Brief Description
This is a birth cohort study that examines prenatal exposure to endocrine disrupting chemicals and physical and behavioral characteristics in infants.
Schantz, Susan Prenatal, Infant, Youth Neurobehavioral outcomes, Neurodevelopmental outcomes

BPA, Phthalates, Benzophenone-3, Parabens, Triclosan, Chlorinated compounds
Urbana, Illinois
Prenatal PCE Exposure in New England()
Brief Description
This is a population-based case-control study examining the connection between prenatal exposure to tetrachloroethylene (PCE) through drinking and the development of adverse pregnancy outcomes. It uses a source population of 268,339 livebirths and stillbirths whose public drinking water was contaminated with PCE between 1969 and 1995. The group has identified cases of oral clefts, central nervous system defects, male genital defects and stillbirths due to placental dysfunction and controls that were unaffected. Prenatal exposure to PCE is being assessed using a fate and transport model in a geographic information system (GIS) platform.
Aschengrau, Ann Prenatal, Infant Oral clefts, Central nervous system defects, Male genital defects, Stillbirths due to placental dysfunction

PCE
Massachusetts; Rhode Island
Programming Research in Environment and Social Stressors (PROGRESS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8708859)
Brief Description
This is a birth cohort study designed to examine the effects of prenatal exposures to bisphenol A (BPA) and phthalates on childhood obesity, metabolic dysfunction, and cord blood DNA methylation in Mexico. The study has enrolled over 300 mother-child pairs since 2012.
Baccarelli, Andrea; Wright, Robert Prenatal, Infant, Youth, Adulthood Cardiovascular outcomes, Diabetes, Metabolic syndrome, Obesity/Body weight

BPA, Phthalates, Psychosocial stress
Mexico
Russian Children's Study(http://projectreporter.nih.gov/project_info_description.cfm?aid=8038775)
Brief Description
This is a prospective children’s cohort study designed to examine the association of dioxins, furans, polychlorinated biphenyls (PCB), arsenic, and lead on growth and pubertal development among 500 boys in Chapaevsk, Russia. Peripubertal boys at 8 to 9 years of age, and their mothers, were recruited between 2003 and 2005. The boys were followed until 21 years of age and provided semen samples to assess markers of fertility in relation to early life environmental exposures.
Hauser, Russ Youth, Adulthood Premature/Delayed puberty, Growth, Metabolic outcomes, Hypertension

Arsenic, Lead, Dioxins, Furans, PCBs
Chapayevsk, Russia
SPIROMICS - Air Pollution Study(http://projectreporter.nih.gov/project_info_description.cfm?aid=8613581)
Brief Description
This is an ancillary study to the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) to examine the effects of indoor and outdoor air pollution on COPD-associated morbidity. SPIROMICS will enroll approximately 3,200 participants, to which SPIROMICS-Air will add a home assessment questionnaire for all participants, ambient air pollution exposure modeling, and indoor air monitoring on a subset of participants.
Hansel, Nadia; Kaufman, Joel Adulthood Chronic obstructive pulmonary disease (COPD)

NO/NO2, Ozone, Particulate matter, Environmental tobacco smoke
Birmingham, Alabama; Los Angeles, California; San Francisco, California; Denver, Colorado; Baltimore, Maryland; New York, New York; Winston-Salem, North Carolina; Philadelphia, Pennsylvania; Salt Lake City, Utah
Seveso Women’s Health Study Follow Up(http://projectreporter.nih.gov/project_info_description.cfm?aid=7319510)
Brief Description
This is an historical cohort study investigating the effects of dioxin exposure on the reproductive health of women exposed during a 1976 industrial accident in Seveso, Italy. Between 1996 and 1998, the study enrolled approximately 1,000 women exposed during the initial incident.
Eskenazi, Brenda; Warner, Marcella Prenatal, Infant, Youth, Adulthood, Transgenerational Bone density, Fertility, Fibroids, Breast cancers, Diabetes, Metabolic syndrome, Thyroid function, Neurodevelopmental outcomes, Obesity/Body weight, Premature/Delayed puberty

TCDD, Organophosphates
Seveso, Italy
Seychelles Child Development and Nutrition Study (SCDNS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8008582)
Brief Description
This study, which began in the mid-1980s, includes several large cohorts of children whose mothers consumed fish frequently during their pregnancy. The study objective is to determine if prenatal methylmercury exposure from fish consumption has adverse effects on the children’s neurodevelopment as well as to document child development in the Seychelles. The Main cohort was recruited in 1989 and is comprised of 779 children. A subsequent Nutrition cohort (NC1) of 300 mothers was enrolled in 2001 during their first trimester of pregnancy. Most recently, a second Nutrition cohort (NC2) of 1,535 mother-child pairs was enrolled between 2008 and 2011.
Davidson, Philip Prenatal, Infant, Youth, Adulthood Cardiovascular outcomes, Neurobehavioral outcomes, Neurodevelopmental outcomes

Me/MeHg, Nutrition/Diet, PUFA
The Seychelles
Study of Traffic, Air Quality and Respiratory health (STAR)(http://projectreporter.nih.gov/project_info_description.cfm?aid=8759108)
Brief Description
The STAR study examined the role of exposures to indoor allergens and indoor and outdoor nitrogen dioxide (NO2) on the severity of asthma. The study enrolled approximately 1,400 asthmatic children ages 5-11 years old from urban and suburban Connecticut and Massachusetts between 2006 and 2009. This study led to an intervention trial to test the efficacy of indoor air cleaners in reducing NO2 exposure and improving health in asthmatic children.
Leaderer, Brian Youth Asthma severity

NO2, Allergens
Connecticut; Massachusetts
The Children's Health Study (CHS)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7434307)
Brief Description
This is a prospective study examining the roles of the environment and genetic susceptibility in children's respiratory health in Southern California. The study has recruited over 11,000 school children living in southern California.
Gilliland, Frank Prenatal, Infant, Youth, Adulthood, Transgenerational Airway hyperreactivity, Allergic response, Asthma, Lung function, Coronary artery disease, Diabetes, Obesity/Body weight, Metabolic syndrome, Neurobehavioral outcomes, Neurodevelopmental outcomes, Mental health

Traffic-related air pollutants, NO/NO2, Ozone, PAHs, Particulate matter, Diesel exhaust particles, Elemental carbon, Environmental tobacco smoke, Metals, Psychosocial stress
Southern California
The Infant Development and Environment Study (TIDES)(http://projectreporter.nih.gov/project_info_description.cfm?aid=7728916)
Brief Description
This is a multi-site pregnancy study examining how the mother’s exposure to everyday chemicals while pregnant may affect the developing fetus. The study recruited approximately 1,000 pregnant women in 2010-2012 and examined 758 children at birth.
Swan, Shanna Prenatal, Infant, Youth Reproductive tract malformations, Anogenital distance, Ano-scrotal distance, Penile width, Testicular volume and location, Placental hormone expression, Placental damage, Anthropometric outcomes, Neurodevelopmental outcomes, Blood pressure

Phthalates, Psychosocial stress
Rochester, New York; Seattle, Washington; Minneapolis, Minnesota; San Francisco, California
The New Hampshire Birth Cohort Study(http://projectreporter.nih.gov/project_info_description.cfm?aid=8533618)
Brief Description
This is a prospective pregnancy cohort study of mothers who use private wells for household water in New Hampshire designed to evaluate maternal/child health impacts of arsenic and other contaminants. The study has recruited over 1,500 mother-infant pairs (over 3,000 individuals) since 2009.
Karagas, Margaret Prenatal, Infant, Youth, Adulthood Birthweight, Gestational age, Growth, Cardiovascular disease, Allergic response, Asthma, Immune function, Infection, Neurobehavioral outcomes, Neurodevelopmental outcomes

Arsenic, Me/MeHg, Nutrition/Diet, Air pollution
New Hampshire; Vermont
Venda Health Examination of Mothers, Babies, and Their Environment(http://projectreporter.nih.gov/project_info_description.cfm?aid=8161112)
Brief Description
This is a birth cohort study designed to examine the association between insecticides for malaria control and birth outcomes in Limpopo, South Africa. The study began in 2012 and plans to enroll 750 pregnant women.
Eskenazi, Brenda Prenatal, Infant, Youth Neurodevelopmental outcomes, Fetal growth, Birthweight, Gestational age

Pyrethroids, DDT/DDE
South Africa

    Contact

    Not Pictured
    Martha Barnes
    Program Analyst

    Tel 984-287-3235
    barnes@niehs.nih.gov