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Economic implications of manganese neurotoxicity

Environmental Health Economic Analysis Annotated Bibliography


Review Cost analysis (CA)
Weiss B
This review discussed factors to consider for monetizing the economic costs associated with declining capacities in the context of manganese-induced neurodegenerative diseases (e.g., Parkinson's disease). The author suggested that slight elevations in airborne manganese may produce a small but economically significant shift to an earlier onset of neurodegenerative diseases, such as Parkinson’s disease.
Not available

Health Outcomes

  • Reviewed publications that examined — neurological/cognitive outcomes (Parkinson's disease, other neurodegenerative diseases (Manganism))

Environmental Agents

List of Environmental Agents:

  • Reviewed publications that examined — metal (manganese)

Source of Environmental Agents:

  • Reviewed publications that examined — inhaled manganese (hazardous air pollutant)

Economic Evaluation / Methods and Source


  • Cost analysis (CA)

Cost Measured:

  • Reviewed publications that examined — costs associated with Parkinson's disease, such as annual medical costs

Potential Cost Measures:

  • Costs of institutionalization
  • costs related to remedial care and/or education
  • decline in functional capacity

Benefits Measures: (Not available)

Potential Benefits: (Not available)

Location: (Not available)

Models Used: (Not available)

Methods Used:

  • The author reviewed previous literature to analyze how manganese neurotoxicity elevates Parkinson's risk and explored the influence of aging along with the economic implications of these risks.

Sources Used:

  • Rate of cell death in Parkinsonism indicates active neuropathological process (McGeer et al., 1988); Ageing and Parkinson's disease: substantia nigra regional selectivity (Fearnley and Lees, 1991); additional sources cited in publication

Economic Evaluation / Methods and Source


  • Weiss B. 2006. Economic implications of manganese neurotoxicity. NeuroToxicology.


DOI: (Not available)

NIEHS Funding:

  • P01ES001247
  • P50ES001247
  • P30ES001247

Other Funding: (Not available)