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Details

Research article
Authors

Gough CM, Quintero Y, Godde K

Journal

Archives of Osteoporosis

Summary
The authors demonstrated that inflammation from prolonged stress did not cause changes to bone health through inflammation but instead impacted access to health care, social inequalities, and overall health, which in turn impacted bone health. The study provided a comprehensive assessment of how determinants of health across demographic, psychological, mobility-related, health, environmental, and economic domains are associated with the diagnosis of osteoporosis and tested three hypotheses: (1) a diverse set of variables across domains will predict osteoporosis, (2) chronic inflammation as a result of stress (represented by high-sensitivity C-reactive protein) will not be associated with osteoporosis, and (3) the model developed will have high accuracy in predicting osteoporosis.
Population

Participants from the 2012 - 2016 waves of the Health and Retirement Study

Health Outcomes

  • Osteoporosis

Health Outcome List:

  • Not available

Environmental Agents

List of Environmental Agents:

  • Not available

Source of Environmental Agents:

  • Not available

Economic Evaluation / Methods and Source

Type:

  • Cost-utility analysis (CUA)

Cost Measures:

  • Demographic, psychological, mobility-related, health, environmental, and economic domains

Potential Cost Measures:

  • Not available

Benefits Measures:

  • Not available

Potential Benefits Measures:

  • Not available

Location:

  • Not available

Models Used:

  • Cox proportional hazards models

Models References:

  • Not available

Methods Used:

  • The authors used a Cox proportional hazards model of osteoporosis diagnoses. The authors used — 1) logistic regression; and 2)k-nearest Neighbors Discriminant Analysis to assess predictive accuracy.

Sources Used:

  • Data from 14,792 and 13,169 participants (depending on model) in the 2012–2016 waves of the Health and Retirement Study, including the Biomarker Study, the Contextual Data Resource (Vable et al., 2017); Additional sources cited in the publication.

Economic Citation / Fundings

Citation:

  • Gough CM, Quintero Y, Godde K. Assessing the Roles of Demographic, Social, Economic, Environmental, Health-related, and Political Factors on Risk of Osteoporosis Diagnosis Among Older Adults. Archives of Osteoporosis. 2021. 16; 1.
  • Pubmed
  • DOI

NIEHS Funding:

  • Not available

Other Funding:

  • R15AG063330, P01AG017625, R21AG045625