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Environmental Health Economic Analysis Annotated Bibliography

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Details

Review
Authors

Huat TJ, Camats-Perna J, Newcombe EA, Valmas N, Kitazawa M, Medeiros R

Journal

Journal of Molecular Biology

Summary
In this review article, the authors explore how essential and non-essential metals affect brain physiology and immunity, as well as their roles in the accumulation of toxic Alzheimer’s disease (AD) proteinaceous species (i.e., β-amyloid and tau). The authors reviewed studies that validate the disruption of immune-related pathways as an important mechanism of toxicity by which metals can contribute to AD. They explored research on iron, copper, zinc, manganese, lead, aluminum, and cadmium. Evidence strongly supports that disruption in the homeostasis of essential metals and the accumulation of non-essential metals disturb the cellular metabolism, antioxidant defense, and immune responses, leading to the onset and progression of AD.
Population

Not available

Health Outcomes

  • Alzheimer's disease (AD)

Health Outcome List:

  • Not available

Environmental Agents

List of Environmental Agents:

  • Reviewed publications that examined metals (iron, copper, zinc, manganese, lead, aluminum, and cadmium)

Source of Environmental Agents:

  • Anthropogenic activities

Economic Evaluation / Methods and Source

Type:

  • Not available

Cost Measures:

  • Not available

Potential Cost Measures:

  • Not available

Benefits Measures:

  • Not available

Potential Benefits Measures:

  • Not available

Location:

  • Not available

Models Used:

  • Mouse model

Models References:

  • Not available

Methods Used:

  • The authors performed a review of existing literature to examine research related to 6 metals and their relation to brain physiology, immunity, and their roles in the accumulation of toxic AD proteinaceous species. Metals studied were iron, copper, zinc, manganese, lead, aluminum, and cadmium.

Sources Used:

  • Mouse models (Xian-Hui et al., 2015. Kitazawa et al., 2009. Sparks et al., 2006. Sparks et al., 2003. Yu et a., 2015); United Nations, Department of Economic and Social Affairs, Population Division (2017); Lifestyle factors also affect an individual’s risk of developing AD (Livingston et al., 2017); Reduced levels of LRP-1 further impair the transcytotic clearance of Aβ and exacerbate neuroinflammation (Newcombe et al., 2018); Additional sources cited in the publication.

Economic Citation / Fundings

Citation:

  • Huat TJ, Camats-Perna J, Newcombe EA, Valmas N, Kitazawa M, Medeiros R. Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation. Journal of Molecular Biology. 2019. 431; 9.
  • Pubmed
  • DOI

NIEHS Funding:

  • R01ES024331

Other Funding:

  • Not available