Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis

Environmental Health Economic Analysis Annotated Bibliography

Details

Research article Cost analysis (CA), Cost-utility analysis (CUA)
Authors
Gibb H, Devleesschauwer B, Bolger PM, Wu F, Ezendam J, Cliff J, Zeilmaker M, Verger P, Pitt J, Baines J, Adegoke G, Afshari R, Liu Y, Bokkers B, Van Loveren H, Mengelers M, Brandon E, Havelaar AH, Bellinger D
Journal
F1000Res
Summary
This cost analysis estimated the global and regional burden of disease from four foodborne chemicals: aflatoxin, cyanide in cassava, peanut allergen, and dioxin. These four agents were estimated to be associated with 339,000 illnesses (95 percent UI: 186,000–1,239,000); 20,000 deaths (95 percent UI: 8,000–52,000); and 1,012,000 disability adjusted life years (DALYs) (95 percent UI: 562,000–2,822,000) in the year 2010. These results show that chemicals in the food supply can have a significant impact on the global burden of disease, particularly in low- and middle-income countries.
Population
Not available

Health Outcomes

  • Cancer outcomes (liver cancer), Neurological/cognitive outcomes (Konzo), Immune outcomes (allergic response), Reproductive outcomes (reduced fertility), Thyroid dysfunction (hypothyroidism)

Environmental Agents

List of Environmental Agents:

  • Natural toxicants (cyanide in cassava), Allergen (peanut allergen), Mycotoxins (aflatoxin), Chlorinated compounds (dioxin)

Source of Environmental Agents:

  • Food

Economic Evaluation / Methods and Source

Type:

  • Cost analysis (CA)
  • Cost-utility analysis (CUA)

Cost Measured:

  • Disability adjusted life years (DALYs)

Potential Cost Measures: (Not available)

Benefits Measures: (Not available)

Potential Benefits: (Not available)

Location: (Not available)

Models Used: (Not available)

Methods Used:

  • The authors estimated the burden of disease for four foodborne chemicals: aflatoxin, cyanide in cassava, peanut allergen, and dioxin. The authors — 1) conducted a systematic literature review for each chemical to develop age- and sex-specific disease incidence and mortality estimates due to these chemicals; and 2) used these estimates to calculate the number of cases, deaths, and disability adjusted life years (DALYs) for each chemical.

Sources Used:

  • Incidence and prevalence estimates of cassava cyanide-induced diseases (WHO/FERG report, 2011); Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010 (Lancet, 2012); Parameters needed to estimate the global burden of peanut allergy: systematic literature review (Ezendam et al. 2012); International Agency for Research on Cancer. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality, and Prevalence Worldwide in 2012 (WHO, 2012); Human exposure to POPs across the globe: POPs levels and human health implication: results of the WHO/UNEP human milk survey (UNEP, 2013); additional sources cited in publication

Economic Evaluation / Methods and Source

Citation:

  • Gibb H, Devleesschauwer B, Bolger PM, Wu F, Ezendam J, Cliff J, Zeilmaker M, Verger P, Pitt J, Baines J, Adegoke G, Afshari R, Liu Y, Bokkers B, Van Loveren H, Mengelers M, Brandon E, Havelaar AH, Bellinger D. 2015. World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis. F1000Res.

Pubmed:

DOI:

NIEHS Funding: (Not available)

Other Funding:

  • WHO
  • National Institute for Public Health and the Environment (Netherlands)
  • Ministry of Public Health, Welfare, and Sport (Netherlands)
Back
to Top