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Your Environment. Your Health.

NIEHS Supported Publications on Per- and Polyfluoroalkyl Substances (PFAS)

NIEHS is supporting research on human health and exposure to per- and polyfluoroalkyl substances (PFAS). Below is a searchable list of published scientific papers with the results of PFAS research that were supported by NIEHS. More information about PFAS is also available on our Environmental Health Topics page.

Citation by Author Funding Year
Alcala CS, Basilio C, White I, Marchitti SA, Hines EP, Berlin CM, Fenton SE. 2019. Environmental Chemicals in Breast Milk. In: Nriagu, J. (Ed.), Encyclopedia of Environmental Health. Elsevier, vol. 2, pp. 392–407. [Abstract(https://doi.org/10.1016/B978-0-12-409548-9.02139-4)] NIEHS-DNTP 2019
Blake BE, Cope HA, Hall SM, Keys RD, Mahler BW, McCord J, Scott B, Stapleton HM, Strynar MJ, Elmore SA, Fenton SE. 2020. Evaluation of maternal, embryo, and placental effects in CD-1 mice following gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide dimer acid (HFPO-DA or GenX). Environ Health Perspect. 2020;128(2):27006. doi:10.1289/EHP6233. [Abstract(https://doi.org/10.1289/EHP6233)] NIEHS-DNTP 2020
Blake BE, Pinney SM, Hines EP, Fenton SE, Ferguson KK. 2018. Associations Between Longitudinal Serum Perfluoroalkyl Substance (PFAS) Levels and Measures of Thyroid Hormone, Kidney Function, and Body Mass Index in the Fernald Community Cohort. Environ Pollut. 242(Pt A):894–904. doi:10.1016/j.envpol.2018.07.042. [Abstract(https://doi.org/10.1016/j.envpol.2018.07.042)] NIEHS-DNTP 2018
Brewster DW, Birnbaum LS. 1989. The Biochemical Toxicity of Perfluorodecanoic Acid in the Mouse Is Different From That of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharm. 99(3):544-54. Epub 1989/07/01. doi: 10.1016/0041-008X(89)90161-0. PubMed PMID: 2749739. [Abstract(http://dx.doi.org/10.1016/0041-008X(89)90161-0)] NIEHS-DNTP 1989
Cannon RE, Richards AC, Trexler AW, Juberg CT, Sinha B, Knudsen GA, Birnbaum LS. 2020. Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 at the Blood-Brain Barrier. Environ Health Perspect. 128(3):37002. doi:10.1289/EHP5884. [Abstract(https://doi.org/10.1289/EHP5884)] NIEHS-DNTP 2020
Crawford NM, Fenton SE, Strynar M, Hines EP, Pritchard DA, Steiner AZ. 2017. Effects of Perfluorinated Chemicals on Thyroid Function, Markers of Ovarian Reserve, and Natural Fertility. Reprod Toxicol. 69:53–59. doi:10.1016/j.reprotox.2017.01.006. [Abstract(https://doi.org/10.1016/j.reprotox.2017.01.006)] NIEHS-DNTP 2017
Dixon D, Reed C, Moore AB, Wallace E, Hines EP, Gibbs-Flournoy EA, Stanko JP, Newbold R, Jefferson W, Fenton SE. 2012. Histopathologic Changes in the Uterus, Cervix and Vagina of Immature CD-1 Mice Exposed to Low Doses of Perfluorooctanoic Acid (PFOA) in the Uterotrophic Assay. Reprod Toxicol. Special Issue on Perfluorinated Chemicals. 33(4): 506-512. [Abstract(https://doi.org/10.1016/j.reprotox.2011.10.011)] NIEHS-DNTP 2012
Fenton SE, Beck LM, Borde AR, Rayner JL. 2012. Developmental exposure to environmental endocrine disruptors and adverse effects on mammary gland development. In Diamanti-Kandarakis, E., and Gore, A. C. (Eds.): Contemporary Endocrinology Series; Endocrine Disruptors and Puberty. New York, Springer/Humana Press. Invited Chapter 7, pp. 201-224. NIEHS-DNTP 2012
Fenton SE, Birnbaum LS. 2015. Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk. J. Clin. Endocrinol. Metab. 100: 3245-3250 doi: 10.1210/jc.2015-2848. [Abstract(https://doi.org/10.1210/jc.2015-2848)] NIEHS-DNTP 2015
Fenton SE, Reed C, Newbold RR. 2012. Perinatal Environmental Exposures Affect Mammary Development, Function, and Cancer Risk in Adulthood. Ann Rev Pharmacol Toxicol. 52: 455-479. [Abstract(https://doi.org/10.1146/annurev-pharmtox-010611-134659)] NIEHS-DNTP 2012
Fenton SE, Reiner JL, Nakayama SF, Delinsky AD, Stanko JP, Hines EP, White SS, Lindstrom AB, Strynar MJ, Petropoulou S. 2009. Analysis of PFOA in Dosed CD-1 Mice Part 2: Disposition of PFOA in Tissues and Fluids From Pregnant and Lactating Mice and Their Pups. Reprod. Toxicol. 27: 365-372. [Abstract(https://doi.org/10.1016/j.reprotox.2009.02.012)] NIEHS-DNTP 2009
Fenton SE. 2009. The mammary gland: a tissue sensitive to environmental exposures. Rev Environ Health. 24(4):319‐325. doi:10.1515/reveh.2009.24.4.319. [Abstract(https://doi.org/10.1515/REVEH.2009.24.4.319)] NIEHS-DNTP 2009
Fenton SE. 2019. Curated Collection on PFAS. Environ Health Perspect. [Abstract(https://ehp.niehs.nih.gov/curated-collections/PFAS)] NIEHS-DNTP 2019
Filgo AJ, Quist E, Hoenerhoff M, Brix A, Kissling G, Abbott B, Fenton SE. 2015. Perfluorooctanoic acid (PFOA)-induced liver lesions in two strains of mice following developmental exposures: PPARα is not required. Toxicol Pathol. 43: 558-568. [Abstract(https://doi.org/10.1177/0192623314558463)] NIEHS-DNTP 2015
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT. 2015. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-disrupting Chemicals. Endocr Rev. 36: E1-E150 doi: 10.1210/er.2015-1010. [Abstract(https://doi.org/10.1210/er.2015-1010)] NIEHS-DNTP 2015
Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT. 2015. Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 36: 593-602 doi: 10.1210/er.2015-1093 [Abstract(https://doi.org/10.1210/er.2015-1093)] NIEHS-DNTP 2015
Goulding D, White SS, McBride SJ, Fenton SE, and Harry GJ. 2016. Gestational Exposure to Perfluorooctanoic Acid (PFOA): Alterations in Motor Related Behaviors. Neurotoxicology. 58:110-119. doi: 10.1016/j.neuro.2016.11.008. [Abstract(https://doi.org/10.1016/j.neuro.2016.11.008)] NIEHS-DNTP 2016
Harris MW, Birnbaum LS. 1989. Developmental Toxicity of Perfluorodecanoic Acid in C57BL/6N Mice. Fund Appl Toxicol. 12(3):442-8. Epub 1989/04/01. doi: 10.1016/0272-0590(89)90018-3. PubMed PMID: 2731659 [Abstract(https://doi.org/10.1016/0272-0590(89)90018-3)] NIEHS-DNTP 1989
Harris MW, Uraih LC, Birnbaum LS. 1989. Acute Toxicity of Perfluorodecanoic Acid in C57BL/6 Mice Differs From 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fund Appl Toxicol. 13(4):723-36. Epub 1989/11/01. doi: 10.1016/0272-0590(89)90330-8. PubMed PMID: 2620793. [Abstract(http://dx.doi.org/10.1016/0272-0590(89)90330-8)] NIEHS-DNTP 1989
Hines EP, White SS, Stanko JP, Gibbs-Flournoy JE, Lau C, Fenton SE. 2009. Phenotypic Dichotomy Following Developmental Exposure to Perfluorooctanoic Acid (PFOA) in Female CD-1 Mice: Low Doses Induce Elevated Serum Leptin and Insulin, and Overweight in Mid-life. Mol Cell Endocrinol. 304: 97-105. [Abstract(https://doi.org/10.1016/j.mce.2009.02.021)] NIEHS-DNTP 2009
Interagency Breast Cancer and the Environment Research Coordinating Committee (SE Fenton contributing writer). 2013. Breast Cancer and the Environment: Prioritizing Prevention. Department of Health and Human Services. [Abstract(http://www.niehs.nih.gov/about/assets/docs/ibcercc_full_508.pdf)] NIEHS-DNTP 2013
LaKind JS, Berlin CM, Fenton SE. 2011. Environmental Chemicals in Breast Milk. In Nriagu, J. O. (Ed.):Encyclopedia of Environmental Health, Volume 2. Burlington, Elsevier, pp. 347-356. NIEHS-DNTP 2011
Macon MB, Fenton SE. 2013. Endocrine Disruptors and the Breast: Early Life Effects and Later Life Disease. J. Mammary Gland Biol. Neoplasia18: 43-61. [Abstract(https://doi.org/10.1007/s10911-013-9275-7)] NIEHS-DNTP 2013
Macon MB, Villanueva LR, Tatum-Gibbs K, Zehr RD, Strynar MJ, Stanko JP, White SS, Helfant L, Fenton SE. 2011. Prenatal Perfluorooctanoic Acid Exposure in CD-1 Mice: Low Dose Developmental Effects and Internal Dosimetry. Toxicol Sci. 122: 134-145. [Abstract(https://doi.org/10.1093/toxsci/kfr076)] NIEHS-DNTP 2011
Marchitti SA, Hines EP, LaKind JS, Berlin CM, Fenton SE, Kenneke JF. 2013. Environmental chemicals in breast milk. Encyclopedia of Environmental Health, Earth Systems and Environmental Sciences, Volume 3, Elsevier Inc., pp1-13. 2013. [Abstract(https://doi.org/10.1016/B978-0-12-409548-9.02139-4)] NIEHS-DNTP 2013
Patisaul HB, Fenton SE, Aylor D. 2018. Animal Models of Endocrine Disruption. Best Pract Res Clin Endocrinol Metab. 32(3):283–297. doi:10.1016/j.beem.2018.03.011. [Abstract(https://doi.org/10.1016/j.beem.2018.03.011)] NIEHS-DNTP 2018
Quist E, Filgo AJ, Cummings C, Kissling GE, Hoenerhoff MF, Fenton SE. 2015. Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA). Toxicol Pathol. 43: 546-557. [Abstract(https://doi.org/10.1177/0192623314551841)] NIEHS-DNTP 2015
Reed CE, Fenton SE. 2015. Effects of PFOA on endocrine-related systems. In: J.C. DeWitt (Ed.): Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances, Molecular and Integrative Toxicology, Springer Int’l. Chapter 11, pp. 249-264. [Abstract(http://dx.doi.org/10.1007/978-3-319-15518-0_11)] NIEHS-DNTP 2015
Reiner JL, Nakayama SF, Delinsky AD, Stanko JP, Fenton SE, Lindstrom AB, Strynar MJ. 2009. Analysis of PFOA in dosed CD1 mice. Part 1. Methods development for the analysis of tissues and fluids from pregnant and lactating mice and their pups. Reprod Toxicol. 27: 360-364. [Abstract(https://www.ncbi.nlm.nih.gov/pubmed/19028561)] NIEHS-DNTP 2009
Rudel RA, Fenton SE, Ackerman JM, Euling SY, Makris SL. 2011. Environmental Exposures and Mammary Gland Development: State of the Science, Public Health Implications, and Research Recommendations. Environ Health Perspect. 119: 1053-1061. [Abstract(https://doi.org/10.1289/ehp.1002864)] NIEHS-DNTP 2011
Tucker DK, Macon MB, Strynar, MJ, Dagnino S, Andersen E, Fenton SE. 2015. The Mammary Gland is a Sensitive Pubertal Target in CD-1 and C57Bl/6 Mice Following Perinatal Perfluorooctanoic Acid (PFOA) Exposure. Reprod Toxicol. 54: 26-36. [Abstract(https://doi.org/10.1016/j.reprotox.2014.12.002)] NIEHS-DNTP 2015
White SS, Calafat AM, Kuklenyik Z, Thibodeaux J, Wood C, Fenton SE. 2007. Gestational PFOA Exposure of Mice Is Associated With Altered Mammary Gland Development in Dams and Female Offspring. Toxicol Sci. 96: 133-144. [Abstract(https://doi.org/10.1093/toxsci/kfl177)] NIEHS-DNTP 2007
White SS, Fenton SE, Yang CF, Haslam SZ. 2011. Mammary gland as a sensitive tissue to developmental exposures of perfluorooctanoic acid (PFOA) in the mouse. In Russo, J. (Ed.): Environment and Breast Cancer. New York, Springer. Invited Chapter 8, pp. 147-166. NIEHS-DNTP 2011
White SS, Kato K, Jia LT, Basden BJ, Calafat AM, Hines EP, Stanko JP, Wolf CJ, Abbott BD, Fenton SE. 2009. Effects of Perfluorooctanoic Acid on Mouse Mammary Gland Development and Differentiation Resulting From Cross-foster and Restricted Gestational Exposures. Reprod Toxicol. 27: 289-298. [Abstract(https://doi.org/10.1016/j.reprotox.2008.11.054)] NIEHS-DNTP 2009
White SS, Stanko JP, Kato K, Calafat AM, Hines EP, Fenton SE. 2011. Gestational and Chronic Low-dose PFOA Exposures and Mammary Gland Growth and Differentiation in Three Generations of CD-1 Mice. Environ Health Perspect. 119: 1070-1076. [Abstract(https://doi.org/10.1289/ehp.1002741)] NIEHS-DNTP 2011
White SS. Fenton SE, Hines EP. 2011. Endocrine Disrupting Properties of Perfluorooctanoic Acid. Invited peer-reviewed summary. J Ster Biochem Mol Biol. 127 (1-2): 16-26. [Abstract(https://doi.org/10.1016/j.jsbmb.2011.03.011)] NIEHS-DNTP 2011
Wolf CJ, Fenton SE, Schmid JE, Calafat AM, Kuklenyik Z, Thibodeaux J, Das K, White SS, Lau C, Abbott BD. 2007. Developmental Toxicity of Perfluorooctanoic Acid (PFOA) After Cross-foster and Restricted Gestational Exposures. Toxicol Sci. 95: 462-473. [Abstract(https://doi.org/10.1093/toxsci/kfl159)] NIEHS-DNTP 2007
von Ehrenstein OS, Fenton SE, Kato K, Kuklenyik Z, Calafat AM, Hines EP. 2009. Polyfluoroalkyl Chemicals in the Serum and Milk of Breastfeeding Women. Reprod Toxicol. 27: 239-245. [Abstract(https://doi.org/10.1016/j.reprotox.2009.03.001)] NIEHS-DNTP 2009

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