Coronavirus Research and Information From NIEHS

Environmental Factor Articles

Annual awards ceremony celebrates NIEHS scientists and staff – November 2022
Employees were honored for developing new scientific techniques and collaborations, addressing environmental disparities, and more.

Hispanic Heritage Month recognized by NIEHS with special lecture – November 2022
Fernando Rivera, Ph.D., discussed how personal experiences influenced his research into mental health, climate-related disasters, and more.

Monitoring COVID-19 breakthrough infections over time – November 2022
There may be an antibody threshold associated with breakthrough COVID-19 infections, and this threshold could possibly be used to aid decision-making regarding booster vaccinations, according to NIEHS researchers and their collaborators.

Papers From NIEHS Researchers

Gibson EA, Li H, Fruh V, Gabra M, Asokan G, Jukic AMZ, Baird DD, Curry CL, Fischer-Colbrie T, Onnela JP, Williams MA, Hauser R, Coull BA, Mahalingaiah S. 2022. Covid-19 vaccination and menstrual cycle length in the Apple Women’s Health Study. NPJ Digit Medicine v.5:165. [Full Text Gibson EA, Li H, Fruh V, Gabra M, Asokan G, Jukic AMZ, Baird DD, Curry CL, Fischer-Colbrie T, Onnela JP, Williams MA, Hauser R, Coull BA, Mahalingaiah S. 2022. Covid-19 vaccination and menstrual cycle length in the Apple Women’s Health Study. NPJ Digit Medicine v.5:165.]

Wang Y, Duan Z, Romm KF, Ma Y, Douglas Evans W, Bennett B, Fuss C, Klinkhammer KE, Wysota CN, Berg CJ. Bidirectional associations between depressive symptoms and cigarette, e-cigarette, cannabis, and alcohol use: Cross-lagged panel analyses among young adults before and during COVID-19. 2022. Addictive Behaviors v. 134: 107422. NIEHS Grant No. D43ES030927 [Full Text Wang Y, Duan Z, Romm KF, Ma Y, Douglas Evans W, Bennett B, Fuss C, Klinkhammer KE, Wysota CN, Berg CJ. Bidirectional associations between depressive symptoms and cigarette, e-cigarette, cannabis, and alcohol use: Cross-lagged panel analyses among young adults before and during COVID-19. 2022. Addictive Behaviors v. 134: 107422. NIEHS Grant No. D43ES030927]

Leibler JH, SA Keogh, E Jarquín, R Garcia-Trabanino, JJA Velázquez, DL Pilarte, M Beltran, IS Delgado, ZE Petropoulos, DJ Friedman, DR Brooks and MK Scammell. 2022. COVID-19 and CKD: Employment, Food Security and Healthcare in El Salvador. Annals of Global Health v. 88 (1): 101. NIEHS Grant No. R01ES027584, F31ES030974, T32ES014562. [Full Text Leibler JH, SA Keogh, E Jarquín, R Garcia-Trabanino, JJA Velázquez, DL Pilarte, M Beltran, IS Delgado, ZE Petropoulos, DJ Friedman, DR Brooks and MK Scammell. 2022. COVID-19 and CKD: Employment, Food Security and Healthcare in El Salvador. Annals of Global Health v. 88 (1): 101. NIEHS Grant No. R01ES027584, F31ES030974, T32ES014562.]

Furmanek S, V Salunkhe, S Pahwa, H Samanapally, P Nathala, Q Xu, T Ali, F Deepti, A Glynn, T McGuffin, D Titus, I Farah, CM Jones, JA Ramirez, SP Clifford, FW Arnold, M Kong, L Roser, J Huang, and Center of Excellence for Research in Infectious Diseases Coronavirus Study Group on behalf of the COVID-19 CardioVascular Research Group. 2022. Correlations of Before and After Event Echocardiographic Parameters with Troponin and BNP in Hospitalized COVID-19 Patients with Cardiovascular Events. Journal of Cardiothoracic and Vascular Anesthesia v. 36 (12): pp. 4553-4555. NIEHS Grant No. P30ES030283. [Full Text Furmanek S, V Salunkhe, S Pahwa, H Samanapally, P Nathala, Q Xu, T Ali, F Deepti, A Glynn, T McGuffin, D Titus, I Farah, CM Jones, JA Ramirez, SP Clifford, FW Arnold, M Kong, L Roser, J Huang, and Center of Excellence for Research in Infectious Diseases Coronavirus Study Group on behalf of the COVID-19 CardioVascular Research Group. 2022. Correlations of Before and After Event Echocardiographic Parameters with Troponin and BNP in Hospitalized COVID-19 Patients with Cardiovascular Events. Journal of Cardiothoracic and Vascular Anesthesia v. 36 (12): pp. 4553-4555. NIEHS Grant No. P30ES030283.]

Oh DL, D Meltzer, K Wang, AJ Canchola, MC DeRouen, C McDaniels-Davidson, J Gibbons, L CarvajalCarmona, JN Nodora, L Hill, SL Gomez and ME Martinez. 2022. Neighborhood Factors Associated with COVID-19 Cases in California. Journal of Racial and Ethnic Health Disparities. NIEHS Grant No. P30ES023513. [Full Text Oh DL, D Meltzer, K Wang, AJ Canchola, MC DeRouen, C McDaniels-Davidson, J Gibbons, L CarvajalCarmona, JN Nodora, L Hill, SL Gomez and ME Martinez. 2022. Neighborhood Factors Associated with COVID-19 Cases in California. Journal of Racial and Ethnic Health Disparities. NIEHS Grant No. P30ES023513.]

Grube AM, CK Coleman, CD LaMontagne, ME Miller, NP Kothegal, DA Holcomb, AD Blackwood, TJ Clerkin, ML Serre, LS Engel, VT Guidry, RT Noble and JR Stewart. 2022. Detection of SARS-CoV-2 RNA in wastewater and comparison to COVID-19 cases in two sewersheds, North Carolina, USA. Science of the Total Environment (2023) v. 858: 159996. NIEHS Grant No. T32ES007018. [Full Text Grube AM, CK Coleman, CD LaMontagne, ME Miller, NP Kothegal, DA Holcomb, AD Blackwood, TJ Clerkin, ML Serre, LS Engel, VT Guidry, RT Noble and JR Stewart. 2022. Detection of SARS-CoV-2 RNA in wastewater and comparison to COVID-19 cases in two sewersheds, North Carolina, USA. Science of the Total Environment (2023) v. 858: 159996. NIEHS Grant No. T32ES007018.]

Environmental Factor Articles

Majority of North Carolinians have antibodies against coronavirus – October 2022
NIEHS COVID-19 serological surveillance study tracked the presence and rate of development of anti-SARS-CoV-2 antibodies in North Carolina.

PFAS, worker safety, data sharing, and more on tap at Council meeting – October 2022
Translational toxicology and strategic planning efforts were also discussed during the Sept. 13-14 event.

Papers From NIEHS Researchers

Paul P, Edmonds KL, Baldridge KC, Bhattacharyya D, Dziubla T, Dutch RE, Hilt JZ. 2022. Enhanced inactivation of pseudoparticles containing SARS-CoV-2 S protein using magnetic nanoparticles and an alternating magnetic field. ACS Applied Bio Materials v.5(11):pp.5140-5147. NIEHS Grant No. P42ES007380. [Full Text Paul P, Edmonds KL, Baldridge KC, Bhattacharyya D, Dziubla T, Dutch RE, Hilt JZ. 2022. Enhanced inactivation of pseudoparticles containing SARS-CoV-2 S protein using magnetic nanoparticles and an alternating magnetic field. ACS Applied Bio Materials v.5(11):pp.5140-5147. NIEHS Grant No. P42ES007380.]

Cormier SA, Yamamoto A, Short KR, Vu L, Suk WA. 2022. Environmental impacts on COVID-19: Mechanisms of increased susceptibility. Annals of Global Health v.88(1):94. [Full Text Cormier SA, Yamamoto A, Short KR, Vu L, Suk WA. 2022. Environmental impacts on COVID-19: Mechanisms of increased susceptibility. Annals of Global Health v.88(1):94.]

Hogberg HT, Lam A, Ohayon E, Shahbaz MA, Clerbaux LA, Bal-Price A, Coecke S, Concha R, De Bernardi F, Edrosa E, Hargreaves AJ, Kanninen KM, Munoz A, Pistollato F, Saravanan S, Garcia-Reyero N, Wittwehr C, Sachana M. 2022. The adverse outcome pathway framework applied to neurological symptoms of COVID-19. Cells v.11(21):3411. [Full Text Hogberg HT, Lam A, Ohayon E, Shahbaz MA, Clerbaux LA, Bal-Price A, Coecke S, Concha R, De Bernardi F, Edrosa E, Hargreaves AJ, Kanninen KM, Munoz A, Pistollato F, Saravanan S, Garcia-Reyero N, Wittwehr C, Sachana M. 2022. The adverse outcome pathway framework applied to neurological symptoms of COVID-19. Cells v.11(21):3411.]

Chiu WA, Ndeffo-Mbah ML. 2022. Calibrating COVID-19 community transmission risk levels to reflect infection prevalence. Epidemics v.41:100646. NIEHS Grant No. P30ES029067. [Full Text Chiu WA, Ndeffo-Mbah ML. 2022. Calibrating COVID-19 community transmission risk levels to reflect infection prevalence. Epidemics v.41:100646. NIEHS Grant No. P30ES029067.]

Mavri M, Mennis V. 2022. Is COVID-19 the "catalyst" to incorporate 3D printing technology into the manufacturing industry? 3D Printing and Additive Manufacturing v.9(5):pp.450-459. NIEHS Grant No. K01ES026837. [Full Text Mavri M, Mennis V. 2022. Is COVID-19 the "catalyst" to incorporate 3D printing technology into the manufacturing industry? 3D Printing and Additive Manufacturing v.9(5):pp.450-459. NIEHS Grant No. K01ES026837.]

He Y, Yu H, Huffman A, Lin AY, Natale DA, Beverley J, Zheng L, Perl Y, Wang Z, Liu Y, Ong E, Wang Y, Huang P, Tran L, Du J, Shah Z, Shah E, Desai R, Huang HH, Tian Y, Merrell E, Duncan WD, Arabandi S, Schriml LM, Zheng J, Masci AM, Wang L, Liu H, Smaili FZ, Hoehndorf R, Pendlington ZM, Roncaglia P, Ye X, Xie J, Tang YW, Yang X, Peng S, Zhang L, Chen L, Hur J, Omenn GS, Athey B, Smith B. 2022. A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology. J Biomed Semantics. 2022 Oct 21;13(1):25. [Full Text He Y, Yu H, Huffman A, Lin AY, Natale DA, Beverley J, Zheng L, Perl Y, Wang Z, Liu Y, Ong E, Wang Y, Huang P, Tran L, Du J, Shah Z, Shah E, Desai R, Huang HH, Tian Y, Merrell E, Duncan WD, Arabandi S, Schriml LM, Zheng J, Masci AM, Wang L, Liu H, Smaili FZ, Hoehndorf R, Pendlington ZM, Roncaglia P, Ye X, Xie J, Tang YW, Yang X, Peng S, Zhang L, Chen L, Hur J, Omenn GS, Athey B, Smith B. 2022. A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology. J Biomed Semantics. 2022 Oct 21;13(1):25.]

Majumder N, Deepak V, Hadique S, Aesoph D, Velayutham M, Ye Q, Mazumder MHH, Lewis SE, Kodali V, Roohollahi A, Guo NL, Hu G, Khramtsov VV, Johnson RJ, Wen S, Kelley EE, Hussain S. 2022. Redox imbalance in COVID-19 pathophysiology. Redox Biology v.56:102465. NIEHS Grant No. R01ES031253. [Full Text Majumder N, Deepak V, Hadique S, Aesoph D, Velayutham M, Ye Q, Mazumder MHH, Lewis SE, Kodali V, Roohollahi A, Guo NL, Hu G, Khramtsov VV, Johnson RJ, Wen S, Kelley EE, Hussain S. 2022. Redox imbalance in COVID-19 pathophysiology. Redox Biology v.56:102465. NIEHS Grant No. R01ES031253.]

Banzon TM, Sheehan WJ, Petty CR, Hauptman M, Flanagan S, Bell D Jr, Shamosh B, Bartnikas LM, Phipatanakul W. 2022. The Coronavirus Disease 2019 Pandemic and Mental Health-Related School-Nurse Visits in United States Schools. Academic pediatrics, S1876-2859(22)00427-2. NIEHS Grant No. K23ES031663. [Full Text Banzon TM, Sheehan WJ, Petty CR, Hauptman M, Flanagan S, Bell D Jr, Shamosh B, Bartnikas LM, Phipatanakul W. 2022. The Coronavirus Disease 2019 Pandemic and Mental Health-Related School-Nurse Visits in United States Schools. Academic pediatrics, S1876-2859(22)00427-2. NIEHS Grant No. K23ES031663.]

Xing J, Shankar R, Ko M, Zhang K, Zhang S, Drelich A, Paithankar S, Chekalin E, Chua MS, Rajasekaran S, Kent Tseng CT, Zheng M, Kim S, Chen B. 2022. Deciphering COVID-19 host transcriptomic complexity and variations for therapeutic discovery against new variants. iScience (2022) v.25 (10): 105068. NIEHS Grant No. K01ES028047. [Full Text Xing J, Shankar R, Ko M, Zhang K, Zhang S, Drelich A, Paithankar S, Chekalin E, Chua MS, Rajasekaran S, Kent Tseng CT, Zheng M, Kim S, Chen B. 2022. Deciphering COVID-19 host transcriptomic complexity and variations for therapeutic discovery against new variants. iScience (2022) v.25 (10): 105068. NIEHS Grant No. K01ES028047.]

Nottmeyer L, Armstrong B, Lowe R, Abbott S, Meakin S, O'Reilly K, von Borries R, Schneider R, Royé D, Hashizume M, Pascal M, Tobias A, Vicedo-Cabrera AM, Lavigne E, Correa PM, Ortega NV, Kynčl J, Urban A, Orru H, Ryti N, Jaakkola J, Dallavalle M, Schneider A, Honda Y, Ng CFS, Alahmad B, Carrasco G, Holobâc IH, Kim H, Lee W, Íñiguez C, Bell ML, Zanobetti A, Schwartz J, Scovronick N, Coélho MSZS, Saldiva PHN, Diaz MH, Gasparrini A, Sera F. 2022. The association of COVID-19 incidence with temperature, humidity, and UV radiation - A global multi-city analysis. Science of the Total Environment (2023) v. 854: 158636. NIEHS Grant No. P30ES019776. [Full Text Nottmeyer L, Armstrong B, Lowe R, Abbott S, Meakin S, O'Reilly K, von Borries R, Schneider R, Royé D, Hashizume M, Pascal M, Tobias A, Vicedo-Cabrera AM, Lavigne E, Correa PM, Ortega NV, Kynčl J, Urban A, Orru H, Ryti N, Jaakkola J, Dallavalle M, Schneider A, Honda Y, Ng CFS, Alahmad B, Carrasco G, Holobâc IH, Kim H, Lee W, Íñiguez C, Bell ML, Zanobetti A, Schwartz J, Scovronick N, Coélho MSZS, Saldiva PHN, Diaz MH, Gasparrini A, Sera F. 2022. The association of COVID-19 incidence with temperature, humidity, and UV radiation - A global multi-city analysis. Science of the Total Environment (2023) v. 854: 158636. NIEHS Grant No. P30ES019776.]

Ahmad S, Matalon S, Kuebler WM. Understanding COVID-19 susceptibility and presentation based on its underlying physiology. 2022. Physiological Reviews v. 102 (4): pp. 1579-1585. NIEHS Grant No. R21ES030525, U01ES027697, U01ES028182, R21ES032956 [Full Text Ahmad S, Matalon S, Kuebler WM. Understanding COVID-19 susceptibility and presentation based on its underlying physiology. 2022. Physiological Reviews v. 102 (4): pp. 1579-1585. NIEHS Grant No. R21ES030525, U01ES027697, U01ES028182, R21ES032956]

Environmental Factor Articles

COVID-19 virus hijacks lipid metabolism in the body to cause disease – September 2022
The coronavirus that causes COVID-19 establishes infection by rewiring how cells make and process lipids, or fats, according to researchers funded in part by NIEHS.

Rat oral toxicity studies can produce inconsistent results – September 2022
The reproducibility of studies that evaluate rodent oral toxicity resulting from short-term chemical exposure is lower than expected, according to researchers from the NIEHS Division of the National Toxicology Program.

Papers From NIEHS Researchers

Browne SK, Feemster KA, Shen AK, Green-McKenzie J, Momplaisir FM, Faig W, Offit PA, Kuter BJ. Coronavirus disease 2019 (COVID-19) vaccine hesitancy among physicians, physician assistants, nurse practitioners, and nurses in two academic hospitals in Philadelphia. Infection Control and Hospital Epidemiology v.43(10):pp.1424-1432. NIEHS Grant No. P30ES013508. [Full Text Browne SK, Feemster KA, Shen AK, Green-McKenzie J, Momplaisir FM, Faig W, Offit PA, Kuter BJ. Coronavirus disease 2019 (COVID-19) vaccine hesitancy among physicians, physician assistants, nurse practitioners, and nurses in two academic hospitals in Philadelphia. Infection Control and Hospital Epidemiology v.43(10):pp.1424-1432. NIEHS Grant No. P30ES013508.]

Emery RJ, Patlovich SJ, King KG, Rios J. 2022. Pivoting the biosafety program in response to COVID-19: Recommendations of key services and tasks to consider for the next pandemic. Applied Biosafety v.27(3):pp.119-126. NIEHS Grant No. U45ES019360. [Full Text Emery RJ, Patlovich SJ, King KG, Rios J. 2022. Pivoting the biosafety program in response to COVID-19: Recommendations of key services and tasks to consider for the next pandemic. Applied Biosafety v.27(3):pp.119-126. NIEHS Grant No. U45ES019360.]

Hernandez-Castro I, Toledo-Corral CM, Chavez T, Habre R, Grubbs B, Al-Marayati L, Lerner D, Lurvey N, Lagomasino I, Eckel SP, Dunton GF, Farzan SF, Breton CV, Bastain TM. 2022. Perceived vulnerability to immigration policies among postpartum Hispanic/Latina women in the MADRES pregnancy cohort before and during the COVID-19 pandemic. Women’s Health v.18:17455057221125103. NIEHS Grant No. P50ES026086, P30ES007048. [Full Text Hernandez-Castro I, Toledo-Corral CM, Chavez T, Habre R, Grubbs B, Al-Marayati L, Lerner D, Lurvey N, Lagomasino I, Eckel SP, Dunton GF, Farzan SF, Breton CV, Bastain TM. 2022. Perceived vulnerability to immigration policies among postpartum Hispanic/Latina women in the MADRES pregnancy cohort before and during the COVID-19 pandemic. Women’s Health v.18:17455057221125103. NIEHS Grant No. P50ES026086, P30ES007048.]

Acer PT, Kelly LM, Lover AA, Butler CS. 2022. Quantifying the relationship between SARS-CoV-2 wastewater concentrations and building-level COVID-19 prevalence at an isolation residence: A passive sampling approach. International Journal of Environmental Research and Public Health v.19(18):11245. NIEHS Grant No. R25ES031498. [Full Text Acer PT, Kelly LM, Lover AA, Butler CS. 2022. Quantifying the relationship between SARS-CoV-2 wastewater concentrations and building-level COVID-19 prevalence at an isolation residence: A passive sampling approach. International Journal of Environmental Research and Public Health v.19(18):11245. NIEHS Grant No. R25ES031498.]

McGee C, Shi M, House J, Drude A, Gonzalez G, Martin N, Chen SH, Rogers H, Njunge A, Hodge X, Mosley B, George M, Agrawal R, Wild C, Smith C, Brown A, Barber L, Garantziotis S. 2022. Longitudinal serological surveillance for COVID-19 antibodies after infection and vaccination. Microbiology Spectrum e0202622. [Full Text McGee C, Shi M, House J, Drude A, Gonzalez G, Martin N, Chen SH, Rogers H, Njunge A, Hodge X, Mosley B, George M, Agrawal R, Wild C, Smith C, Brown A, Barber L, Garantziotis S. 2022. Longitudinal serological surveillance for COVID-19 antibodies after infection and vaccination. Microbiology Spectrum e0202622.]

Spangler KR, JI Levy, MP Fabian, BM Haley, F Carnes, P Patil, K Tieskens, RM Klevens, EA Erdman, TS Troppy, JH Leibler and KJ Lane. 2022. Missing Race and Ethnicity Data among COVID-19 Cases in Massachusetts. Journal of Racial and Ethnic Health Disparities [ePub]. NIEHS Grant No. T32ES014562. [Full Text Spangler KR, JI Levy, MP Fabian, BM Haley, F Carnes, P Patil, K Tieskens, RM Klevens, EA Erdman, TS Troppy, JH Leibler and KJ Lane. 2022. Missing Race and Ethnicity Data among COVID-19 Cases in Massachusetts. Journal of Racial and Ethnic Health Disparities [ePub]. NIEHS Grant No. T32ES014562.]

Esther CR, Jr., KS Kimura, Y Mikami, CE Edwards, SR Das, MH Freeman, BA Strickland, HM Brown, BC Wessinger, VC Gupta, K Von Wahlde, Q Sheng, LC Huang, DR Bacon, AJ Kimple, AS Ceppe, T Kato, RJ Pickles, SH Randell, RS Baric, JH Turner and RC Boucher. 2022. Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial. International Forum of Allergy and Rhinology v. 12 (9): pp. 1137-1147. NIEHS Grant No. P30ES010126. [Full Text Esther CR, Jr., KS Kimura, Y Mikami, CE Edwards, SR Das, MH Freeman, BA Strickland, HM Brown, BC Wessinger, VC Gupta, K Von Wahlde, Q Sheng, LC Huang, DR Bacon, AJ Kimple, AS Ceppe, T Kato, RJ Pickles, SH Randell, RS Baric, JH Turner and RC Boucher. 2022. Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial. International Forum of Allergy and Rhinology v. 12 (9): pp. 1137-1147. NIEHS Grant No. P30ES010126.]

Patrone PN, Bedekar P, Pisanic N, Manabe YC, Thomas DL, Heaney CD, Kearsley AJ. Optimal decision theory for diagnostic testing: Minimizing indeterminate classes with applications to saliva-based SARS-CoV-2 antibody assays. 2022. Mathematical Biosciences v. 351: 108858. NIEHS Grant No. R01ES026973 [Full Text Patrone PN, Bedekar P, Pisanic N, Manabe YC, Thomas DL, Heaney CD, Kearsley AJ. Optimal decision theory for diagnostic testing: Minimizing indeterminate classes with applications to saliva-based SARS-CoV-2 antibody assays. 2022. Mathematical Biosciences v. 351: 108858. NIEHS Grant No. R01ES026973]

Fruh V, Lyons G, Scalise AL, Gallagher NJ, Jukic AM, Baird DD, Chaturvedi U, Suharwardy S, Onnela JP, Williams MA, Hauser R, Coull BA, Mahalingaiah S. Attempts to conceive and the COVID-19 pandemic: data from the Apple Women’s Health Study. 2022. American Journal of Obstetrics and Gynecology [Full Text Fruh V, Lyons G, Scalise AL, Gallagher NJ, Jukic AM, Baird DD, Chaturvedi U, Suharwardy S, Onnela JP, Williams MA, Hauser R, Coull BA, Mahalingaiah S. Attempts to conceive and the COVID-19 pandemic: data from the Apple Women’s Health Study. 2022. American Journal of Obstetrics and Gynecology]

Worker Training Program

WTP MUSTID
The Material Upload and Search Tool for Infectious Disease (MUSTID) is a searchable portal that provides easy access to resources on infectious disease and worker safety shared by and relevant to WTP and others interested in worker safety and health. It is now available to the general public.

COVID-19
The NIEHS Worker Training Program (WTP) has been tracking information about the coronavirus disease 2019 (COVID-19) as it pertains to protecting workers involved in emergency response and cleanup activities performed in the United States. This page contains health and safety resources for workers who may be at risk of exposure to COVID-19.

Environmental Factor Articles

Links between pandemic stress, brain circuitry explored during lecture – August 2022
Renowned neuroscientist Amy Arnsten, Ph.D., delivered the 2022 NIEHS Martin Rodbell Lecture.

Papers From NIEHS Researchers

Casey JA, Kioumourtzoglou MA, Ogburn EL, Melamed A, Shaman J, Kandula S, Neophytou A, Darwin KC, Sheffield JS, Gyamfi-Bannerman C. 2022. Long-term fine particulate matter concentrations and prevalence of severe acute respiratory syndrome Coronavirus 2: Differential relationships by socioeconomic status among pregnant individuals in New York City. American Journal of Epidemiology kwac139 [ePub]. NIEHS Grant No. R00ES027023, P30ES009089. [Full Text Casey JA, Kioumourtzoglou MA, Ogburn EL, Melamed A, Shaman J, Kandula S, Neophytou A, Darwin KC, Sheffield JS, Gyamfi-Bannerman C. 2022. Long-term fine particulate matter concentrations and prevalence of severe acute respiratory syndrome Coronavirus 2: Differential relationships by socioeconomic status among pregnant individuals in New York City. American Journal of Epidemiology kwac139 [ePub]. NIEHS Grant No. R00ES027023, P30ES009089.]

Callender R, JM Canales, C Avendano, E Craft, KB Ensor and ML Miranda. 2022. Economic and mental health impacts of multiple adverse events: Hurricane Harvey, other flooding events, and the COVID-19 pandemic. Environmental Research v. 214 (Pt 3): 114020. NIEHS Grant No. R21ES029461 [Full Text Callender R, JM Canales, C Avendano, E Craft, KB Ensor and ML Miranda. 2022. Economic and mental health impacts of multiple adverse events: Hurricane Harvey, other flooding events, and the COVID-19 pandemic. Environmental Research v. 214 (Pt 3): 114020. NIEHS Grant No. R21ES029461]

Lisonkova S, JN Bone, GM Muraca, N Razaz, A Boutin, JS Brandt, MA Bedaiwy, CV Ananth and KS Joseph. 2022. Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth. Paediatric and Perinatal Epidemiology. NIEHS Grant No. R01ES033190. [Full Text Lisonkova S, JN Bone, GM Muraca, N Razaz, A Boutin, JS Brandt, MA Bedaiwy, CV Ananth and KS Joseph. 2022. Early coronavirus disease 2019 restrictive measures and changes in maternal characteristics, use of assisted reproductive technology, and stillbirth. Paediatric and Perinatal Epidemiology. NIEHS Grant No. R01ES033190.]

Fu Y, da Fonseca Rezende e Mello J, Fleming BD, Renn A, Chen CZ, Hu X, et al. (2022) A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike. PLoS ONE 17(8): e0272364. [Full Text Fu Y, da Fonseca Rezende e Mello J, Fleming BD, Renn A, Chen CZ, Hu X, et al. (2022) A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike. PLoS ONE 17(8): e0272364.]

Gozalo AS, Clark TS, Kurtz DM. 2022. Coronaviruses: Troubling crown of the animal kingdom. Comparative Medicine v. 77 (5): pp. 1-39. [Full Text Gozalo AS, Clark TS, Kurtz DM. 2022. Coronaviruses: Troubling crown of the animal kingdom. Comparative Medicine v. 77 (5): pp. 1-39.]

Marian B, Yan Y, Chen Z, Lurmann F, Li K, Gilliland F, Eckel SP, Garcia E. 2022. Independent associations of short- and long-term air pollution exposure with COVID-19 mortality among Californians. Environmental Advances v. 9:100280. NIEHS Grant No. P30ES007048. [Full Text Marian B, Yan Y, Chen Z, Lurmann F, Li K, Gilliland F, Eckel SP, Garcia E. 2022. Independent associations of short- and long-term air pollution exposure with COVID-19 mortality among Californians. Environmental Advances v. 9:100280. NIEHS Grant No. P30ES007048.]

Pinku H, Huls A, Feany PT, Baumer N, Dierssen M, Bargagna S, Costa AC, Chicoine BA, Rebillat AS, Sgandurra G, Valentini D, Rohrer RT, Levin J, Lakhanpaul M, Carfi A, Sherman SL, Strydom A, Ghosh S, Trisomy 21 Research Society Covid-19 Initiative Study Group. 2022. Differences in clinical presentation, severity, and treatment of COVID-19 among individuals with Down syndrome from India and high-income countries: Data from the Trisomy 21 Research Society survey. Journal of Global Health v. 12:05035. NIEHS Grant No. P30ES019776. [Full Text Pinku H, Huls A, Feany PT, Baumer N, Dierssen M, Bargagna S, Costa AC, Chicoine BA, Rebillat AS, Sgandurra G, Valentini D, Rohrer RT, Levin J, Lakhanpaul M, Carfi A, Sherman SL, Strydom A, Ghosh S, Trisomy 21 Research Society Covid-19 Initiative Study Group. 2022. Differences in clinical presentation, severity, and treatment of COVID-19 among individuals with Down syndrome from India and high-income countries: Data from the Trisomy 21 Research Society survey. Journal of Global Health v. 12:05035. NIEHS Grant No. P30ES019776.]

Lee RC, Hu H, Kawaguchi ES, Kim AE, Soto DW, Shanker K, Klausner JD, Van Orman S, Unger JB. COVID-19 booster vaccine attitudes and behaviors among university students and staff in the United States: The USC Trojan pandemic research Initiative. Preventive Medicine Reports 2022 v. 28: 101866. NIEHS Grant No. P30ES007048, T32ES013678 [Full Text Lee RC, Hu H, Kawaguchi ES, Kim AE, Soto DW, Shanker K, Klausner JD, Van Orman S, Unger JB. COVID-19 booster vaccine attitudes and behaviors among university students and staff in the United States: The USC Trojan pandemic research Initiative. Preventive Medicine Reports 2022 v. 28: 101866. NIEHS Grant No. P30ES007048, T32ES013678]

Piscitelli P, Miani A, Setti L, De Gennaro G, Rodo X, Artinano B, Vara E, Rancan L, Arias J, Passarini F, Barbieri P, Pallavicini A, Parente A, D'Oro EC, De Maio C, Saladino F, Borelli M, Colicino E, Gonçalves LMG, Di Tanna G, Colao A, Leonardi GS, Baccarelli A, Dominici F, Ioannidis JPA, Domingo JL. 2022. The role of outdoor and indoor air quality in the spread of SARS-CoV-2: Overview and recommendations by the research group on COVID-19 and particulate matter (RESCOP commission). Environmental Research v. 211: 113038. NIEHS Grant No. P30ES023515 [Full Text Piscitelli P, Miani A, Setti L, De Gennaro G, Rodo X, Artinano B, Vara E, Rancan L, Arias J, Passarini F, Barbieri P, Pallavicini A, Parente A, D'Oro EC, De Maio C, Saladino F, Borelli M, Colicino E, Gonçalves LMG, Di Tanna G, Colao A, Leonardi GS, Baccarelli A, Dominici F, Ioannidis JPA, Domingo JL. 2022. The role of outdoor and indoor air quality in the spread of SARS-CoV-2: Overview and recommendations by the research group on COVID-19 and particulate matter (RESCOP commission). Environmental Research v. 211: 113038. NIEHS Grant No. P30ES023515]

Persaud E, Weinstock D, Wright DS. Biosafety and infectious disease occupational health training from the NIEHS Worker Training Program: A historical look at capacity building that supported a COVID-19 response. 2022. Journal of Emergency Management v. 20 (7): pp. 9-18 [Full Text Persaud E, Weinstock D, Wright DS. Biosafety and infectious disease occupational health training from the NIEHS Worker Training Program: A historical look at capacity building that supported a COVID-19 response. 2022. Journal of Emergency Management v. 20 (7): pp. 9-18]

Nathala P, Salunkhe V, Samanapally H, Xu Q, Furmanek S, Fahmy OH, Deepti F, Glynn A, McGuffin T, Goldsmith DC, Petrey J, Ali T, Titus D, Carrico R, Ramirez J, Antimisiaris D, Clifford SP, Pahwa S, Roser L, Kong M, Huang J. 2022. Electrocardiographic Features and Outcome: Correlations in 124 Hospitalized Patients With COVID-19 and Cardiovascular Events. Journal of Cardiothoracic and Vascular Anesthesia. NIEHS Grant No. P30ES030283 [Full Text Nathala P, Salunkhe V, Samanapally H, Xu Q, Furmanek S, Fahmy OH, Deepti F, Glynn A, McGuffin T, Goldsmith DC, Petrey J, Ali T, Titus D, Carrico R, Ramirez J, Antimisiaris D, Clifford SP, Pahwa S, Roser L, Kong M, Huang J. 2022. Electrocardiographic Features and Outcome: Correlations in 124 Hospitalized Patients With COVID-19 and Cardiovascular Events. Journal of Cardiothoracic and Vascular Anesthesia. NIEHS Grant No. P30ES030283]

Ingram C, Min E, Seto E, Cummings BJ, Farquhar S. 2022. Cumulative Impacts and COVID-19: Implications for Low-income, Minoritized, and Health-Compromised Communities in King County, WA. J Racial Ethn Health Disparities 2022 Aug;9(4):1210-1224. Epub 2021 Jun 14. NIEHS Grant No. P30ES007033 [Full Text Ingram C, Min E, Seto E, Cummings BJ, Farquhar S. 2022. Cumulative Impacts and COVID-19: Implications for Low-income, Minoritized, and Health-Compromised Communities in King County, WA. J Racial Ethn Health Disparities 2022 Aug;9(4):1210-1224. Epub 2021 Jun 14. NIEHS Grant No. P30ES007033]

Ahmad S, Manzoor S, Siddiqui S, Mariappan N, Zafar I, Ahmad A, Ahmad A. 2022. Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19. Semin Cancer Biol 2022 Aug;83:384-398. Epub 2021 Jan 20. NIEHS Grant No. U01ES025069, U01ES028182 [Full Text Ahmad S, Manzoor S, Siddiqui S, Mariappan N, Zafar I, Ahmad A, Ahmad A. 2022. Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19. Semin Cancer Biol 2022 Aug;83:384-398. Epub 2021 Jan 20. NIEHS Grant No. U01ES025069, U01ES028182]

Environmental Factor Articles

Antiviral membranes boost masks’ ability to stop COVID – July 2022
Funded by NIEHS and the National Science Foundation, the new membranes capture and deactivate SARS-CoV-2 on contact, preventing the spread of COVID-19.

Papers From NIEHS Researchers

Frazier MN, Wilson IM, Krahn JM, Butay KJ, Dillard LB, Borgnia MJ, Stanley RE. 2022. Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease. Nucleic Acids Research : gkac589 [ePub]. [Full Text Frazier MN, Wilson IM, Krahn JM, Butay KJ, Dillard LB, Borgnia MJ, Stanley RE. 2022. Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease. Nucleic Acids Research : gkac589 [ePub].]

Berg CJ, Sturua L, Marsit CJ, Baramidze L, Kiladze N, Caudle WM. 2022. Research capacity training on environmental health and noncommunicable diseases in the country of Georgia: Challenges and lessons learned during the COVID-19 pandemic. International Journal of Environmental Research and Public Health v. 19 (13): 8154. NIEHS Grant No. P2CES033430, R24ES028507, P30ES019776, R01ES02912, R01ES032440. [Full Text Berg CJ, Sturua L, Marsit CJ, Baramidze L, Kiladze N, Caudle WM. 2022. Research capacity training on environmental health and noncommunicable diseases in the country of Georgia: Challenges and lessons learned during the COVID-19 pandemic. International Journal of Environmental Research and Public Health v. 19 (13): 8154. NIEHS Grant No. P2CES033430, R24ES028507, P30ES019776, R01ES02912, R01ES032440.]

Wilson AM, Ogunseye OO, Digioia O, Gerald LB, Lowe AA. 2022. Barriers to COVID-19 intervention implementation in K-5 classrooms: A survey of teachers from a district with mask mandates despite a statewide mask mandate ban. International journal of Environmental Research and Public Health v. 19 (14): 8311. NIEHS Grant No. P30ES006694. [Full Text Wilson AM, Ogunseye OO, Digioia O, Gerald LB, Lowe AA. 2022. Barriers to COVID-19 intervention implementation in K-5 classrooms: A survey of teachers from a district with mask mandates despite a statewide mask mandate ban. International journal of Environmental Research and Public Health v. 19 (14): 8311. NIEHS Grant No. P30ES006694.]

Thomason ME, Hendrix CL, Werchan D, Brito NH. 2022. Perceived discrimination as a modifier of health, disease, and medicine: empirical data from the COVID-19 pandemic. Translational Psychiatry v. 12:284. NIEHS Grant No. ES032294. [Full Text Thomason ME, Hendrix CL, Werchan D, Brito NH. 2022. Perceived discrimination as a modifier of health, disease, and medicine: empirical data from the COVID-19 pandemic. Translational Psychiatry v. 12:284. NIEHS Grant No. ES032294.]

Gemmill A, Casey JA, Catalano R, Karasek D, Margerison CE, Bruckner T. 2022. Changes in preterm birth and caesarean deliveries in the United States during the SARS-CoV-2 pandemic. Paediatr Perinat Epidemiol 36:485–489. NIEHS Grant No. P30ES009089. [Full Text Gemmill A, Casey JA, Catalano R, Karasek D, Margerison CE, Bruckner T. 2022. Changes in preterm birth and caesarean deliveries in the United States during the SARS-CoV-2 pandemic. Paediatr Perinat Epidemiol 36:485–489. NIEHS Grant No. P30ES009089.]

Wang S, J Mortazavi, JE Hart, JA Hankins, LM Katuska, LV Farland, AJ Gaskins, YX Wang, RM Tamimi, KL Terry, JW Rich-Edwards, SA Missmer and JE Chavarro. 2022. A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics. American Journal of Obstetrics and Gynecology [In Press]. NIEHS Grant No. R24ES028521, P30ES000002. [Full Text Wang S, J Mortazavi, JE Hart, JA Hankins, LM Katuska, LV Farland, AJ Gaskins, YX Wang, RM Tamimi, KL Terry, JW Rich-Edwards, SA Missmer and JE Chavarro. 2022. A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics. American Journal of Obstetrics and Gynecology [In Press]. NIEHS Grant No. R24ES028521, P30ES000002.]

Foo ACY, Lafont BAP, Mueller GA. Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligands. 2022. FEBS Letters [Full Text Foo ACY, Lafont BAP, Mueller GA. Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligands. 2022. FEBS Letters]

Eldeirawi KM, Nyenhuis SM, Huntington-Moskos L, Polivka BJ. Coronavirus disease 2019–related anxiety is associated with uncontrolled asthma in adults. 2022. Annals of Allergy, Asthma and Immunology. NIEHS Grant No. P30ES030283. [Full Text Eldeirawi KM, Nyenhuis SM, Huntington-Moskos L, Polivka BJ. Coronavirus disease 2019–related anxiety is associated with uncontrolled asthma in adults. 2022. Annals of Allergy, Asthma and Immunology. NIEHS Grant No. P30ES030283.]

Badon SE, Croen LA, Ferrara A, Ames JL, Hedderson MM, Young-Wolff KC, Zhu Y, Avalos LA. Coping strategies for COVID-19 pandemic-related stress and mental health during pregnancy. 2022. Journal of Affective Disorders v. 309: pp. 309-313. NIEHS Grant No. K99ES032481 [Full Text Badon SE, Croen LA, Ferrara A, Ames JL, Hedderson MM, Young-Wolff KC, Zhu Y, Avalos LA. Coping strategies for COVID-19 pandemic-related stress and mental health during pregnancy. 2022. Journal of Affective Disorders v. 309: pp. 309-313. NIEHS Grant No. K99ES032481]

Environmental Factor Articles

Understanding RNA structure could reveal how viruses interact in cells – June 2022
New methods for studying viruses and how they function were described by Eric Miska, Ph.D., during his May 10 NIEHS Distinguished Lecture.

Researchers identify risk factors for disease flares after COVID-19 vaccination – June 2022
Flares are infrequently reported after COVID-19 vaccination in patients with systemic rheumatic disease (SRD), according to NIEHS researchers and their collaborators.

Webinar explores sailors’ mental health during COVID, how pollutants can affect the microbiome – June 2022
Event showcased work of early-career scientists affiliated with NIEHS Environmental Health Sciences Core Centers.

Papers From NIEHS Researchers

Farley SE, Kyle JE, Leier HC, Bramer LM, Weinstein JB, Bates TA, Lee JY, Metz TO, Schultz C, Tafesse FG. 2022. A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants. Nature Communications v. 13: 3487. NIEHS Grant No. U2CES030170. [Full Text Farley SE, Kyle JE, Leier HC, Bramer LM, Weinstein JB, Bates TA, Lee JY, Metz TO, Schultz C, Tafesse FG. 2022. A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants. Nature Communications v. 13: 3487. NIEHS Grant No. U2CES030170.]

McCollum CR, Courtney CM, O'Connor NJ, Aunins TR, Ding Y, Jordan TX, Rogers KL, Brindley S, Brown JM, Nagpal P, Chatterjee A. 2022. Nanoligomers targeting human miRNA for the treatment of severe COVID-19 are safe and nontoxic in mice. ACS Biomaterials Science and Engineering v. 8 (7): pp. 3087-3106. NIEHS Grant No. T32ES029074. [Full Text McCollum CR, Courtney CM, O'Connor NJ, Aunins TR, Ding Y, Jordan TX, Rogers KL, Brindley S, Brown JM, Nagpal P, Chatterjee A. 2022. Nanoligomers targeting human miRNA for the treatment of severe COVID-19 are safe and nontoxic in mice. ACS Biomaterials Science and Engineering v. 8 (7): pp. 3087-3106. NIEHS Grant No. T32ES029074.]

Brumfield KD, Leddy M, Usmani M, Cotruvo JA, Tien CT, Dorsey S, Graubics K, Fanelli B, Zhou I, Registe N, Dadlani M, Wimalarante M, Jinasena D, Abayagunawardena R, Withanachchi C, Huq A, Jutla A, Colwell RR. 2022. Microbiome analysis for wastewater surveillance during COVID-19. mBio e00591-22. NIEHS Grant No. R01ES030317. [Full Text Brumfield KD, Leddy M, Usmani M, Cotruvo JA, Tien CT, Dorsey S, Graubics K, Fanelli B, Zhou I, Registe N, Dadlani M, Wimalarante M, Jinasena D, Abayagunawardena R, Withanachchi C, Huq A, Jutla A, Colwell RR. 2022. Microbiome analysis for wastewater surveillance during COVID-19. mBio e00591-22. NIEHS Grant No. R01ES030317.]

Bulka CM, AE Enggasser and RC Fry. 2022. Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures. Current Environmental Health Reports v. 9 (3): pp. 477-489. NIEHS Grant No. P42ES031007. [Full Text Bulka CM, AE Enggasser and RC Fry. 2022. Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures. Current Environmental Health Reports v. 9 (3): pp. 477-489. NIEHS Grant No. P42ES031007.]

Luke RA, Kearsley AJ, Pisanic N, Manabe YC, Thomas DL, Heaney CD, Patrone PN. Modeling in higher dimensions to improve diagnostic testing accuracy: theory and examples for multiplex saliva-based SARS-CoV-2 antibody assays.2022. ArXiv Jun 28:arXiv:2206.14316v1. NIEHS Grant No. R01ES026973 [Full Text Luke RA, Kearsley AJ, Pisanic N, Manabe YC, Thomas DL, Heaney CD, Patrone PN. Modeling in higher dimensions to improve diagnostic testing accuracy: theory and examples for multiplex saliva-based SARS-CoV-2 antibody assays.2022. ArXiv Jun 28:arXiv:2206.14316v1. NIEHS Grant No. R01ES026973]

Weber GM, Hong C, Xia Z, Palmer NP, Avillach P, L'Yi S, Keller MS, Murphy SN,Gutiérrez-Sacristán A, Bonzel CL, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Benoit V, Bourgeois FT, Chiovato L, Cho K, Dagliati A, DuVall SL, Barrio NG, Hanauer DA, Ho YL, Holmes JH, Issitt RW, Liu M, Luo Y, Lynch KE, Maidlow SE, Malovini A, Mandl KD, Mao C, Matheny ME, Moore JH, Morris JS, Morris M, Mowery DL, Ngiam KY, Patel LP, Pedrera-Jimenez M, Ramoni RB, Schriver ER, Schubert P, Balazote PS, Spiridou A, Tan ALM, Tan BWL, Tibollo V, Torti C, Trecarichi EM, Wang X, Kohane IS, Cai T, Brat GA. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality. 2022. NPJ Digital Medicine v. 5: 74. NIEHS Grant No. P30ES017885 [Full Text Weber GM, Hong C, Xia Z, Palmer NP, Avillach P, L'Yi S, Keller MS, Murphy SN,Gutiérrez-Sacristán A, Bonzel CL, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Benoit V, Bourgeois FT, Chiovato L, Cho K, Dagliati A, DuVall SL, Barrio NG, Hanauer DA, Ho YL, Holmes JH, Issitt RW, Liu M, Luo Y, Lynch KE, Maidlow SE, Malovini A, Mandl KD, Mao C, Matheny ME, Moore JH, Morris JS, Morris M, Mowery DL, Ngiam KY, Patel LP, Pedrera-Jimenez M, Ramoni RB, Schriver ER, Schubert P, Balazote PS, Spiridou A, Tan ALM, Tan BWL, Tibollo V, Torti C, Trecarichi EM, Wang X, Kohane IS, Cai T, Brat GA. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality. 2022. NPJ Digital Medicine v. 5: 74. NIEHS Grant No. P30ES017885]

Dickey-Chasins R, Romm KF, Vyas AN, McDonnell K, Wang Y, Ma Y, Berg CJ. Social distancing and related factors during the COVID-19 pandemic in relation to COVID-19 symptoms and diagnosis and mental health. 2022. Journal of Public Health. NIEHS Grant No. D43ES03092701 [Full Text Dickey-Chasins R, Romm KF, Vyas AN, McDonnell K, Wang Y, Ma Y, Berg CJ. Social distancing and related factors during the COVID-19 pandemic in relation to COVID-19 symptoms and diagnosis and mental health. 2022. Journal of Public Health. NIEHS Grant No. D43ES03092701]

Haque R, Moe CL, Raj SJ, Ong L, Charles K, Ross AG, Shirin T, Raqib R, Sarker P, Rahman M, Rahman MZ, Amin N, Mahmud ZH, Rahman M, Johnston D, Akter N, Khan TA, Hossain MA, Hasan R, Islam MT, Bhattacharya P. Wastewater surveillance of SARS-CoV-2 in Bangladesh: Opportunities and challenges. 2022. Current Opinion in Environmental Science and Health v. 27: 100334. NIEHS Grant No. D43TW010540 [Full Text Haque R, Moe CL, Raj SJ, Ong L, Charles K, Ross AG, Shirin T, Raqib R, Sarker P, Rahman M, Rahman MZ, Amin N, Mahmud ZH, Rahman M, Johnston D, Akter N, Khan TA, Hossain MA, Hasan R, Islam MT, Bhattacharya P. Wastewater surveillance of SARS-CoV-2 in Bangladesh: Opportunities and challenges. 2022. Current Opinion in Environmental Science and Health v. 27: 100334. NIEHS Grant No. D43TW010540] 

Klinkhammer KE, Romm KF, Kerrigan D, McDonnell KA, Vyas A, Wang Y, Ma Y, Berg CJ. Sociopolitical, mental health, and sociodemographic correlates of COVID-19 vaccine hesitancy among young adults in 6 US metropolitan areas. 2022. Preventive Medicine Reports v. 27: 101812. NIEHS Grant No. D43ES030927 [Full Text Klinkhammer KE, Romm KF, Kerrigan D, McDonnell KA, Vyas A, Wang Y, Ma Y, Berg CJ. Sociopolitical, mental health, and sociodemographic correlates of COVID-19 vaccine hesitancy among young adults in 6 US metropolitan areas. 2022. Preventive Medicine Reports v. 27: 101812. NIEHS Grant No. D43ES030927]

Zhong X, Zhou Z, Li G, Kwizera MH, Muennig P, Chen Q. Neighborhood disparities in COVID-19 outcomes in New York city over the first two waves of the outbreak. 2O22. Annals of Epidemiology v. 70: pp. 45-52. NIEHS Grant No. R21ES029668 [Full Text Zhong X, Zhou Z, Li G, Kwizera MH, Muennig P, Chen Q. Neighborhood disparities in COVID-19 outcomes in New York city over the first two waves of the outbreak. 2O22. Annals of Epidemiology v. 70: pp. 45-52. NIEHS Grant No. R21ES029668]

Rayasam SDG, Aung MT, Cooper C, Kwiatkowski C, Germolec DR, Rooney AA, Walker VR, Forte C, Woodruff TJ, Chartres N. 2022. Identifying environmental factors that influence immune response to SARS-CoV-2: Systematic evidence map protocol. Environment International v. 164: 107230 [Full Text Rayasam SDG, Aung MT, Cooper C, Kwiatkowski C, Germolec DR, Rooney AA, Walker VR, Forte C, Woodruff TJ, Chartres N. 2022. Identifying environmental factors that influence immune response to SARS-CoV-2: Systematic evidence map protocol. Environment International v. 164: 107230]

Larson PS, Bergmans RS. 2022. Impact of the COVID-19 pandemic on temporal patterns of mental health and substance abuse related mortality in Michigan: An interrupted time series analysis. Lancet Regional Health – Americas v. 10: 100218. NIEHS Grant No. P30ES017885, R00ES026198 [Full Text Larson PS, Bergmans RS. 2022. Impact of the COVID-19 pandemic on temporal patterns of mental health and substance abuse related mortality in Michigan: An interrupted time series analysis. Lancet Regional Health – Americas v. 10: 100218. NIEHS Grant No. P30ES017885, R00ES026198]

Sundberg A, Gottschalk R, Wicker S. 2022. Occupationally acquired SARS-CoV-2 infections among healthcare personnel in Frankfurt am Main from March to August 2020. Bundesgesundheitsblatt -Gesundheitsforschung -Gesundheitsschutz. NIEHS Grant No. R25ES029052 [Full Text Sundberg A, Gottschalk R, Wicker S. 2022. Occupationally acquired SARS-CoV-2 infections among healthcare personnel in Frankfurt am Main from March to August 2020. Bundesgesundheitsblatt -Gesundheitsforschung -Gesundheitsschutz. NIEHS Grant No. R25ES029052]

Environmental Factor Articles

Empowering women, improving health: NIEHS conference a resounding success – May 2022
Annual Women’s Health Awareness event addressed environmental health disparities and promoted health access, resiliency.

Scientific moonshot: Now is the time to sequence RNA, expert says – May 2022
Vivian Cheung, M.D., spoke with me about how such an undertaking will expand knowledge of disease and advance therapeutics.

NIH Statement on World Asthma Day 2022: Toward improved asthma care – May 2022
On May 3, the National Institutes of Health reaffirmed its commitment to research aimed at understanding, preventing, and treating asthma.

Earth Day events highlight planning ahead for environmental health – May 2022
Aubrey Miller receives award at University of Kentucky Earth Day event; Environmental Awareness and Advisory Committee hosts two seminars.

Papers From NIEHS Researchers

McLeish KR, Shrestha R, Vashishta A, Rane MJ, Barati MT, Brier ME, Lau MG, Hu XL, Chen OS, Wessel CR, Spalding T, Bush SE, Ijemere K, Hopkins CD, Cooke EA, Tandon S, Manning T, Uriarte SM, Huang JP, Yan J. 2022. Differential functional responses of Neutrophil subsets in severe COVID-19 patients. Frontiers in Immunology v. 13 [ePub]. NIEHS Grant No. P30ES030283. [Full Text McLeish KR, Shrestha R, Vashishta A, Rane MJ, Barati MT, Brier ME, Lau MG, Hu XL, Chen OS, Wessel CR, Spalding T, Bush SE, Ijemere K, Hopkins CD, Cooke EA, Tandon S, Manning T, Uriarte SM, Huang JP, Yan J. 2022. Differential functional responses of Neutrophil subsets in severe COVID-19 patients. Frontiers in Immunology v. 13 [ePub]. NIEHS Grant No. P30ES030283.]

Chen Z, Sidell MA, Huang BZ, Chow T, Eckel SP, Martinez MP, Gheissari R, Lurmann F, Thomas DC, Gilliland FD, Xiang AH. 2022. Ambient air pollutant exposures and COVID-19 severity and mortality in a cohort of patients with COVID-19 in Southern California. American Journal of Respiratory and Critical Care Medicine v. 206 (4): pp. 440-448. NIEHS Grant No. R01ES029963. [Full Text Chen Z, Sidell MA, Huang BZ, Chow T, Eckel SP, Martinez MP, Gheissari R, Lurmann F, Thomas DC, Gilliland FD, Xiang AH. 2022. Ambient air pollutant exposures and COVID-19 severity and mortality in a cohort of patients with COVID-19 in Southern California. American Journal of Respiratory and Critical Care Medicine v. 206 (4): pp. 440-448. NIEHS Grant No. R01ES029963.]

Gaston S, Alhasan D, Strassle P, Stewart A, Perez-Stable EEJ, Napoles A, Jackson C. 2022. Job loss, financial hardship, and sleep during the COVID-19 pandemic: differences by sex/gender and race/ethnicity. Sleep v. 45 (Suppl. 1): p. A20. [Full Text Gaston S, Alhasan D, Strassle P, Stewart A, Perez-Stable EEJ, Napoles A, Jackson C. 2022. Job loss, financial hardship, and sleep during the COVID-19 pandemic: differences by sex/gender and race/ethnicity. Sleep v. 45 (Suppl. 1): p. A20.]

Hussain S, Majumder N, Deepak V, Velayutham M, Mazumder M, Roohollahi A, Wen S, Khramtsov V, Kelley E, Hadique S. Biochemical Predictors for Covid-19 Disease Course and Mortality 2022. American Journal of Respiratory and Critical Care Medicine v. 205: A4576. NIEHS Grant No. ES031253 [Full Text Hussain S, Majumder N, Deepak V, Velayutham M, Mazumder M, Roohollahi A, Wen S, Khramtsov V, Kelley E, Hadique S. Biochemical Predictors for Covid-19 Disease Course and Mortality 2022. American Journal of Respiratory and Critical Care Medicine v. 205: A4576. NIEHS Grant No. ES031253]

Hinds D, Nick HJ, Vallin T, White CW, Bosco-Lauth A. Effect of vaping on lung inflammation and sars-cov-2 infection in a hamster model. 2022. American Journal of Respiratory and Critical Care Medicine v. 205: A1151 [Full Text Hinds D, Nick HJ, Vallin T, White CW, Bosco-Lauth A. Effect of vaping on lung inflammation and sars-cov-2 infection in a hamster model. 2022. American Journal of Respiratory and Critical Care Medicine v. 205: A1151]

Stober V, Martin N, Cronce M, Chen S, Sakamachi Y, Gabel S, Mueller G, Petrovich R, Stanley T, Rowe S, Garantziotis S. Hyaluronan ameliorates SARS-CoV-2 infection via steric inhibition of virion attachment to cells. 2022. American Journal of Respiratoryand Critical Care Medicine v. 205: A3684 [Full Text Stober V, Martin N, Cronce M, Chen S, Sakamachi Y, Gabel S, Mueller G, Petrovich R, Stanley T, Rowe S, Garantziotis S. Hyaluronan ameliorates SARS-CoV-2 infection via steric inhibition of virion attachment to cells. 2022. American Journal of Respiratoryand Critical Care Medicine v. 205: A3684]

Avalos LA, Nance N, Badon SE, Young-Wolff K, Ames J, Zhu YY, Hedderson MM, Ferrara A, Zerbo O, Greenberg M, Croen LA. Associations of COVID-19-related health, healthcare and economic factors with prenatal depression and anxiety. 2022. International Journal of Public Health v. 67. NIEHS Grant No. K99ES032481 [Full Text Avalos LA, Nance N, Badon SE, Young-Wolff K, Ames J, Zhu YY, Hedderson MM, Ferrara A, Zerbo O, Greenberg M, Croen LA. Associations of COVID-19-related health, healthcare and economic factors with prenatal depression and anxiety. 2022. International Journal of Public Health v. 67. NIEHS Grant No. K99ES032481]

Hau RK, Wright SH, Cherrington NJ. PF-07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID19 patients. 2022. Clinical and Translational Science. NIEHS Grant No. T32ES007091, R01ES028668 [Full Text Hau RK, Wright SH, Cherrington NJ. PF-07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID19 patients. 2022. Clinical and Translational Science. NIEHS Grant No. T32ES007091, R01ES028668]

Deierlein AL, Grayon AR, Zhu X, Sun Y, Liu X, Kohlasch K, Stein CR. Personal care and household cleaning product use among pregnant women and new mothers during the COVID-19 pandemic. 2022. International Journal of Environmental Research and Public Health 19(9):5645. NIEHS Grant No. R00ES023474 [Full Text Deierlein AL, Grayon AR, Zhu X, Sun Y, Liu X, Kohlasch K, Stein CR. Personal care and household cleaning product use among pregnant women and new mothers during the COVID-19 pandemic. 2022. International Journal of Environmental Research and Public Health 19(9):5645. NIEHS Grant No. R00ES023474]

Wolkin A, Collier S, House J, Reif D, Motsinger-Reif A, Duca L, Sharpe D. Comparison of national vulnerability indices used by the centers for disease control and prevention for the COVID-19 response. 2022. Public Health Reports 333549221090262 [Full Text Wolkin A, Collier S, House J, Reif D, Motsinger-Reif A, Duca L, Sharpe D. Comparison of national vulnerability indices used by the centers for disease control and prevention for the COVID-19 response. 2022. Public Health Reports 333549221090262]

Huang BZ, Sidell MA, Wu BU, Setiawan VW, Chen Z, Xiang AH. Pre-existing pancreatitis and elevated risks of COVID-19 severity and mortality. 2022. Gastroenterology v. 162 (6): pp. 1758-1760.e3. NIEHS Grant No. R01ES029963 [Full Text Huang BZ, Sidell MA, Wu BU, Setiawan VW, Chen Z, Xiang AH. Pre-existing pancreatitis and elevated risks of COVID-19 severity and mortality. 2022. Gastroenterology v. 162 (6): pp. 1758-1760.e3. NIEHS Grant No. R01ES029963]

Wurth R, Hajdenberg M, Barrera FJ, Shekhar S, Copacino CE, Moreno-Peña PJ, Gharib OAM, Porter F, Hiremath S, Hall JE, Schiffrin EL, Eisenhofer G, Bornstein SR, Brito JP, González-González JG, Stratakis CA, Rodríguez-Gutiérrez R, Hannah-Shmouni F. 2022. Scoping review of COVID-19-related systematic reviews and meta-analyses: can we really have confidence in their results? Postgrad Med J 2022 May;98(1159):372-379. Epub 2021 Feb 26 [Full Text Wurth R, Hajdenberg M, Barrera FJ, Shekhar S, Copacino CE, Moreno-Peña PJ, Gharib OAM, Porter F, Hiremath S, Hall JE, Schiffrin EL, Eisenhofer G, Bornstein SR, Brito JP, González-González JG, Stratakis CA, Rodríguez-Gutiérrez R, Hannah-Shmouni F. 2022. Scoping review of COVID-19-related systematic reviews and meta-analyses: can we really have confidence in their results? Postgrad Med J 2022 May;98(1159):372-379. Epub 2021 Feb 26]

Environmental Factor Articles

Falk Memorial Lecture focuses on how inflammation ends – April 2022
Charles Serhan described the biological mechanisms that are key to stopping runaway inflammation, which is linked to many diseases.

Language justice boosts worker safety, empowers people, experts say – April 2022
The NIEHS Worker Training Program has adopted a multilingual approach to advance communities’ environmental, occupational health.

2022 NIEHS Spirit Lecture honoree recognized for diversity efforts – April 2022
Marie A. Bernard, M.D., discussed the science behind scientific workforce diversity during her March 2 virtual lecture.

Papers From NIEHS Researchers

Le VT, Fulton-Kehoe D, Sears JM, Nkyekyer EW, Ehde DM, Young M, Franklin GM. Trends and disparities in the use of telehealth among injured workers during the COVID-19 pandemic. 2022. Journal of Occupational and Environmental Medicine v. 64 (4): pp. e249-e256. NIEHS Grant No. T32ES015459 [Full Text Le VT, Fulton-Kehoe D, Sears JM, Nkyekyer EW, Ehde DM, Young M, Franklin GM. Trends and disparities in the use of telehealth among injured workers during the COVID-19 pandemic. 2022. Journal of Occupational and Environmental Medicine v. 64 (4): pp. e249-e256. NIEHS Grant No. T32ES015459]

Myers NT, Laumbach RJ, Black KG, Ohman-Strickland P, Alimokhtari S, Legard A, De Resende A, Calderón L, Lu FT, Mainelis G, Kipen HM. Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: A real-world study. 2022. Indoor Air v. 32 (4): e13029. NIEHS Grant No. P30ES05022, T32ES019854 [Full Text Myers NT, Laumbach RJ, Black KG, Ohman-Strickland P, Alimokhtari S, Legard A, De Resende A, Calderón L, Lu FT, Mainelis G, Kipen HM. Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: A real-world study. 2022. Indoor Air v. 32 (4): e13029. NIEHS Grant No. P30ES05022, T32ES019854]

Hazlehurst MF, Muqueeth S, Wolf KL, Simmons C, Kroshus E, Tandon PS. Park access and mental health among parents and children during the COVID-19 pandemic. 2022. BMC Public Health v. 22: 800. NIEHS Grant No. T32ES015459 [Full Text Hazlehurst MF, Muqueeth S, Wolf KL, Simmons C, Kroshus E, Tandon PS. Park access and mental health among parents and children during the COVID-19 pandemic. 2022. BMC Public Health v. 22: 800. NIEHS Grant No. T32ES015459]

Hong J, Kwon HJ, Cachau R, Chen CZ, Butay KJ, Duan Z, Li D, Ren H, Liang T, Zhu J, Dandey VP, Martin NP, Esposito D, Ortega-Rodriguez U, Xu M, Borgnia MJ, Xie H, Ho M. Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants. 2022. Proceedings of the National Academy of Sciences v. 119 (18): e2201433119 [Full Text Hong J, Kwon HJ, Cachau R, Chen CZ, Butay KJ, Duan Z, Li D, Ren H, Liang T, Zhu J, Dandey VP, Martin NP, Esposito D, Ortega-Rodriguez U, Xu M, Borgnia MJ, Xie H, Ho M. Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants. 2022. Proceedings of the National Academy of Sciences v. 119 (18): e2201433119]

Acer PT, Kelly LM, Lover AA, Butler CS. 2022. Quantifying the relationship between SARS-CoV-2 wastewater concentrations and building-level COVID-19 prevalence at an isolation residence using a passive sampling approach. medRxiv. NIEHS Grant No. R25ES031498 [Full Text Acer PT, Kelly LM, Lover AA, Butler CS. 2022. Quantifying the relationship between SARS-CoV-2 wastewater concentrations and building-level COVID-19 prevalence at an isolation residence using a passive sampling approach. medRxiv. NIEHS Grant No. R25ES031498]

Kenney DJ, O'Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. 2022. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. 2022. Cell Reports v. 39 (3): 110714. NIEHS Grant No. R21ES032882 [Full Text Kenney DJ, O'Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. 2022. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. 2022. Cell Reports v. 39 (3): 110714. NIEHS Grant No. R21ES032882]

Frazier MN, Riccio AA, Wilson IM, Copeland WC, Stanley RE. 2022. Recent insights into the structure and function of coronavirus ribonucleases. FEBS Open Bio [Full Text Frazier MN, Riccio AA, Wilson IM, Copeland WC, Stanley RE. 2022. Recent insights into the structure and function of coronavirus ribonucleases. FEBS Open Bio]

Rider LG, Parks CG, Wilkerson J, Schiffenbauer AI, Kwok RK, Noroozi Farhadi P, Nazir S, Ritter R, Sirotich E, Kennedy K, Larche MJ, Levine M, Sattui SE, Liew JW, Harrison CO, Moni TT, Miller AK, Putman M, Hausmann J, Simard JF, Sparks JA, Miller FW. 2022. Baseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: results from the COVID-19 global rheumatology alliance vaccine survey. Rheumatology [Full Text Rider LG, Parks CG, Wilkerson J, Schiffenbauer AI, Kwok RK, Noroozi Farhadi P, Nazir S, Ritter R, Sirotich E, Kennedy K, Larche MJ, Levine M, Sattui SE, Liew JW, Harrison CO, Moni TT, Miller AK, Putman M, Hausmann J, Simard JF, Sparks JA, Miller FW. 2022. Baseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: results from the COVID-19 global rheumatology alliance vaccine survey. Rheumatology]

Yang X, Rutkovsky AC, Zhou J, Zhong Y, Reese J, Schnell T, Albrecht H, Owens WB, Nagarkatti PS, Nagarkatti M. 2022. Characterization of altered gene expression and histone methylation in peripheral blood mononuclear cells regulating inflammation in COVID-19 patients. Journal of Immunology v. 208 (8): pp. 1968-1977. NIEHS Grant No. R01ES030144 [Full Text Yang X, Rutkovsky AC, Zhou J, Zhong Y, Reese J, Schnell T, Albrecht H, Owens WB, Nagarkatti PS, Nagarkatti M. 2022. Characterization of altered gene expression and histone methylation in peripheral blood mononuclear cells regulating inflammation in COVID-19 patients. Journal of Immunology v. 208 (8): pp. 1968-1977. NIEHS Grant No. R01ES030144]

Klann JG, Strasser ZH, Hutch MR, Kennedy CJ, Marwaha JS, Morris M, Samayamuthu MJ, Pfaff AC, Estiri H, South AM, Weber GM, Yuan W, Avillach P, Wagholikar KB, Luo Y, Omenn GS, Visweswaran S, Holmes JH, Xia Z, Brat GA, Murphy SN. 2022. Distinguishing admissions specifically for COVID-19 from incidental SARS-CoV-2 admissions: A national EHR research consortium study. medRxiv. NIEHS Grant No. P30ES017885 [Full Text Klann JG, Strasser ZH, Hutch MR, Kennedy CJ, Marwaha JS, Morris M, Samayamuthu MJ, Pfaff AC, Estiri H, South AM, Weber GM, Yuan W, Avillach P, Wagholikar KB, Luo Y, Omenn GS, Visweswaran S, Holmes JH, Xia Z, Brat GA, Murphy SN. 2022. Distinguishing admissions specifically for COVID-19 from incidental SARS-CoV-2 admissions: A national EHR research consortium study. medRxiv. NIEHS Grant No. P30ES017885]

Vannorsdall TD, Brigham E, Fawzy A, Raju S, Gorgone A, Pletnikova A, Lyketsos CG, Parker AM, Oh ES. 2022. Cognitive dysfunction, psychiatric distress, and functional decline after COVID-19. Journal of the Academy Consultation-Liaison Psychiatry v. 63 (2): pp. 133-143. NIEHS Grant No. K23ES029105 [Full Text Vannorsdall TD, Brigham E, Fawzy A, Raju S, Gorgone A, Pletnikova A, Lyketsos CG, Parker AM, Oh ES. 2022. Cognitive dysfunction, psychiatric distress, and functional decline after COVID-19. Journal of the Academy Consultation-Liaison Psychiatry v. 63 (2): pp. 133-143. NIEHS Grant No. K23ES029105]

Environmental Factor Articles

Educational tool highlights COVID-19 and arsenic research – March 2022
NIEHS-funded researchers teamed up with high school teachers to create a digital resource that encourages students to think like scientists.

Purifying SARS-CoV-2 proteins may produce targeted therapies – March 2022
NIEHS researchers have developed a simple protocol to produce pure and high quantities of two proteins required for the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Papers From NIEHS Researchers

Shi A, Gaynor SM, Dey R, Zhang H, Quick C, Lin X. 2022. COVID-19 Spread Mapper: a multi-resolution, unified framework and open-source tool. Bioinformatics v.38(9):pp.2661-2663. NIEHS Grant No. T32ES007142. [Full Text Shi A, Gaynor SM, Dey R, Zhang H, Quick C, Lin X. 2022. COVID-19 Spread Mapper: a multi-resolution, unified framework and open-source tool. Bioinformatics v.38(9):pp.2661-2663. NIEHS Grant No. T32ES007142.]

Stadnick NA, Cain KL, Oswald W, Watson P, Ibarra M, Lagoc R, Ayers LO, Salgin L, Broyles SL, Laurent LC, Pezzoli K, Rabin B. Co-creating a Theory of Change to advance COVID-19 testing and vaccine uptake in underserved communities. 2022. Health Services Research v. 57 (Suppl 1): pp. 149-157. NIEHS Grant No. P42ES010337 [Full Text Stadnick NA, Cain KL, Oswald W, Watson P, Ibarra M, Lagoc R, Ayers LO, Salgin L, Broyles SL, Laurent LC, Pezzoli K, Rabin B. Co-creating a Theory of Change to advance COVID-19 testing and vaccine uptake in underserved communities. 2022. Health Services Research v. 57 (Suppl 1): pp. 149-157. NIEHS Grant No. P42ES010337]

Hüls A, Feany PT, Zisman SI, Costa ACS, Dierssen M, Balogh R, Bargagna S, Baumer NT, Brandão AC, Carfi A, Chicoine BA, Ghosh S, Lakhanpaul M, Levin J, Lunsky Y, Manso C, Okun E, Real de Asua D, Rebillat A-S, Rohrer TR, Sgandurra G, Valentini D, Sherman SL, Strydom A, on behalf of the Trisomy 21 Research Society COVID-19 Initiative. 2022. COVID-19 vaccination of individuals with Down syndrome—data from the trisomy 21 research society survey on safety, efficacy, and factors associated with the decision to be vaccinated. Vaccines 10(4):530. NIEHS Grant No. P30ES019776 [Full Text Hüls A, Feany PT, Zisman SI, Costa ACS, Dierssen M, Balogh R, Bargagna S, Baumer NT, Brandão AC, Carfi A, Chicoine BA, Ghosh S, Lakhanpaul M, Levin J, Lunsky Y, Manso C, Okun E, Real de Asua D, Rebillat A-S, Rohrer TR, Sgandurra G, Valentini D, Sherman SL, Strydom A, on behalf of the Trisomy 21 Research Society COVID-19 Initiative. 2022. COVID-19 vaccination of individuals with Down syndrome—data from the trisomy 21 research society survey on safety, efficacy, and factors associated with the decision to be vaccinated. Vaccines 10(4):530. NIEHS Grant No. P30ES019776]

Satta S, Meng Z, Hernandez R, Cavallero S, Zhou T, Hsiai TK, Zhou C. 2022. An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages. Theranostics 12(6):2639-2657 [Full Text Satta S, Meng Z, Hernandez R, Cavallero S, Zhou T, Hsiai TK, Zhou C. 2022. An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages. Theranostics 12(6):2639-2657]

Avalos LA, Nance N, Zhu Y, Croen LA, Young-Wolff KC, Zerbo O, Hedderson MM, Ferrara A, Ames JL, Badon SE. 2022. Contributions of COVID-19 pandemic-related stressors to racial and ethnic disparities in mental health during pregnancy. Frontiers in Psychiatry 13:837659. NIEHS Grant No. K99ES032481 [Full Text Avalos LA, Nance N, Zhu Y, Croen LA, Young-Wolff KC, Zerbo O, Hedderson MM, Ferrara A, Ames JL, Badon SE. 2022. Contributions of COVID-19 pandemic-related stressors to racial and ethnic disparities in mental health during pregnancy. Frontiers in Psychiatry 13:837659. NIEHS Grant No. K99ES032481]

Sprague NL, Rundle AG, Ekenga CC. 2022. The COVID-19 pandemic as a threat multiplier for childhood health disparities: Evidence from St. Louis, MO. Journal of Urban Health. NIEHS Grant No. T32ES007322 [Full Text Sprague NL, Rundle AG, Ekenga CC. 2022. The COVID-19 pandemic as a threat multiplier for childhood health disparities: Evidence from St. Louis, MO. Journal of Urban Health. NIEHS Grant No. T32ES007322]

Duan Z, Romm KF, Henriksen L, Schleicher NC, Johnson TO, Wagener TL, Sussman SY, Schillo BA, Huang J, Berg CJ. 2022. The impact of recent tobacco regulations and COVID-19 restrictions and implications for future e-cigarette retail: perspectives from vape and vape-and-smoke shop merchants. International Journal of Environmental Research and Public Health 19(7):3855. NIEHS Grant No. D43ES030927 [Full Text Duan Z, Romm KF, Henriksen L, Schleicher NC, Johnson TO, Wagener TL, Sussman SY, Schillo BA, Huang J, Berg CJ. 2022. The impact of recent tobacco regulations and COVID-19 restrictions and implications for future e-cigarette retail: perspectives from vape and vape-and-smoke shop merchants. International Journal of Environmental Research and Public Health 19(7):3855. NIEHS Grant No. D43ES030927]

Miller NL, Clark T, Raman R, Sasisekharan R. 2022. A structural dynamic explanation for observed escape of SARS-CoV-2 BA.2 variant mutation S371L/F. bioRxiv. NIEHS Grant No. T32ES007020 [Full Text Miller NL, Clark T, Raman R, Sasisekharan R. 2022. A structural dynamic explanation for observed escape of SARS-CoV-2 BA.2 variant mutation S371L/F. bioRxiv. NIEHS Grant No. T32ES007020]

Bozack A, Pierre S, DeFelice N, Colicino E, Jack D, Chillrud SN, Rundle A, Astua A, Quinn JW, McGuinn L, Yang Q, Johnson K, Masci J, Lukban L, Maru D, Lee AG. 2022. Long-term air pollution exposure and COVID-19 mortality: A patient-level analysis from New York City. American Journal of Respiratory and Critical Care Medicine v. 205 (6): pp. 651-662 [Full Text Bozack A, Pierre S, DeFelice N, Colicino E, Jack D, Chillrud SN, Rundle A, Astua A, Quinn JW, McGuinn L, Yang Q, Johnson K, Masci J, Lukban L, Maru D, Lee AG. 2022. Long-term air pollution exposure and COVID-19 mortality: A patient-level analysis from New York City. American Journal of Respiratory and Critical Care Medicine v. 205 (6): pp. 651-662]

Idris MY, Korin M, Araya F, Chowdhury S, Medina P, Cruz L, Hawkins TR, Brown H, Claudio L. 2022. Including the public in public eHealth: The need for community participation in the development of state-sponsored COVID-19-related mobile apps. JMIR mHealth uHealth v. 10 (3): e30872. NIEHS Grant No. P30ES023515 [Full Text Idris MY, Korin M, Araya F, Chowdhury S, Medina P, Cruz L, Hawkins TR, Brown H, Claudio L. 2022. Including the public in public eHealth: The need for community participation in the development of state-sponsored COVID-19-related mobile apps. JMIR mHealth uHealth v. 10 (3): e30872. NIEHS Grant No. P30ES023515]

Esparza TJ, Chen Y, Martin NP, Bielefeldt-Ohmann H, Bowen RA, Tolbert WD, Pazgier M, Brody DL. 2022. Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19. mAbs v. 14 (1): 2047144 [Full Text Esparza TJ, Chen Y, Martin NP, Bielefeldt-Ohmann H, Bowen RA, Tolbert WD, Pazgier M, Brody DL. 2022. Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19. mAbs v. 14 (1): 2047144]

Razjouyan J, Helmer DA, Li A, Naik AD, Amos CI, Bandi V, Sharafkhaneh A. 2022. Differences in COVID-19-related testing and healthcare utilization by race and ethnicity in the veterans health administration. Journal of Racial and Ethnic Health Disparities v. 9 (2): pp. 519-526. NIEHS Grant No. P30ES030285 [Full Text Razjouyan J, Helmer DA, Li A, Naik AD, Amos CI, Bandi V, Sharafkhaneh A. 2022. Differences in COVID-19-related testing and healthcare utilization by race and ethnicity in the veterans health administration. Journal of Racial and Ethnic Health Disparities v. 9 (2): pp. 519-526. NIEHS Grant No. P30ES030285]

Pivniouk V, Pivniouk O, DeVries A, Uhrlaub JL, Michael A, Pivniouk D, VanLinden SR, Conway MY, Hahn S, Malone SP, Ezeh P, Churko JM, Anderson D, Kraft M, Nikolich-Zugich J, Vercelli D. 2022. The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. Journal of Allergy and Clinical Immunology v. 149 (3): pp. 923-933.e6. NIEHS Grant No. T32ES007091 [Full Text Pivniouk V, Pivniouk O, DeVries A, Uhrlaub JL, Michael A, Pivniouk D, VanLinden SR, Conway MY, Hahn S, Malone SP, Ezeh P, Churko JM, Anderson D, Kraft M, Nikolich-Zugich J, Vercelli D. 2022. The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. Journal of Allergy and Clinical Immunology v. 149 (3): pp. 923-933.e6. NIEHS Grant No. T32ES007091]

Ley CA, Cintron CM, McCamant KL, Karpman MB, Meisenberg BR. COVID-19-related anxieties: Impact on duty to care among nurses. 2022. Nursing Ethics 2022;29(4):787-801. doi:10.1177/09697330211057192. NIEHS Grant No. R01ES027815, R01ES030743, R21ES032161 [Full Text Ley CA, Cintron CM, McCamant KL, Karpman MB, Meisenberg BR. COVID-19-related anxieties: Impact on duty to care among nurses. 2022. Nursing Ethics 2022;29(4):787-801. doi:10.1177/09697330211057192. NIEHS Grant No. R01ES027815, R01ES030743, R21ES032161]

Lin AW, Granata FA, Trippel AK, Tello L, Stump TK, Wong M, Carnethon MR, Kershaw KN, Makelarski J, Weller D. 2022. Food Handling Concerns and Practices at Home during the COVID-19 Pandemic by Food Security Status. Journal of Food Protection v. 85 (3): pp. 518-526. NIEHS Grant No. T32ES007271 [Full Text Lin AW, Granata FA, Trippel AK, Tello L, Stump TK, Wong M, Carnethon MR, Kershaw KN, Makelarski J, Weller D. 2022. Food Handling Concerns and Practices at Home during the COVID-19 Pandemic by Food Security Status. Journal of Food Protection v. 85 (3): pp. 518-526. NIEHS Grant No. T32ES007271]

Brocke SA, Billings GT, Taft-Benz S, Alexis NE, Heise MT, Jaspers I. 2022. Woodsmoke particle exposure prior to SARS-CoV-2 infection alters antiviral response gene expression in human nasal epithelial cells in a sex-dependent manner. Am J Physiol Lung Cell Mol Physiol. NIEHS Grant No. R01ES031173, T32ES007126 [Full Text Brocke SA, Billings GT, Taft-Benz S, Alexis NE, Heise MT, Jaspers I. 2022. Woodsmoke particle exposure prior to SARS-CoV-2 infection alters antiviral response gene expression in human nasal epithelial cells in a sex-dependent manner. Am J Physiol Lung Cell Mol Physiol. NIEHS Grant No. R01ES031173, T32ES007126]

Environmental Factor Articles

Autoimmune diseases and women’s health spotlighted during webinar – February 2022
Members of the NIEHS Women’s Health Awareness community learned how conditions such as lupus can affect pregnancy, during Jan. 13 event.

NIEHS employees shatter expectations for charity drive – February 2022
The theme of the 2021 Combined Federal Campaign was “You can be the face of change.”

Papers From NIEHS Researchers

Rocha SM, Fagre AC, Latham AS, Cummings JE, Aboellail TA, Reigan P, Aldaz DA, McDermott CP, Popichak KA, Kading RC, Schountz T, Theise ND, Slayden RA and Tjalkens RB. 2022. A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection. Front Immunol 13:811430 [Full Text Rocha SM, Fagre AC, Latham AS, Cummings JE, Aboellail TA, Reigan P, Aldaz DA, McDermott CP, Popichak KA, Kading RC, Schountz T, Theise ND, Slayden RA and Tjalkens RB. 2022. A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection. Front Immunol 13:811430]

Miller NL, T Clark, R Raman and R Sasisekharan. 2022. Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domain. Cell Reports Medicine v. 3 (2): 100527. NIEHS Grant No. T32ES007020 [Full Text Miller NL, T Clark, R Raman and R Sasisekharan. 2022. Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domain. Cell Reports Medicine v. 3 (2): 100527. NIEHS Grant No. T32ES007020]

Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Piedra FA, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PA. 2022. The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics. mBio v. 13: e0351121. NIEHS Grant No. P30ES030285 [Full Text Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Piedra FA, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PA. 2022. The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics. mBio v. 13: e0351121. NIEHS Grant No. P30ES030285]

Healy EF. 2022. How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17. Biochemical and Biophysical Research Communications v. 593: pp. 52-56. NIEHS Grant No. T32ES019854 [Full Text Healy EF. 2022. How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17. Biochemical and Biophysical Research Communications v. 593: pp. 52-56. NIEHS Grant No. T32ES019854]

Laumbach RJ, Mainelis G, Black KG, Myers NT, Ohman-Strickland P, Alimokhtari S, Hastings S, Legard A, de Resende A, Calderón L, Lu FT, Kipen HM. 2022. Presence of SARS-CoV-2 Aerosol in Residences of Adults with COVID-19. Ann Am Thorac Soc 2022 Feb;19(2):338-341. NIEHS Grant No. ES05022, T32ES019854 [Full Text Laumbach RJ, Mainelis G, Black KG, Myers NT, Ohman-Strickland P, Alimokhtari S, Hastings S, Legard A, de Resende A, Calderón L, Lu FT, Kipen HM. 2022. Presence of SARS-CoV-2 Aerosol in Residences of Adults with COVID-19. Ann Am Thorac Soc 2022 Feb;19(2):338-341. NIEHS Grant No. ES05022, T32ES019854]

Piper BJ, Sanchez BV, Madera JD, Sulzinski MA. 2022. Profiles of U.S. Hispanics unvaccinated for COVID-19. Journal of Racial and Ethnic Health Disparities. NIEHS Grant No. T32ES007060 [Full Text Piper BJ, Sanchez BV, Madera JD, Sulzinski MA. 2022. Profiles of U.S. Hispanics unvaccinated for COVID-19. Journal of Racial and Ethnic Health Disparities. NIEHS Grant No. T32ES007060]

Bai B, Belovodskiy A, Hena M, Kandadai AS, Joyce MA, Saffran HA, Shields JA, Khan MB, Arutyunova E, Lu J, Bajwa SK, Hockman D, Fischer C, Lamer T, Vuong W, van Belkum MJ, Gu Z, Lin F, Du Y, Xu J, Rahim M, Young HS, Vederas JC, Tyrrell DL, Lemieux MJ, Nieman JA. 2022. Peptidomimetic α-acyloxymethylketone warheads with six-membered lactam P1 glutamine mimic: SARS-CoV-2 3CL protease inhibition, coronavirus antiviral activity, and in vitro biological stability. J Med Chem 2022 Feb 24;65(4):2905-2925. NIEHS Grant No. R01ES027408 [Full Text Bai B, Belovodskiy A, Hena M, Kandadai AS, Joyce MA, Saffran HA, Shields JA, Khan MB, Arutyunova E, Lu J, Bajwa SK, Hockman D, Fischer C, Lamer T, Vuong W, van Belkum MJ, Gu Z, Lin F, Du Y, Xu J, Rahim M, Young HS, Vederas JC, Tyrrell DL, Lemieux MJ, Nieman JA. 2022. Peptidomimetic α-acyloxymethylketone warheads with six-membered lactam P1 glutamine mimic: SARS-CoV-2 3CL protease inhibition, coronavirus antiviral activity, and in vitro biological stability. J Med Chem 2022 Feb 24;65(4):2905-2925. NIEHS Grant No. R01ES027408]

Tan SB, deSouza P, Raifman M. 2022. Structural Racism and COVID-19 in the USA: a County-Level Empirical Analysis. J Racial Ethn Health Disparities 2022 Feb;9(1):236-246. Epub 2021 Jan 19. NIEHS Grant No. T32ES014562 [Full Text Tan SB, deSouza P, Raifman M. 2022. Structural Racism and COVID-19 in the USA: a County-Level Empirical Analysis. J Racial Ethn Health Disparities 2022 Feb;9(1):236-246. Epub 2021 Jan 19. NIEHS Grant No. T32ES014562]

Environmental Factor Articles

2021 Papers of the Year – January 2022
Of 3,942 publications by NIEHS researchers and grantees in 2021, institute leaders selected 35 as Papers of the Year.

Hazards of Disaster Cleanup, Support for Workers Focus of NIEHS Talk – January 2022
A consortium funded by the institute’s Worker Training Program helps crews stay safe in the aftermath of climate-related emergencies.

Wastewater-based Epidemiology Comes of Age During Pandemic – January 2022
Wastewater sampling provides noninvasive, cost-effective tool for tracking disease prevalence and spread, say experts at NIEHS event.

Environmental Health Sciences Core Centers

Wastewater-based Epidemiology Comes of Age During Pandemic – January 1, 2022
Environmental Health Sciences Core Center researchers stood out at a December 2021 webinar focused on wastewater-based epidemiology.

Papers From NIEHS Researchers

Baker J, Krishnan N, Abroms LC, Berg CJ. 2022. The impact of tobacco use on COVID-19 outcomes: A systematic review. Journal of Smoking Cessation v. 2022: 5474397. NIEHS Grant No. D43ES030927 [Full Text Baker J, Krishnan N, Abroms LC, Berg CJ. 2022. The impact of tobacco use on COVID-19 outcomes: A systematic review. Journal of Smoking Cessation v. 2022: 5474397. NIEHS Grant No. D43ES030927]

Wilson AM, Aviles N, Petrie JI, Beamer PI, Szabo Z, Xie M, McIllece J, Chen Y, Son YJ, Halai S, White T, Ernst KC, Masel J. 2022. Quantifying SARS-CoV-2 infection risk within the Google/Apple exposure notification framework to inform quarantine recommendations. Risk Analysis v. 42 (1): pp. 162-176. NIEHS Grant No. P30ES006694 [Full Text Wilson AM, Aviles N, Petrie JI, Beamer PI, Szabo Z, Xie M, McIllece J, Chen Y, Son YJ, Halai S, White T, Ernst KC, Masel J. 2022. Quantifying SARS-CoV-2 infection risk within the Google/Apple exposure notification framework to inform quarantine recommendations. Risk Analysis v. 42 (1): pp. 162-176. NIEHS Grant No. P30ES006694]

Vo T, Paudel K, Choudhary I, Patial S, Saini Y. 2022. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARSCoV-2. Scientific Reports v. 12: 1357. NIEHS Grant No. R01ES030125 [Full Text Vo T, Paudel K, Choudhary I, Patial S, Saini Y. 2022. Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARSCoV-2. Scientific Reports v. 12: 1357. NIEHS Grant No. R01ES030125]

Stapleton EM, Welch JL, Ubeda EA, Xiang J, Zabner J, Thornell IM, Nonnenmann MW, Stapleton JT, Comellas AP. 2022. Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation. Journal of Infectious Diseases v. 225 (2): pp. 214-218. NIEHS Grant No. P30ES005605 [Full Text Stapleton EM, Welch JL, Ubeda EA, Xiang J, Zabner J, Thornell IM, Nonnenmann MW, Stapleton JT, Comellas AP. 2022. Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation. Journal of Infectious Diseases v. 225 (2): pp. 214-218. NIEHS Grant No. P30ES005605]

Romm KF, Patterson B, Wysota CN, Wang Y, Berg CJ. 2022. Predictors of negative psychosocial and health behavior impact of COVID-19 among young adults. Health Education Research v. 36 (4): pp. 385-397. NIEHS Grant No. D43ES030927 [Full Text Romm KF, Patterson B, Wysota CN, Wang Y, Berg CJ. 2022. Predictors of negative psychosocial and health behavior impact of COVID-19 among young adults. Health Education Research v. 36 (4): pp. 385-397. NIEHS Grant No. D43ES030927]

Baldridge KC, Edmonds K, Dziubla T, Hilt JZ, Dutch RE, Bhattacharyya D. 2022. Demonstration of Hollow Fiber Membrane-based Enclosed Space Air Remediation for Capture of an Aerosolized Synthetic SARS-CoV-2 Mimic and Pseudovirus Particles. ACS ES&T Engineering 2022 2 (2), 251-262. NIEHS Grant No. P42ES007380 [Full Text Baldridge KC, Edmonds K, Dziubla T, Hilt JZ, Dutch RE, Bhattacharyya D. 2022. Demonstration of Hollow Fiber Membrane-based Enclosed Space Air Remediation for Capture of an Aerosolized Synthetic SARS-CoV-2 Mimic and Pseudovirus Particles. ACS ES&T Engineering 2022 2 (2), 251-262. NIEHS Grant No. P42ES007380]

Memel ZN, Lee JJ, Foulkes AS, Chung RT, Thaweethai T, Bloom PP. 2022. Association of Statins and 28-day Mortality Rates in Patients Hospitalized with Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Journal of Infectious Diseases (2022) v. 225 (1): pp. 19-29. NIEHS Grant No. T32ES007142 [Full Text Memel ZN, Lee JJ, Foulkes AS, Chung RT, Thaweethai T, Bloom PP. 2022. Association of Statins and 28-day Mortality Rates in Patients Hospitalized with Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Journal of Infectious Diseases (2022) v. 225 (1): pp. 19-29. NIEHS Grant No. T32ES007142]

Zevit N, Chehade M, Leung J, Marderfeld L, Dellon ES. 2022. Eosinophilic Esophagitis Patients Are Not at Increased Risk of Severe COVID-19: A Report from a Global Registry. Journal of Allergy and Clinical Immunology: In Practice (2022) v. 10 (1): pp. 143-149.e9. NIEHS Grant No. R01ES031940 [Full Text Zevit N, Chehade M, Leung J, Marderfeld L, Dellon ES. 2022. Eosinophilic Esophagitis Patients Are Not at Increased Risk of Severe COVID-19: A Report from a Global Registry. Journal of Allergy and Clinical Immunology: In Practice (2022) v. 10 (1): pp. 143-149.e9. NIEHS Grant No. R01ES031940]

Trogen B, Jin H, Cianferoni A, Chehade M, Schultz F, Chavez A, Warren C, Nowak-Wegrzyn AH. 2022. A survey examining the impact of COVID-19 on food protein-induced enterocolitis syndrome. Journal of Allergy and Clinical Immunology: In Practice (2022) v. 10 (1): pp. 312-314.e3. NIEHS Grant No. R01ES031940 [Full Text Trogen B, Jin H, Cianferoni A, Chehade M, Schultz F, Chavez A, Warren C, Nowak-Wegrzyn AH. 2022. A survey examining the impact of COVID-19 on food protein-induced enterocolitis syndrome. Journal of Allergy and Clinical Immunology: In Practice (2022) v. 10 (1): pp. 312-314.e3. NIEHS Grant No. R01ES031940]

Sayed S, Diwadkar AR, Dudley JW, O'Brien J, Dvorin D, Kenyon CC, Himes BE, Hill DA, Henrickson SE. 2022. COVID-19 Pandemic-related Reductions in Pediatric Asthma Exacerbations Corresponded with an Overall Decrease in Respiratory Viral Infections. Journal of Allergy and Clinical Immunology: In Practice (2022) v. 10 (1): pp. 91-99.e12. NIEHS Grant No. P30ES013508 [Full Text Sayed S, Diwadkar AR, Dudley JW, O'Brien J, Dvorin D, Kenyon CC, Himes BE, Hill DA, Henrickson SE. 2022. COVID-19 Pandemic-related Reductions in Pediatric Asthma Exacerbations Corresponded with an Overall Decrease in Respiratory Viral Infections. Journal of Allergy and Clinical Immunology: In Practice (2022) v. 10 (1): pp. 91-99.e12. NIEHS Grant No. P30ES013508]

Li H, Shankar SN, Witanachchi CT, Lednicky JA, Loeb JC, Alam MM, Fan ZH, Mohamed K, Boyette JA, Eiguren-Fernandez A, Wu CY. 2022. Environmental Surveillance for SARS-CoV-2 in Two Restaurants from a Mid-scale City that Followed U.S. CDC Reopening Guidance. Aerosol and Air Quality Research (2022) v. 22: 210304. NIEHS Grant No. R44ES030649 [Full Text Li H, Shankar SN, Witanachchi CT, Lednicky JA, Loeb JC, Alam MM, Fan ZH, Mohamed K, Boyette JA, Eiguren-Fernandez A, Wu CY. 2022. Environmental Surveillance for SARS-CoV-2 in Two Restaurants from a Mid-scale City that Followed U.S. CDC Reopening Guidance. Aerosol and Air Quality Research (2022) v. 22: 210304. NIEHS Grant No. R44ES030649]

Garcia E, Marian B, Chen Z, Li K, Lurmann F, Gilliland F, Eckel SP. 2022. Long-term air pollution and COVID-19 mortality rates in California: Findings from the Spring/Summer and Winter surges of COVID-19. Environ Pollut 2022;292(Pt B):118396. NIEHS Grant No. P30ES007048 [Full Text Garcia E, Marian B, Chen Z, Li K, Lurmann F, Gilliland F, Eckel SP. 2022. Long-term air pollution and COVID-19 mortality rates in California: Findings from the Spring/Summer and Winter surges of COVID-19. Environ Pollut 2022;292(Pt B):118396. NIEHS Grant No. P30ES007048]

Olak AS, Santos WS, Susuki AM, Pott-Junior H, V Skalny A, Tinkov AA, Aschner M, Pinese JPP, Urbano MR, Paoliello MMB. 2022. Meteorological parameters and cases of COVID-19 in Brazilian cities: an observational study. J Toxicol Environ Health A 2022 Jan 2;85(1):14-28. NIEHS Grant No. R01ES10563, R01ES07331 [Full Text Olak AS, Santos WS, Susuki AM, Pott-Junior H, V Skalny A, Tinkov AA, Aschner M, Pinese JPP, Urbano MR, Paoliello MMB. 2022. Meteorological parameters and cases of COVID-19 in Brazilian cities: an observational study. J Toxicol Environ Health A 2022 Jan 2;85(1):14-28. NIEHS Grant No. R01ES10563, R01ES07331]

Eggert LE, He Z, Collins W, Lee AS, Dhondalay G, Jiang SY, Fitzpatrick J, Snow TT, Pinsky BA, Artandi M, Barman L, Puri R, Wittman R, Ahuja N, Blomkalns A, O'Hara R, Cao S, Desai M, Sindher SB, Nadeau K, Chinthrajah RS. 2022. Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19. Allergy 2022 Jan;77(1):173-185. Epub 2021 Jun 19 [Full Text Eggert LE, He Z, Collins W, Lee AS, Dhondalay G, Jiang SY, Fitzpatrick J, Snow TT, Pinsky BA, Artandi M, Barman L, Puri R, Wittman R, Ahuja N, Blomkalns A, O'Hara R, Cao S, Desai M, Sindher SB, Nadeau K, Chinthrajah RS. 2022. Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19. Allergy 2022 Jan;77(1):173-185. Epub 2021 Jun 19]

Papers From NIEHS Researchers

Hu S, McCartney MM, Arredondo J, Sankaran-Walters S, Borras E, Harper RW, Schivo M, Davis CE, Kenyon NJ, Dandekar S. 2021. Inactivation of SARS-CoV-2 in clinical exhaled breath condensate samples for metabolomic analysis. Journal of Breath Research (2021) v. 16. NIEHS Grant No. P30ES023513 [Full Text Hu S, McCartney MM, Arredondo J, Sankaran-Walters S, Borras E, Harper RW, Schivo M, Davis CE, Kenyon NJ, Dandekar S. 2021. Inactivation of SARS-CoV-2 in clinical exhaled breath condensate samples for metabolomic analysis. Journal of Breath Research (2021) v. 16. NIEHS Grant No. P30ES023513]

Roh T, Moreno-Rangel A, Baek J, Obeng A, Hasan NT, Carrillo G. 2021. Indoor air quality and health outcomes in employees working from home during the COVID-19 pandemic: A pilot study. Atmosphere 2021; 12(12):1665. NIEHS Grant No. P30ES029067 [Full Text Roh T, Moreno-Rangel A, Baek J, Obeng A, Hasan NT, Carrillo G. 2021. Indoor air quality and health outcomes in employees working from home during the COVID-19 pandemic: A pilot study. Atmosphere 2021; 12(12):1665. NIEHS Grant No. P30ES029067]

Romm KF, Patterson B, Arem H, Price OA, Wang Y, Berg CJ. 2021. Cross-sectional retrospective assessments versus longitudinal prospective assessments of substance use change among young adults during COVID-19: Magnitude and correlates of discordant findings. Subst Use Misuse 2021 57:3, 484-489. NIEHS Grant No. D43ES030927 [Full Text Romm KF, Patterson B, Arem H, Price OA, Wang Y, Berg CJ. 2021. Cross-sectional retrospective assessments versus longitudinal prospective assessments of substance use change among young adults during COVID-19: Magnitude and correlates of discordant findings. Subst Use Misuse 2021 57:3, 484-489. NIEHS Grant No. D43ES030927]

Heaney CD, Pisanic N, Randad PR, Kruczynski K, Howard T, Zhu X, Littlefield K, Patel EU, Shrestha R, Laeyendecker O, Shoham S, Sullivan D, Gebo K, Hanley D, Redd AD, Quinn TC, Casadevall A, Zenilman JM, Pekosz A, Bloch EM, Tobian AAR. 2021. Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers. J Clin Virol 2021 v. 145: 104997. NIEHS Grant No. R01ES026973 [Full Text Heaney CD, Pisanic N, Randad PR, Kruczynski K, Howard T, Zhu X, Littlefield K, Patel EU, Shrestha R, Laeyendecker O, Shoham S, Sullivan D, Gebo K, Hanley D, Redd AD, Quinn TC, Casadevall A, Zenilman JM, Pekosz A, Bloch EM, Tobian AAR. 2021. Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers. J Clin Virol 2021 v. 145: 104997. NIEHS Grant No. R01ES026973]

Dashdorj NJ, Wirz OF, Röltgen K, Haraguchi E, Buzzanco AS III, Sibai M, Wang H, Miller JA, Solis D, Sahoo MK, Arunachalam PS, Lee AS, Shah MM, Liu J, Byambabaatar S, Bat-Ulzii P, Enkhbat A, Batbold E, Zulkhuu D, Ochirsum B, Khurelsukh T, Dalantai G, Burged N, Baatarsuren U, Ariungerel N, Oidovsambuu O, Bungert AS, Genden Z, Yagaanbuyant D, Mordorj A, Pulendran B, Chinthrajah S, Nadeau KC, Jardetzky T, Wilbur JL, Wohlstadter JN, Sigal GB, Pinsky BA, Boyd SD, Dashdorj ND. 2021. Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia. Cell Host and Microbe 2021 v. 29 (12):1738-1743.e4 [Full Text Dashdorj NJ, Wirz OF, Röltgen K, Haraguchi E, Buzzanco AS III, Sibai M, Wang H, Miller JA, Solis D, Sahoo MK, Arunachalam PS, Lee AS, Shah MM, Liu J, Byambabaatar S, Bat-Ulzii P, Enkhbat A, Batbold E, Zulkhuu D, Ochirsum B, Khurelsukh T, Dalantai G, Burged N, Baatarsuren U, Ariungerel N, Oidovsambuu O, Bungert AS, Genden Z, Yagaanbuyant D, Mordorj A, Pulendran B, Chinthrajah S, Nadeau KC, Jardetzky T, Wilbur JL, Wohlstadter JN, Sigal GB, Pinsky BA, Boyd SD, Dashdorj ND. 2021. Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia. Cell Host and Microbe 2021 v. 29 (12):1738-1743.e4]

Merianos AL, Russell AM, Mahabee-Gittens EM, Barry AE, Yang M, Lin H-C. 2021. Assessment of Exclusive, Dual, and Polytobacco E-Cigarette Use and COVID-19 Outcomes Among College Students. American Journal of Health Promotion 2021;36(3):421-428. NIEHS Grant No. R21ES032161, R01ES030743, R01ES027815 [Full Text Merianos AL, Russell AM, Mahabee-Gittens EM, Barry AE, Yang M, Lin H-C. 2021. Assessment of Exclusive, Dual, and Polytobacco E-Cigarette Use and COVID-19 Outcomes Among College Students. American Journal of Health Promotion 2021;36(3):421-428. NIEHS Grant No. R21ES032161, R01ES030743, R01ES027815]

Dey T, Tyagi P, Sabath MB, Kamareddine L, Henneman L, Braun D, Dominici F. Counterfactual time series analysis of short-term change in air pollution following the COVID-19 state of emergency in the United States. Scientific Reports 2021 v. 11:23517. NIEHS Grant No. R01ES026217 [Full Text Dey T, Tyagi P, Sabath MB, Kamareddine L, Henneman L, Braun D, Dominici F. Counterfactual time series analysis of short-term change in air pollution following the COVID-19 state of emergency in the United States. Scientific Reports 2021 v. 11:23517. NIEHS Grant No. R01ES026217]

Miller MF, Shi M, Motsinger-Reif A, Weinberg CR, Miller JD, Nichols E. Community-Based Testing Sites for SARS-CoV-2 — United States, March 2020–November 2021. MMWR Morb Mortal Wkly Rep 2021;70:1706–1711 [Full Text Miller MF, Shi M, Motsinger-Reif A, Weinberg CR, Miller JD, Nichols E. Community-Based Testing Sites for SARS-CoV-2 — United States, March 2020–November 2021. MMWR Morb Mortal Wkly Rep 2021;70:1706–1711]

Sarkar A, Harty S, Moeller AH, Klein SL, Erdman SE, Friston KJ, Carmody RN. 2021. The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-2. Trends in Molecular Medicine (2021) v. 27 (12): pp. 1115-1134. NIEHS Grant No. P30ES002109 [Full Text Sarkar A, Harty S, Moeller AH, Klein SL, Erdman SE, Friston KJ, Carmody RN. 2021. The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-2. Trends in Molecular Medicine (2021) v. 27 (12): pp. 1115-1134. NIEHS Grant No. P30ES002109]

Miller SR, McGrath ME, Zorn KM, Ekins S, Wright SH, Cherrington NJ. 2021. Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites. Molecular Pharmacology (2021) v. 100 (6): pp. 548-557. NIEHS Grant No. P30ES006694, T32ES007091 [Full Text Miller SR, McGrath ME, Zorn KM, Ekins S, Wright SH, Cherrington NJ. 2021. Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites. Molecular Pharmacology (2021) v. 100 (6): pp. 548-557. NIEHS Grant No. P30ES006694, T32ES007091]

Xu Q, Samanapally H, Nathala P, Salunkhe V, Furmanek S, Cahill MN, McGuffin T, Mohammad T, Marsili B, Petrey J, Carrico R, Ramirez J, Akca O, Clifford SP, Pahwa S, Roser L, Kong M, Huang J. 2021. Outcomes and Risk Factors for Cardiovascular Events in Hospitalized COVID-19 Patients. Journal of Cardiothoracic and Vascular Anesthesia 2021 v. 35 (12): pp. 3581-3593. NIEHS Grant No. P30ES030283 [Full Text Xu Q, Samanapally H, Nathala P, Salunkhe V, Furmanek S, Cahill MN, McGuffin T, Mohammad T, Marsili B, Petrey J, Carrico R, Ramirez J, Akca O, Clifford SP, Pahwa S, Roser L, Kong M, Huang J. 2021. Outcomes and Risk Factors for Cardiovascular Events in Hospitalized COVID-19 Patients. Journal of Cardiothoracic and Vascular Anesthesia 2021 v. 35 (12): pp. 3581-3593. NIEHS Grant No. P30ES030283]

Chen Z, Huang BZ, Sidell MA, Chow T, Eckel SP, Pavlovic N, Martinez MP, Lurmann F, Thomas DC, Gilliland FD, Xiang AH. 2021. Near-roadway air pollution associated with COVID-19 severity and mortality - Multiethnic cohort study in Southern California. Environ Int. 2021;157:106862. NIEHS Grant No. R01ES029963 [Full Text Chen Z, Huang BZ, Sidell MA, Chow T, Eckel SP, Pavlovic N, Martinez MP, Lurmann F, Thomas DC, Gilliland FD, Xiang AH. 2021. Near-roadway air pollution associated with COVID-19 severity and mortality - Multiethnic cohort study in Southern California. Environ Int. 2021;157:106862. NIEHS Grant No. R01ES029963]

Mendy A, Wu X, Keller JL, Fassler CS, Apewokin S, Mersha TB, Xie C, Pinney SM. 2021. Air pollution and the pandemic: Long-term PM (2.5) exposure and disease severity in COVID-19 patients. 2021 Dec;26(12):1181-1187. NIEHS Grant No. P30ES006096, T32ES010957 [Full Text Mendy A, Wu X, Keller JL, Fassler CS, Apewokin S, Mersha TB, Xie C, Pinney SM. 2021. Air pollution and the pandemic: Long-term PM (2.5) exposure and disease severity in COVID-19 patients. 2021 Dec;26(12):1181-1187. NIEHS Grant No. P30ES006096, T32ES010957]

Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K. 2021. Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach. Environ Int 2021 Dec;157:106232. NIEHS Grant No. P42ES027706 [Full Text Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K. 2021. Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach. Environ Int 2021 Dec;157:106232. NIEHS Grant No. P42ES027706]

Environmental Factor Articles

Artist Uses Tribal Symbolism, Traditions to Communicate Science – November 2021
Artist Mallery Quetawki and NIEHS Superfund Research Program (SRP) scientists are turning complex environmental health concepts into meaningful images for Native American communities.

Outstanding Achievement, Effort by NIEHS Staff Honored During Ceremony – November 2021
Scientific accomplishments, staff dedication, and perseverance during COVID-19 pandemic celebrated at institute’s annual event.

Papers From NIEHS Researchers

Duncan GE, Avery AR, Tsang S, Williams BD, Seto E. 2021. Changes in Physical Activity Levels and Mental Health During COVID-19: Prospective Findings among Adult Twin Pairs. PLoS One (2021) v. 16 (11): e0260218. NIEHS Grant No. R33ES024715 [Full Text Duncan GE, Avery AR, Tsang S, Williams BD, Seto E. 2021. Changes in Physical Activity Levels and Mental Health During COVID-19: Prospective Findings among Adult Twin Pairs. PLoS One (2021) v. 16 (11): e0260218. NIEHS Grant No. R33ES024715]

Zhang LP, Mann M, Syed ZA, Reynolds HM, Tian E, Samara NL, Zeldin DC, Tabak LA, Ten Hagen KG. Furin Cleavage of the SARS-CoV-2 Spike Is Modulated by O-Glycosylation. PNAS 2021 118(47):e2109905118 [Full Text Zhang LP, Mann M, Syed ZA, Reynolds HM, Tian E, Samara NL, Zeldin DC, Tabak LA, Ten Hagen KG. Furin Cleavage of the SARS-CoV-2 Spike Is Modulated by O-Glycosylation. PNAS 2021 118(47):e2109905118]

Berg CJ, Callanan R, Johnson TO, Schliecher NC, Sussman S, Wagener TL, Meaney M, Henriksen L. 2021. Vape shop and consumer activity during COVID-19 non-essential business closures in the USA. Tobacco Control (2021) v. 30 (e1): pp. e41-e44. NIEHS Grant No. D43ES030927 [Full Text Berg CJ, Callanan R, Johnson TO, Schliecher NC, Sussman S, Wagener TL, Meaney M, Henriksen L. 2021. Vape shop and consumer activity during COVID-19 non-essential business closures in the USA. Tobacco Control (2021) v. 30 (e1): pp. e41-e44. NIEHS Grant No. D43ES030927]

Schmidt AJ, Salman D, Pleil J, Thomas CLP, Davis CE. 2021. IABR Symposium 2021 meeting report: breath standardization, sampling, and testing in a time of COVID-19. Journal of Breath Research 2022 v. 16:010201. NIEHS Grant No. P30ES023513 [Full Text Schmidt AJ, Salman D, Pleil J, Thomas CLP, Davis CE. 2021. IABR Symposium 2021 meeting report: breath standardization, sampling, and testing in a time of COVID-19. Journal of Breath Research 2022 v. 16:010201. NIEHS Grant No. P30ES023513]

Kahn LG, Ghassabian A, Jacobson MH, Yu K, Trasande L. 2021. COVID-19 Symptoms and Diagnoses among a Sociodemographically Diverse Cohort of Children from New York City: Lessons from the First Wave, Spring 2020. International Journal of Environmental Research and Public Health. 2021; 18(22):11886. NIEHS Grant No. K99ES030403 [Full Text Kahn LG, Ghassabian A, Jacobson MH, Yu K, Trasande L. 2021. COVID-19 Symptoms and Diagnoses among a Sociodemographically Diverse Cohort of Children from New York City: Lessons from the First Wave, Spring 2020. International Journal of Environmental Research and Public Health. 2021; 18(22):11886. NIEHS Grant No. K99ES030403]

Moschovis PP, Lu M, Hayden D, Yonker LM, Lombay J, Taveras E, Arauz Boudreau A, Triant VA, Foulkes AS, Bassett I, Hibberd PL, Kinane TB. Effect modification by age of the association between obstructive lung diseases, smoking, and COVID-19 severity. BMJ Open Respiratory Research 2021 v. 8. NIEHS Grant No. K23ES030399. [Full Text Moschovis PP, Lu M, Hayden D, Yonker LM, Lombay J, Taveras E, Arauz Boudreau A, Triant VA, Foulkes AS, Bassett I, Hibberd PL, Kinane TB. Effect modification by age of the association between obstructive lung diseases, smoking, and COVID-19 severity. BMJ Open Respiratory Research 2021 v. 8. NIEHS Grant No. K23ES030399.]

Troppy S, Wilt GE, Whiteman A, Hallisey E, Crockett M, Sharpe JD, Haney G, Cranston K, Klevens RM. 2021. Geographic Associations Between Social Factors and SARS-CoV-2 Testing Early in the COVID-19 Pandemic, February–June 2020, Massachusetts. Public Health Reports. 2021;136(6):765-773. NIEHS Grant No. T32ES007069 [Full Text Troppy S, Wilt GE, Whiteman A, Hallisey E, Crockett M, Sharpe JD, Haney G, Cranston K, Klevens RM. 2021. Geographic Associations Between Social Factors and SARS-CoV-2 Testing Early in the COVID-19 Pandemic, February–June 2020, Massachusetts. Public Health Reports. 2021;136(6):765-773. NIEHS Grant No. T32ES007069]

Ren X, Weisel CP, Georgopoulos PG. 2021. Modeling effects of spatial heterogeneities and layered exposure interventions on the spread of COVID-19 across New Jersey. International Journal of Environmental Research and Public Health 2021; 18(22):11950. NIEHS Grant No. P30ES005022 [Full Text Ren X, Weisel CP, Georgopoulos PG. 2021. Modeling effects of spatial heterogeneities and layered exposure interventions on the spread of COVID-19 across New Jersey. International Journal of Environmental Research and Public Health 2021; 18(22):11950. NIEHS Grant No. P30ES005022]

Merianos AL, Russell AM, Mahabee-Gittens EM, Barry AE, Yang M, Lin HC. 2021. Concurrent use of e-cigarettes and cannabis and associated COVID-19 symptoms, testing, and diagnosis among student e-cigarette users at four U.S. Universities. Addictive Behaviors 2021. NIEHS Grant No. R21ES032161, R01ES03743, R01ES027815 [Full Text Merianos AL, Russell AM, Mahabee-Gittens EM, Barry AE, Yang M, Lin HC. 2021. Concurrent use of e-cigarettes and cannabis and associated COVID-19 symptoms, testing, and diagnosis among student e-cigarette users at four U.S. Universities. Addictive Behaviors 2021. NIEHS Grant No. R21ES032161, R01ES03743, R01ES027815]

Korn D, Pervitsky V, Bobrowski T, Alves VM, Schmitt C, Bizon C, Baker N, Chirkova R, Cherkasov A, Muratov E, Tropsha A. COVID-19 Knowledge Extractor (COKE): ACurated Repository of Drug-Target Associations Extracted from the CORD-19 Corpus of Scientific Publications on COVID-19. Journal of Chemical Information and Modeling 2021 [Full Text Korn D, Pervitsky V, Bobrowski T, Alves VM, Schmitt C, Bizon C, Baker N, Chirkova R, Cherkasov A, Muratov E, Tropsha A. COVID-19 Knowledge Extractor (COKE): ACurated Repository of Drug-Target Associations Extracted from the CORD-19 Corpus of Scientific Publications on COVID-19. Journal of Chemical Information and Modeling 2021]

Senay E, Bernstein A, Shephard P, Salas R, Rizzo A, Sherman JD, Richardson L, Butts G, Marwah H, Solomon C, Galvez M, Thanik E, Pezeshki G, Zajac L, Lee A, Sheffield P, Wright R. 2021. Improving Patient Outcomes in the Dual Crises of Climate Change and COVID-19: Proceedings of the Third Annual Clinical Climate Change Meeting, January 8, 2021. Journal of Occupational and Environmental Medicine 2021 v. 63 (11): pp. e813-e818. NIEHS Grant No. P30ES023515, R01ES013744, R24ES028522 [Full Text Senay E, Bernstein A, Shephard P, Salas R, Rizzo A, Sherman JD, Richardson L, Butts G, Marwah H, Solomon C, Galvez M, Thanik E, Pezeshki G, Zajac L, Lee A, Sheffield P, Wright R. 2021. Improving Patient Outcomes in the Dual Crises of Climate Change and COVID-19: Proceedings of the Third Annual Clinical Climate Change Meeting, January 8, 2021. Journal of Occupational and Environmental Medicine 2021 v. 63 (11): pp. e813-e818. NIEHS Grant No. P30ES023515, R01ES013744, R24ES028522]

Rich-Edwards JW, Ding M, Rocheleau CM, Boiano JM, Kang JH, Becene I, Nguyen LH, Chan AT, Hart JE, Chavarro JE, Lawson CC. 2021. American Frontline Healthcare Personnel's Access to and Use of Personal Protective Equipment Early in the COVID-19 Pandemic. Journal of Occupational and Environmental Medicine 2021 v. 63 (11):913-920. NIEHS Grant No. R24ES028521, P30ES000002 [Full Text Rich-Edwards JW, Ding M, Rocheleau CM, Boiano JM, Kang JH, Becene I, Nguyen LH, Chan AT, Hart JE, Chavarro JE, Lawson CC. 2021. American Frontline Healthcare Personnel's Access to and Use of Personal Protective Equipment Early in the COVID-19 Pandemic. Journal of Occupational and Environmental Medicine 2021 v. 63 (11):913-920. NIEHS Grant No. R24ES028521, P30ES000002]

Magnus MC, Gjessing HK, Eide HN, Wilcox AJ, Fell DB, Håberg SE. 2021. COVID-19 Vaccination during Pregnancy and First-trimester Miscarriage. New England Journal of Medicine 2021 [Full Text Magnus MC, Gjessing HK, Eide HN, Wilcox AJ, Fell DB, Håberg SE. 2021. COVID-19 Vaccination during Pregnancy and First-trimester Miscarriage. New England Journal of Medicine 2021]

Merino J, Joshi AD, Nguyen LH, Leeming ER, Mazidi M, Drew DA, Gibson R, Graham MS, Lo CH, Capdevila J, Murray B, Hu C, Selvachandran S, Hammers A, Bhupathiraju SN, Sharma SV, Sudre C, Astley CM, Chavarro JE, Kwon S, Ma W, Menni C, Willett WC, Ourselin S, Steves CJ, Wolf J, Franks PW, Spector TD, Berry S, Chan AT. 2021. Diet quality and risk and severity of COVID-19: a prospective cohort study. Gut 2021;70:2096-2104. NIEHS Grant No. R24ES028521 [Full Text Merino J, Joshi AD, Nguyen LH, Leeming ER, Mazidi M, Drew DA, Gibson R, Graham MS, Lo CH, Capdevila J, Murray B, Hu C, Selvachandran S, Hammers A, Bhupathiraju SN, Sharma SV, Sudre C, Astley CM, Chavarro JE, Kwon S, Ma W, Menni C, Willett WC, Ourselin S, Steves CJ, Wolf J, Franks PW, Spector TD, Berry S, Chan AT. 2021. Diet quality and risk and severity of COVID-19: a prospective cohort study. Gut 2021;70:2096-2104. NIEHS Grant No. R24ES028521]

Peterson DR, Baran AM, Bhattacharya S, Branche AR, Croft DP, Corbett AM, Walsh EE, Falsey AR, Mariani TJ. 2021. Gene Expression Risk Scores for COVID-19 Illness Severity. J Infect Dis 2021 Nov 30:jiab568. NIEHS Grant No. K23ES032459 [Full Text Peterson DR, Baran AM, Bhattacharya S, Branche AR, Croft DP, Corbett AM, Walsh EE, Falsey AR, Mariani TJ. 2021. Gene Expression Risk Scores for COVID-19 Illness Severity. J Infect Dis 2021 Nov 30:jiab568. NIEHS Grant No. K23ES032459]

Gaurav R, Anderson DR, Radio SJ, Bailey KL, England BR, Mikuls TR, Thiele GM, Strah HM, Romberger DJ, Wyatt TA, Dickinson JD, Duryee MJ, Katafiasz DM, Nelson AJ, Poole JA. 2021. IL-33 depletion in COVID-19 lungs. Chest 2021 Nov;160(5):1656-1659 [Full Text Gaurav R, Anderson DR, Radio SJ, Bailey KL, England BR, Mikuls TR, Thiele GM, Strah HM, Romberger DJ, Wyatt TA, Dickinson JD, Duryee MJ, Katafiasz DM, Nelson AJ, Poole JA. 2021. IL-33 depletion in COVID-19 lungs. Chest 2021 Nov;160(5):1656-1659]

Cauwenberghs N, Prunicki M, Sabovčik F, Perelman D, Contrepois K, Li X, Snyder MP, Nadeau KC, Kuznetsova T, Haddad F, Gardner CD. 2021. Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic. Am J Clin Nutr 2021 Nov 8;114(5):1655-1665. NIEHS Grant No. R21ES033049 [Full Text Cauwenberghs N, Prunicki M, Sabovčik F, Perelman D, Contrepois K, Li X, Snyder MP, Nadeau KC, Kuznetsova T, Haddad F, Gardner CD. 2021. Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic. Am J Clin Nutr 2021 Nov 8;114(5):1655-1665. NIEHS Grant No. R21ES033049]

Hilbert TJ, Brancato C, Carter K, Westneat S, Bush HM, Haynes EN. 2021. Disinfectant use by K-12 school staff to combat SARS-CoV-2. Am J Infect Control 2021 Nov;49(11):1432-1434. NIEHS Grant No. ES02644601, ES016531, P30ES026529 [Full Text Hilbert TJ, Brancato C, Carter K, Westneat S, Bush HM, Haynes EN. 2021. Disinfectant use by K-12 school staff to combat SARS-CoV-2. Am J Infect Control 2021 Nov;49(11):1432-1434. NIEHS Grant No. ES02644601, ES016531, P30ES026529]

Kleinstreuer N, Holmes A. 2021. Harnessing the power of microphysiological systems for COVID-19 research. Drug Discov Today 2021 Nov;26(11):2496-2501 [Full Text Kleinstreuer N, Holmes A. 2021. Harnessing the power of microphysiological systems for COVID-19 research. Drug Discov Today 2021 Nov;26(11):2496-2501]

Environmental Factor Articles

Coping With Grief and Loss During COVID-19 Focus of Webinar – October 2021
The NIEHS Women’s Health Awareness program hosted the September 9 event, which featured insights from grief expert Alesia Alexander.

SARS-CoV-2 Nonstructural Proteins a Target for Antiviral Measures – October 2021
NIEHS scientists determined that the SARS-CoV-2 nonstructural protein 15 (Nsp15) relies on recognition of the nucleoside uridine to cleave viral RNA and evade detection by the host immune system.

Whole Person Health, COVID-19 Research Hot Topics at Council Meeting – October 2021
Whole person health, innovative COVID-19 research, and efforts to enhance diversity both in study populations and the scientific workforce were some of the topics discussed during the September 13 meeting of the National Advisory Environmental Health Sciences Council (NAEHSC).

Wildfire Smoke Linked to Increase in COVID-19 Cases and Deaths – October 2021
Thousands of COVID-19 cases and deaths in the western U.S. may be attributable to increases in fine particulate matter air pollution (PM2.5) from wildfires, according to NIEHS-funded research.

Papers From NIEHS Researchers

Lieberman-Cribbin W, Galanti M, Shaman J. 2021. Socioeconomic Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 Serological Testing and Positivity in New York City. Open Forum Infectious Diseases (2021) v. 8 (12): ofab534. NIEHS Grant No. T32ES007322 [Full Text Lieberman-Cribbin W, Galanti M, Shaman J. 2021. Socioeconomic Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 Serological Testing and Positivity in New York City. Open Forum Infectious Diseases (2021) v. 8 (12): ofab534. NIEHS Grant No. T32ES007322]

Emes D, Hüls A, Baumer N, Dierssen M, Puri S, Russell L, Sherman SL, Strydom A, Bargagna S, Brandão AC, Costa ACS, Feany PT, Chicoine BA, Ghosh S, Rebillat A-S, Sgandurra G, Valentini D, Rohrer TR, Levin J, Lakhanpaul M, on behalf of the Trisomy 21 Research Society COVID-19 Initiative Study Group. COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey. Journal of Clinical Medicine. 2021; 10(21):5125. NIEHS Grant No. P30ES019776 [Full Text Emes D, Hüls A, Baumer N, Dierssen M, Puri S, Russell L, Sherman SL, Strydom A, Bargagna S, Brandão AC, Costa ACS, Feany PT, Chicoine BA, Ghosh S, Rebillat A-S, Sgandurra G, Valentini D, Rohrer TR, Levin J, Lakhanpaul M, on behalf of the Trisomy 21 Research Society COVID-19 Initiative Study Group. COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey. Journal of Clinical Medicine. 2021; 10(21):5125. NIEHS Grant No. P30ES019776]

Martinez-Guerrero L, Zhang X, Zorn KM, Ekins S, Wright SH. 2021. Cationic Compounds with SARS-CoV-2 Antiviral Activity and Their Interaction with Organic Cation Transporter/Multidrug and Toxin Extruder Secretory Transporters. Journal of Pharmacological and Experimental Therapeutics 2021 v. 379 (1):96-107. NIEHS Grant No. P30ES006694 [Full Text Martinez-Guerrero L, Zhang X, Zorn KM, Ekins S, Wright SH. 2021. Cationic Compounds with SARS-CoV-2 Antiviral Activity and Their Interaction with Organic Cation Transporter/Multidrug and Toxin Extruder Secretory Transporters. Journal of Pharmacological and Experimental Therapeutics 2021 v. 379 (1):96-107. NIEHS Grant No. P30ES006694]

Horton DB, Barrett ES, Roy J, Gennaro ML, Andrews T, Greenberg P, Bruiners N, Datta P, Ukey R, Velusamy SK, Fine D, Honnen WJ, Yin YS, Pinter A, Brooks A, Tischfield J, Hussain S, Jagpal S, Swaminathan S, Parmar V, Reilly N, Gaur S, Panettieri RA, Carson JL, Blaser MJ. 2021. Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study. Journal of Infectious Diseases 2021 v. 224 (8):1345-1356. NIEHS Grant No. P30ES005022 [Full Text Horton DB, Barrett ES, Roy J, Gennaro ML, Andrews T, Greenberg P, Bruiners N, Datta P, Ukey R, Velusamy SK, Fine D, Honnen WJ, Yin YS, Pinter A, Brooks A, Tischfield J, Hussain S, Jagpal S, Swaminathan S, Parmar V, Reilly N, Gaur S, Panettieri RA, Carson JL, Blaser MJ. 2021. Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study. Journal of Infectious Diseases 2021 v. 224 (8):1345-1356. NIEHS Grant No. P30ES005022]

Niemeyer BF, Benam KH. 2021. Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2. Pharmacology and Therapeutics 2021: 108027. NIEHS Grant No. R41ES031639 [Full Text Niemeyer BF, Benam KH. 2021. Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2. Pharmacology and Therapeutics 2021: 108027. NIEHS Grant No. R41ES031639]

Zheng G, Webster TF, Salamova A. 2021. Quaternary Ammonium Compounds: Bioaccumulation Potentials in Humans and Levels in Blood before and during the Covid-19 Pandemic. Environmental Science and Technology 2021 v. 55 (21):14689-14698. NIEHS Grant No. R01ES019620 [Full Text Zheng G, Webster TF, Salamova A. 2021. Quaternary Ammonium Compounds: Bioaccumulation Potentials in Humans and Levels in Blood before and during the Covid-19 Pandemic. Environmental Science and Technology 2021 v. 55 (21):14689-14698. NIEHS Grant No. R01ES019620]

Ramphal B, Dworkin JD, Pagliaccio D, Margolis AE. 2021. Noise complaint patterns in New York City from January 2010 through February 2021: Socioeconomic disparities and COVID-19 exacerbations. Environmental Research 2021. NIEHS Grant No. R01ES030950, K23ES026239 [Full Text Ramphal B, Dworkin JD, Pagliaccio D, Margolis AE. 2021. Noise complaint patterns in New York City from January 2010 through February 2021: Socioeconomic disparities and COVID-19 exacerbations. Environmental Research 2021. NIEHS Grant No. R01ES030950, K23ES026239]

Miller NL, Clark T, Raman R, Sasisekharan R. 2021. An Antigenic Space Framework for Understanding Antibody Escape of SARS-CoV-2 Variants. Viruses 2021; 13(10):2009. NIEHS Grant No. T32ES007020 [Full Text Miller NL, Clark T, Raman R, Sasisekharan R. 2021. An Antigenic Space Framework for Understanding Antibody Escape of SARS-CoV-2 Variants. Viruses 2021; 13(10):2009. NIEHS Grant No. T32ES007020]

Sera F, Armstrong B, Abbott S, Meakin S, O'Reilly K, von Borries R, Schneider R, Royé D, Hashizume M, Pascal M, Tobias A, Vicedo-Cabrera AM, Gasparrini A, Lowe R. 2021. A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries. Nature Communications 2021 v. 12: 5968. NIEHS Grant No. P30ES019776 [Full Text Sera F, Armstrong B, Abbott S, Meakin S, O'Reilly K, von Borries R, Schneider R, Royé D, Hashizume M, Pascal M, Tobias A, Vicedo-Cabrera AM, Gasparrini A, Lowe R. 2021. A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries. Nature Communications 2021 v. 12: 5968. NIEHS Grant No. P30ES019776]

Sun SZ, Savitz DA, Wellenius GA. 2021. Changes in Adverse Pregnancy Outcomes Associated With the COVID-19 Pandemic in the United States. JAMA Network Open 2021 v. 4 (10):e2129560. NIEHS Grant No. R01ES029950 [Full Text Sun SZ, Savitz DA, Wellenius GA. 2021. Changes in Adverse Pregnancy Outcomes Associated With the COVID-19 Pandemic in the United States. JAMA Network Open 2021 v. 4 (10):e2129560. NIEHS Grant No. R01ES029950]

Khan SA, Goliwas KF, Deshane JS. 2021. Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage. Frontiers in Physiology 2021 v. 12: 760638. NIEHS Grant No. P42ES027723 [Full Text Khan SA, Goliwas KF, Deshane JS. 2021. Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage. Frontiers in Physiology 2021 v. 12: 760638. NIEHS Grant No. P42ES027723]

Kang I, Smirnova L, Kuhn JH, Hogberg HT, Kleinstreuer NC, Hartung T. 2021. COVID-19 – prime time for microphysiological systems, as illustrated for the brain [Journal Article] Alternatives to Animal Experimentation 2021 v. 38 (4):535-549 [Full Text Kang I, Smirnova L, Kuhn JH, Hogberg HT, Kleinstreuer NC, Hartung T. 2021. COVID-19 – prime time for microphysiological systems, as illustrated for the brain [Journal Article] Alternatives to Animal Experimentation 2021 v. 38 (4):535-549]

Le TT, Gutiérrez-Sacristán A, Son J, Hong C, South AM, Beaulieu-Jones BK, Loh NHW, Luo Y, Morris M, Ngiam KY, Patel LP, Samayamuthu MJ, Schriver E, Tan ALM, Moore J, Cai T, Omenn GS, Avillach P, Kohane IS, Visweswaran S, Mowery DL, Xia Z. 2021. Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19. Sci Rep 2021 v. 11:20238. NIEHS Grant No. P30ES017885 [Full Text Le TT, Gutiérrez-Sacristán A, Son J, Hong C, South AM, Beaulieu-Jones BK, Loh NHW, Luo Y, Morris M, Ngiam KY, Patel LP, Samayamuthu MJ, Schriver E, Tan ALM, Moore J, Cai T, Omenn GS, Avillach P, Kohane IS, Visweswaran S, Mowery DL, Xia Z. 2021. Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19. Sci Rep 2021 v. 11:20238. NIEHS Grant No. P30ES017885]

Kannoth S, Kandula S, Shaman J. 2022. The association between early country-level COVID-19 testing capacity and later COVID-19 mortality outcomes. Influenza Other Respi Viruses. 2022;16(1):56-62 [Full Text Kannoth S, Kandula S, Shaman J. 2022. The association between early country-level COVID-19 testing capacity and later COVID-19 mortality outcomes. Influenza Other Respi Viruses. 2022;16(1):56-62]

Zauche LH, Wallace B, Smoots AN, Olson CK, Oduyebo T, Kim SY, Petersen EE, Ju J, Beauregard J, Wilcox AJ, Rose CE, Meaney-Delman DM, Ellington SR; CDC v-safe COVID-19 Pregnancy Registry Team. 2021. Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion. N Engl J Med 2021 Oct 14;385(16):1533-1535 [Full Text Zauche LH, Wallace B, Smoots AN, Olson CK, Oduyebo T, Kim SY, Petersen EE, Ju J, Beauregard J, Wilcox AJ, Rose CE, Meaney-Delman DM, Ellington SR; CDC v-safe COVID-19 Pregnancy Registry Team. 2021. Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion. N Engl J Med 2021 Oct 14;385(16):1533-1535]

Huang BZ, Chen Z, Sidell MA, Eckel SP, Martinez MP, Lurmann F, Thomas DC, Gilliland FD, Xiang AH. 2021. Asthma Disease Status, COPD, and COVID-19 Severity in a Large Multiethnic Population. J Allergy Clin Immunol Pract 2021 Oct;9(10):3621-3628.e2. NIEHS Grant No. R01ES029963 [Full Text Huang BZ, Chen Z, Sidell MA, Eckel SP, Martinez MP, Lurmann F, Thomas DC, Gilliland FD, Xiang AH. 2021. Asthma Disease Status, COPD, and COVID-19 Severity in a Large Multiethnic Population. J Allergy Clin Immunol Pract 2021 Oct;9(10):3621-3628.e2. NIEHS Grant No. R01ES029963]

Hahn G, Wu CM, Lee S, Lutz SM, Khurana S, Baden LR, Haneuse S, Qiao D, Hecker J, DeMeo DL, Tanzi RE, Choudhary MC, Etemad B, Mohammadi A, Esmaeilzadeh E, Cho MH, Li JZ, Randolph AG, Laird NM, Weiss ST, Silverman EK, Ribbeck K, Lange C. 2021. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol 2021 Oct;45(7):685-693. NIEHS Grant No. P30ES002109 [Full Text Hahn G, Wu CM, Lee S, Lutz SM, Khurana S, Baden LR, Haneuse S, Qiao D, Hecker J, DeMeo DL, Tanzi RE, Choudhary MC, Etemad B, Mohammadi A, Esmaeilzadeh E, Cho MH, Li JZ, Randolph AG, Laird NM, Weiss ST, Silverman EK, Ribbeck K, Lange C. 2021. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol 2021 Oct;45(7):685-693. NIEHS Grant No. P30ES002109]

Bergmans RS, Larson PS. 2021. Suicide attempt and intentional self-harm during the earlier phase of the COVID-19 pandemic in Washtenaw County, Michigan. J Epidemiol Community Health 2021;75:963-969. NIEHS Grant No. P30ES017885 [Full Text Bergmans RS, Larson PS. 2021. Suicide attempt and intentional self-harm during the earlier phase of the COVID-19 pandemic in Washtenaw County, Michigan. J Epidemiol Community Health 2021;75:963-969. NIEHS Grant No. P30ES017885]

Environmental Factor Articles

Chris Long, NIEHS Executive Officer and proud public servant, retires – September 2021
He spearheaded efforts related to employee safety and health, and he helped to position the institute as a national leader in sustainability.

Interns research PFAS, disease vulnerability, cancer, and more – September 2021
Poster sessions capped their two-month NIEHS experience, and mentors from the institute guided them along the way.

Scientific art competition showcases trainees’ research, imagination – September 2021
The NIEHS Superfund Research Program hosted the competition, highlighting early-career scientists’ projects during the COVID-19 pandemic.

Papers From NIEHS Researchers

Immel AL, Sipos Y, Khan AS, Errett NA. 2021. Getting the food out: A content analysis of the online communication of Seattle food banks during the initial response to COVID-19. J Agric Food Syst Community Dev v. 10 (4): pp. 267-282. NIEHS Grant No. T32ES015459 [Full Text Immel AL, Sipos Y, Khan AS, Errett NA. 2021. Getting the food out: A content analysis of the online communication of Seattle food banks during the initial response to COVID-19. J Agric Food Syst Community Dev v. 10 (4): pp. 267-282. NIEHS Grant No. T32ES015459]

Patchett S, Lv Z, Rut W, Békés M, Drag M, Olsen SK, Huang TT. 2021. A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell reports 2021 v. 36 (13):109754. NIEHS Grant No. R01ES025166 [Full Text Patchett S, Lv Z, Rut W, Békés M, Drag M, Olsen SK, Huang TT. 2021. A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell reports 2021 v. 36 (13):109754. NIEHS Grant No. R01ES025166]

Korfmacher KS, Harris-Lovett S, Nelson KL. 2021. Campus collaborations as a model for transforming SARS-CoV-2 wastewater surveillance research into public health action. Environ Sci Technol. 2021;55(19):12770-12772. NIEHS Grant No. P30ES001247 [Full Text Korfmacher KS, Harris-Lovett S, Nelson KL. 2021. Campus collaborations as a model for transforming SARS-CoV-2 wastewater surveillance research into public health action. Environ Sci Technol. 2021;55(19):12770-12772. NIEHS Grant No. P30ES001247]

Chiu WA, Ndeffo-Mbah ML. 2021. Using test positivity and reported case rates to estimate state-level COVID-19 prevalence and seroprevalence in the United States. PLoS Comput Biol 2021;17(9):e1009374. NIEHS Grant No. P30ES029067 [Full Text Chiu WA, Ndeffo-Mbah ML. 2021. Using test positivity and reported case rates to estimate state-level COVID-19 prevalence and seroprevalence in the United States. PLoS Comput Biol 2021;17(9):e1009374. NIEHS Grant No. P30ES029067]

Pettit R, Peng B, Yu P, Matos PG, Greninger AL, McCashin J, Amos CI. 2021. Optimized post-vaccination strategies and preventative measures for SARS-CoV-2. medRxiv [Preprint] 2021 Sep 21:2021.09.17.21263723. NIEHS Grant No. T32ES027801 [Full Text Pettit R, Peng B, Yu P, Matos PG, Greninger AL, McCashin J, Amos CI. 2021. Optimized post-vaccination strategies and preventative measures for SARS-CoV-2. medRxiv [Preprint] 2021 Sep 21:2021.09.17.21263723. NIEHS Grant No. T32ES027801]

Ogbogu PU, Matsui EC, Apter AJ. 2021. COVID-19, health disparities, and what the allergist-immunologist can do. J Allergy Clin Immunol 2021 Nov;148(5):1172-1175. NIEHS Grant No. R01ES026170R01ES023447 [Full Text Ogbogu PU, Matsui EC, Apter AJ. 2021. COVID-19, health disparities, and what the allergist-immunologist can do. J Allergy Clin Immunol 2021 Nov;148(5):1172-1175. NIEHS Grant No. R01ES026170R01ES023447]

Kahn LG, Trasande L, Liu M, Mehta-Lee SS, Brubaker SG, Jacobson MH. 2021. Factors Associated With Changes in Pregnancy Intention Among Women Who Were Mothers of Young Children in New York City Following the COVID-19 Outbreak. JAMA Netw Open 2021 Sep 1;4(9):e2124273. NIEHS Grant No. K99ES030403 [Full Text Kahn LG, Trasande L, Liu M, Mehta-Lee SS, Brubaker SG, Jacobson MH. 2021. Factors Associated With Changes in Pregnancy Intention Among Women Who Were Mothers of Young Children in New York City Following the COVID-19 Outbreak. JAMA Netw Open 2021 Sep 1;4(9):e2124273. NIEHS Grant No. K99ES030403]

Avery AR, Tsang S, Seto EYW, Duncan GE. 2021. Differences in Stress and Anxiety Among Women With and Without Children in the Household During the Early Months of the COVID-19 Pandemic. Front Public Health 2021 Sep 1;9:688462. NIEHS Grant No. R33ES024715

Ames JL, Ferrara A, Avalos LA, Badon SE, Greenberg MB, Hedderson MM, Kuzniewicz MW, Qian Y, Young-Wolff KC, Zerbo O, Zhu Y, Croen LA. 2021. COVID-19 prevalence, symptoms, and sociodemographic disparities in infection among insured pregnant women in Northern California. PLoS One. 2021 Sep 3;16(9):e0256891. NIEHS Grant No. K99ES032481 [Full Text Ames JL, Ferrara A, Avalos LA, Badon SE, Greenberg MB, Hedderson MM, Kuzniewicz MW, Qian Y, Young-Wolff KC, Zerbo O, Zhu Y, Croen LA. 2021. COVID-19 prevalence, symptoms, and sociodemographic disparities in infection among insured pregnant women in Northern California. PLoS One. 2021 Sep 3;16(9):e0256891. NIEHS Grant No. K99ES032481]

Sattui SE, Liew JW, Kennedy K, Sirotich E, Putman M, Moni TT, Akpabio A, Alpízar-Rodríguez D, Berenbaum F, Bulina I, Conway R, Singh AD, Duff E, Durrant KL, Gheita TA, Hill CL, Howard RA, Hoyer BF, Hsieh E, El Kibbi L, Kilian A, Kim AH, Liew DFL, Lo C, Miller B, Mingolla S, Nudel M, Palmerlee CA, Singh JA, Singh N, Ugarte-Gil MF, Wallace J, Young KJ, Bhana S, Costello W, Grainger R, Machado PM, Robinson PC, Sufka P, Wallace ZS, Yazdany J, Harrison C, Larché M, Levine M, Foster G, Thabane L, Rider LG, Hausmann JS, Simard JF, Sparks JA. 2021. Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. RMD Open 2021 Sep;7(3):e001814 [Full Text Sattui SE, Liew JW, Kennedy K, Sirotich E, Putman M, Moni TT, Akpabio A, Alpízar-Rodríguez D, Berenbaum F, Bulina I, Conway R, Singh AD, Duff E, Durrant KL, Gheita TA, Hill CL, Howard RA, Hoyer BF, Hsieh E, El Kibbi L, Kilian A, Kim AH, Liew DFL, Lo C, Miller B, Mingolla S, Nudel M, Palmerlee CA, Singh JA, Singh N, Ugarte-Gil MF, Wallace J, Young KJ, Bhana S, Costello W, Grainger R, Machado PM, Robinson PC, Sufka P, Wallace ZS, Yazdany J, Harrison C, Larché M, Levine M, Foster G, Thabane L, Rider LG, Hausmann JS, Simard JF, Sparks JA. 2021. Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. RMD Open 2021 Sep;7(3):e001814]

Frazier MN, Dillard LB, Krahn JM, Perera L, Williams JG, Wilson IM, Stewart ZD, Pillon MC, Deterding LJ, Borgnia MJ, Stanley RE. 2021. Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. Nucleic Acids Res 2021 Sep 27;49(17):10136-10149 [Full Text Frazier MN, Dillard LB, Krahn JM, Perera L, Williams JG, Wilson IM, Stewart ZD, Pillon MC, Deterding LJ, Borgnia MJ, Stanley RE. 2021. Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. Nucleic Acids Res 2021 Sep 27;49(17):10136-10149]

DuPre NC, Karimi S, Zhang CH, Blair L, Gupta A, Alharbi LMA, Alluhibi M, Mitra R, McKinney WP, Little B. 2021. County-level demographic, social, economic, and lifestyle correlates of COVID-19 infection and death trajectories during the first wave of the pandemic in the United States. Sci Total Environ 2021 Sep 10;786:147495. Epub 2021 May 3. NIEHS Grant No. P30ES030283 [Full Text DuPre NC, Karimi S, Zhang CH, Blair L, Gupta A, Alharbi LMA, Alluhibi M, Mitra R, McKinney WP, Little B. 2021. County-level demographic, social, economic, and lifestyle correlates of COVID-19 infection and death trajectories during the first wave of the pandemic in the United States. Sci Total Environ 2021 Sep 10;786:147495. Epub 2021 May 3. NIEHS Grant No. P30ES030283]

Papers From NIEHS Researchers

Wang G, Foney DM, DiBari J, Hong X, Showell N, Kim KS, Ji H, Pearson C, Mirolli G, Rusk S, Sharfstein J, Cheng TL, Zuckerman B, Wang X. 2021. A prospective cohort study on the intersectionality of obesity, chronic disease, social factors, and incident risk of COVID-19 in US low-income minority middle-age mothers. International Journal of Obesity 2021 v. 45 (12):2577-2584. NIEHS Grant No. R01ES031521, R01ES031272 [Full Text Wang G, Foney DM, DiBari J, Hong X, Showell N, Kim KS, Ji H, Pearson C, Mirolli G, Rusk S, Sharfstein J, Cheng TL, Zuckerman B, Wang X. 2021. A prospective cohort study on the intersectionality of obesity, chronic disease, social factors, and incident risk of COVID-19 in US low-income minority middle-age mothers. International Journal of Obesity 2021 v. 45 (12):2577-2584. NIEHS Grant No. R01ES031521, R01ES031272]

Giovannoni F, Li Z, Remes-Lenicov F, Dávola ME, Elizalde M, Paletta A, Ashkar AA, Mossman KL, Dugour AV, Figueroa JM, Barquero AA, Ceballos A, Garcia CC, Quintana FJ. 2021. AHR signaling is induced by infection with coronaviruses. Nat Commun 2021 Aug 26;12(1):5148. NIEHS Grant No. R21ES025304, R01ES029136 [Full Text Giovannoni F, Li Z, Remes-Lenicov F, Dávola ME, Elizalde M, Paletta A, Ashkar AA, Mossman KL, Dugour AV, Figueroa JM, Barquero AA, Ceballos A, Garcia CC, Quintana FJ. 2021. AHR signaling is induced by infection with coronaviruses. Nat Commun 2021 Aug 26;12(1):5148. NIEHS Grant No. R21ES025304, R01ES029136]

Sobolik JS, Sajewski ET, Jaykus LA, Cooper DK, Lopman BA, Kraay AN, Ryan PB, Guest JL, Webb-Girard A, Leon JS. 2021. Low risk of SARS-CoV-2 transmission via fomite, even in cold-chain. medRxiv [Preprint] 2021 Aug 26:2021.08.23.21262477. NIEHS Grant No. T32ES012870 [Full Text Sobolik JS, Sajewski ET, Jaykus LA, Cooper DK, Lopman BA, Kraay AN, Ryan PB, Guest JL, Webb-Girard A, Leon JS. 2021. Low risk of SARS-CoV-2 transmission via fomite, even in cold-chain. medRxiv [Preprint] 2021 Aug 26:2021.08.23.21262477. NIEHS Grant No. T32ES012870]

Real de Asua D, Mayer MA, Ortega MdC, Borrel JM, Bermejo TdJ, González-Lamuño D, Manso C, Moldenhauer F, Carmona-Iragui M, Hüls A, Sherman SL, Strydom A, de la Torre R, Dierssen M on behalf of the Spanish Trisomy 21 Research Society COVID-19 Taskforce. 2021. Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome. Journal of Clinical Medicine 2021; 10(16):3748. NIEHS Grant No. P30ES019776 [Full Text Real de Asua D, Mayer MA, Ortega MdC, Borrel JM, Bermejo TdJ, González-Lamuño D, Manso C, Moldenhauer F, Carmona-Iragui M, Hüls A, Sherman SL, Strydom A, de la Torre R, Dierssen M on behalf of the Spanish Trisomy 21 Research Society COVID-19 Taskforce. 2021. Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome. Journal of Clinical Medicine 2021; 10(16):3748. NIEHS Grant No. P30ES019776]

Mahabee-Gittens EM, Mendy A, Merianos AL. 2021. Assessment of Severe COVID-19 Outcomes Using Measures of Smoking Status and Smoking Intensity. Int J Environ Res Public Health 2021 Aug 25;18(17):8939. NIEHS Grant No. R21ES032161, R01ES030743, R01ES027815, P30ES006096 [Full Text Mahabee-Gittens EM, Mendy A, Merianos AL. 2021. Assessment of Severe COVID-19 Outcomes Using Measures of Smoking Status and Smoking Intensity. Int J Environ Res Public Health 2021 Aug 25;18(17):8939. NIEHS Grant No. R21ES032161, R01ES030743, R01ES027815, P30ES006096]

Zhang L, Vunnamadala SP, Yagi S, Meraj R, Carbone M. 2021. Delayed positive COVID-19 nasopharyngeal test, a case study with clinical and pathological correlation. BMC Pulm Med 2021 Aug 31;21(1):278. NIEHS Grant No. R01ES030948 [Full Text Zhang L, Vunnamadala SP, Yagi S, Meraj R, Carbone M. 2021. Delayed positive COVID-19 nasopharyngeal test, a case study with clinical and pathological correlation. BMC Pulm Med 2021 Aug 31;21(1):278. NIEHS Grant No. R01ES030948]

Huffman A, Masci AM, Zheng J, Sanati N, Brunson T, Wu G, He Y. 2021. CIDO ontology updates and secondary analysis of host responses to COVID-19 infection based on ImmPort reports and literature. J Biomed Semantics 2021 Aug 28;12(1):18 [Full Text Huffman A, Masci AM, Zheng J, Sanati N, Brunson T, Wu G, He Y. 2021. CIDO ontology updates and secondary analysis of host responses to COVID-19 infection based on ImmPort reports and literature. J Biomed Semantics 2021 Aug 28;12(1):18]

Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. 2021. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv 2021 Aug 18;7(34):eabf8609. NIEHS Grant No. P30ES000002 [Full Text Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. 2021. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv 2021 Aug 18;7(34):eabf8609. NIEHS Grant No. P30ES000002]

Rivera Rivera NY, McGuinn L, Osorio-Valencia E, Martinez-Medina S, Schnaas L, Wright RJ, Téllez-Rojo MM, Wright RO, Tamayo-Ortiz M, Rosa MJ. Changes in Depressive Symptoms, Stress and Social Support in Mexican Women during the COVID-19 Pandemic. 2021. International Journal of Environmental Research and Public Health 2021; 18(16):8775. NIEHS Grant No. R00ES027496, R01ES014930, R01ES013744, R24ES028522, P30ES023515, R01ES021357 [Full Text Rivera Rivera NY, McGuinn L, Osorio-Valencia E, Martinez-Medina S, Schnaas L, Wright RJ, Téllez-Rojo MM, Wright RO, Tamayo-Ortiz M, Rosa MJ. Changes in Depressive Symptoms, Stress and Social Support in Mexican Women during the COVID-19 Pandemic. 2021. International Journal of Environmental Research and Public Health 2021; 18(16):8775. NIEHS Grant No. R00ES027496, R01ES014930, R01ES013744, R24ES028522, P30ES023515, R01ES021357]

Charrez B, Charwat V, Siemons BA, Goswami I, Sakolish C, Luo YS, Finsberg H, Edwards AG, Miller EW, Rusyn I, Healy KE. 2021. Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics. Front Pharmacol 2021 Aug 4;12:684252. NIEHS Grant No. T32ES026568 [Full Text Charrez B, Charwat V, Siemons BA, Goswami I, Sakolish C, Luo YS, Finsberg H, Edwards AG, Miller EW, Rusyn I, Healy KE. 2021. Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics. Front Pharmacol 2021 Aug 4;12:684252. NIEHS Grant No. T32ES026568]

Tomchaney M, Contoli M, Mayo J, Baraldo S, Shuaizhi L, Cabel CR, Bull DA, Lick S, Malo J, Knoper S, Kim SS, Tram J, Rojas-Quintero J, Kraft M, Ledford J, Tesfaigzi Y, Martinez FD, Thorne CA, Kheradmand F, Campos SK, Papi A, Polverino F. 2021. Paradoxical effects of cigarette smoke and COPD on SARS-CoV-2 infection and disease. FBMC Pulmonary Medicine 2021 v. 21: 275. NIEHS Grant No. ES006614 [Full Text Tomchaney M, Contoli M, Mayo J, Baraldo S, Shuaizhi L, Cabel CR, Bull DA, Lick S, Malo J, Knoper S, Kim SS, Tram J, Rojas-Quintero J, Kraft M, Ledford J, Tesfaigzi Y, Martinez FD, Thorne CA, Kheradmand F, Campos SK, Papi A, Polverino F. 2021. Paradoxical effects of cigarette smoke and COPD on SARS-CoV-2 infection and disease. FBMC Pulmonary Medicine 2021 v. 21: 275. NIEHS Grant No. ES006614]

Zhou X, Josey K, Kamareddine L, Caine MC, Liu T, Mickley LJ, Cooper M, Dominici F. 2021. Excess of COVID-19 cases and deaths due to fine particulate matter exposure during the 2020 wildfires in the United States. Sci Adv. 2021 Aug 13;7(33):eabi8789. NIEHS Grant No. R01ES026217, R01ES028033, R01ES030616, R01ES029950, T32ES007142, P30ES000002 [Full Text Zhou X, Josey K, Kamareddine L, Caine MC, Liu T, Mickley LJ, Cooper M, Dominici F. 2021. Excess of COVID-19 cases and deaths due to fine particulate matter exposure during the 2020 wildfires in the United States. Sci Adv. 2021 Aug 13;7(33):eabi8789. NIEHS Grant No. R01ES026217, R01ES028033, R01ES030616, R01ES029950, T32ES007142, P30ES000002]

Dey T, Lee J, Chakraborty S, Chandra J, Bhaskar A, Zhang K, Bhaskar A, Dominici F. 2021. Lag time between state-level policy interventions and change points in COVID-19 outcomes in the United States. Patterns (N Y) 2021 Aug 13;2(8):100306. NIEHS Grant No. P30ES000002 [Full Text Dey T, Lee J, Chakraborty S, Chandra J, Bhaskar A, Zhang K, Bhaskar A, Dominici F. 2021. Lag time between state-level policy interventions and change points in COVID-19 outcomes in the United States. Patterns (N Y) 2021 Aug 13;2(8):100306. NIEHS Grant No. P30ES000002]

Teng Y, Xu F, Zhang X, Mu J, Sayed M, Hu X, Lei C, Sriwastva M, Kumar A, Sundaram K, Zhang L, Park JW, Chen SY, Zhang S, Yan J, Merchant ML, Zhang X, McClain CJ, Wolfe JK, Adcock RS, Chung D, Palmer KE, Zhang HG. 2021. Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12. Mol Ther 2021 Aug 4;29(8):2424-2440. NIEHS Grant No. P30ES030283 [Full Text Teng Y, Xu F, Zhang X, Mu J, Sayed M, Hu X, Lei C, Sriwastva M, Kumar A, Sundaram K, Zhang L, Park JW, Chen SY, Zhang S, Yan J, Merchant ML, Zhang X, McClain CJ, Wolfe JK, Adcock RS, Chung D, Palmer KE, Zhang HG. 2021. Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12. Mol Ther 2021 Aug 4;29(8):2424-2440. NIEHS Grant No. P30ES030283]

Klompmaker JO, Hart JE, Holland I, Sabath MB, Wu X, Laden F, Dominici F, James P. 2021. County-level exposures to greenness and associations with COVID-19 incidence and mortality in the United States. Environ Res 2021 Aug;199:111331. Epub 2021 May 15. NIEHS Grant No. P30ES000002, R01ES028033 [Full Text Klompmaker JO, Hart JE, Holland I, Sabath MB, Wu X, Laden F, Dominici F, James P. 2021. County-level exposures to greenness and associations with COVID-19 incidence and mortality in the United States. Environ Res 2021 Aug;199:111331. Epub 2021 May 15. NIEHS Grant No. P30ES000002, R01ES028033]

Das D, Ramachandran G. Risk analysis of different transport vehicles in India during COVID-19 pandemic. 2021. Environmental Research 2021 v. 199: e111268. NIEHS Grant No. R01ES030210 [Full Text Das D, Ramachandran G. Risk analysis of different transport vehicles in India during COVID-19 pandemic. 2021. Environmental Research 2021 v. 199: e111268. NIEHS Grant No. R01ES030210]

Nogara PA, Omage FB, Bolzan GR, Delgado CP, Aschner M, Orian L, Teixeira Rocha JB. 2021. In silico Studies on the Interaction between Mpro and PLpro From SARS-CoV-2 and Ebselen, its Metabolites and Derivatives. Mol Inform 2021 Aug;40(8):e2100028. Epub 2021 May 21. NIEHS Grant No. R01ES10563, R01ES07331 [Full Text Nogara PA, Omage FB, Bolzan GR, Delgado CP, Aschner M, Orian L, Teixeira Rocha JB. 2021. In silico Studies on the Interaction between Mpro and PLpro From SARS-CoV-2 and Ebselen, its Metabolites and Derivatives. Mol Inform 2021 Aug;40(8):e2100028. Epub 2021 May 21. NIEHS Grant No. R01ES10563, R01ES07331]

Ciccone EJ, Zivich PN, Lodge EK, Zhu D, Law E, Miller E, Taylor JL, Chung S, Xu J, Volfovsky A, Beatty C, Abernathy H, King E, Garrett HE, Markmann AJ, Rebuli ME, Sellers S, Weber DJ, Reyes R, Alavian N, Juliano JJ, Boyce RM, Aiello AE. 2021. SARS-CoV-2 infection in health care personnel and their household contacts at a tertiary academic medical center: Protocol for a longitudinal cohort study. JMIR Res Protoc 2021 Apr 30;10(4):e25410. NIEHS Grant No. T32ES007018 [Full Text Ciccone EJ, Zivich PN, Lodge EK, Zhu D, Law E, Miller E, Taylor JL, Chung S, Xu J, Volfovsky A, Beatty C, Abernathy H, King E, Garrett HE, Markmann AJ, Rebuli ME, Sellers S, Weber DJ, Reyes R, Alavian N, Juliano JJ, Boyce RM, Aiello AE. 2021. SARS-CoV-2 infection in health care personnel and their household contacts at a tertiary academic medical center: Protocol for a longitudinal cohort study. JMIR Res Protoc 2021 Apr 30;10(4):e25410. NIEHS Grant No. T32ES007018]

Environmental Factor Articles

NIH Disaster Research Response Program Launches New Website – June 2021
NIEHS is providing a new home for the Disaster Research Response (DR2) program and its vast collection of web-based resources needed for scientists to conduct vital and timely public health research in the aftermath of disasters.

Sharon Beard Recognized by American Industrial Hygiene Association – June 2021
Sharon Beard, Acting Chief of the NIEHS Worker Training Program (WTP) has received the 2021 Rachel Carson Award from the American Industrial Hygiene Association (AIHA).

New Marker of COVID-19 Severity Points to Potential Therapies – June 2021
Certain fatty acids in the blood of COVID-19 patients may predict the severity of adult respiratory distress syndrome (ARDS) and offer a target for treatment, according to a new NIEHS-funded study.

Papers From NIEHS Researchers

Bock J, Srivastava P, Jessel S, Klopp JM, Parks RM. Compounding risks caused by heat exposure and COVID-19 in New York City: A review of policies, tools, and pilot survey results. 2021. Journal of Extreme Events v. 8 (2): 2150015. NIEHS Grant No. K99ES033742 [Full Text Bock J, Srivastava P, Jessel S, Klopp JM, Parks RM. Compounding risks caused by heat exposure and COVID-19 in New York City: A review of policies, tools, and pilot survey results. 2021. Journal of Extreme Events v. 8 (2): 2150015. NIEHS Grant No. K99ES033742]

Abdulhasan M, Ruden X, Rappolee B, Dutta S, Gurdziel K, Ruden DM, Awonuga AO, Korzeniewski SJ, Puscheck EE, Rappolee DA. 2021. Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells. Stem Cell Rev Rep 2021 v. 17 (6):2164-2177. NIEHS Grant No. R41ES028991 [Full Text Abdulhasan M, Ruden X, Rappolee B, Dutta S, Gurdziel K, Ruden DM, Awonuga AO, Korzeniewski SJ, Puscheck EE, Rappolee DA. 2021. Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells. Stem Cell Rev Rep 2021 v. 17 (6):2164-2177. NIEHS Grant No. R41ES028991]

Quintana AV, M Clemons, Hoevemeyer K, Liu A, Balbus J. A Descriptive Analysis of the Scientific Literature on Meteorological and Air Quality Factors and COVID-19. GeoHealth 2021 v. 5 (7) [Full Text Quintana AV, M Clemons, Hoevemeyer K, Liu A, Balbus J. A Descriptive Analysis of the Scientific Literature on Meteorological and Air Quality Factors and COVID-19. GeoHealth 2021 v. 5 (7)]

Huang X, Pearce R, Omenn GS, Zhang Y. 2021. Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment. International Journal of Molecular Sciences. 2021; 22(13):7060. NIEHS Grant No. P30ES017885 [Full Text Huang X, Pearce R, Omenn GS, Zhang Y. 2021. Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment. International Journal of Molecular Sciences. 2021; 22(13):7060. NIEHS Grant No. P30ES017885]

Ruran HB, Adamkiewicz G, Cunningham A, Petty CR, Greco KF, Gunnlaugsson S, Stamatiadis N, Sierra G, Vallarino J, Alvarez M, Hayden LP, Sheils CA, Weller E, Phipatanakul W, Gaffin JM. 2021. Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic. BMJ Open Respir Res 2021 Jun;8(1):e000915. NIEHS Grant No. R01ES030100, P30ES000002 [Full Text Ruran HB, Adamkiewicz G, Cunningham A, Petty CR, Greco KF, Gunnlaugsson S, Stamatiadis N, Sierra G, Vallarino J, Alvarez M, Hayden LP, Sheils CA, Weller E, Phipatanakul W, Gaffin JM. 2021. Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic. BMJ Open Respir Res 2021 Jun;8(1):e000915. NIEHS Grant No. R01ES030100, P30ES000002]

Kockler ZW, Gordenin DA. 2021. From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution. Cells 2021; 10(6):1557 [Full Text Kockler ZW, Gordenin DA. 2021. From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution. Cells 2021; 10(6):1557]

Kwon S, Joshi AD, Lo CH, Drew DA, Nguyen LH, Guo CG, Ma W, Mehta RS, Shebl FM, Warner ET, Astley CM, Merino J, Murray B, Wolf J, Ourselin S, Steves CJ, Spector TD, Hart JE, Song M, VoPham T, Chan AT. 2021. Association of social distancing and face mask use with risk of COVID-19. Nat Commun. 2021 Jun 18;12(1):3737. NIEHS Grant No. P30ES000002 [Full Text Kwon S, Joshi AD, Lo CH, Drew DA, Nguyen LH, Guo CG, Ma W, Mehta RS, Shebl FM, Warner ET, Astley CM, Merino J, Murray B, Wolf J, Ourselin S, Steves CJ, Spector TD, Hart JE, Song M, VoPham T, Chan AT. 2021. Association of social distancing and face mask use with risk of COVID-19. Nat Commun. 2021 Jun 18;12(1):3737. NIEHS Grant No. P30ES000002]

Sokolowska M, Eiwegger T, Ollert M, Torres MJ, Barber D, Del Giacco S, Jutel M, Nadeau KC, Palomares O, Rabin RL, Riggioni C, Vieths S, Agache I, Shamji MH. 2021. EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines. Allergy 2021 Jun;76(6):1629-1639 [Full Text Sokolowska M, Eiwegger T, Ollert M, Torres MJ, Barber D, Del Giacco S, Jutel M, Nadeau KC, Palomares O, Rabin RL, Riggioni C, Vieths S, Agache I, Shamji MH. 2021. EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines. Allergy 2021 Jun;76(6):1629-1639]

Esther CR Jr, Kimura KS, Mikami Y, Edwards CE, Das SR, Freeman MH, Strickland BA, Brown HM, Wessinger BC, Gupta VC, Von Wahlde K, Sheng Q, Huang LC, Bacon DR, Kimple AJ, Ceppe AS, Kato T, Pickles RJ, Randell SH, Baric RS, Turner JH, Boucher RC. 2021. Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections. Res Sq [Preprint] 2021 May 14:rs.3.rs-500168. Update in: Int Forum Allergy Rhinol 2022 Jan 18 NIEHS Grant No. P30ES010126 [Full Text Esther CR Jr, Kimura KS, Mikami Y, Edwards CE, Das SR, Freeman MH, Strickland BA, Brown HM, Wessinger BC, Gupta VC, Von Wahlde K, Sheng Q, Huang LC, Bacon DR, Kimple AJ, Ceppe AS, Kato T, Pickles RJ, Randell SH, Baric RS, Turner JH, Boucher RC. 2021. Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections. Res Sq [Preprint] 2021 May 14:rs.3.rs-500168. Update in: Int Forum Allergy Rhinol 2022 Jan 18 NIEHS Grant No. P30ES010126]

Carrión D, Colicino E, Pedretti NF, Arfer KB, Rush J, DeFelice N, Just AC. 2021. Neighborhood-level disparities and subway utilization during the COVID-19 pandemic in New York City. Nat Commun 2021 Jun 17;12(1):3692. NIEHS Grant No. P30ES023515 [Full Text Carrión D, Colicino E, Pedretti NF, Arfer KB, Rush J, DeFelice N, Just AC. 2021. Neighborhood-level disparities and subway utilization during the COVID-19 pandemic in New York City. Nat Commun 2021 Jun 17;12(1):3692. NIEHS Grant No. P30ES023515]

Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S, Weston S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Curry HM, Oom AL, Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw ML, Chang MW, Benner C, Hope TJ, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. 2021. Functional landscape of SARS-CoV-2 cellular restriction. Mol Cell. 2021 Jun 17;81(12):2656-2668.e8. Epub 2021 Apr 13. NIEHS Grant No. R01ES014811 [Full Text Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S, Weston S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Curry HM, Oom AL, Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw ML, Chang MW, Benner C, Hope TJ, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. 2021. Functional landscape of SARS-CoV-2 cellular restriction. Mol Cell. 2021 Jun 17;81(12):2656-2668.e8. Epub 2021 Apr 13. NIEHS Grant No. R01ES014811]

Miller NL, Clark T, Raman R, Sasisekharan R. 2021. Mapping Potential Antigenic Drift Sites (PADS) on SARS-CoV-2 Spike in Continuous Epitope-Paratope Space. bioRxiv [Preprint] 2021 Jun 8:2021.06.07.446560. NIEHS Grant No. T32ES007020 [Full Text Miller NL, Clark T, Raman R, Sasisekharan R. 2021. Mapping Potential Antigenic Drift Sites (PADS) on SARS-CoV-2 Spike in Continuous Epitope-Paratope Space. bioRxiv [Preprint] 2021 Jun 8:2021.06.07.446560. NIEHS Grant No. T32ES007020]

Romm KF, Patterson B, Crawford ND, Posner H, West CD, Wedding D, Horn K, Berg CJ. 2021. Changes in young adult substance use during COVID-19 as a function of ACEs, depression, prior substance use and resilience. Subst Abus. 2022;43(1):212-221. Epub 2021 Jun 4. NIEHS Grant No. D43ES030927 [Full Text Romm KF, Patterson B, Crawford ND, Posner H, West CD, Wedding D, Horn K, Berg CJ. 2021. Changes in young adult substance use during COVID-19 as a function of ACEs, depression, prior substance use and resilience. Subst Abus. 2022;43(1):212-221. Epub 2021 Jun 4. NIEHS Grant No. D43ES030927]

Mollan KR, Eron JJ, Krajewski TJ, Painter W, Duke ER, Morse CG, Goecker EA, Premkumar L, Wolfe CR, Szewczyk LJ, Alabanza PL, Loftis AJ, Degli-Angeli EJ, Brown AJ, Dragavon JA, Won JJ, Keys J, Hudgens MG, Fang L, Wohl DA, Cohen MS, Baric RS, Coombs RW, Sheahan TP, Fischer WA 2nd. 2021. Infectious SARS-CoV-2 Virus in Symptomatic COVID-19 Outpatients: Host, Disease, and Viral Correlates. medRxiv [Preprint] 2021 Jun 25:2021.05.28.21258011. Update in: Clin Infect Dis. 2021 Nov 23;: PMID: 34100024; PMCID: PMC8183023. NIEHS Grant No. T32ES007018 [Full Text Mollan KR, Eron JJ, Krajewski TJ, Painter W, Duke ER, Morse CG, Goecker EA, Premkumar L, Wolfe CR, Szewczyk LJ, Alabanza PL, Loftis AJ, Degli-Angeli EJ, Brown AJ, Dragavon JA, Won JJ, Keys J, Hudgens MG, Fang L, Wohl DA, Cohen MS, Baric RS, Coombs RW, Sheahan TP, Fischer WA 2nd. 2021. Infectious SARS-CoV-2 Virus in Symptomatic COVID-19 Outpatients: Host, Disease, and Viral Correlates. medRxiv [Preprint] 2021 Jun 25:2021.05.28.21258011. Update in: Clin Infect Dis. 2021 Nov 23;: PMID: 34100024; PMCID: PMC8183023. NIEHS Grant No. T32ES007018]

Ranjan P, Thomas V, Kumar P. 2021. 2D materials as a diagnostic platform for the detection and sensing of the SARS-CoV-2 virus: a bird's-eye view. J Mater Chem B 2021 Jun 16;9(23):4608-4619. NIEHS Grant No. P42ES027723 [Full Text Ranjan P, Thomas V, Kumar P. 2021. 2D materials as a diagnostic platform for the detection and sensing of the SARS-CoV-2 virus: a bird's-eye view. J Mater Chem B 2021 Jun 16;9(23):4608-4619. NIEHS Grant No. P42ES027723]

Clifford SP, Ramirez J, Akca O, Ghafghazi S, Huang J. 2021. Perioperative Cardiac Research Considerations During the Coronavirus Disease 2019 (COVID-19) Pandemic. J Cardiothorac Vasc Anesth 2021 Jun;35(6):1573-1577. Epub 2021 Feb 5. NIEHS Grant No. P30ES030283 [Full Text Clifford SP, Ramirez J, Akca O, Ghafghazi S, Huang J. 2021. Perioperative Cardiac Research Considerations During the Coronavirus Disease 2019 (COVID-19) Pandemic. J Cardiothorac Vasc Anesth 2021 Jun;35(6):1573-1577. Epub 2021 Feb 5. NIEHS Grant No. P30ES030283]

Moschovis PP, Yonker LM, Shah J, Singh D, Demokritou P, Kinane TB. 2021. Aerosol transmission of SARS-CoV-2 by children and adults during the COVID-19 pandemic. Pediatr Pulmonol 2021 Jun;56(6):1389-1394. Epub 2021 Mar 15. NIEHS Grant No. K23ES030399, U24ES026946 [Full Text Moschovis PP, Yonker LM, Shah J, Singh D, Demokritou P, Kinane TB. 2021. Aerosol transmission of SARS-CoV-2 by children and adults during the COVID-19 pandemic. Pediatr Pulmonol 2021 Jun;56(6):1389-1394. Epub 2021 Mar 15. NIEHS Grant No. K23ES030399, U24ES026946]

Environmental Factor Articles

New NIH Funding Advances COVID-19 Testing – May 2021
Four new Funding Opportunity Announcements (FOAs), issued April 13, will move a program called RADx(SM) Underserved Populations (RADx[SM]-UP) rapidly into its next phase.

COVID-19 Resilience and Recovery for Workers, Communities – May 2021
In April, NIEHS Worker Training Program (WTP) awardees began work on COVID-19 recovery centers to promote health, safety, and recovery training for essential workers and their communities.

Scholars Find New Ways to Research Amidst a Global Pandemic – May 2021
Members of the 2020-2021 NIEHS Scholars Connect Program (NSCP) presented their research at the April 16 Spring Symposium.

Biomarker Suggests Severity of COVID-19 Respiratory Distress – May 2021
In a study funded in part by NIEHS, researchers reported April 1 that certain fatty acids in the blood of COVID-19 patients may predict the severity of adult respiratory distress syndrome (ARDS).

NIEHS Earns WELL Building Rating, First Among Feds – May 2021
On March 30, NIEHS became the first U.S. federal agency to achieve the International WELL Building Institute’s (IWBI) Health-Safety Rating.

Papers From NIEHS Researchers

Kosmider B, Lin C, Simborio H, Bolla S, Marchetti N, Criner GJ, Bahmed K. 2021. SARS-CoV-2-related Gene Expression in Alveolar Type II Cells in Aging and Emphysema. American Journal of Respiratory and Critical Care Medicine 2021;203:A4192 [Full Text Kosmider B, Lin C, Simborio H, Bolla S, Marchetti N, Criner GJ, Bahmed K. 2021. SARS-CoV-2-related Gene Expression in Alveolar Type II Cells in Aging and Emphysema. American Journal of Respiratory and Critical Care Medicine 2021;203:A4192]

Huntington-Moskos L, Nyenhuis SM, Polivka BJ, Eldeirawi K. 2021. IImpact of COVID-19 on Individual Behavior and Household Exposure Related to Smoking, Vaping and Marijuana Use Among Adults with Asthma. American Journal of Respiratory and Critical Care Medicine 2021 v. 203 (9): A1482. NIEHS Grant No. P30ES030283 [Full Text Huntington-Moskos L, Nyenhuis SM, Polivka BJ, Eldeirawi K. 2021. IImpact of COVID-19 on Individual Behavior and Household Exposure Related to Smoking, Vaping and Marijuana Use Among Adults with Asthma. American Journal of Respiratory and Critical Care Medicine 2021 v. 203 (9): A1482. NIEHS Grant No. P30ES030283]

Solopov P, Colunga Biancatelli R, Sharlow E, Lazo J, Catravas J. 2021. Single intratracheal exposure to SARS‐CoV‐2 S1 spike protein induces acute lung injury in K18‐hACE2 transgenic mice. FASEB J 2021 May;35(Suppl 1):10.1096/fasebj.2021.35.S1.04183. NIEHS Grant No. R21ES030528 [Full Text Solopov P, Colunga Biancatelli R, Sharlow E, Lazo J, Catravas J. 2021. Single intratracheal exposure to SARS‐CoV‐2 S1 spike protein induces acute lung injury in K18‐hACE2 transgenic mice. FASEB J 2021 May;35(Suppl 1):10.1096/fasebj.2021.35.S1.04183. NIEHS Grant No. R21ES030528]

Nicol MP, MacGinty R, Workman L, Stadler JAM, Myer L, Allen V, Ah Tow Edries L, Zar HJ. 2021. A Longitudinal Study of the Epidemiology of Seasonal Coronaviruses in an African Birth Cohort. J Pediatric Infect Dis Soc 2021 May 28;10(5):607-614 [Full Text Nicol MP, MacGinty R, Workman L, Stadler JAM, Myer L, Allen V, Ah Tow Edries L, Zar HJ. 2021. A Longitudinal Study of the Epidemiology of Seasonal Coronaviruses in an African Birth Cohort. J Pediatric Infect Dis Soc 2021 May 28;10(5):607-614]

Lewnard JA, Mora AM, Nkwocha O, Kogut K, Rauch SA, Morga N, Hernandez S, Wong MP, Huen K, Andrejko K, Jewell NP, Parra KL, Holland N, Harris E, Cuevas M, Eskenazi B; CHAMACOS-Project-19 Study Team. 2021. Prevalence and Clinical Profile of Severe Acute Respiratory Syndrome Coronavirus 2 Infection among Farmworkers, California, USA, June-November 2020. Emerg Infect Dis 2021 May;27(5):1330-1342. NIEHS Grant No. R24ES028529 [Full Text Lewnard JA, Mora AM, Nkwocha O, Kogut K, Rauch SA, Morga N, Hernandez S, Wong MP, Huen K, Andrejko K, Jewell NP, Parra KL, Holland N, Harris E, Cuevas M, Eskenazi B; CHAMACOS-Project-19 Study Team. 2021. Prevalence and Clinical Profile of Severe Acute Respiratory Syndrome Coronavirus 2 Infection among Farmworkers, California, USA, June-November 2020. Emerg Infect Dis 2021 May;27(5):1330-1342. NIEHS Grant No. R24ES028529]

Mishra PK, Bruiners N, Ukey R, Datta P, Onyuka A, Handler D, Hussain S, Honnen W, Singh S, Guerrini V, Yin Y, Dewald H, Choudhary A, Horton DB, Barrett ES, Roy J, Weiss SH, Fitzgerald-Bocarsly P, Blaser MJ, Carson JL, Panettieri RA Jr, Lardizabal A, Chang TL, Pinter A, Gennaro ML. 2021. Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cells. medRxiv [Preprint] 2021 May 12:2021.04.11.21255153. NIEHS Grant No. P30ES005022 [Full Text Mishra PK, Bruiners N, Ukey R, Datta P, Onyuka A, Handler D, Hussain S, Honnen W, Singh S, Guerrini V, Yin Y, Dewald H, Choudhary A, Horton DB, Barrett ES, Roy J, Weiss SH, Fitzgerald-Bocarsly P, Blaser MJ, Carson JL, Panettieri RA Jr, Lardizabal A, Chang TL, Pinter A, Gennaro ML. 2021. Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cells. medRxiv [Preprint] 2021 May 12:2021.04.11.21255153. NIEHS Grant No. P30ES005022]

Pawloski KR, Kolod B, Khan RF, Midya V, Chen T, Oduwole A, Camins B, Colicino E, Leitman IM, Nabeel I, Oliver K, Valvi D. 2021. Factors Associated with SARS-CoV-2 Infection in Physician Trainees in New York City during the First COVID-19 Wave. International Journal of Environmental Research and Public Health 2021; 18(10):5274. NIEHS Grant No. P30ES023515 [Full Text Pawloski KR, Kolod B, Khan RF, Midya V, Chen T, Oduwole A, Camins B, Colicino E, Leitman IM, Nabeel I, Oliver K, Valvi D. 2021. Factors Associated with SARS-CoV-2 Infection in Physician Trainees in New York City during the First COVID-19 Wave. International Journal of Environmental Research and Public Health 2021; 18(10):5274. NIEHS Grant No. P30ES023515]

Brandt K, Goel V, Keeler C, Bell GJ, Aiello AE, Corbie-Smith G, Wilson E, Fleischauer A, Emch M, Boyce RM. 2021. SARS-CoV-2 testing in North Carolina: Racial, ethnic, and geographic disparities. Health Place 2021 May;69:102576. Epub 2021 Apr 19. NIEHS Grant No. T32ES007018 [Full Text Brandt K, Goel V, Keeler C, Bell GJ, Aiello AE, Corbie-Smith G, Wilson E, Fleischauer A, Emch M, Boyce RM. 2021. SARS-CoV-2 testing in North Carolina: Racial, ethnic, and geographic disparities. Health Place 2021 May;69:102576. Epub 2021 Apr 19. NIEHS Grant No. T32ES007018]

Islam N, Shkolnikov VM, Acosta RJ, Klimkin I, Kawachi I, Irizarry RA, Alicandro G, Khunti K, Yates T, Jdanov DA, White M, Lewington S, Lacey B. 2021. Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries. BMJ 2021 May 19;373:n1137. NIEHS Grant No. T32ES007142 [Full Text Islam N, Shkolnikov VM, Acosta RJ, Klimkin I, Kawachi I, Irizarry RA, Alicandro G, Khunti K, Yates T, Jdanov DA, White M, Lewington S, Lacey B. 2021. Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries. BMJ 2021 May 19;373:n1137. NIEHS Grant No. T32ES007142]

Zhang X, Smith N, Spear E, Stroustrup A. Neighborhood characteristics associated with COVID-19 burden-the modifying effect of age. 2021. J Expo Sci Environ Epidemiol 2021 May;31(3):525-537. Epub 2021 May 4. NIEHS Grant No. K23ES022268 [Full Text Zhang X, Smith N, Spear E, Stroustrup A. Neighborhood characteristics associated with COVID-19 burden-the modifying effect of age. 2021. J Expo Sci Environ Epidemiol 2021 May;31(3):525-537. Epub 2021 May 4. NIEHS Grant No. K23ES022268]

Stoler J, Miller JD, Brewis A, Freeman MC, Harris LM, Jepson W, Pearson AL, Rosinger AY, Shah SH, Staddon C, Workman C, Wutich A, Young SL; Household Water Insecurity Experiences Research Coordination Network (HWISE RCN). 2021. Household water insecurity will complicate the ongoing COVID-19 response: Evidence from 29 sites in 23 low- and middle-income countries. Int J Hyg Environ Health 2021 May;234:113715. NIEHS Grant No. R01ES019841 [Full Text Stoler J, Miller JD, Brewis A, Freeman MC, Harris LM, Jepson W, Pearson AL, Rosinger AY, Shah SH, Staddon C, Workman C, Wutich A, Young SL; Household Water Insecurity Experiences Research Coordination Network (HWISE RCN). 2021. Household water insecurity will complicate the ongoing COVID-19 response: Evidence from 29 sites in 23 low- and middle-income countries. Int J Hyg Environ Health 2021 May;234:113715. NIEHS Grant No. R01ES019841]

Mousavi A, Wu J. 2021. Indoor-generated PM2.5 During COVID-19 Shutdowns Across California: Application of the PurpleAir Indoor-outdoor Low-cost Sensor Network. Environ Sci Technol 2021 May 4;55(9):5648-5656. Epub 2021 Apr 19. NIEHS Grant No. ES030353 [Full Text Mousavi A, Wu J. 2021. Indoor-generated PM2.5 During COVID-19 Shutdowns Across California: Application of the PurpleAir Indoor-outdoor Low-cost Sensor Network. Environ Sci Technol 2021 May 4;55(9):5648-5656. Epub 2021 Apr 19. NIEHS Grant No. ES030353]

Quandt SA, LaMonto NJ, Mora DC, Talton JW, Laurienti PJ, Arcury TA. 2021. COVID-19 Pandemic Among Immigrant Latinx Farmworker and Non-farmworker Families: A Rural-urban Comparison of Economic, Educational, Healthcare, and Immigration Concerns. New Solut 2021 May;31(1):30-47. Epub 2021 Feb 8. NIEHS Grant No. R01ES08739 [Full Text Quandt SA, LaMonto NJ, Mora DC, Talton JW, Laurienti PJ, Arcury TA. 2021. COVID-19 Pandemic Among Immigrant Latinx Farmworker and Non-farmworker Families: A Rural-urban Comparison of Economic, Educational, Healthcare, and Immigration Concerns. New Solut 2021 May;31(1):30-47. Epub 2021 Feb 8. NIEHS Grant No. R01ES08739]

Hu H, Zheng Y, Wen X, Smith SS, Nizomov J, Fishe J, Hogan WR, Shenkman EA, Bian J. 2021. An external exposome-wide association study of COVID-19 mortality in the United States. Sci Total Environ 2021 May 10;768:144832. Epub 2021 Jan 7. NIEHS Grant No. R21ES032762 [Full Text Hu H, Zheng Y, Wen X, Smith SS, Nizomov J, Fishe J, Hogan WR, Shenkman EA, Bian J. 2021. An external exposome-wide association study of COVID-19 mortality in the United States. Sci Total Environ 2021 May 10;768:144832. Epub 2021 Jan 7. NIEHS Grant No. R21ES032762]

Environmental Factor Articles

Freezer donations add COVID-19 vaccine storage capacity in North Carolina – April 1, 2021
On March 16, NIEHS shipped 11 ultracold laboratory-grade freezers to the North Carolina (NC) Department of Health and Human Services (DHHS), thanks to a grassroots project from within the institute's Office of Management.

Press Releases

NIEHS Earns WELL Building Rating Amid Pandemic – April 12, 2021
On March 30, 2021, the National Institute of Environmental Health Sciences (NIEHS) became the first federal agency to achieve the International WELL Building Institute’s Health-Safety Rating.

Antar AAR, Yu T, Pisanic N, Azamfirei R, Tornheim JA, Brown DM, Kruczynski K, Hardick JP, Sewell T, Jang M, Church T, Walch SN, Reuland C, Bachu VS, Littlefield K, Park HS, Ursin RL, Ganesan A, Kusemiju O, Barnaba B, Charles C, Prizzi M, Johnstone JR, Payton C, Dai W, Fuchs J, Massaccesi G, Armstrong DT, Townsend JL, Keller SC, Demko ZO, Hu C, Wang MC, Sauer LM, Mostafa HH, Keruly JC, Mehta SH, Klein SL, Cox AL, Pekosz A, Heaney CD, Thomas DL, Blair PW, Manabe YC. 2021. Delayed Rise of Oral Fluid Antibodies, Elevated BMI, and Absence of Early Fever Correlate With Longer Time to SARS-CoV-2 RNA Clearance in a Longitudinally Sampled Cohort of COVID-19 Outpatients. Open Forum Infect Dis 2021 Apr 16;8(6):ofab195. NIEHS Grant No. R01ES026973 [Full Text Antar AAR, Yu T, Pisanic N, Azamfirei R, Tornheim JA, Brown DM, Kruczynski K, Hardick JP, Sewell T, Jang M, Church T, Walch SN, Reuland C, Bachu VS, Littlefield K, Park HS, Ursin RL, Ganesan A, Kusemiju O, Barnaba B, Charles C, Prizzi M, Johnstone JR, Payton C, Dai W, Fuchs J, Massaccesi G, Armstrong DT, Townsend JL, Keller SC, Demko ZO, Hu C, Wang MC, Sauer LM, Mostafa HH, Keruly JC, Mehta SH, Klein SL, Cox AL, Pekosz A, Heaney CD, Thomas DL, Blair PW, Manabe YC. 2021. Delayed Rise of Oral Fluid Antibodies, Elevated BMI, and Absence of Early Fever Correlate With Longer Time to SARS-CoV-2 RNA Clearance in a Longitudinally Sampled Cohort of COVID-19 Outpatients. Open Forum Infect Dis 2021 Apr 16;8(6):ofab195. NIEHS Grant No. R01ES026973]

Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC. 2021. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med 2021 Apr 21;13(590):eabf7872. Epub 2021 Mar 15. NIEHS Grant No. U01ES032673 [Full Text Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC. 2021. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med 2021 Apr 21;13(590):eabf7872. Epub 2021 Mar 15. NIEHS Grant No. U01ES032673]

Cacari Stone L, Roary MC, Diana A, Grady PA. 2021. State health disparities research in Rural America: Gaps and future directions in an era of COVID-19. J Rural Health 2021 Jun;37(3):460-466. Epub 2021 Apr 21 [Full Text Cacari Stone L, Roary MC, Diana A, Grady PA. 2021. State health disparities research in Rural America: Gaps and future directions in an era of COVID-19. J Rural Health 2021 Jun;37(3):460-466. Epub 2021 Apr 21]

VoPham T, Weaver MD, Adamkiewicz G, Hart JE. 2021. Social Distancing Associations with COVID-19 Infection and Mortality Are Modified by Crowding and Socioeconomic Status. International Journal of Environmental Research and Public Health 2021; 18(9):4680. NIEHS Grant No. P30ES000002 [Full Text VoPham T, Weaver MD, Adamkiewicz G, Hart JE. 2021. Social Distancing Associations with COVID-19 Infection and Mortality Are Modified by Crowding and Socioeconomic Status. International Journal of Environmental Research and Public Health 2021; 18(9):4680. NIEHS Grant No. P30ES000002]

Simkovich SM, Thompson LM, Clark ML, Balakrishnan K, Bussalleu A, Checkley W, Clasen T, Davila-Roman VG, Diaz-Artiga A, Dusabimana E, Fuentes LL, Harvey S, Kirby MA, Lovvorn A, McCollum ED, Mollinedo EE, Peel JL, Quinn A, Rosa G, Underhill LJ, Williams KN, Young BN, Rosenthal J; HAPIN Investigators. 2021. A risk assessment tool for resumption of research activities during the COVID-19 pandemic for field trials in low resource settings. BMC Med Res Methodol 2021 Apr 12;21(1):68 [Full Text Simkovich SM, Thompson LM, Clark ML, Balakrishnan K, Bussalleu A, Checkley W, Clasen T, Davila-Roman VG, Diaz-Artiga A, Dusabimana E, Fuentes LL, Harvey S, Kirby MA, Lovvorn A, McCollum ED, Mollinedo EE, Peel JL, Quinn A, Rosa G, Underhill LJ, Williams KN, Young BN, Rosenthal J; HAPIN Investigators. 2021. A risk assessment tool for resumption of research activities during the COVID-19 pandemic for field trials in low resource settings. BMC Med Res Methodol 2021 Apr 12;21(1):68]

McReynolds CB, Cortes-Puch I, Ravindran R, Khan IH, Hammock BG, Shih PB, Hammock BD, Yang J. 2021. Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Front Physiol 2021 Apr 1;12:663869. NIEHS Grant No. P42ES004699, R35ES030443 [Full Text McReynolds CB, Cortes-Puch I, Ravindran R, Khan IH, Hammock BG, Shih PB, Hammock BD, Yang J. 2021. Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Front Physiol 2021 Apr 1;12:663869. NIEHS Grant No. P42ES004699, R35ES030443]

Li Q, Zhu Q, Xu M, Zhao Y, Narayan KMV, Liu Y. 2021. Estimating the Impact of COVID-19 on the PM2.5 Levels in China with a Satellite-Driven Machine Learning Model. Remote Sensing. 2021; 13(7):1351. NIEHS Grant No. R01ES032140 [Full Text Li Q, Zhu Q, Xu M, Zhao Y, Narayan KMV, Liu Y. 2021. Estimating the Impact of COVID-19 on the PM2.5 Levels in China with a Satellite-Driven Machine Learning Model. Remote Sensing. 2021; 13(7):1351. NIEHS Grant No. R01ES032140]

Correa-Agudelo E, Mersha TB, Branscum AJ, MacKinnon NJ, Cuadros DF. 2021. Identification of Vulnerable Populations and Areas at Higher Risk of COVID-19-Related Mortality during the Early Stage of the Epidemic in the United States. International Journal of Environmental Research and Public Health 2021; 18(8):4021. NIEHS Grant No. P30ES006096 [Full Text Correa-Agudelo E, Mersha TB, Branscum AJ, MacKinnon NJ, Cuadros DF. 2021. Identification of Vulnerable Populations and Areas at Higher Risk of COVID-19-Related Mortality during the Early Stage of the Epidemic in the United States. International Journal of Environmental Research and Public Health 2021; 18(8):4021. NIEHS Grant No. P30ES006096]

Simoneau T, Greco KF, Hammond A, Nelson K, Gaffin JM. 2021. Impact of the COVID-19 Pandemic on Pediatric Emergency Department Use for Asthma. Ann Am Thorac Soc 2021 Apr;18(4):717-719. NIEHS Grant No. R01ES030100 [Full Text Simoneau T, Greco KF, Hammond A, Nelson K, Gaffin JM. 2021. Impact of the COVID-19 Pandemic on Pediatric Emergency Department Use for Asthma. Ann Am Thorac Soc 2021 Apr;18(4):717-719. NIEHS Grant No. R01ES030100]

Li J, Wang Z, Yuan B, Zhao H. 2021. Exposure to Air Pollutants and Mortality Rate of Novel Coronavirus Disease: Potential Risk in Occupational Safety. Journal of Occupational and Environmental Medicine (2021) v. 63 (4): pp. e252-e254. NIEHS Grant No. R01ES024332, R21ES024012, R01ES026217, R01ES028033, R01ES030616 [Full Text Li J, Wang Z, Yuan B, Zhao H. 2021. Exposure to Air Pollutants and Mortality Rate of Novel Coronavirus Disease: Potential Risk in Occupational Safety. Journal of Occupational and Environmental Medicine (2021) v. 63 (4): pp. e252-e254. NIEHS Grant No. R01ES024332, R21ES024012, R01ES026217, R01ES028033, R01ES030616]

Kraay ANM, Hayashi MAL, Berendes DM, Sobolik JS, Leon JS, Lopman BA. 2021. Risk for fomite-mediated transmission of SARS-CoV-2 in child daycares, schools, nursing homes, and offices. Emerg Infect Dis 2021 Apr;27(4):1229-1231. NIEHS Grant No. T32ES012870 [Full Text Kraay ANM, Hayashi MAL, Berendes DM, Sobolik JS, Leon JS, Lopman BA. 2021. Risk for fomite-mediated transmission of SARS-CoV-2 in child daycares, schools, nursing homes, and offices. Emerg Infect Dis 2021 Apr;27(4):1229-1231. NIEHS Grant No. T32ES012870]

Ajmera V, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Sriram K, Insel PA, Collier S, Richards L, Loomba R. 2021. RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19. Contemp Clin Trials 2021 Apr;103:106330. Epub 2021 Feb 22. NIEHS Grant No. P42ES010337 [Full Text Ajmera V, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Sriram K, Insel PA, Collier S, Richards L, Loomba R. 2021. RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19. Contemp Clin Trials 2021 Apr;103:106330. Epub 2021 Feb 22. NIEHS Grant No. P42ES010337]

Carbone M, Lednicky J, Xiao SY, Venditti M, Bucci E. 2021. Coronavirus 2019 Infectious Disease Epidemic: Where We Are, What Can Be Done and Hope For. J Thorac Oncol 2021 Apr;16(4):546-571. Epub 2021 Jan 7. NIEHS Grant No. R01ES030948 [Full Text Carbone M, Lednicky J, Xiao SY, Venditti M, Bucci E. 2021. Coronavirus 2019 Infectious Disease Epidemic: Where We Are, What Can Be Done and Hope For. J Thorac Oncol 2021 Apr;16(4):546-571. Epub 2021 Jan 7. NIEHS Grant No. R01ES030948]

De Angelis E, Renzetti S, Volta M, Donato F, Calza S, Placidi D, Lucchini RG, Rota M. 2021. COVID-19 incidence and mortality in Lombardy, Italy: An ecological study on the role of air pollution, meteorological factors, demographic and socioeconomic variables. Environ Res 2021 Apr;195:110777. Epub 2021 Jan 22. NIEHS Grant No. R01ES019222, R56ES01922 [Full Text De Angelis E, Renzetti S, Volta M, Donato F, Calza S, Placidi D, Lucchini RG, Rota M. 2021. COVID-19 incidence and mortality in Lombardy, Italy: An ecological study on the role of air pollution, meteorological factors, demographic and socioeconomic variables. Environ Res 2021 Apr;195:110777. Epub 2021 Jan 22. NIEHS Grant No. R01ES019222, R56ES01922]

Brigham E, O'Toole J, Kim SY, Friedman M, Daly L, Kaplin A, Swarthout M, Hasselfeld B, Lantz-Garnish M, Vannorsdall T, Agranovich A, Raju S, Parker A. 2021. The Johns Hopkins Post-acute COVID-19 Team (PACT): A Multidisciplinary, Collaborative, Ambulatory Framework Supporting COVID-19 Survivors. Am J Med 2021 Apr;134(4):462-467.e1. Epub 2021 Jan 12. NIEHS Grant No. K23ES029105 [Full Text Brigham E, O'Toole J, Kim SY, Friedman M, Daly L, Kaplin A, Swarthout M, Hasselfeld B, Lantz-Garnish M, Vannorsdall T, Agranovich A, Raju S, Parker A. 2021. The Johns Hopkins Post-acute COVID-19 Team (PACT): A Multidisciplinary, Collaborative, Ambulatory Framework Supporting COVID-19 Survivors. Am J Med 2021 Apr;134(4):462-467.e1. Epub 2021 Jan 12. NIEHS Grant No. K23ES029105]

Environmental Factor Articles

Organs-on-a-chip for COVID-19 Research Group Led by NTP Center – March 1, 2021
Federal agencies collaborate on microphysiological systems to accelerate development of new treatments.

Fighting Misinformation, Preventing Workplace COVID-19 Exposure – March 1, 2021
The NIEHS Worker Training Program’s monthly COVID-19−focused webinars aim to protect workers who may be at risk of exposure.

A Tool for Visualizing County-level COVID-19 Risk Factors – March 1, 2021
>The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard, created by NIEHS researchers and collaborators at North Carolina State University and Texas A & M University, addresses knowledge gaps in pandemic risk at the county level.

Papers From NIEHS Researchers

Vaidya U, Hopkins J. 2021. IACMI-The Composites Institute Efforts in Current and Post-COVID-19 Manufacturing Era-innovations and Sustainability. Smart and Sustainable Manufacturing Systems 2021 v. 5 (1): pp. 113-119. NIEHS Grant No. P42ES027723 [Full Text Vaidya U, Hopkins J. 2021. IACMI-The Composites Institute Efforts in Current and Post-COVID-19 Manufacturing Era-innovations and Sustainability. Smart and Sustainable Manufacturing Systems 2021 v. 5 (1): pp. 113-119. NIEHS Grant No. P42ES027723]

Hilser JR, Han Y, Biswas S, Gukasyan J, Cai Z, Zhu R, Tang WHW, Deb A, Lusis AJ, Hartiala JA, Allayee H. 2021. Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection. J Lipid Res 2021;62:100061. Epub 2021 Mar 2. NIEHS Grant No. R01ES025786 [Full Text Hilser JR, Han Y, Biswas S, Gukasyan J, Cai Z, Zhu R, Tang WHW, Deb A, Lusis AJ, Hartiala JA, Allayee H. 2021. Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection. J Lipid Res 2021;62:100061. Epub 2021 Mar 2. NIEHS Grant No. R01ES025786]

Xing J, Paithankar S, Liu K, Uhl K, Li X, Ko M, Kim S, Haskins J, Chen B. 2021. Published Anti-SARS-CoV-2 In Vitro Hits Share Common Mechanisms of Action that Synergize with Antivirals. bioRxiv [Preprint] 2021 Mar 4:2021.03.04.433931. Update in: Brief Bioinform 2021 Jul 09. NIEHS Grant No. K01ES028047 [Full Text Xing J, Paithankar S, Liu K, Uhl K, Li X, Ko M, Kim S, Haskins J, Chen B. 2021. Published Anti-SARS-CoV-2 In Vitro Hits Share Common Mechanisms of Action that Synergize with Antivirals. bioRxiv [Preprint] 2021 Mar 4:2021.03.04.433931. Update in: Brief Bioinform 2021 Jul 09. NIEHS Grant No. K01ES028047]

Fiore VG, DeFelice N, Glicksberg BS, Perl O, Shuster A, Kulkarni K, O'Brien M, Pisauro MA, Chung D, Gu X. 2021. Containment of COVID-19: Simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation. PLoS One 2021 Mar 31;16(3):e0247614. NIEHS Grant No. R24ES028522 [Full Text Fiore VG, DeFelice N, Glicksberg BS, Perl O, Shuster A, Kulkarni K, O'Brien M, Pisauro MA, Chung D, Gu X. 2021. Containment of COVID-19: Simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation. PLoS One 2021 Mar 31;16(3):e0247614. NIEHS Grant No. R24ES028522]

Welch JL, Xiang J, Mackin SR, Perlman S, Thorne P, O'Shaughnessy P, Strzelecki B, Aubin P, Ortiz-Hernandez M, Stapleton JT. 2021. Inactivation of Severe Acute Respiratory Coronavirus Virus 2 (SARS-CoV-2) and Diverse RNA and DNA Viruses on Three-dimensionally Printed Surgical Mask Materials. Infect Control Hosp Epidemiol 2021 Mar;42(3):253-260. Epub 2020 Aug 12. NIEHS Grant No. P30ES005605 [Full Text Welch JL, Xiang J, Mackin SR, Perlman S, Thorne P, O'Shaughnessy P, Strzelecki B, Aubin P, Ortiz-Hernandez M, Stapleton JT. 2021. Inactivation of Severe Acute Respiratory Coronavirus Virus 2 (SARS-CoV-2) and Diverse RNA and DNA Viruses on Three-dimensionally Printed Surgical Mask Materials. Infect Control Hosp Epidemiol 2021 Mar;42(3):253-260. Epub 2020 Aug 12. NIEHS Grant No. P30ES005605]

Sly PD, Trottier BA, Bulka CM, Cormier SA, Fobil J, Fry RC, Kim KW, Kleeberger S, Kumar P, Landrigan PJ, Lodrop Carlsen KC, Pascale A, Polack F, Ruchirawat M, Zar HJ, Suk WA. 2021. The interplay between environmental exposures and COVID-19 risks in the health of children. Environ Health 2021 Mar 26;20(1):34 [Full Text Sly PD, Trottier BA, Bulka CM, Cormier SA, Fobil J, Fry RC, Kim KW, Kleeberger S, Kumar P, Landrigan PJ, Lodrop Carlsen KC, Pascale A, Polack F, Ruchirawat M, Zar HJ, Suk WA. 2021. The interplay between environmental exposures and COVID-19 risks in the health of children. Environ Health 2021 Mar 26;20(1):34]

Bauza V, Sclar GD, Bisoyi A, Owens A, Ghugey A, Clasen T. 2021. Experience of the COVID-19 pandemic in rural Odisha, India: Knowledge, preventative actions, and impacts on daily life. International Journal of Environmental Research and Public Health 2021; 18(6):2863. NIEHS Grant No. T32ES012870 [Full Text Bauza V, Sclar GD, Bisoyi A, Owens A, Ghugey A, Clasen T. 2021. Experience of the COVID-19 pandemic in rural Odisha, India: Knowledge, preventative actions, and impacts on daily life. International Journal of Environmental Research and Public Health 2021; 18(6):2863. NIEHS Grant No. T32ES012870]

Altuwayjiri A, Soleimanian E, Moroni S, Palomba P, Borgini A, De Marco C, Ruprecht AA, Sioutas C. 2021. The impact of stay-home policies during Coronavirus-19 pandemic on the chemical and toxicological characteristics of ambient PM2.5 in the metropolitan area of Milan, Italy. Sci Total Environ 2021 Mar 1;758:143582. Epub 2020 Nov 14. NIEHS Grant No. R01ES029395 [Full Text Altuwayjiri A, Soleimanian E, Moroni S, Palomba P, Borgini A, De Marco C, Ruprecht AA, Sioutas C. 2021. The impact of stay-home policies during Coronavirus-19 pandemic on the chemical and toxicological characteristics of ambient PM2.5 in the metropolitan area of Milan, Italy. Sci Total Environ 2021 Mar 1;758:143582. Epub 2020 Nov 14. NIEHS Grant No. R01ES029395]

Skalny AV, Lima TRR, Ke T, Zhou JC, Bornhorst J, Alekseenko SI, Aaseth J, Anesti O, Sarigiannis DA, Tsatsakis A, Aschner M, Tinkov AA. 2021. Corrigendum to "Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases" [Food Chem. Toxicol. 146 111809]. Food Chem Toxicol 2021 Mar;149:111999. Epub 2021 Jan 23. Erratum for: Food Chem Toxicol. 2020 Dec;146:111809. NIEHS Grant No. R01ES007331, R01ES010563 [Full Text Skalny AV, Lima TRR, Ke T, Zhou JC, Bornhorst J, Alekseenko SI, Aaseth J, Anesti O, Sarigiannis DA, Tsatsakis A, Aschner M, Tinkov AA. 2021. Corrigendum to "Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases" [Food Chem. Toxicol. 146 111809]. Food Chem Toxicol 2021 Mar;149:111999. Epub 2021 Jan 23. Erratum for: Food Chem Toxicol. 2020 Dec;146:111809. NIEHS Grant No. R01ES007331, R01ES010563]

Eldeirawi K, Huntington-Moskos L, Nyenhuis SM, Polivka B. 2021. Increased disinfectant use among adults with asthma in the era of COVID-19. J Allergy Clin Immunol Pract 2021 Mar;9(3):1378-1380.e2. Epub 2020 Dec 29. NIEHS Grant No. P30ES030283 [Full Text Eldeirawi K, Huntington-Moskos L, Nyenhuis SM, Polivka B. 2021. Increased disinfectant use among adults with asthma in the era of COVID-19. J Allergy Clin Immunol Pract 2021 Mar;9(3):1378-1380.e2. Epub 2020 Dec 29. NIEHS Grant No. P30ES030283]

Banerjee R, Perera L, Tillekeratne LMV. 2021. Potential SARS-CoV-2 main protease inhibitors. Drug Discov Today 2021 Mar;26(3):804-816. Epub 2020 Dec 9 [Full Text Banerjee R, Perera L, Tillekeratne LMV. 2021. Potential SARS-CoV-2 main protease inhibitors. Drug Discov Today 2021 Mar;26(3):804-816. Epub 2020 Dec 9]

Sayahi T, Nielson C, Yu Y, Neuberger K, Seipp M, Firpo MA, Kelly K, Park AH. 2021. Airborne aerosolized mouse cytomegalovirus from common otolaryngology procedures:implications for COVID-19 infection. Otolaryngol Head Neck Surg 2021 Mar;164(3):547-555. Epub 2020 Sep 15. Erratum in: Otolaryngol Head Neck Surg 2021 Feb 9;:19459982199035. NIEHS Grant No. K25ES027504 [Full Text Sayahi T, Nielson C, Yu Y, Neuberger K, Seipp M, Firpo MA, Kelly K, Park AH. 2021. Airborne aerosolized mouse cytomegalovirus from common otolaryngology procedures:implications for COVID-19 infection. Otolaryngol Head Neck Surg 2021 Mar;164(3):547-555. Epub 2020 Sep 15. Erratum in: Otolaryngol Head Neck Surg 2021 Feb 9;:19459982199035. NIEHS Grant No. K25ES027504]

He B, Garmire L. 2020. Prediction of repurposed drugs for treating lung injury in COVID-19. ArXiv [Preprint] 2020 Mar 30:arXiv:2003.14333v2. Update in: F1000Res 2020 Jun 15;9:609. NIEHS Grant No. K01ES025434 [Full Text He B, Garmire L. 2020. Prediction of repurposed drugs for treating lung injury in COVID-19. ArXiv [Preprint] 2020 Mar 30:arXiv:2003.14333v2. Update in: F1000Res 2020 Jun 15;9:609. NIEHS Grant No. K01ES025434]

Womens's Health Awareness

Know the Facts: COVID-19 Vaccines
If you are a Black/African American woman or man aged 18 and older and living in North Carolina, we want to hear from you. Please join an important study on community concerns and/or acceptance and beliefs about vaccines and immunizations.

Worker Training Program

COVID-19, Social Vulnerability, and Environmental Injustice – March 2, 2021

COVID-19 Vaccine

Answers for Concerns & Questions - Dr. Darryl Zeldin NIH/NIEHS Scientific Director – February 1, 2021

Environmental Factor Articles

Pandemic Vulnerability Tool Provides County-level Snapshots – February 1, 2021
Visualizations of 12 risk factors support localized public health interventions to stem the pandemic’s spread.

COVID-19 Testing Staff Greeted With Tasty Thanks – February 1, 2021
In a grassroots effort, Division of the National Toxicology Program volunteers surprised testers with an edible expression of gratitude.

Papers From NIEHS Researchers

Zhang L, Mann M, Syed Z, Reynolds HM, Tian E, Samara NL, Zeldin DC, Tabak LA, Ten Hagen KG. 2021. Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation. bioRxiv [Preprint] 2021 Feb 5:2021.02.05.429982 [Full Text Zhang L, Mann M, Syed Z, Reynolds HM, Tian E, Samara NL, Zeldin DC, Tabak LA, Ten Hagen KG. 2021. Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation. bioRxiv [Preprint] 2021 Feb 5:2021.02.05.429982]

Tieskens K, Patil P, Levy JI, Brochu P, Lane KJ, Fabian MP, Carnes F, Haley BM, Spangler KR, Leibler JH. 2021. Time-varying associations between COVID-19 case incidence and community-level sociodemographic, occupational, environmental, and mobility risk factors in Massachusetts. Res Sq [Preprint] 2021 Feb 17:rs.3.rs-237622. Update in: BMC Infect Dis. 2021 Jul 16;21(1):686. NIEHS Grant No. T32ES014562 [Full Text Tieskens K, Patil P, Levy JI, Brochu P, Lane KJ, Fabian MP, Carnes F, Haley BM, Spangler KR, Leibler JH. 2021. Time-varying associations between COVID-19 case incidence and community-level sociodemographic, occupational, environmental, and mobility risk factors in Massachusetts. Res Sq [Preprint] 2021 Feb 17:rs.3.rs-237622. Update in: BMC Infect Dis. 2021 Jul 16;21(1):686. NIEHS Grant No. T32ES014562]

Heaney CD, Pisanic N, Randad PR, Kruczynski K, Howard T, Zhu X, Littlefield K, Patel EU, Shrestha R, Laeyendecker O, Shoham S, Sullivan D, Gebo K, Hanley D, Redd AD, Quinn TC, Casadevall A, Zenilman JM, Pekosz A, Bloch EM, Tobian AAR. 2021. Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers. medRxiv [Preprint] 2021 Feb 1:2021.01.28.21250717. Update in: J Clin Virol 2021 Oct 9;145:104997. NIEHS Grant No. R01ES026973 [Full Text Heaney CD, Pisanic N, Randad PR, Kruczynski K, Howard T, Zhu X, Littlefield K, Patel EU, Shrestha R, Laeyendecker O, Shoham S, Sullivan D, Gebo K, Hanley D, Redd AD, Quinn TC, Casadevall A, Zenilman JM, Pekosz A, Bloch EM, Tobian AAR. 2021. Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers. medRxiv [Preprint] 2021 Feb 1:2021.01.28.21250717. Update in: J Clin Virol 2021 Oct 9;145:104997. NIEHS Grant No. R01ES026973]

Harris-Lovett S, Nelson K, Beamer P, Bischel HN, Bivins A, Bruder A, Butler C, Camenisch TD, De Long SK, Karthikeyan S, Larsen DA, Meierdiercks K, Mouser P, Pagsuyoin S, Prasek S, Radniecki TS, Ram JL, Roper DK, Safford H, Sherchan SP, Shuster W, Stalder T, Wheeler RT, Korfmacher KS. 2021. Wastewater surveillance for SARS-CoV-2 on college campuses: Initial efforts, lessons learned and research needs. medRxiv [Preprint] 2021 Feb 3:2021.02.01.21250952. Update in: Int J Environ Res Public Health 2021 Apr 22;18(9). NIEHS Grant No. P30ES001247 [Full Text Harris-Lovett S, Nelson K, Beamer P, Bischel HN, Bivins A, Bruder A, Butler C, Camenisch TD, De Long SK, Karthikeyan S, Larsen DA, Meierdiercks K, Mouser P, Pagsuyoin S, Prasek S, Radniecki TS, Ram JL, Roper DK, Safford H, Sherchan SP, Shuster W, Stalder T, Wheeler RT, Korfmacher KS. 2021. Wastewater surveillance for SARS-CoV-2 on college campuses: Initial efforts, lessons learned and research needs. medRxiv [Preprint] 2021 Feb 3:2021.02.01.21250952. Update in: Int J Environ Res Public Health 2021 Apr 22;18(9). NIEHS Grant No. P30ES001247]

Ma M, Xu Y, Su Y, Ong SB, Hu X, Chai M, Zhao M, Li H, Fan X, Chen Y, Xu D, Xu X. 2021. Single-cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2. Front Cardiovasc Med 2021 Feb 23;8:628885 [Full Text Ma M, Xu Y, Su Y, Ong SB, Hu X, Chai M, Zhao M, Li H, Fan X, Chen Y, Xu D, Xu X. 2021. Single-cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2. Front Cardiovasc Med 2021 Feb 23;8:628885]

Smith CJ, Bilbo SD. 2021. Sickness and the social brain: Love in the time of COVID. Front Psychiatry 2021 Feb 22;12:633664. NIEHS Grant No. F32ES029912 [Full Text Smith CJ, Bilbo SD. 2021. Sickness and the social brain: Love in the time of COVID. Front Psychiatry 2021 Feb 22;12:633664. NIEHS Grant No. F32ES029912]

Weber GM, Hong C, Palmer NP, Avillach P, Murphy SN, Gutiérrez-Sacristán A, Xia Z, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Bellasi A, Benoit V, Beraghi M, Boeker M, Booth J, Bosari S, Bourgeois FT, Brown NW, Bucalo M, Chiovato L, Chiudinelli L, Dagliati A, Devkota B, DuVall SL, Follett RW, Ganslandt T, García Barrio N, Gradinger T, Griffier R, Hanauer DA, Holmes JH, Horki P, Huling KM, Issitt RW, Jouhet V, Keller MS, Kraska D, Liu M, Luo Y, Lynch KE, Malovini A, Mandl KD, Mao C, Maram A, Matheny ME, Maulhardt T, Mazzitelli M, Milano M, Moore JH, Morris JS, Morris M, Mowery DL, Naughton TP, Ngiam KY, Norman JB, Patel LP, Pedrera Jimenez M, Ramoni RB, Schriver ER, Scudeller L, Sebire NJ, Serrano Balazote P, Spiridou A, Tan AL, Tan BW, Tibollo V, Torti C, Trecarichi EM, Vitacca M, Zambelli A, Zucco C; Consortium for Clinical Characterization of COVID-19 by EHR (4CE), Kohane IS, Cai T, Brat GA. 2021. International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study. medRxiv [Preprint]. 2021 Feb 5:2020.12.16.20247684. NIEHS Grant No. P30ES017885 [Full Text Weber GM, Hong C, Palmer NP, Avillach P, Murphy SN, Gutiérrez-Sacristán A, Xia Z, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Bellasi A, Benoit V, Beraghi M, Boeker M, Booth J, Bosari S, Bourgeois FT, Brown NW, Bucalo M, Chiovato L, Chiudinelli L, Dagliati A, Devkota B, DuVall SL, Follett RW, Ganslandt T, García Barrio N, Gradinger T, Griffier R, Hanauer DA, Holmes JH, Horki P, Huling KM, Issitt RW, Jouhet V, Keller MS, Kraska D, Liu M, Luo Y, Lynch KE, Malovini A, Mandl KD, Mao C, Maram A, Matheny ME, Maulhardt T, Mazzitelli M, Milano M, Moore JH, Morris JS, Morris M, Mowery DL, Naughton TP, Ngiam KY, Norman JB, Patel LP, Pedrera Jimenez M, Ramoni RB, Schriver ER, Scudeller L, Sebire NJ, Serrano Balazote P, Spiridou A, Tan AL, Tan BW, Tibollo V, Torti C, Trecarichi EM, Vitacca M, Zambelli A, Zucco C; Consortium for Clinical Characterization of COVID-19 by EHR (4CE), Kohane IS, Cai T, Brat GA. 2021. International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study. medRxiv [Preprint]. 2021 Feb 5:2020.12.16.20247684. NIEHS Grant No. P30ES017885]

Tomasso LP, Yin J, Cedeño Laurent JG, Chen JT, Catalano PJ, Spengler JD. 2021. The Relationship between Nature Deprivation and Individual Wellbeing across Urban Gradients under COVID-19 International Journal of Environmental Research and Public Health. 2021; 18(4):1511. NIEHS Grant No. T32ES007069 [Full Text Tomasso LP, Yin J, Cedeño Laurent JG, Chen JT, Catalano PJ, Spengler JD. 2021. The Relationship between Nature Deprivation and Individual Wellbeing across Urban Gradients under COVID-19 International Journal of Environmental Research and Public Health. 2021; 18(4):1511. NIEHS Grant No. T32ES007069]

Perera F, Berberian A, Cooley D, Shenaut E, Olmstead H, Ross Z, Matte T. 2021. Potential health benefits of sustained air quality improvements in New York City: A simulation based on air pollution levels during the COVID-19 shutdown. Environ Res 2021 Feb;193:110555. Epub 2020 Dec 4. NIEHS Grant No. P50ES09600

Press Releases

Workplace Chemical Exposure Study Leads to Small Business COVID-19 Awareness Campaign – February 16, 2021
Small business owners can take advantage of one-on-one training in preventing the spread of SARS-CoV-2, the virus that causes COVID-19, thanks to a project led by researchers at the University of Arizona Health Sciences in collaboration with the Sonora Environmental Resources Institute (SERI) and El Rio Health.

Worker Training Program

Addressing COVID Challenges With Community Partners – February 25, 2021

Mental Health Impacts of COVID-19 Response – February 4, 2021

Environmental Factor Articles

Global Health in the COVID-19 Era Explored at Local Conference – January 1, 2021
Health system preparedness, equity of access, culture, and misinformation challenges dominate discussions.

COVID-19 Impacts on Children With Special Needs, Their Families – January 1, 2021
Diversity Speaker Series features NIEHS parents sharing how young people with disabilities and their families are dealing with the crisis.

Papers From NIEHS Researchers

Bauza V, Sclar GD, Bisoyi A, Majorin F, Ghugey A, Clasen T. 2021. Water, sanitation, and hygiene practices and challenges during the COVID-19 pandemic: a cross-sectional study in rural Odisha, India. medRxiv [Preprint] 2021 Jan 27:2021.01.26.21250274. Update in: Am J Trop Med Hyg 2021 Apr 27. NIEHS Grant No. T32ES012870 [Full Text Bauza V, Sclar GD, Bisoyi A, Majorin F, Ghugey A, Clasen T. 2021. Water, sanitation, and hygiene practices and challenges during the COVID-19 pandemic: a cross-sectional study in rural Odisha, India. medRxiv [Preprint] 2021 Jan 27:2021.01.26.21250274. Update in: Am J Trop Med Hyg 2021 Apr 27. NIEHS Grant No. T32ES012870]

Chen F, Zhang Y, Sucgang R, Ramani S, Corry D, Kheradmand F, Creighton CJ. 2021. Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors. Sci Rep 2021 Jan 28;11(1):2459. NIEHS Grant No. R01ES029442 [Full Text Chen F, Zhang Y, Sucgang R, Ramani S, Corry D, Kheradmand F, Creighton CJ. 2021. Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors. Sci Rep 2021 Jan 28;11(1):2459. NIEHS Grant No. R01ES029442]

Haynes EN, Hilbert TJ, Westneat S, Leger KA, Keynton K, Bush H. 2021. Impact of the COVID-19 Shutdown on Mental Health in Appalachia by Working Status. J Appalach Health 2021;3(1):18-28. NIEHS Grant No. P30ES026529, R01ES026446, R24ES030904 [Full Text Haynes EN, Hilbert TJ, Westneat S, Leger KA, Keynton K, Bush H. 2021. Impact of the COVID-19 Shutdown on Mental Health in Appalachia by Working Status. J Appalach Health 2021;3(1):18-28. NIEHS Grant No. P30ES026529, R01ES026446, R24ES030904]

Zheng J, Wong LR, Li K, Verma AK, Ortiz ME, Wohlford-Lenane C, Leidinger MR, Knudson CM, Meyerholz DK, McCray PB Jr, Perlman S. 2021. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature 2021 Jan;589(7843):603-607. Epub 2020 Nov 9. NIEHS Grant No. P30ES005605 [Full Text Zheng J, Wong LR, Li K, Verma AK, Ortiz ME, Wohlford-Lenane C, Leidinger MR, Knudson CM, Meyerholz DK, McCray PB Jr, Perlman S. 2021. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature 2021 Jan;589(7843):603-607. Epub 2020 Nov 9. NIEHS Grant No. P30ES005605]

Merianos AL, Fevrier B, Mahabee-Gittens EM. 2021. Telemedicine for Tobacco Cessation and Prevention to Combat COVID-19 Morbidity and Mortality in Rural Areas. Front Public Health 2021 Jan 18;8:598905. NIEHS Grant No. R01ES027815, R01ES030743 [Full Text Merianos AL, Fevrier B, Mahabee-Gittens EM. 2021. Telemedicine for Tobacco Cessation and Prevention to Combat COVID-19 Morbidity and Mortality in Rural Areas. Front Public Health 2021 Jan 18;8:598905. NIEHS Grant No. R01ES027815, R01ES030743]

Davis CE, Schivo M, Kenyon NJ. 2021. A breath of fresh air - the potential for COVID-19 breath diagnostics. EBioMedicine 2021 Jan;63:103183. Epub 2021 Jan 6. NIEHS Grant No. P30ES023513 [Full Text Davis CE, Schivo M, Kenyon NJ. 2021. A breath of fresh air - the potential for COVID-19 breath diagnostics. EBioMedicine 2021 Jan;63:103183. Epub 2021 Jan 6. NIEHS Grant No. P30ES023513]

Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE. 2021. Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun 2021 Jan 27;12(1):636 [Full Text Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE. 2021. Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun 2021 Jan 27;12(1):636]

Tanwar V, Adelstein JM, Wold LE. 2021. Double trouble: combined cardiovascular effects of particulate matter exposure and coronavirus disease 2019. Cardiovasc Res 2021 Jan 1;117(1):85-95. NIEHS Grant No. R01ES019923 [Full Text Tanwar V, Adelstein JM, Wold LE. 2021. Double trouble: combined cardiovascular effects of particulate matter exposure and coronavirus disease 2019. Cardiovasc Res 2021 Jan 1;117(1):85-95. NIEHS Grant No. R01ES019923]

Barouki R, Kogevinas M, Audouze K, Belesova K, Bergman A, Birnbaum L, Boekhold S, Denys S, Desseille C, Drakvik E, Frumkin H, Garric J, Destoumieux-Garzon D, Haines A, Huss A, Jensen G, Karakitsios S, Klanova J, Koskela IM, Laden F, Marano F, Franziska Matthies-Wiesler E, Morris G, Nowacki J, Paloniemi R, Pearce N, Peters A, Rekola A, Sarigiannis D, Šebková K, Slama R, Staatsen B, Tonne C, Vermeulen R, Vineis P; HERA-COVID-19 working group. 2021. The COVID-19 pandemic and global environmental change: Emerging research needs. Environ Int 2021 Jan;146:106272. Epub 2020 Nov 19 [Full Text Barouki R, Kogevinas M, Audouze K, Belesova K, Bergman A, Birnbaum L, Boekhold S, Denys S, Desseille C, Drakvik E, Frumkin H, Garric J, Destoumieux-Garzon D, Haines A, Huss A, Jensen G, Karakitsios S, Klanova J, Koskela IM, Laden F, Marano F, Franziska Matthies-Wiesler E, Morris G, Nowacki J, Paloniemi R, Pearce N, Peters A, Rekola A, Sarigiannis D, Šebková K, Slama R, Staatsen B, Tonne C, Vermeulen R, Vineis P; HERA-COVID-19 working group. 2021. The COVID-19 pandemic and global environmental change: Emerging research needs. Environ Int 2021 Jan;146:106272. Epub 2020 Nov 19]

Marvel SW, House JS, Wheeler M, Song K, Zhou YH, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning. Environ Health Perspect 2021 Jan;129(1):17701. Epub 2021 Jan 5 [Full Text Marvel SW, House JS, Wheeler M, Song K, Zhou YH, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning. Environ Health Perspect 2021 Jan;129(1):17701. Epub 2021 Jan 5]

Alves VM, Bobrowski T, Melo-Filho CC, Korn D, Auerbach S, Schmitt C, Muratov EN, Tropsha A. 2021. QSAR Modeling of SARS-CoV Mpro Inhibitors Identifies Sufugolix, Cenicriviroc, Proglumetacin, and other Drugs as Candidates for Repurposing against SARS-CoV-2. Mol Inform 2021 Jan;40(1):e2000113. Epub 2020 Aug 24 [Full Text Alves VM, Bobrowski T, Melo-Filho CC, Korn D, Auerbach S, Schmitt C, Muratov EN, Tropsha A. 2021. QSAR Modeling of SARS-CoV Mpro Inhibitors Identifies Sufugolix, Cenicriviroc, Proglumetacin, and other Drugs as Candidates for Repurposing against SARS-CoV-2. Mol Inform 2021 Jan;40(1):e2000113. Epub 2020 Aug 24]

Worker Training Program

Routes of Transmission and Exposure Mitigation – January 13, 2021

Environmental Factor Articles

Keep indoor air clean during pandemic with tips shared in webinar – December 2020
The second in a series of women’s health seminars focused on indoor air as one aspect of staying healthy while sheltering at home.

Papers From NIEHS Researchers

Yee M, David Cohen E, Haak J, Dylag AM, O'Reilly MA. 2020. Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice. Sci Rep 2020 Dec 28;10(1):22401. NIEHS Grant No. P30ES001247 [Full Text Yee M, David Cohen E, Haak J, Dylag AM, O'Reilly MA. 2020. Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice. Sci Rep 2020 Dec 28;10(1):22401. NIEHS Grant No. P30ES001247]

Huang X, Zhang C, Pearce R, Omenn GS, Zhang Y. 2020. Identifying zoonotic origin of SARS-CoV-2 by modeling the binding affinity between Spike receptor-binding domain and host ACE2. J Proteome Res 2020 Dec 4;19(12):4844-4856. Epub 2020 Nov 11. NIEHS Grant No. P30ES017885 [Full Text Huang X, Zhang C, Pearce R, Omenn GS, Zhang Y. 2020. Identifying zoonotic origin of SARS-CoV-2 by modeling the binding affinity between Spike receptor-binding domain and host ACE2. J Proteome Res 2020 Dec 4;19(12):4844-4856. Epub 2020 Nov 11. NIEHS Grant No. P30ES017885]

Skalny AV, Lima TRR, Ke T, Zhou JC, Bornhorst J, Alekseenko SI, Aaseth J, Anesti O, Sarigiannis DA, Tsatsakis A, Aschner M, Tinkov AA. 2020. Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases. Food Chem Toxicol 2020 Dec;146:111809. Epub 2020 Oct 16. Erratum in: Food Chem Toxicol 2021 Mar;149:111999. NIEHS Grant No. R01ES007331, R01ES010563 [Full Text Skalny AV, Lima TRR, Ke T, Zhou JC, Bornhorst J, Alekseenko SI, Aaseth J, Anesti O, Sarigiannis DA, Tsatsakis A, Aschner M, Tinkov AA. 2020. Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases. Food Chem Toxicol 2020 Dec;146:111809. Epub 2020 Oct 16. Erratum in: Food Chem Toxicol 2021 Mar;149:111999. NIEHS Grant No. R01ES007331, R01ES010563]

Tsatsakis A, Calina D, Falzone L, Petrakis D, Mitrut R, Siokas V, Pennisi M, Lanza G, Libra M, Doukas SG, Doukas PG, Kavali L, Bukhari A, Gadiparthi C, Vageli DP, Kofteridis DP, Spandidos DA, Paoliello MMB, Aschner M, Docea AO. 2020. SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19. Food Chem Toxicol 2020 Dec;146:111769. Epub 2020 Sep 30. NIEHS Grant No. R01ES10563, R01ES07331 [Full Text Tsatsakis A, Calina D, Falzone L, Petrakis D, Mitrut R, Siokas V, Pennisi M, Lanza G, Libra M, Doukas SG, Doukas PG, Kavali L, Bukhari A, Gadiparthi C, Vageli DP, Kofteridis DP, Spandidos DA, Paoliello MMB, Aschner M, Docea AO. 2020. SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19. Food Chem Toxicol 2020 Dec;146:111769. Epub 2020 Sep 30. NIEHS Grant No. R01ES10563, R01ES07331]

Seto E, Min E, Ingram C, Cummings B, Farquhar SA. 2020. Community-level factors associated with COVID-19 cases and testing equity in King County, Washington. International Journal of Environmental Research and Public Health 2020; 17(24):9516. NIEHS Grant No. P30ES007033 [Full Text Seto E, Min E, Ingram C, Cummings B, Farquhar SA. 2020. Community-level factors associated with COVID-19 cases and testing equity in King County, Washington. International Journal of Environmental Research and Public Health 2020; 17(24):9516. NIEHS Grant No. P30ES007033]

Esparza TJ, Martin NP, Anderson GP, Goldman ER, Brody DL. 2020. High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme. Sci Rep 2020 Dec 22;10(1):22370 [Full Text Esparza TJ, Martin NP, Anderson GP, Goldman ER, Brody DL. 2020. High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme. Sci Rep 2020 Dec 22;10(1):22370]

Fang Z, Li AI, Wang H, Zhang R, Mai X, Pan T. 2020. AmbuBox: a fast-deployable low-cost ventilator for COVID-19 emergent care. SLAS Technol 2020 Dec;25(6):573-584. Epub 2020 Sep 3. NIEHS Grant No. P42ES004699 [Full Text Fang Z, Li AI, Wang H, Zhang R, Mai X, Pan T. 2020. AmbuBox: a fast-deployable low-cost ventilator for COVID-19 emergent care. SLAS Technol 2020 Dec;25(6):573-584. Epub 2020 Sep 3. NIEHS Grant No. P42ES004699]

Xiang J, Austin E, Gould T, Larson T, Shirai J, Liu Y, Marshall J, Seto E. 2020. Impacts of the COVID-19 responses on traffic-related air pollution in a Northwestern US city. Sci Total Environ 2020 Dec 10;747:141325. Epub 2020 Jul 28. NIEHS Grant No. R33ES024715 [Full Text Xiang J, Austin E, Gould T, Larson T, Shirai J, Liu Y, Marshall J, Seto E. 2020. Impacts of the COVID-19 responses on traffic-related air pollution in a Northwestern US city. Sci Total Environ 2020 Dec 10;747:141325. Epub 2020 Jul 28. NIEHS Grant No. R33ES024715]

Press Releases

NIH to Support Radical Approaches to Nationwide COVID-19 Testing and Surveillance – December 21, 2020
RADx-rad program will fund non-traditional and repurposed technologies to combat the current pandemic and address future viral disease outbreaks.

Research Ethics Timeline

2020
During the COVID-19 pandemic, which killed millions of people around the world, scientists worked feverishly to conduct research that could help combat this public health crisis. To make data and results available as quickly as possible, many journals expedited their peer review process for COVID-19 submissions and scientists published articles on pre-print servers before undergoing peer review.

Superfund Research Program

Special COVID-19 Supplements and Activities – December 9, 2020
In response to the rapidly evolving nature of the pandemic, SRP provided supplemental funding to Centers to expand upon the foundation established under their existing SRP grants to meet immediate needs to address the public health crisis.

Environmental Factor Articles

Climate Change, COVID-19 a Double Whammy for Vulnerable Populations – November 1, 2020
Extreme weather can worsen health problems for poor communities and minority groups battling COVID-19, said experts at NIEHS event.

Papers From NIEHS Researchers

Wang JJ, Edin ML, Zeldin DC, Li C, Wang DW, Chen C. Good or bad: application of RAAS inhibitors in COVID-19 patients with cardiovascularcomorbidities. Pharmacology & Therapeutics 2020 v. 215: e107628 [Abstract Wang JJ, Edin ML, Zeldin DC, Li C, Wang DW, Chen C. Good or bad: application of RAAS inhibitors in COVID-19 patients with cardiovascularcomorbidities. Pharmacology & Therapeutics 2020 v. 215: e107628]

El Moheb M, Naar L, Christensen MA, Kapoen C, Maurer LR, Farhat M, Kaafarani HMA. 2020. Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19. JAMA 2020 Nov 10;324(18):1899-1901. Erratum in: JAMA 2021 Mar 16;325(11):1113. NIEHS Grant No. K01ES026835 [Full Text El Moheb M, Naar L, Christensen MA, Kapoen C, Maurer LR, Farhat M, Kaafarani HMA. 2020. Gastrointestinal Complications in Critically Ill Patients With and Without COVID-19. JAMA 2020 Nov 10;324(18):1899-1901. Erratum in: JAMA 2021 Mar 16;325(11):1113. NIEHS Grant No. K01ES026835]

Elmore R, Schmidt L, Lam J, Howard BE, Tandon A, Norman C, Phillips J, Shah M, Patel S, Albert T, Taxman DJ, Shah RR. 2020. Risk and Protective Factors in the COVID-19 Pandemic: A Rapid Evidence Map. Front Public Health 2020 Nov 24;8:582205. NIEHS Grant No. R43ES029001 [Full Text Elmore R, Schmidt L, Lam J, Howard BE, Tandon A, Norman C, Phillips J, Shah M, Patel S, Albert T, Taxman DJ, Shah RR. 2020. Risk and Protective Factors in the COVID-19 Pandemic: A Rapid Evidence Map. Front Public Health 2020 Nov 24;8:582205. NIEHS Grant No. R43ES029001]

Sriram K, Loomba R, Insel PA. 2020. Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges. Proc Natl Acad Sci U S A 2020 Nov 24;117(47):29274-29282. Epub 2020 Nov 17. NIEHS Grant No. P42ES010337 [Full Text Sriram K, Loomba R, Insel PA. 2020. Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges. Proc Natl Acad Sci U S A 2020 Nov 24;117(47):29274-29282. Epub 2020 Nov 17. NIEHS Grant No. P42ES010337]

Sirpilla O, Bauss J, Gupta R, Underwood A, Qutob D, Freeland T, Bupp C, Carcillo J, Hartog N, Rajasekaran S, Prokop JW. 2020. SARS-CoV-2-encoded Proteome and Human Genetics: From Interaction-based to Ribosomal Biology Impact on Disease and Risk Processes. J Proteome Res 2020 Nov 6;19(11):4275-4290. Epub 2020 Aug 10. NIEHS Grant No. K01ES025435 [Full Text Sirpilla O, Bauss J, Gupta R, Underwood A, Qutob D, Freeland T, Bupp C, Carcillo J, Hartog N, Rajasekaran S, Prokop JW. 2020. SARS-CoV-2-encoded Proteome and Human Genetics: From Interaction-based to Ribosomal Biology Impact on Disease and Risk Processes. J Proteome Res 2020 Nov 6;19(11):4275-4290. Epub 2020 Aug 10. NIEHS Grant No. K01ES025435]

Verna EC, Serper M, Chu J, Corey K, Fix OK, Hoyt K, Page KA, Loomba R, Li M, Everson GT, Fried MW, Garcia-Tsao G, Terrault N, Lok AS, Chung RT, Reddy KR. 2020. Clinical Research in Hepatology in the COVID-19 Pandemic and Post-pandemic Era: Challenges and the Need for Innovation. Hepatology 2020 Nov;72(5):1819-1837. NIEHS Grant No. P42ES010337 [Full Text Verna EC, Serper M, Chu J, Corey K, Fix OK, Hoyt K, Page KA, Loomba R, Li M, Everson GT, Fried MW, Garcia-Tsao G, Terrault N, Lok AS, Chung RT, Reddy KR. 2020. Clinical Research in Hepatology in the COVID-19 Pandemic and Post-pandemic Era: Challenges and the Need for Innovation. Hepatology 2020 Nov;72(5):1819-1837. NIEHS Grant No. P42ES010337]

Sun M, Shankar R, Ko M, Chang CD, Yeh SJ, Li S, Liu K, Zhou G, Xing J, VanVelsen A, VanVelsen T, Paithankar S, Feng BY, Young K, Strug M, Turco L, Wang Z, Schadt E, Chen R, Li X, Oskotsky T, Sirota M, Glicksberg BS, Nadkarni GN, Moeser AJ, Li L, Kim S, Zhou J, Chen B. 2020. Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19. Res Sq [Preprint] 2020 Nov 4:rs.3.rs-100914. NIEHS Grant No. K01ES028047 [Full Text Sun M, Shankar R, Ko M, Chang CD, Yeh SJ, Li S, Liu K, Zhou G, Xing J, VanVelsen A, VanVelsen T, Paithankar S, Feng BY, Young K, Strug M, Turco L, Wang Z, Schadt E, Chen R, Li X, Oskotsky T, Sirota M, Glicksberg BS, Nadkarni GN, Moeser AJ, Li L, Kim S, Zhou J, Chen B. 2020. Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19. Res Sq [Preprint] 2020 Nov 4:rs.3.rs-100914. NIEHS Grant No. K01ES028047]

Quandt SA, LaMonto NJ, Mora DC, Talton JW, Laurienti PJ, Arcury TA. 2020. COVID-19 Pandemic Among Immigrant Latinx Farmworker and Non-farmworker Families: A Rural-Urban Comparison of Economic, Educational, Healthcare, and Immigration Concerns. medRxiv [Preprint] 2020 Nov 3:2020.10.30.20223156. Update in: New Solut. 2021 Feb 8;:1048291121992468. NIEHS Grant No. R01ES008739 [Full Text Quandt SA, LaMonto NJ, Mora DC, Talton JW, Laurienti PJ, Arcury TA. 2020. COVID-19 Pandemic Among Immigrant Latinx Farmworker and Non-farmworker Families: A Rural-Urban Comparison of Economic, Educational, Healthcare, and Immigration Concerns. medRxiv [Preprint] 2020 Nov 3:2020.10.30.20223156. Update in: New Solut. 2021 Feb 8;:1048291121992468. NIEHS Grant No. R01ES008739]

McClure ES, Vasudevan P, Bailey Z, Patel S, Robinson WR. 2020. Racial Capitalism Within Public Health-How Occupational Settings Drive COVID-19 Disparities. Am J Epidemiol 2020 Nov 2;189(11):1244-1253. NIEHS Grant No. T32ES007018 [Full Text McClure ES, Vasudevan P, Bailey Z, Patel S, Robinson WR. 2020. Racial Capitalism Within Public Health-How Occupational Settings Drive COVID-19 Disparities. Am J Epidemiol 2020 Nov 2;189(11):1244-1253. NIEHS Grant No. T32ES007018]

Wu X, Nethery RC, Sabath MB, Braun D, Dominici F. 2020. Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis. Sci Adv 2020 Nov 4;6(45):eabd4049. NIEHS Grant No. R01ES024332, R01ES026217, R01ES028033, R01ES030616 [Full Text Wu X, Nethery RC, Sabath MB, Braun D, Dominici F. 2020. Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis. Sci Adv 2020 Nov 4;6(45):eabd4049. NIEHS Grant No. R01ES024332, R01ES026217, R01ES028033, R01ES030616]

Lednicky JA, Lauzard M, Fan ZH, Jutla A, Tilly TB, Gangwar M, Usmani M, Shankar SN, Mohamed K, Eiguren-Fernandez A, Stephenson CJ, Alam MM, Elbadry MA, Loeb JC, Subramaniam K, Waltzek TB, Cherabuddi K, Morris JG Jr, Wu CY. 2020. Viable SARS-CoV-2 in the air of a hospital room with COVID-19 patients. Int J Infect Dis 2020 Nov;100:476-482. Epub 2020 Sep 16. NIEHS Grant No. R43ES030649 [Full Text Lednicky JA, Lauzard M, Fan ZH, Jutla A, Tilly TB, Gangwar M, Usmani M, Shankar SN, Mohamed K, Eiguren-Fernandez A, Stephenson CJ, Alam MM, Elbadry MA, Loeb JC, Subramaniam K, Waltzek TB, Cherabuddi K, Morris JG Jr, Wu CY. 2020. Viable SARS-CoV-2 in the air of a hospital room with COVID-19 patients. Int J Infect Dis 2020 Nov;100:476-482. Epub 2020 Sep 16. NIEHS Grant No. R43ES030649]

Taquechel K, Diwadkar AR, Sayed S, Dudley JW, Grundmeier RW, Kenyon CC, Henrickson SE, Himes BE, Hill DA. 2020. Pediatric Asthma health care utilization, viral testing, and air pollution changes during the COVID19 pandemic. J Allergy Clin Immunol Pract 2020 Nov-Dec;8(10):3378-3387.e11. Epub 2020 Aug 20. NIEHS Grant No. P30ES013508 [Full Text Taquechel K, Diwadkar AR, Sayed S, Dudley JW, Grundmeier RW, Kenyon CC, Henrickson SE, Himes BE, Hill DA. 2020. Pediatric Asthma health care utilization, viral testing, and air pollution changes during the COVID19 pandemic. J Allergy Clin Immunol Pract 2020 Nov-Dec;8(10):3378-3387.e11. Epub 2020 Aug 20. NIEHS Grant No. P30ES013508]

Molyvdas A, Matalon S. 2020. Cyclosporine: an old weapon in the fight against coronaviruses. Eur Respir J 2020 Nov 26;56(5):2002484. NIEHS Grant No. U01ES026458, U01ES027697 [Full Text Molyvdas A, Matalon S. 2020. Cyclosporine: an old weapon in the fight against coronaviruses. Eur Respir J 2020 Nov 26;56(5):2002484. NIEHS Grant No. U01ES026458, U01ES027697]

Hudda N, Simon MC, Patton AP, Durant JL. 2020. Reductions in traffic-related black carbon and ultrafine particle number concentrations in an urban neighborhood during the COVID-19 pandemic. Sci Total Environ 2020 Nov 10;742:140931. Epub 2020 Jul 14. NIEHS Grant No. R01-ES026980 [Full Text Hudda N, Simon MC, Patton AP, Durant JL. 2020. Reductions in traffic-related black carbon and ultrafine particle number concentrations in an urban neighborhood during the COVID-19 pandemic. Sci Total Environ 2020 Nov 10;742:140931. Epub 2020 Jul 14. NIEHS Grant No. R01-ES026980]

Liang D, Shi L, Zhao J, Liu P, Sarnat JA, Gao S, Schwartz J, Liu Y, Ebelt ST, Scovronick N, Chang HH. 2020. Urban air pollution may enhance COVID-19 case-fatality and mortality rates in the United States. Innovation (Camb) 2020 Nov 25;1(3):100047. Epub 2020 Sep 21. NIEHS Grant No. P30ES019776 [Full Text Liang D, Shi L, Zhao J, Liu P, Sarnat JA, Gao S, Schwartz J, Liu Y, Ebelt ST, Scovronick N, Chang HH. 2020. Urban air pollution may enhance COVID-19 case-fatality and mortality rates in the United States. Innovation (Camb) 2020 Nov 25;1(3):100047. Epub 2020 Sep 21. NIEHS Grant No. P30ES019776]

Environmental Factor Articles

Airborne Transmission of SARS-CoV-2 Likely, Say Experts – October 1, 2020
National Academies workshop brings clarity to a key question underpinning the global pandemic’s spread.

COVID-19 Research Funding Targets Role of Genes, Environment – October 1, 2020
NIEHS and the National Institute of Allergy and Infectious Diseases seek to understand why ome people are more vulnerable to the disease.

NIEHS Pandemic Vulnerability Tool a Hit in Wake County School – October 1, 2020
New lesson plans enhance students’ critical thinking skills by encouraging them to assess various COVID-19 risk factors.

SARS-CoV-2 Blocked by Newly Discovered Nanobodies — From a Llama – October 1, 2020
Antibody fragments that blocked the novel coronavirus from entering human cells show promise for treating COVID-19, yet need more study.

Computational Modeling Identifies Drug Candidates for SARS-CoV-2 – October 1, 2020
Scientists from the Division of the National Toxicology Program and their collaborators used computational modeling to probe databases and identify existing drugs that could be repurposed to fight SARS-CoV-2, the virus that causes COVID-19.

COVID-19 Safety Plan Brought All Hands on Deck at NIEHS – October 1, 2020
Behind-the-scenes efforts ensured employees can return safely to work and have resulted in zero on-site transmissions.

Lesson Plans

COVID-19 PVI Lessons Plans – October 6, 2020
Examining Risk Factors Associated With COVID-19 Using the Pandemic Vulnerability Index.

Papers From NIEHS Researchers

Barrett ES, Horton DB, Roy J, Xia W, Greenberg P, Andrews T, Gennaro ML, Parmar V, Russell WD, Reilly N, Uprety P, Gantner JJ, Stockman L, Trooskin SZ, Blaser MJ, Carson JL, Panettieri RA Jr. 2020. Risk Factors for Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospital Workers: Results From a Screening Study in New Jersey, United States in Spring 2020. Open Forum Infect Dis 2020 Oct 31;7(12):ofaa534. NIEHS Grant No. P30ES005022 [Full Text Barrett ES, Horton DB, Roy J, Xia W, Greenberg P, Andrews T, Gennaro ML, Parmar V, Russell WD, Reilly N, Uprety P, Gantner JJ, Stockman L, Trooskin SZ, Blaser MJ, Carson JL, Panettieri RA Jr. 2020. Risk Factors for Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospital Workers: Results From a Screening Study in New Jersey, United States in Spring 2020. Open Forum Infect Dis 2020 Oct 31;7(12):ofaa534. NIEHS Grant No. P30ES005022]

Kimmig LM, Wu D, Gold M, Pettit NN, Pitrak D, Mueller J, Husain AN, Mutlu EA, Mutlu GM. 2020. IL-6 Inhibition in Critically Ill COVID-19 Patients Is Associated With Increased Secondary Infections. Front Med (Lausanne) 2020 Oct 28;7:583897. NIEHS Grant No. R01ES010524 [Full Text Kimmig LM, Wu D, Gold M, Pettit NN, Pitrak D, Mueller J, Husain AN, Mutlu EA, Mutlu GM. 2020. IL-6 Inhibition in Critically Ill COVID-19 Patients Is Associated With Increased Secondary Infections. Front Med (Lausanne) 2020 Oct 28;7:583897. NIEHS Grant No. R01ES010524]

Grandjean P, Timmermann CAG, Kruse M, Nielsen F, Vinholt PJ, Boding L, Heilmann C, Mølbak K. 2020. Severity of COVID-19 at elevated exposure to perfluorinated alkylates. medRxiv [Preprint]. 2020 Oct 26:2020.10.22.20217562. Update in: PLoS One. 2020 Dec 31;15(12):e0244815. NIEHS Grant No. P42ES027706 [Full Text Grandjean P, Timmermann CAG, Kruse M, Nielsen F, Vinholt PJ, Boding L, Heilmann C, Mølbak K. 2020. Severity of COVID-19 at elevated exposure to perfluorinated alkylates. medRxiv [Preprint]. 2020 Oct 26:2020.10.22.20217562. Update in: PLoS One. 2020 Dec 31;15(12):e0244815. NIEHS Grant No. P42ES027706]

Zheng G, Filippelli GM, Salamova A. 2020. Increased indoor exposure to commonly used disinfectants during the COVID-19 pandemic. Environ Sci Technol Lett 2020 Aug 20:acs.estlett.0c00587. NIEHS Grant No. R01ES019620 [Full Text Zheng G, Filippelli GM, Salamova A. 2020. Increased indoor exposure to commonly used disinfectants during the COVID-19 pandemic. Environ Sci Technol Lett 2020 Aug 20:acs.estlett.0c00587. NIEHS Grant No. R01ES019620]

Rut W, Lv Z, Zmudzinski M, Patchett S, Nayak D, Snipas SJ, El Oualid F, Huang TT, Bekes M, Drag M, Olsen SK. 2020. Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design. Sci Adv 2020 Oct 16;6(42):eabd4596. NIEHS Grant No. R01ES025166 [Full Text Rut W, Lv Z, Zmudzinski M, Patchett S, Nayak D, Snipas SJ, El Oualid F, Huang TT, Bekes M, Drag M, Olsen SK. 2020. Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design. Sci Adv 2020 Oct 16;6(42):eabd4596. NIEHS Grant No. R01ES025166]

Hoover AG, Heiger-Bernays W, Ojha S, Pennell KG. 2020. Balancing incomplete COVID-19 evidence and local priorities: risk communication and stakeholder engagement strategies for school re-opening. Rev Environ Health 2020 Oct 1;36(1):27-37. NIEHS Grant No. P42ES007380, P42ES007381, P30ES026529 [Full Text Hoover AG, Heiger-Bernays W, Ojha S, Pennell KG. 2020. Balancing incomplete COVID-19 evidence and local priorities: risk communication and stakeholder engagement strategies for school re-opening. Rev Environ Health 2020 Oct 1;36(1):27-37. NIEHS Grant No. P42ES007380, P42ES007381, P30ES026529]

Flynn JA, Purushotham D, Choudhary MNK, Zhuo X, Fan C, Matt G, Li D, Wang T. 2020. Exploring the coronavirus pandemic with the WashU Virus Genome Browser. Nat Genet 2020 Oct;52(10):986-991. Erratum in: Nat Genet 2020 Sep 16. NIEHS Grant No. U24ES026699 [Full Text Flynn JA, Purushotham D, Choudhary MNK, Zhuo X, Fan C, Matt G, Li D, Wang T. 2020. Exploring the coronavirus pandemic with the WashU Virus Genome Browser. Nat Genet 2020 Oct;52(10):986-991. Erratum in: Nat Genet 2020 Sep 16. NIEHS Grant No. U24ES026699]

Sajuthi SP, DeFord P, Li Y, Jackson ND, Montgomery MT, Everman JL, Rios CL, Pruesse E, Nolin JD, Plender EG, Wechsler ME, Mak ACY, Eng C, Salazar S, Medina V, Wohlford EM, Huntsman S, Nickerson DA, Germer S, Zody MC, Abecasis G, Kang HM, Rice KM, Kumar R, Oh S, Rodriguez-Santana J, Burchard EG, Seibold MA. 2020. Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium. Nat Commun 2020 Oct 12;11(1):5139. NIEHS Grant No. R01ES015794 [Full Text Sajuthi SP, DeFord P, Li Y, Jackson ND, Montgomery MT, Everman JL, Rios CL, Pruesse E, Nolin JD, Plender EG, Wechsler ME, Mak ACY, Eng C, Salazar S, Medina V, Wohlford EM, Huntsman S, Nickerson DA, Germer S, Zody MC, Abecasis G, Kang HM, Rice KM, Kumar R, Oh S, Rodriguez-Santana J, Burchard EG, Seibold MA. 2020. Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium. Nat Commun 2020 Oct 12;11(1):5139. NIEHS Grant No. R01ES015794]

Yang R, Mei H, Zheng T, Fu Q, Zhang Y, Buka S, Yao X, Tang Z, Zhang X, Qiu L, Zhang Y, Zhou J, Cao J, Wang Y, Zhou A. 2020. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Med 2020 Oct 19;18(1):330. NIEHS Grant No. R01ES029082 [Full Text Yang R, Mei H, Zheng T, Fu Q, Zhang Y, Buka S, Yao X, Tang Z, Zhang X, Qiu L, Zhang Y, Zhou J, Cao J, Wang Y, Zhou A. 2020. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Med 2020 Oct 19;18(1):330. NIEHS Grant No. R01ES029082]

Chiu WA, Fischer R, Ndeffo-Mbah ML. 2020. State-level needs for social distancing and contact tracing to contain COVID-19 in the United States. Nat Hum Behav 2020 Oct;4(10):1080-1090. Epub 2020 Oct 6. NIEHS Grant No. P30ES029067 [Full Text Chiu WA, Fischer R, Ndeffo-Mbah ML. 2020. State-level needs for social distancing and contact tracing to contain COVID-19 in the United States. Nat Hum Behav 2020 Oct;4(10):1080-1090. Epub 2020 Oct 6. NIEHS Grant No. P30ES029067]

Nielsen SCA, Yang F, Jackson KJL, Hoh RA, Röltgen K, Jean GH, Stevens BA, Lee JY, Rustagi A, Rogers AJ, Powell AE, Hunter M, Najeeb J, Otrelo-Cardoso AR, Yost KE, Daniel B, Nadeau KC, Chang HY, Satpathy AT, Jardetzky TS, Kim PS, Wang TT, Pinsky BA, Blish CA, Boyd SD. 2020. Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2. Cell Host Microbe 2020 Oct 7;28(4):516-525.e5. Epub 2020 Sep 3 [Full Text Nielsen SCA, Yang F, Jackson KJL, Hoh RA, Röltgen K, Jean GH, Stevens BA, Lee JY, Rustagi A, Rogers AJ, Powell AE, Hunter M, Najeeb J, Otrelo-Cardoso AR, Yost KE, Daniel B, Nadeau KC, Chang HY, Satpathy AT, Jardetzky TS, Kim PS, Wang TT, Pinsky BA, Blish CA, Boyd SD. 2020. Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2. Cell Host Microbe 2020 Oct 7;28(4):516-525.e5. Epub 2020 Sep 3]

Klimczak LJ, Randall TA, Saini N, Li JL, Gordenin DA. 2020. Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic. PLoS One 2020 Oct 2;15(10):e0237689 [Full Text Klimczak LJ, Randall TA, Saini N, Li JL, Gordenin DA. 2020. Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic. PLoS One 2020 Oct 2;15(10):e0237689]

Cain DW, Cidlowski JA. 2020. After 62 years of regulating immunity, dexamethasone meets COVID-19. Nat Rev Immunol 2020 Oct;20(10):587-588 [Full Text Cain DW, Cidlowski JA. 2020. After 62 years of regulating immunity, dexamethasone meets COVID-19. Nat Rev Immunol 2020 Oct;20(10):587-588]

Environmental Factor Articles

Sleep Well During the Pandemic – September 1, 2021
Jackson shared practical tips for getting adequate, restful sleep during the pandemic on the NIH #CopingWithCOVID19 livestream series.

Pandemic Preparedness Requires Weather, Health Data, Experts Say – September 1, 2020
National Oceanic and Atmospheric Administration scientists discussed how to bolster infectious disease modeling during an NIEHS webinar.

NIEHS Supports Workers With Essential COVID-19 Training – September 1, 2020
Health care professionals and vulnerable populations benefit from targeted education.

Virtual COVID-19 Education Reaches U.S. and International Students – September 1, 2020
An NIEHS grant recipient started a new teaching series at Johns Hopkins University that helps youth protect themselves and others.

Partnerships for Environmental Public Health

New Story Map Shows COVID-19 Disparities Along Racial and Ethnic Lines – September 1, 2020
A new interactive story map developed by NIEHS-funded researchers sheds light on how certain Los Angeles communities are faring in the COVID-19 pandemic.

Papers From NIEHS Researchers

Avery AR, Tsang S, Seto EYW, Duncan GE. 2020. Stress, anxiety, and change in alcohol use during the COVID-19 pandemic: Findings among adult twin pairs. Front Psychiatry 2020 Sep 25;11:571084. NIEHS Grant No. R33ES024715

Puscheck EE, Dutta S, Abdulhasan MA, Gurdziel K, Korzeniewski SJ, Ruden D, Rappolee D. 2020. Stress-forces embryonic stem cells to increase expression of hepatitis A and herpes simplex 1 virus receptors and two genes necessary for COVID-19 uptake. Fertil Steril 2020 Sep;114(3):e217. Epub 2020 Oct 12. NIEHS Grant No. R41ES028991 [Full Text Puscheck EE, Dutta S, Abdulhasan MA, Gurdziel K, Korzeniewski SJ, Ruden D, Rappolee D. 2020. Stress-forces embryonic stem cells to increase expression of hepatitis A and herpes simplex 1 virus receptors and two genes necessary for COVID-19 uptake. Fertil Steril 2020 Sep;114(3):e217. Epub 2020 Oct 12. NIEHS Grant No. R41ES028991]

Hill WC, Hull MS, MacCuspie RI. 2020. Testing of commercial masks and respirators and cotton mask insert materials using SARS-CoV2 virion-sized particulates: Comparison of ideal aerosol filtration efficiency versus fitted filtration efficiency. Nano Lett 2020 Oct 14;20(10):7642-7647. Epub 2020 Sep 29. NIEHS Grant No. R43ES030650 [Full Text Hill WC, Hull MS, MacCuspie RI. 2020. Testing of commercial masks and respirators and cotton mask insert materials using SARS-CoV2 virion-sized particulates: Comparison of ideal aerosol filtration efficiency versus fitted filtration efficiency. Nano Lett 2020 Oct 14;20(10):7642-7647. Epub 2020 Sep 29. NIEHS Grant No. R43ES030650]

Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC. 2020. SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients. bioRxiv [Preprint] 2020 Sep 12:2020.08.25.265561. Update in: Sci Transl Med 2021 Mar 15. NIEHS Grant No. U01ES032673 [Full Text Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC. 2020. SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients. bioRxiv [Preprint] 2020 Sep 12:2020.08.25.265561. Update in: Sci Transl Med 2021 Mar 15. NIEHS Grant No. U01ES032673]

Barzin A, Schmitz JL, Rosin S, Sirpal R, Almond M, Robinette C, Wells S, Hudgens M, Olshan A, Deen S, Krejci P, Quackenbush E, Chronowski K, Cornaby C, Goins J, Butler L, Aucoin J, Boyer K, Faulk J, Alston-Johnson D, Page C, Zhou Y, Fiscus L, Damania B, Dittmer DP, Peden DB. 2020. SSARS-CoV-2 seroprevalence among a southern U.S. Population indicates limited asymptomatic spread under physical distancing measures. mBio 2020 Sep 29;11(5):e02426-20. NIEHS Grant No. R01ES025124 [Full Text Barzin A, Schmitz JL, Rosin S, Sirpal R, Almond M, Robinette C, Wells S, Hudgens M, Olshan A, Deen S, Krejci P, Quackenbush E, Chronowski K, Cornaby C, Goins J, Butler L, Aucoin J, Boyer K, Faulk J, Alston-Johnson D, Page C, Zhou Y, Fiscus L, Damania B, Dittmer DP, Peden DB. 2020. SSARS-CoV-2 seroprevalence among a southern U.S. Population indicates limited asymptomatic spread under physical distancing measures. mBio 2020 Sep 29;11(5):e02426-20. NIEHS Grant No. R01ES025124]

Errett NA, Howarth M, Shoaf K, Couture M, Ramsey S, Rosselli R, Webb S, Bennett A, Miller A. 2020. Developing an environmental health sciences COVID-19 research agenda: results from the NIEHS Disaster Research Response (DR2) Work Group’s Modified Delphi Method. International Journal of Environmental Research and Public Health 2020; 17(18):6842 [Full Text Errett NA, Howarth M, Shoaf K, Couture M, Ramsey S, Rosselli R, Webb S, Bennett A, Miller A. 2020. Developing an environmental health sciences COVID-19 research agenda: results from the NIEHS Disaster Research Response (DR2) Work Group’s Modified Delphi Method. International Journal of Environmental Research and Public Health 2020; 17(18):6842]

Kumar N, Mishra B, Mehmood A, Mohammad Athar, M Shahid Mukhtar. 2020. Integrative network biology framework elucidates molecular mechanisms of SARS-CoV-2 pathogenesis. iScience 2020 Sep 25;23(9):101526. Epub 2020 Sep 3. NIEHS Grant No. U54ES030246 [Full Text Kumar N, Mishra B, Mehmood A, Mohammad Athar, M Shahid Mukhtar. 2020. Integrative network biology framework elucidates molecular mechanisms of SARS-CoV-2 pathogenesis. iScience 2020 Sep 25;23(9):101526. Epub 2020 Sep 3. NIEHS Grant No. U54ES030246]

Tizabi Y, Getachew B, Copeland RL, Aschner M. 2020. Nicotine and the nicotinic cholinergic system in COVID-19. FEBS J 2020 Sep;287(17):3656-3663. Epub 2020 Aug 25. NIEHS Grant No: R01ES10563, R01ES07331 [Full Text Tizabi Y, Getachew B, Copeland RL, Aschner M. 2020. Nicotine and the nicotinic cholinergic system in COVID-19. FEBS J 2020 Sep;287(17):3656-3663. Epub 2020 Aug 25. NIEHS Grant No: R01ES10563, R01ES07331]

Hammock BD, Wang W, Gilligan MM, Panigrahy D. 2020. Eicosanoids: the overlooked storm in coronavirus disease 2019 (COVID-19)? Am J Pathol 2020 Sep;190(9):1782-1788. Epub 2020 Jul 8. NIEHS Grant No: P42ES004699, R35ES030443 [Full Text Hammock BD, Wang W, Gilligan MM, Panigrahy D. 2020. Eicosanoids: the overlooked storm in coronavirus disease 2019 (COVID-19)? Am J Pathol 2020 Sep;190(9):1782-1788. Epub 2020 Jul 8. NIEHS Grant No: P42ES004699, R35ES030443]

Marvel SW, House JS, Wheeler M, Song K, Zhou Y, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2020. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. medRxiv [Preprint] 2020 Sep 13:2020.08.10.20169649. Update in: Environ Health Perspect 2021 Jan;129(1):17701 [Full Text Marvel SW, House JS, Wheeler M, Song K, Zhou Y, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2020. The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. medRxiv [Preprint] 2020 Sep 13:2020.08.10.20169649. Update in: Environ Health Perspect 2021 Jan;129(1):17701]

Slominski RM, Stefan J, Athar M, Holick MF, Jetten AM, Raman C, Slominski AT. 2020. COVID-19 and Vitamin D: A lesson from the skin. Exp Dermatol 2020 Sep;29(9):885-890. Epub 2020 Sep 9. [Full Text Slominski RM, Stefan J, Athar M, Holick MF, Jetten AM, Raman C, Slominski AT. 2020. COVID-19 and Vitamin D: A lesson from the skin. Exp Dermatol 2020 Sep;29(9):885-890. Epub 2020 Sep 9.]

Environmental Factor Articles

COVID-19 Antibody Study Launched by NIEHS – August 1, 2020
Year-long research project seeks much-needed information about antibodies from SARS-CoV-2 infection.

COVID-19 Testing Technologies Boosted by New Funding – August 1, 2020
NIH supports diagnostic test research, including $1 million to NIEHS scientists Oswaldo Lozoya and Douglas Bell.

NIEHS Biomedical Career Symposium Attracts National Audience – August 1, 2020
Early-career scientists gained insight from leaders in industry, government, and academia during the virtual event.

NIEHS Employees Unite to Support Food Drive – August 1, 2020
Annual food drive goes virtual, meeting needs greater than ever, during coronavirus pandemic.

Teachers Take Virtual Tour of NIEHS, Brainstorm COVID-19 Lesson Plans – August 1, 2020
The institute hosted 55 educators from Wake County, North Carolina, as part of the annual SummerSTEM program.

Global Environmental Health

COVID-19 Recovery Plans Should Put Children First, Experts Say – August 1, 2020
A new commentary from the World Health Organization (WHO)-UNICEF-Lancet Commission highlights the impacts of COVID-19 on children and calls for putting children at the center of recovery plans.

Papers From NIEHS Researchers

Rodriguez-Lonebear D, Barceló NE, Akee R, Caroll SR. 2020. American Indian reservations and COVID-19: correlates of early infection rates in the pandemic. Journal of Public Health Management and Practice v. 26 (4): pp. 371-377. NIEHS Grant No. P50ES026089 [Abstract Rodriguez-Lonebear D, Barceló NE, Akee R, Caroll SR. 2020. American Indian reservations and COVID-19: correlates of early infection rates in the pandemic. Journal of Public Health Management and Practice v. 26 (4): pp. 371-377. NIEHS Grant No. P50ES026089]

He B, Garmire L. 2020. Prediction of repurposed drugs for treating lung injury in COVID-19 [version 2; peer review: 2 approved]. F1000Research 2020, 9:609. NIEHS Grant No. K01ES025434 [Full Text He B, Garmire L. 2020. Prediction of repurposed drugs for treating lung injury in COVID-19 [version 2; peer review: 2 approved]. F1000Research 2020, 9:609. NIEHS Grant No. K01ES025434]

Zhang L, Guo H. 2020. Biomarkers of COVID-19 and technologies to combat SARS-CoV-2. Adv Biomark Sci Technol 2020;2:1-23. Epub 2020 Aug 19. NIEHS Grant No. P42ES004705 [Full Text Zhang L, Guo H. 2020. Biomarkers of COVID-19 and technologies to combat SARS-CoV-2. Adv Biomark Sci Technol 2020;2:1-23. Epub 2020 Aug 19. NIEHS Grant No. P42ES004705]

McClure EM, Kinney MV, Leisher SH, Nam SL, Quigley P, Storey C, Christou A, Blencowe H; Stillbirth Advocacy Working Group. 2020. Impact of COVID-19 on maternal and child health. Lancet Glob Health 2020 Oct;8(10):e1258. Epub 2020 Aug 3. NIEHS Grant No. T32ES023772 [Full Text McClure EM, Kinney MV, Leisher SH, Nam SL, Quigley P, Storey C, Christou A, Blencowe H; Stillbirth Advocacy Working Group. 2020. Impact of COVID-19 on maternal and child health. Lancet Glob Health 2020 Oct;8(10):e1258. Epub 2020 Aug 3. NIEHS Grant No. T32ES023772]

Pal A, Gowdy KM, Oestreich KJ, Beck M, Shaikh SR. 2020. Obesity-driven deficiencies of specialized pro-resolving mediators may drive adverse outcomes during SARS-CoV-2 infection. Front Immunol 2020 Aug 11;11:1997. NIEHS Grant No. R01ES031378 [Full Text Pal A, Gowdy KM, Oestreich KJ, Beck M, Shaikh SR. 2020. Obesity-driven deficiencies of specialized pro-resolving mediators may drive adverse outcomes during SARS-CoV-2 infection. Front Immunol 2020 Aug 11;11:1997. NIEHS Grant No. R01ES031378]

Mueller V, Sheriff G, Keeler C, Jehn M. 2020. COVID-19 Policy Modeling in Sub-Saharan Africa. Appl Econ Perspect Policy, 43: 24-38. NIEHS Grant No. T32ES007018 [Full Text Mueller V, Sheriff G, Keeler C, Jehn M. 2020. COVID-19 Policy Modeling in Sub-Saharan Africa. Appl Econ Perspect Policy, 43: 24-38. NIEHS Grant No. T32ES007018]

Duncan GE, Avery AR, Seto E, Tsang S. 2020. Perceived change in physical activity levels and mental health during COVID-19: Findings among adult twin pairs. PLoS One 2020 Aug 13;15(8):e0237695. NIEHS Grant No. P30ES007033, R33ES024715 [Full Text Duncan GE, Avery AR, Seto E, Tsang S. 2020. Perceived change in physical activity levels and mental health during COVID-19: Findings among adult twin pairs. PLoS One 2020 Aug 13;15(8):e0237695. NIEHS Grant No. P30ES007033, R33ES024715]

Gupta R, Charron J, Stenger CL, Painter J, Steward H, Cook TW, Faber W, Frisch A, Lind E, Bauss J, Li X, Sirpilla O, Soehnlen X, Underwood A, Hinds D, Morris M, Lamb N, Carcillo JA, Bupp C, Uhal BD, Rajasekaran S, Prokop JW. 2020. SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics. J Biol Chem 2020 Aug 14;295(33):11742-11753. Epub 2020 Jun 25. NIEHS Grant No. K01ES025435 [Full Text Gupta R, Charron J, Stenger CL, Painter J, Steward H, Cook TW, Faber W, Frisch A, Lind E, Bauss J, Li X, Sirpilla O, Soehnlen X, Underwood A, Hinds D, Morris M, Lamb N, Carcillo JA, Bupp C, Uhal BD, Rajasekaran S, Prokop JW. 2020. SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics. J Biol Chem 2020 Aug 14;295(33):11742-11753. Epub 2020 Jun 25. NIEHS Grant No. K01ES025435]

Jackson CL, Johnson DA. 2020. Sleep disparities in the era of the COVID-19 pandemic highlight the urgent need to address social determinants of health like the virus of racism. J Clin Sleep Med 2020 Aug 15;16(8):1401-1402 [Full Text Jackson CL, Johnson DA. 2020. Sleep disparities in the era of the COVID-19 pandemic highlight the urgent need to address social determinants of health like the virus of racism. J Clin Sleep Med 2020 Aug 15;16(8):1401-1402]

Bektas A, Schurman SH, Franceschi C, Ferrucci L. 2020. A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging? Immun Ageing 2020 Aug 24;17:23 [Full Text Bektas A, Schurman SH, Franceschi C, Ferrucci L. 2020. A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging? Immun Ageing 2020 Aug 24;17:23]

Quandt SA, LaMonto NJ, Mora DC, Talton JW, Laurienti PJ, Arcury TA. 2020. COVID-19 pandemic among Latinx farmworker and nonfarmworker families in North Carolina:knowledge, risk perceptions, and preventive behaviors. International Journal of Environmental Research and Public Health 2020; 17(16):5786. NIEHS Grant No. ES08739 [Full Text Quandt SA, LaMonto NJ, Mora DC, Talton JW, Laurienti PJ, Arcury TA. 2020. COVID-19 pandemic among Latinx farmworker and nonfarmworker families in North Carolina:knowledge, risk perceptions, and preventive behaviors. International Journal of Environmental Research and Public Health 2020; 17(16):5786. NIEHS Grant No. ES08739]

Slominski AT, Slominski RM, Goepfert PA, Kim TK, Holick MF, Jetten AM, Raman C. 2020. Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness? Am J Physiol Endocrinol Metab 2020 Aug 1;319(2):E455-E457 [Full Text Slominski AT, Slominski RM, Goepfert PA, Kim TK, Holick MF, Jetten AM, Raman C. 2020. Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness? Am J Physiol Endocrinol Metab 2020 Aug 1;319(2):E455-E457]

Papers From NIEHS Researchers

Chan AT, Drew DA, Nguyen LH, Joshi AD, Ma W, Guo CG, Lo CH, Mehta RS, Kwon S, Sikavi DR, Magicheva-Gupta MV, Fatehi ZS, Flynn JJ, Leonardo BM, Albert CM, Andreotti G, Beane-Freeman LE, Balasubramanian BA, Brownstein JS, Bruinsma F, Cowan AN, Deka A, Ernst ME, Figueiredo JC, Franks PW, Gardner CD, Ghobrial IM, Haiman CA, Hall JE, Deming-Halverson SL, Kirpach B, Lacey JV Jr., Marchand LL, Marinac CR, Martinez ME, Milne RL, Murray AM, Nash D, Palmer JR, Patel AV, Rosenberg L, Sandler DP, Sharma SV, Schurman SH, Wilkens LR, Chavarro JE, Eliassen AH, Hart JE, Kang JH, Koenen KC, Kubzansky LD, Mucci LA, Ourselin S, Rich-Edwards JW, Song M, Stampfer MJ, Steves CJ, Willett WC, Wolf J, Spector T. The COronavirus Pandemic Epidemiology (COPE) Consortium: a call to action. Cancer Epidemiology, Biomarkers & Prevention (2020) 29 (7): 1283–1289. [Abstract Chan AT, Drew DA, Nguyen LH, Joshi AD, Ma W, Guo CG, Lo CH, Mehta RS, Kwon S, Sikavi DR, Magicheva-Gupta MV, Fatehi ZS, Flynn JJ, Leonardo BM, Albert CM, Andreotti G, Beane-Freeman LE, Balasubramanian BA, Brownstein JS, Bruinsma F, Cowan AN, Deka A, Ernst ME, Figueiredo JC, Franks PW, Gardner CD, Ghobrial IM, Haiman CA, Hall JE, Deming-Halverson SL, Kirpach B, Lacey JV Jr., Marchand LL, Marinac CR, Martinez ME, Milne RL, Murray AM, Nash D, Palmer JR, Patel AV, Rosenberg L, Sandler DP, Sharma SV, Schurman SH, Wilkens LR, Chavarro JE, Eliassen AH, Hart JE, Kang JH, Koenen KC, Kubzansky LD, Mucci LA, Ourselin S, Rich-Edwards JW, Song M, Stampfer MJ, Steves CJ, Willett WC, Wolf J, Spector T. The COronavirus Pandemic Epidemiology (COPE) Consortium: a call to action. Cancer Epidemiology, Biomarkers & Prevention (2020) 29 (7): 1283–1289.]

Radbel J, Jagpal S, Roy J, Brooks A, Tischfield J, Sheldon M, Bixby C, Witt D, Gennaro ML, Horton DB, Barrett ES, Carson JL, Panettieri RA Jr., Blaser MJ. Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is comparable in clinical samples preserved in saline or viral transport medium. J Mol Diagn 2020 v. 22 (7): pp. 871-5. NIEHS Grant No. P30ES005022 [Abstract Radbel J, Jagpal S, Roy J, Brooks A, Tischfield J, Sheldon M, Bixby C, Witt D, Gennaro ML, Horton DB, Barrett ES, Carson JL, Panettieri RA Jr., Blaser MJ. Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is comparable in clinical samples preserved in saline or viral transport medium. J Mol Diagn 2020 v. 22 (7): pp. 871-5. NIEHS Grant No. P30ES005022]

Hantoushzadeh S, Shamshirsaz AA, Aleyasin A, Seferovic MD, Aski SK, Arian SE, Pooransari P, Ghotbizadeh F, Aalipour S, Soleimani Z, Naemi M, Molaei B, Ahangari R, Salehi M, Oskoei AD, Pirozan P, Darkhaneh RF, Laki MG, Farani AK, Atrak S, Miri MM, Kouchek M, Shojaei S, Hadavand F, Keikha F, Hosseini MS, Borna S, Ariana S, Shariat M, Fatemi A, Nouri B, Nekooghadam SM, Aagaard K. Maternal death due to COVID-19. American Journal of Obstetrics and Gynecology 2020 v. 223 (1): pp. 109.e1-109.e16. NIEHS Grant No. R21ES029462 [Abstract Hantoushzadeh S, Shamshirsaz AA, Aleyasin A, Seferovic MD, Aski SK, Arian SE, Pooransari P, Ghotbizadeh F, Aalipour S, Soleimani Z, Naemi M, Molaei B, Ahangari R, Salehi M, Oskoei AD, Pirozan P, Darkhaneh RF, Laki MG, Farani AK, Atrak S, Miri MM, Kouchek M, Shojaei S, Hadavand F, Keikha F, Hosseini MS, Borna S, Ariana S, Shariat M, Fatemi A, Nouri B, Nekooghadam SM, Aagaard K. Maternal death due to COVID-19. American Journal of Obstetrics and Gynecology 2020 v. 223 (1): pp. 109.e1-109.e16. NIEHS Grant No. R21ES029462]

Diffenbaugh NS, Field CB, Appel EA, Azevedo IL, Baldocchi DD, Burke M, Burney JA, Ciais P, Davis SJ, Fiore AM, Fletcher SM, Hertel TW, Horton DE, Hsiang SM, Jackson RB, Jin XM, Levi M, Lobell DB, McKinley GA, Moore FC, Montgomery A, Nadeau KC, Pataki DE, Randerson JT, Reichstein M, Schnell JL, Seneviratne SI, Singh D, Steiner AL, Wong-Parodi G. 2020. The COVID-19 lockdowns: a window into the Earth System. Nature Reviews Earth and Environment 2020 v. 1 (9):470-481 [Full Text Diffenbaugh NS, Field CB, Appel EA, Azevedo IL, Baldocchi DD, Burke M, Burney JA, Ciais P, Davis SJ, Fiore AM, Fletcher SM, Hertel TW, Horton DE, Hsiang SM, Jackson RB, Jin XM, Levi M, Lobell DB, McKinley GA, Moore FC, Montgomery A, Nadeau KC, Pataki DE, Randerson JT, Reichstein M, Schnell JL, Seneviratne SI, Singh D, Steiner AL, Wong-Parodi G. 2020. The COVID-19 lockdowns: a window into the Earth System. Nature Reviews Earth and Environment 2020 v. 1 (9):470-481]

Chiu WA, Fischer R, Ndeffo-Mbah ML. 2020. State-level impact of social distancing and testing on COVID-19 in the United States. Res Sq [Preprint] 2020 Jul 7:rs.3.rs-40364. Update in: Nat Hum Behav 2020 Oct;4(10):1080-1090. NIEHS Grant No. P30ES029067 [Full Text Chiu WA, Fischer R, Ndeffo-Mbah ML. 2020. State-level impact of social distancing and testing on COVID-19 in the United States. Res Sq [Preprint] 2020 Jul 7:rs.3.rs-40364. Update in: Nat Hum Behav 2020 Oct;4(10):1080-1090. NIEHS Grant No. P30ES029067]

Environmental Factor Articles

COVID-19 shines light on Navajo water contamination – June 2020
Three NIEHS grant recipients say exposure to uranium, arsenic, and other metals has increased the tribe’s susceptibility to the disease.

Creative facemasks ease pandemic stress – June 2020
An institute contest inspired staff and contractors to use their imagination while protecting against COVID-19.

Fighting COVID-19 using data science – June 2020
NIEHS-funded researchers develop online tools to better understand the spread of the novel coronavirus.

Health disparities in congressional spotlight – June 2020
Grantee Francesca Dominici and others discussed minority health and COVID-19.

NIEHS, federal employees unite for charities affected by COVID-19 – June 2020
The U.S. government reopens the Combined Federal Campaign so employees can support charities across the world through tough times.

Pandemic communication, zebrafish models discussed by genetics group – June 2020
David Berube, an NTP adviser, discussed pandemic communications research. Others presented studies using zebrafish as physiological models.

Papers From NIEHS Researchers

Kuebler WM, Jordt SE, Liedtke WB. Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition ofTRPV4 represents a promising and feasible approach. Am J Physiology-Lung Cellular and Molecular Physiology 2020 v. 318 (6): pp. L1239-L1243. NIEHS Grant No. U01ES015674 [Abstract Kuebler WM, Jordt SE, Liedtke WB. Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition ofTRPV4 represents a promising and feasible approach. Am J Physiology-Lung Cellular and Molecular Physiology 2020 v. 318 (6): pp. L1239-L1243. NIEHS Grant No. U01ES015674]

Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Quercetin and Vitamin C: an experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19). Frontiers Immunology 2020 v. 11. NIEHS Grant No. R21ES030528 [Abstract Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Quercetin and Vitamin C: an experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19). Frontiers Immunology 2020 v. 11. NIEHS Grant No. R21ES030528]

Prokop JW, Shankar R, Gupta R, Leimanis ML, Nedveck D, Uhl K, Chen B, Hartog NL, Van Veen J, Sisco JS, Sirpilla O, Lydic T, Boville B, Hernandez A, Braunreiter C, Kuk CC, Singh V, Mills J, Wegener M, Adams M, Rhodes M, Bachmann AS, Pan W, Byrne-Steele ML, Smith DC, Depinet M, Brown BE, Eisenhower M, Han J, Haw M, Madura C, Sanfilippo DJ, Seaver LH, Bupp C, Rajasekaran S. 2020. Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19. Physiol Genomics 2020 Jun 1;52(6):255-268. Epub 2020 May 21. NIEHS Grant No. K01ES025435 [Full Text Prokop JW, Shankar R, Gupta R, Leimanis ML, Nedveck D, Uhl K, Chen B, Hartog NL, Van Veen J, Sisco JS, Sirpilla O, Lydic T, Boville B, Hernandez A, Braunreiter C, Kuk CC, Singh V, Mills J, Wegener M, Adams M, Rhodes M, Bachmann AS, Pan W, Byrne-Steele ML, Smith DC, Depinet M, Brown BE, Eisenhower M, Han J, Haw M, Madura C, Sanfilippo DJ, Seaver LH, Bupp C, Rajasekaran S. 2020. Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19. Physiol Genomics 2020 Jun 1;52(6):255-268. Epub 2020 May 21. NIEHS Grant No. K01ES025435]

He Y, Yu H, Ong E, Wang Y, Liu Y, Huffman A, Huang HH, Beverley J, Hur J, Yang X, Chen L, Omenn GS, Athey B, Smith B. 2020. CIDO, a community-based ontology for coronavirus disease knowledge and data integration, sharing, and analysis. Sci Data 2020 Jun 12;7(1):181. NIEHS Grant No. P30ES017885 [Full Text He Y, Yu H, Ong E, Wang Y, Liu Y, Huffman A, Huang HH, Beverley J, Hur J, Yang X, Chen L, Omenn GS, Athey B, Smith B. 2020. CIDO, a community-based ontology for coronavirus disease knowledge and data integration, sharing, and analysis. Sci Data 2020 Jun 12;7(1):181. NIEHS Grant No. P30ES017885]

He B, Garmire L. 2020. Prediction of repurposed drugs for treating lung injury in COVID-19 [version 2; peer review: 2 approved]. F1000Research 2020, 9:609. NIEHS Grant No. K01ES025434 [Full Text He B, Garmire L. 2020. Prediction of repurposed drugs for treating lung injury in COVID-19 [version 2; peer review: 2 approved]. F1000Research 2020, 9:609. NIEHS Grant No. K01ES025434]

Superfund Research Program Science Digest

Director's Letter – June 1, 2020
The spread of coronavirus disease 2019 (COVID-19) has created uncertainty and strained our communities, businesses, and workplaces.

Environmental Factor Articles

COVID-19 Research Grants Get Rapid NIEHS Funding – May 1, 2020
New opportunities for scientists to study how the environment may affect health outcomes related to the disease.

NIEHS Scientists Join the Fight Against COVID-19 – May 1, 2020
Across the institute, researchers are lending their expertise to the fight against the novel coronavirus.

COVID-19 Researchers Gain Quick Access to Surveys, Protocols – May 1, 2020
Ready access to survey questionnaires, study protocols, and other resources makes for quick study launch and more consistent data.

Papers From NIEHS Researchers

Broxmeyer HE, Parker GC. 2020. Impact of COVID-19 and future emerging viruses on hematopoietic cell transplantation and othercellular therapies. Stem Cells and Development. NIEHS Grant No. P30ES020957. [Abstract Broxmeyer HE, Parker GC. 2020. Impact of COVID-19 and future emerging viruses on hematopoietic cell transplantation and othercellular therapies. Stem Cells and Development. NIEHS Grant No. P30ES020957.]

Weinberg CR. 2020. Making the best use of test kits for COVID-19. Am J Epidemiol. Volume 189, Issue 5, May 2020, Pages 363–364. [Abstract Weinberg CR. 2020. Making the best use of test kits for COVID-19. Am J Epidemiol. Volume 189, Issue 5, May 2020, Pages 363–364.]

Panigraphy D, Gilligan MM, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD. 2020. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?. Cancer Metastasis Rev 39, 337–340. NIEHS Grant No. P42ES004699, R35ES030443 [Abstract Panigraphy D, Gilligan MM, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD. 2020. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?. Cancer Metastasis Rev 39, 337–340. NIEHS Grant No. P42ES004699, R35ES030443]

Ahmed S, Mvalo T, Akech, S, Agweyu A, Baker K, Bar-Zeev N, Campbell H, Checkley W, Chisti M, Colbourn T, Cunningham S, Duke T, English M, Falade A, Fancourt N, Ginsburg A, Graham H, Gray D, Gupta M, Hammitt L, Hesseling A, Hooli S, Johnson ABR, King C, Kirby M, Lanata CF, Lufesi N, Mackenzie Ga, McCracken JP, Moschovis PP, Nair H, Oviawe O, Pomat WS, Santosham M, Seddon JA, Thahane LK, Wahl B, Van der Zalm M, Verwet C, Yoshida LM, Zar HJ, Howie SR, McCollum ED. 2020. Protecting children in low-income and middle-income countries from COVID-19. BMJ Global Health 2020;5:e002844. NIEHS Grant No. K23ES030399 [Abstract Ahmed S, Mvalo T, Akech, S, Agweyu A, Baker K, Bar-Zeev N, Campbell H, Checkley W, Chisti M, Colbourn T, Cunningham S, Duke T, English M, Falade A, Fancourt N, Ginsburg A, Graham H, Gray D, Gupta M, Hammitt L, Hesseling A, Hooli S, Johnson ABR, King C, Kirby M, Lanata CF, Lufesi N, Mackenzie Ga, McCracken JP, Moschovis PP, Nair H, Oviawe O, Pomat WS, Santosham M, Seddon JA, Thahane LK, Wahl B, Van der Zalm M, Verwet C, Yoshida LM, Zar HJ, Howie SR, McCollum ED. 2020. Protecting children in low-income and middle-income countries from COVID-19. BMJ Global Health 2020;5:e002844. NIEHS Grant No. K23ES030399]

Henderson R, Edwards RJ , Mansouri K, Janowska K, Stalls V, Gobeil S, Kopp M, Hsu A, Borgnia M, Parks R, Haynes BF, Acharya P. Controlling the SARS-CoV-2 spike glycoprotein conformation. bioRxiv (2020). [Abstract Henderson R, Edwards RJ , Mansouri K, Janowska K, Stalls V, Gobeil S, Kopp M, Hsu A, Borgnia M, Parks R, Haynes BF, Acharya P. Controlling the SARS-CoV-2 spike glycoprotein conformation. bioRxiv (2020).]

Xu D, Ma M, Xu Y, Su Y, Ong SB, Hu X, Chai M, Zhao M, Li H, Chen Y, Xu X. Single-cell transcriptome analysis indicates new potential regulation mechanism of ACE2 and NPs signaling among heart failure patients infected with SARS-CoV-2. medRxiv (2020). [Abstract Xu D, Ma M, Xu Y, Su Y, Ong SB, Hu X, Chai M, Zhao M, Li H, Chen Y, Xu X. Single-cell transcriptome analysis indicates new potential regulation mechanism of ACE2 and NPs signaling among heart failure patients infected with SARS-CoV-2. medRxiv (2020).]

Lednicky JA, Shankar SN, Elbadry MA, Gibson JC, Alam MM, Stephenson CJ, Eiguren-Fernandez A, Morris JG, Mavian CN, Salemi M, Clugston JR, Wu CY. Collection of SARS-CoV-2 virus from the air of a clinic within a university student health care center and analyses of the viral genomic sequence. Aerosol and Air Quality Research (2020) v. 20 (6): pp. 1167-1171. NIEHS Grant No. R43ES030649 [Abstract Lednicky JA, Shankar SN, Elbadry MA, Gibson JC, Alam MM, Stephenson CJ, Eiguren-Fernandez A, Morris JG, Mavian CN, Salemi M, Clugston JR, Wu CY. Collection of SARS-CoV-2 virus from the air of a clinic within a university student health care center and analyses of the viral genomic sequence. Aerosol and Air Quality Research (2020) v. 20 (6): pp. 1167-1171. NIEHS Grant No. R43ES030649] 

Environmental Factor Articles

NIEHS Cryo-EM Resources Support Fight Against Novel Coronavirus – April 1, 2020
NIEHS research on the virus aims to reveal structures suitable for targeted development of potential vaccines and treatments.

Protecting Workers During the COVID-19 Outbreak – April 1, 2020
In the midst of the COVID-19 pandemic, the NIEHS Worker Training Program showcased strategies to protect frontline workers, during a virtual workshop.

Papers From NIEHS Researchers

Ji H-L, Zhao R, Matalon S, Matthay MA. 2020. Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility. Physiol Rev (2020) v. 100 (3): pp. 1065-1075.NIEHS Grant No. U01ES026458, U01ES027697. [Abstract Ji H-L, Zhao R, Matalon S, Matthay MA. 2020. Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility. Physiol Rev (2020) v. 100 (3): pp. 1065-1075.NIEHS Grant No. U01ES026458, U01ES027697.]

Wang Z, Xu X. 2020. scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in Spermatogonia, Leydig and Sertoli Cells. Cells (2020) v. 9 (4): e920. [Abstract Wang Z, Xu X. 2020. scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in Spermatogonia, Leydig and Sertoli Cells. Cells (2020) v. 9 (4): e920.]

Mahabee-Gittens EM, Merianos AL, Matt GE. 2020. Letter to the editor regarding: "An imperative need for research on the role of environmental factors in transmission of novel coronavirus (COVID-19)". Environmental Science & Technology. v. 54 (9): pp. 5309-5310 [Abstract Mahabee-Gittens EM, Merianos AL, Matt GE. 2020. Letter to the editor regarding: "An imperative need for research on the role of environmental factors in transmission of novel coronavirus (COVID-19)". Environmental Science & Technology. v. 54 (9): pp. 5309-5310]

Ahmed S, Mvalo T, Akech, S, Agweyu A, Baker K, Bar-Zeev N, Campbell H, Checkley W, Chisti M, Colbourn T, Cunningham S, Duke T, English M, Falade A, Fancourt N, Ginsburg A, Graham H, Gray D, Gupta M, Hammitt L, Hesseling A, Hooli S, Johnson ABR, King C, Kirby M, Lanata CF, Lufesi N, Mackenzie Ga, McCracken JP, Moschovis PP, Nair H, Oviawe O, Pomat WS, Santosham M, Seddon JA, Thahane LK, Wahl B, Van der Zalm M, Verwet C, Yoshida LM, Zar HJ, Howie SR, McCollum ED. 2020. Protecting children in low-income and middle-income countries from COVID-19. BMJ Global Health 2020;5:e002844. NIEHS Grant No. K23ES030399 [Abstract Ahmed S, Mvalo T, Akech, S, Agweyu A, Baker K, Bar-Zeev N, Campbell H, Checkley W, Chisti M, Colbourn T, Cunningham S, Duke T, English M, Falade A, Fancourt N, Ginsburg A, Graham H, Gray D, Gupta M, Hammitt L, Hesseling A, Hooli S, Johnson ABR, King C, Kirby M, Lanata CF, Lufesi N, Mackenzie Ga, McCracken JP, Moschovis PP, Nair H, Oviawe O, Pomat WS, Santosham M, Seddon JA, Thahane LK, Wahl B, Van der Zalm M, Verwet C, Yoshida LM, Zar HJ, Howie SR, McCollum ED. 2020. Protecting children in low-income and middle-income countries from COVID-19. BMJ Global Health 2020;5:e002844. NIEHS Grant No. K23ES030399]

Shekhar S, Wurth R, Kamilaris CDC, Eisenhofer G, Barrera FJ, Hajdenberg M, Tonleu J, Hall JE, Schiffrin EL, Porter F, Stratakis CA, Hannah-Shmouni F. Endocrine conditions and COVID-19. Horm Metab Res (2020). [Abstract Shekhar S, Wurth R, Kamilaris CDC, Eisenhofer G, Barrera FJ, Hajdenberg M, Tonleu J, Hall JE, Schiffrin EL, Porter F, Stratakis CA, Hannah-Shmouni F. Endocrine conditions and COVID-19. Horm Metab Res (2020).]

Cai G, Bossé Y, Xiao F, Kheradmand F, Amos CI. Tobacco smoking increases the lung gene expression of ACE2, the receptor of SARS-CoV-2. American Journal of Respiratory and Critical Care Medicine 2020 v. 201 (12): pp. 1557-1559. NIEHS Grant No. R01 ES029442 [Abstract Cai G, Bossé Y, Xiao F, Kheradmand F, Amos CI. Tobacco smoking increases the lung gene expression of ACE2, the receptor of SARS-CoV-2. American Journal of Respiratory and Critical Care Medicine 2020 v. 201 (12): pp. 1557-1559. NIEHS Grant No. R01 ES029442]

Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA, Alekseenko SI, Svistunov AA, Petrakis D, Spandidos DA, Aaseth J, Tsatsakis A, Tinkov A. Zinc and respiratory tract infections: Perspectives for COVID-19. International Journal of Molecular Medicine 2020 v. 46 (1): pp. 17-26. NIEHS Grant No. R01ES10563, R01ES07331, R01ES020852 [Abstract Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA, Alekseenko SI, Svistunov AA, Petrakis D, Spandidos DA, Aaseth J, Tsatsakis A, Tinkov A. Zinc and respiratory tract infections: Perspectives for COVID-19. International Journal of Molecular Medicine 2020 v. 46 (1): pp. 17-26. NIEHS Grant No. R01ES10563, R01ES07331, R01ES020852]

Shekhar S, Copacino CE, Barrera FJ, Hall JE, Hannah-Shmouni F. 2020. Insights into the Immunopathophysiology of Severe COVID-19 in Metabolic Disorders. Ann Natl Acad Med Sci 2020 Apr;56(2):112-115 [Full Text Shekhar S, Copacino CE, Barrera FJ, Hall JE, Hannah-Shmouni F. 2020. Insights into the Immunopathophysiology of Severe COVID-19 in Metabolic Disorders. Ann Natl Acad Med Sci 2020 Apr;56(2):112-115]

Bobrowski T, Alves VM, Melo-Filho CC, Korn D, Auerbach S, Schmitt C, Muratov EN, Tropsha A. 2020. Computational Models Identify Several FDA Approved or Experimental Drugs as Putative Agents Against SARS-CoV-2. ChemRxiv [Preprint] 2020 Apr 22. Update in: Mol Inform 2021 Jan;40(1):e2000113 [Full Text Bobrowski T, Alves VM, Melo-Filho CC, Korn D, Auerbach S, Schmitt C, Muratov EN, Tropsha A. 2020. Computational Models Identify Several FDA Approved or Experimental Drugs as Putative Agents Against SARS-CoV-2. ChemRxiv [Preprint] 2020 Apr 22. Update in: Mol Inform 2021 Jan;40(1):e2000113]

Papers From NIEHS Researchers

He B, Garmire L. Prediction of repurposed drugs for treating lung injury in COVID-19. Preprint. ArXiv. 2020;arXiv:2003.14333v2. NIEHS Grant No. K01ES025434 [Abstract He B, Garmire L. Prediction of repurposed drugs for treating lung injury in COVID-19. Preprint. ArXiv. 2020;arXiv:2003.14333v2. NIEHS Grant No. K01ES025434]

Press Releases

COVID-19 Workers Get Training to Protect Their Own Health – March 23, 2020
NIEHS Worker Training Program is creating a COVID-19 virtual safety training initiative for frontline responders including emergency medical personnel, firefighters, law enforcement officers, environmental cleanup workers, high-risk custodial service workers, food processing and delivery workers, water and sewage treatment workers, sanitation workers, and health care facility employees.

Worker Training Program

Communication Concepts to Managing Perceptions, Stigma and Stress Mental Health and Emotional Resiliency for Workers and Communities – March 17, 2020

Protecting Infectious Disease Responders During the COVID-19 Outbreak – March 17, 2020

Papers From NIEHS Researchers

Cai G, Bossé Y, Xiao F, Kheradmand F, Amos CI. Tobacco smoking increases the lung gene expression of ACE2, the receptor of SARS-CoV-2. American Journal of Respiratory and Critical Care Medicine 2020 v. 201 (12): pp. 1557-1559. NIEHS Grant No. R01 ES029442 [Abstract Cai G, Bossé Y, Xiao F, Kheradmand F, Amos CI. Tobacco smoking increases the lung gene expression of ACE2, the receptor of SARS-CoV-2. American Journal of Respiratory and Critical Care Medicine 2020 v. 201 (12): pp. 1557-1559. NIEHS Grant No. R01 ES029442]