Health Outcomes

• Multiple

Health Outcome List:

• Reviewed publications that studied neurological outcomes (loss of IQ, intellectual disability, attention deficit hyperactivity disorder (ADHD), autism))
• Metabolic outcomes (childhood obesity, adult obesity, adult diabetes)
• Cancer outcomes (testicular cancer)
• Birth outcomes (cryptorchidism)
• Reproductive outcomes - male (male infertility resulting in increased assisted reproductive technology, low testosterone resulting in increased early mortality)
• Reproductive outcomes – female (fibroids, endometriosis)

Environmental Agents

List of Environmental Agents:

• Reviewed studies that evaluated hormonal mimics (phthalates, bisphenol A (BPA))
• Brominated compounds (polybrominated diphenyl ethers (PBDEs))
• Organophosphate pesticides
• Chlorinated compounds (dichloro-diphenyldichloroethylene (DDE))

Source of Environmental Agents:

• Not available

Economic Evaluation / Methods and Source

Type:

• Not available

Cost Measures:

• Not available

Potential Cost Measures:

• Not available

Benefits Measures:

• Not available

Potential Benefits Measures:

• Not available

Location:

• Reviewed publications that studied European Union and United States locations

Models Used:

• Not available

Models References:

• Not available

Methods Used:

• The authors critically reviewed seven publications that calculated environmentally attributable factors and associated societal costs for adverse health outcomes from exposures to endocrine disrupting pollutants. The authors critically evaluated the scientific methodology that was used in analyses leading up to the cost analysis and did not critically evaluate the final cost analysis itself. The authors scrutinized: — 1) the role of the self-selected Steering Committee that played a substantial role in the seven publications; 2) the literature search and selection strategy for the basis of the cost analysis; 3) the methods used to assess animal and human data and the probability of causation; 4) the methods used to determine attributable fraction and exposure-response relationships; 5) sources and use of biomonitoring data; 6) sources and uses of cost data; and 7) the cumulative effect of numerous assumptions inherent in each step of the process.

Sources Used:

• Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis (Attina et al., 2016); Neurobehavioral deficits, disease, and associated costs of exposure to endocrine-disrupting chemicals in the European Union (Bellanger et al., 2015); Male reproductive disorders, disease, and costs of exposure to endocrine-disrupting chemicals in the European Union (Hauser et al., 2015); Female reproductive disorders, disease, and costs of exposure to endocrine disrupting chemicals in the European Union (Hunt et al., 2016); Obesity, diabetes, and associated costs of exposure to endocrine-disrupting chemicals in the European Union (Legler et al, 2015); Estimating burden and disease costs of exposure to endocrine-disrupting chemicals in the European Union (Trasande et al., 2015); Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis (Trasande et al., 2016); additional sources cited in publication

Economic Citation / Fundings

Citation:

• Bond GG, Dietrich DR. Human cost burden of exposure to endocrine disrupting chemicals. A critical review. Archives of Toxicology. 2017. 91; 8.
• Pubmed
• DOI

NIEHS Funding:

• Not available

Other Funding:

• Not available