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R code for fitting Random Periods Model

R code for fitting Random Periods Model - Software Usage Agreement and Download

Developed by:

Shyamal D. Peddada
National Institute of Environmental Health Sciences
Biostatistics Branch

Programmed by Mr. Sai Cheemalapati, Summer Intern 2011, Panther Creek High School


You may use this R code for fitting the Random Periods Model (RPM) for cell cycle genes. Since outliers and influential observations are not uncommon, the parameters of RPM are estimated using the L_1 norm. The RPM is a nonlinear model that can be used to model the expression of a cell-cycle gene over time. For details regarding the model one may refer to Liu et al. (2004).

Software info:

Details on how to use is provided in the README.pdf(75KB)


Liu D, Umbach D, Peddada SD, Li L, Crockett P and Weinberg C (2004). A Random-Periods Model for Expression of Cell-Cycle Genes. Proceedings of National Academy of Sciences, 101, No. 19, 7240-7245.




Shyamal Peddada, Ph.D.
Former Chief, Biostatistics & Computational Biology Branch
7128 Parran Hall
130 DeSoto Street
Pittsburgh, PA 15261
Tel 412-383-4802