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Your Environment. Your Health.

Division of the National Toxicology Program Satellite Symposia

Global Toxicologic Pathology Training Program

The annual Division of the National Toxicology Program (DNTP) Satellite Symposium is a one-day meeting that is held in conjunction with the annual Society of Toxicologic Pathology meeting. These DNTP Satellite Symposia focus on challenging diagnostic or nomenclature issues as related to toxicologic pathology. A description of the cases and lesions is provided in the links associated with each satellite symposium.

2019 DNTP Satellite Symposium
Topics included aging mouse lesions from various strains, as well as the following lesions from various rat strains: rete testis sperm granuloma/fibrosis, ovarian cystadenocarcinoma, retro-orbital schwannoma, periductal cholangiofibrosis of the liver and pancreas, pars distalis hypertrophy, chronic progressive nephropathy, and renal tubule regeneration. Other cases presented included polyovular follicles in young beagle dogs, a fungal blood smear contaminant, how immunohistochemistry may improve the diagnosis of some tumors, retinal lesions from a rhesus macaque, and lesions from the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) Non-Rodent Fish Working Group. (Last reviewed January 2022)

2018 DNTP Satellite Symposium
Topics included seminiferous tubule dysgenesis in rats, ameloblast and odontoblast degeneration/necrosis in a rat, intestinal leiomyositis in a dog, gallbladder mucinous hyperplasia, focus of hepatocellular alteration and bile duct alteration in otters, renal tubule cytoplasmic vacuolation with basophilic granules in mice, uterine choriocarcinoma in a rhesus macaque, rete ovarii proliferative ovarian lesions in rats, malignant neoplastic proliferation a cynomolgus macaque, thyroid proliferative lesions in zebra fish, gross findings in fish larvae during routine chemical screening, and lesions from the Rabbit and Minipig INHAND Organ Working Groups. (Last reviewed January 2022)

2017 DNTP Satellite Symposium
Topics included renal papillary degeneration in perinatally exposed animals, atriocaval mesothelioma, alveolar–bronchiolar carcinoma, paraganglioma of the organ of Zuckerkandl (extra-adrenal pheochromocytoma), challenges of manual scoring of fluorescent staining, intertubular spermatocytic seminomas, medical device pathology assessment and discussion of the approval process, collagen-induced arthritis, incisor denticles, ameloblast degeneration and poorly mineralized enamel matrix, connective tissue paragangliomas, microcystin-LR toxicity, perivascular mast cells in the forebrain thalamus, and a review of the INHAND bone nomenclature and recommended application of the terminology in routine nonclinical toxicity studies. (Last reviewed January 2022)

2016 DNTP Satellite Symposium
Topics included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma, and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the INHAND collaborations. (Last reviewed January 2022)

2015 DNTP Satellite Symposium
Topics included hepatocellular lesions, a proposed harmonized diagnostic approach to rat cardiomyopathy, crop milk in a bird, avian feeding accoutrement, heat exchanger in a tuna, metastasis of a tobacco carcinogen–induced pulmonary carcinoma, neurocytoma in a rat, pituicytoma in a rat, rodent mammary gland whole mounts, dog and rat alveolar macrophage ultrastructure, dog and rat pulmonary phospholipidosis, alveolar macrophage aggregation in a dog, degenerating yeast in a cat liver aspirate, myeloid leukemia in lymph node aspirates from a dog, Trypanosoma cruzi in a dog, solanum toxicity in a cow, bovine astrovirus, malignant microglial tumor, and nomenclature challenges from the Special Senses INHAND Organ Working Group. (Last reviewed January 2022)

2014 DNTP Satellite Symposium
Topics included a pulmonary mucinous adenocarcinoma in a mouse; plexiform vasculopathy in rats; staging of the estrous cycle in rats and mice; peri-islet fibrosis, hemorrhage, lobular atrophy and inflammation in male rats; retinal dysplasia in rats and mice; multicentric lymphoma with intravascular microemboli and tumor lysis syndrome, myopathy and vascular anomaly in Tg.rasH2 mice; benign thymomas in rats; angiomatous lesions in the mesenteric lymph nodes rats; an unusual foveal lesion in a cynomolgous monkey; and a series of nomenclatures challenges from the endocrine INHAND Organ Working Group. (Last reviewed January 2022)

2013 DNTP Satellite Symposium
Topics included a caudal tail vertebra duplication in mice, nephroblastematosis in rats, ectopic C cell tumor in a hamster, granular cell aggregates/tumor in the uterus of a hamster, Pneumocystis carinii in the lung of a rat, iatrogenic chronic inflammation in the lungs of control rats, hepatoblastoma arising within an adenoma in a mouse, humoral hypercalcemia of benignancy in a transgenic mouse, acetaminophen-induced hepatotoxicity in rats, electron microscopy images of iatrogenic intraerythrocytic inclusions in transgenic mice, questionable hepatocellular degeneration/cell death/artifact in rats, atypical endometrial hyperplasia in rats, malignant mixed Müllerian tumors/carcinosarcomas in rats, differential diagnoses of proliferative lesions of the intestine of rodents, and obstructive nephropathy caused by melamine poisoning in a rat. (Last reviewed January 2022)

2012 DNTP Satellite Symposium
Topics included eosinophilic crystalline pneumonia in a transgenic mouse model, differentiating adrenal cortical cystic degeneration from adenoma, atypical eosinophilic foci of altered hepatocytes, differentiating cardiac schwannoma from cardiomyopathy, diagnosis of cardiac papillary muscle lesions, intrahepatocytic erythrocytes and venous subendothelial hepatocytes, lesions in Rathke’s cleft and pars distalis, pernicious anemia and megaloblastic disorders, embryonic neuroepithelial dysplasia, holoprosencephaly and exencephaly, and INHAND nomenclature for select cardiovascular lesions. (Last reviewed January 2022)

2011 DNTP Satellite Symposium
Topics included proliferative lesions from various fish species including ameloblastoma, gas gland hyperplasia, nodular regenerative hepatocellular hyperplasia, and malignant granulosa cell tumor; spontaneous cystic hyperplasia in the stomach of mice and histiocytic aggregates in the duodenal villous tips of treated mice; an olfactory neuroblastoma in a cynomolgus monkey; rodent skin lesions, including follicular parakeratotic hyperkeratosis, adnexal degeneration, and epithelial intracytoplasmic accumulations; oligodendroglioma and microgliomas in rats; a microcytic, hypochromic, responsive anemia in rats; a review of microcytes and microcytosis; nasal lesions associated with green tea extract and Ginkgo biloba in rats; corneal dystrophy in rabbits; valvulopathy in rats; and lymphoproliferative disease in a cynomolgus monkey. (Last reviewed January 2022)

2010 DNTP Satellite Symposium
Topics included a comparison of rat and mouse hepatocholangiocarcinoma, a comparison of cholangiofibrosis and cholangiocarcinoma in rats, a mixed pancreatic neoplasm with acinar and islet cell components, an unusual preputial gland tumor, renal hyaline glomerulopathy in rats and mice, eosinophilic substance in the nasal septum of mice, INHAND nomenclature for proliferative and nonproliferative lesions of the CNS/PNS, retinal gliosis in a rat, fibroadnexal hamartoma in rats, intramural plaque in a mouse, a treatment-related chloracne-like lesion in mice, and an overview of mouse ovarian tumors. (Last reviewed January 2022)

2009 DNTP Satellite Symposium
Topics included proliferative adrenal medullary lesions in rats, hepatocholangiocarcinoma in mice, diagnostic value of immunohistochemistry, background neoplastic lesion in the Tg.AC mouse, hematopoietic cell proliferation versus myeloid hyperplasia in mice, an introduction to the INHAND initiative, diagnostic features of ‘glioma type’ tumors in rats and mice, unusual proliferative lesions of the mouse lung, non-granular cell meningiomas in rodents, proliferative lesions in rat stomachs, pulmonary mucous cell proliferation in rats, granular cell lesions in the female genital tract of rats, and nodular hyperplasia in rodents. (Last reviewed January 2022)

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