Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Economic implications of manganese neurotoxicity

Environmental Health Economic Analysis Annotated Bibliography


Review Cost analysis (CA)
Weiss B
This review discussed factors to consider for monetizing the economic costs associated with declining capacities in the context of manganese-induced neurodegenerative diseases (e.g., Parkinson's disease). The author suggested that slight elevations in airborne manganese may produce a small but economically significant shift to an earlier onset of neurodegenerative diseases, such as Parkinson’s disease.
Not available

Health Outcomes

  • Reviewed publications that examined — neurological/cognitive outcomes (Parkinson's disease, other neurodegenerative diseases (Manganism))

Environmental Agents

List of Environmental Agents:

  • Reviewed publications that examined — metal (manganese)

Source of Environmental Agents:

  • Reviewed publications that examined — inhaled manganese (hazardous air pollutant)

Economic Evaluation / Methods and Source


  • Cost analysis (CA)

Cost Measured:

  • Reviewed publications that examined — costs associated with Parkinson's disease, such as annual medical costs

Potential Cost Measures:

  • Costs of institutionalization
  • costs related to remedial care and/or education
  • decline in functional capacity

Benefits Measures: (Not available)

Potential Benefits: (Not available)

Location: (Not available)

Models Used: (Not available)

Methods Used:

  • The author reviewed previous literature to analyze how manganese neurotoxicity elevates Parkinson's risk and explored the influence of aging along with the economic implications of these risks.

Sources Used:

  • Rate of cell death in Parkinsonism indicates active neuropathological process (McGeer et al., 1988); Ageing and Parkinson's disease: substantia nigra regional selectivity (Fearnley and Lees, 1991); additional sources cited in publication

Economic Evaluation / Methods and Source


  • Weiss B. 2006. Economic implications of manganese neurotoxicity. NeuroToxicology.
  • Pubmed
  • DOI: (Not available)

NIEHS Funding:

  • P01ES001247
  • P50ES001247
  • P30ES001247

Other Funding: (Not available)

to Top