This annual report, the first since the redesignation of the NIEHS-WHO Collaborating Centre for Environmental Health Sciences in September 2017, highlights Collaborative Centre activities conducted between September 2017 and August 2018. In addition to a new look and feel, the report is organized to reflect activities within four major focus areas: Children’s Environmental Health, Environmental Influence on Noncommunicable Diseases, Health Consequences of Climate and Weather Extremes, and the WHO Chemical Risk Assessment Network. These focus areas not only incorporate the work of previous years, but also introduce opportunities to address new issues and stimulate innovative, cross-cutting activities around the world.