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Your Environment. Your Health.

Rheumatic Disorders in Siblings (Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders)

Study Background

The goal of this study is to examine the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, when one has an autoimmune disease and the other does not. Adults and children may enroll by completing questionnaires and donating blood and urine samples.

Current evidence suggests that the adult and juvenile forms of systemic rheumatic disorders - defined here as Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (Lupus; SLE), Systemic Sclerosis (Scleroderma; SSC), and Idiopathic Inflammatory Myopathies (Myositis; IIM) - share many common clinical manifestations, immune responses, genetic, hormonal and environmental risk factors, and possible causes. This protocol will explore the risk factors for systemic rheumatic disorders through the evaluation of families with monozygotic (identical) or dizygotic (fraternal) twins or other brothers or sisters (siblings) discordant for systemic rheumatic disorders (twin-sib pairs). Parents, normal volunteers will also be evaluated as needed for the experimental designs of each portion of the protocol.

Principal Investigator

Adult Subjects

Frederick W. Miller
Frederick W. Miller, M.D., Ph.D.
Deputy Chief, Clinical Research Branch and Principal Investigator
Tel 984-287-3593
Fax 301-451-5585
millerf@mail.nih.gov
P.O. Box 12233
Mail Drop F1-09
Durham, N.C. 27709
Adam I. Schiffenbauer
Adam I. Schiffenbauer, M.D.
Staff Clinician
Environmental Autoimmunity Group, Clinical Research Branch
Tel 301-451-6270
adam.schiffenbauer@nih.gov
10 Center Dr
Clinical Center Surgical Wing
Bethesda, MD 20892-1627

Pediatric Subjects

Lisa Rider, M.D.
Lisa Rider, M.D.
Deputy Chief and Staff Clinician, Environmental Autoimmunity Group
Tel 301-451-6272
Fax 301-480-2813
riderl@mail.nih.gov
10 Center Dr
Hatfield Clinical Research Center
Bethesda, MD 20892-1301
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