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Your Environment. Your Health.

Grantees

Children's Environmental Health Supplements

Institution Principal Investigator Existing Grant Grant Number
Cincinnati Children's Hospital Medical Center Frank Biro, M.D. Environmental Epigenetics on Puberty U01-ES-019453
Supplement Description
This proposal will look at blood DNA methylation biomarkers involved in puberty development using samples collected both pre and post-thelarche and evaluate the effect of BPA and PFOA on the methylation profiles using samples from the Cincinnati BCERC cohort. This proposal will explore the effect of BPA and PFOAs on human puberty development and the role of DNA methylation on this vulnerable window of development.
Columbia University Health Sciences Julie Herbstman, Ph.D. DNA methylation and PBDE-related neurotoxicity R01-ES-021806
Supplement Description
This supplement will expand the parent grant by exploring how early life PBDE exposure may alter DNA methylation in umbilical cord blood and how these changes might be associated with either thyroid hormone signaling and/or neurodevelopmental indices.  
Dartmouth College Carmen Marsit, Ph.D. Environment, Imprinting, and Neurodevelopment R01-ES-022223
Supplement Description
The proposed supplemental project will add whole transcriptome assessments utilizing next-generation RNA-sequencing (NGS) technology to the Rhode Island Child Health Study Cohort (RICHS, PI: Marsit), in order to more precisely characterize altered imprinting by assessing allelic specific expression (ASE) and alternative splicing isoforms (ASI) of the placental imprinted genes. The supplemental project will also allow identification of co-regulated and co-altered gene networks related to imprinted genes and examine how these gene networks mediate the associations of environmental exposures and neonatal growth and neurobehavioral outcomes.
Dartmouth College Margaret Karagas, Ph.D. Children's Environmental Health and Disease Prevention Research Center Admin Supp P01-ES-022832
Supplement Description
This proposal is adding proteomics data to the high dimensional data that is being generated in the parent grant to better understand the risks from chemical exposures for placental development and in utero growth and development outcomes. Strengths also the preliminary data from proteomic (iTRAQ) studies in women with endometriosis for whom EDC exposures have been measured. Proteomic analyses will be conducted on human primary cytotrophoblasts and maternal serum samples.  
Harvard School of Public Health Andrea Baccarelli, Ph.D. BPA, Phthalates and Stress: Mechanisms and Interactions for Childhood Obesity R01-ES-021357
Supplement Description
This is a strong use of the PROGRESS (Programming Research in Obesity, Growth, Environment, and Social Stressors) cohort which has repeated longitudinal measures of a wide array of chemical exposures and phenotypes. This supplement will measure epigenome-wide DNA methylation at multiple time points in association with BPA and phthalates in children in this cohort and link these with obesity phenotypes in childhood.
University of California Berkeley Brenda Eskenazi, Ph.D. In Utero Dioxin Exposure in Seveso Italy and Health of the Second Generation R01-ES-007171
Supplement Description
The parent grant is aimed at investigating the health of the 2nd generation of a cohort that was exposed in utero to TCDD due to a chemical plant explosion in Seveso, Italy. The parent grant is following up on a 2nd generation of this cohort and exploring whether in utero TCDD exposure is associated with obesity, metabolic syndrome, thyroid function, age at menarche, and fertility outcomes. This supplement focuses on the expanded collection and processing of blood samples from the cohort of older children and mothers exposed to TCDD. This supplement will also perform targeted genotyping in the aryl hydrocarbon receptor (ahR) pathway to examine how polymorphisms in genes related to dioxin metabolism might modify dioxin toxicity susceptibility.
University of California Berkeley Catherine Metayer, M.D., Ph.D. Prenatal Exposures, DNA Methylation and Childhood Leukemia P01-ES-018172
Supplement Description
This supplement will expand on Project 3 of current parent P01 grant by adding additional leukemia cases and controls participating in the California Childhood Leukemia Study to further explore epigenetic mechanisms liking environmental risk factors with leukemia and the possible role of DNA methylation as a biomarker of early biological effect from environmental exposures.  
University of California Davis Judy Van de Water, Ph.D. Collaborative Activities to promote High Dimensional Molecular Analyses in the UC Davis CCEH P01-ES-011269
Supplement Description
This proposal will add expression data that can be integrated with methylation data. This proposal will utilize existing RNA samples and look at gene expression in relation to key environmental exposure and DNA copy number variation and methylation profiles and in relation to diagnostic outcomes of siblings at high risk for developing autism in the MARBLES prospective pregnancy cohort.
University of California, San Francisco Tracey Woodruff, Ph.D. The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children’s Center P01-ES-022841
Supplement Description
The proposed supplemental project will add whole transcriptome assessments utilizing next-generation RNA-sequencing (NGS) technology to the Rhode Island Child Health Study Cohort (RICHS, PI: Marsit), in order to more precisely characterize altered imprinting by assessing allelic specific expression (ASE) and alternative splicing isoforms (ASI) of the placental imprinted genes. The supplemental project will also allow identification of co-regulated and co-altered gene networks related to imprinted genes and examine how these gene networks mediate the associations of environmental exposures and neonatal growth and neurobehavioral outcomes.
University of California, San Francisco Young Kim, Ph.D. Interaction between environmental factors and germline de novo mutation rate in autism R01-ES-021462
Supplement Description
This supplement is using whole-genome sequencing (WGS) to detect single nucleotide variants and insertion-deletions across the entire genome and will attempt to identify G x E associated with paternal smoking on the rate of de novo mutations.
University of Illinois Susan Schantz, Ph.D. Novel Methods to Assess the Effects of Chemicals on Child Development P01-ES-0022848
Supplement Description
This project will leverage the prospective birth cohort being recruited in our Children's Center to assess the impact of prenatal exposure to phthalates on the intestinal microbiome and host gut gene expression.
University of Michigan Karen Peterson, D.Sc. High-Dimensional Epigenomic and Metabolomic Responses to Metal and EDC Exposures P01-ES-022844
Supplement Description
This supplement leverages the two longitudinal birth cohorts, the Michigan Mother Infant Pairs and the Mexico City-based ELEMENT cohort and builds on the aims of Project 2 of the parent PO1, Metabolic Consequences of In Utero and Peripubertal Toxicant-Diet Exposures.  
University of Southern California Frank Gilliland, M.D., Ph.D. Integrative Genetic Approaches to Gene-Air Pollution Interactions in Asthma U01-ES-019453
Supplement Description
The overall objectives of the research proposed in this supplement are to address these key gaps by investigating 1) the effects of genetics and exposure to diesel exhaust particle (DEP), a model air pollutant on the transcriptome in pulmonary macrophages; 2) to identify genetic variants that modulate transcription; 3) to identify eQTLs that are affected by exposure and 3) to assess if newly identified loci of interest are associated with airway hyperreactivity (AHR), lung function or childhood asthma risk.