Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

SRP Grantees Develop a Better Way to Measure Cell Survival

Researchers from the Massachusetts Institute of Technology (MIT) Superfund Research Program (SRP) Center recently developed a new test that rapidly measures the effect of different chemicals on cell survival. Measuring cell survival is critical for screening potentially toxic chemicals and protecting human health. The technology was developed as part of an NIEHS small business grant, with partial funding from the MIT SRP Center.

Led by Bevin Engelward, Ph.D., the team developed a test that can generate results in just a few days, rather than two or three weeks, while still matching the accuracy and sensitivity of traditional approaches. It also relies on automated rather than manual analyses to measure subtle changes in cell survival. Their method, called MicroColonyChip, was recently published in Cell Reports.

With the new method, they were able to accurately replicate results of previous studies using traditional approaches. According to the authors, the new technique can improve how new medical drugs are tested and can help environmental regulatory agencies responsible for testing chemicals work more efficiently.

The authors added that in the future, the MicroColonyChip may be useful in personalized medicine, where it could be used to test the effect of multiple drugs on a patient’s cells before beginning treatment. The researchers have filed for a patent on their new technology.

Images of cell growth
Images of cell growth on the MicroColonyChip over time, including 40X magnification. From Cell Reports 2019 26(6):1668-1678.e4. DOI: 10.1016/j.celrep.2019.01.053

Back
to Top