A longitudinal, integrated clinical, histological and mRNA profiling study of resistance exercise in myositis
Ingrid Lundberg, M.D., Ph.D.
Resistance exercise should improve strength in patients with polymyositis or dernatomyositis
Types & Number of IIM Studied:
9 patients with adult dermatomyositis or polymyositis
a) Diagnosis of definite or probable PM or DM according to the Bohan and Peter criteria (Bohan 1975 part 1), b) Disease duration > 12 months, c) Unchanged disease activity according to the physicians judgement and d) Stable medication for three months. Exclusion criteria were: a) Diagnosis of inclusion body myositis (IBM), b) Comorbidities preventing vigorous exercise, c) Severe osteoporosis, d) Active malignant disease, and e) Doing exercise more than once a week
IMACS Core Set Measures Included:
Physician Global Activity-VAS, Patient Global Activity-VAS, Muscle Strength Testing-MMT, Functional Assessment Tools-HAQ, Laboratory-Muscle Enzymes, Extramuscular Assessment-Myositis Disease Activity Assessment Tool (MDAAT)
Other Measures Included:
10 VRM, Functional Index-2, Grip strength, The Borg CR-10 scale, The Myositis Activities Profile (MAP)
Improvement criteria were set to 20% or more for at least two of the variables 10 VRM, the FI-2 and the Grippit.
MAP, Disease activity, gene expression profiles in muscle tissue, maximal oxygen uptake
Key Trial Dates:
Completed and Published
Supported by the Vårdal Foundation, The Swedish Rheumatism Association, Swedish Research Council 2001-74-X14045, Gustaf V:th 80-year Foundation, Professor Nanna Svartz Foundation, Magnus Bergvalls stiftelse, Stiftelsen Clas Groschinskys Minnesfond, and Karolinska Institutet Foundation.
Alemo Munters L, Dastmalchi M, Katz A, Esbjörnsson M, Loell I, Hanna B, Lidén M, Westerblad H, Lundberg IE, Alexanderson. Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis., Arthritis Res Ther, 2013 Aug 13;15(4):R83. [Abstract]
- Ingrid Lundberg, M.D., Ph.D.
Department of Medicine
Karolinska University Hospital
Solna, Karolinska Institutet
SE- 171 76 Stockholm, Sweden