Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Effect of Innate Immunity on the Inflammatory Response to Endotoxin

Open for Recruitment

Study Background

Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body’s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancer.

The study will involve one 60-minute visit at the NIEHS Clinical Research Unit (CRU) in Research Triangle Park, North Carolina, and volunteers will be compensated for their time. If eligible, participation includes a review of your medical and family history, collection of vital signs, and a blood draw.

For more information on this study, please visit the Clinical Trials Study webpage.

This content is available to use on your website.
Please visit NIEHS Syndication to get started.


Enrolling by invitation only.

You may be eligible for this study if you meet the following criteria:

  • Current participant in the Environmental Polymorphism Registry (EPR)
  • At least 18 years of age
  • Male or non-pregnant
  • Willing to fast (with the exception of water) from midnight prior to the study visit
  • Ability to travel to the CRU
  • Healthy volunteers as defined by the International Red Cross guidelines (Healthy means that an individual feels well and can perform normal activities. If the individual has a chronic condition such as diabetes or high blood pressure, healthy also means that they are being treated and the condition is under control).

What will you do?

  • Participate in one 60-minute visit at the National Institute of Environmental Health Sciences (NIEHS) Clinical Research Unit (CRU) in Research Triangle Park, NC.
  • Visit includes a review of medical history, collection of vital signs, and providing a blood sample.
  • Compensation for time and effort at the completion of the study visit is $45.
  • If you are eligible, you may be invited to participate in this study more than once. You will receive the same compensation for your time and effort for each visit completed.

Why Participate?

  • Be part of a research study to help scientists at NIEHS understand the role of certain genes in human disease such as cancer and heart disease.
  • Receive compensation for your time and effort.

Study Location

Sample collections are conducted at the NIEHS Clinical Research Unit located in Research Triangle Park, North Carolina

Protocol Number: 10-E-0129

Enrollment and Contact Information

For more information and to enroll in this study, please contact Grace Isshiki at (919) 541-4973.

Principal Investigator

Michael B. Fessler, M.D.
Michael B. Fessler, M.D.
Acting Chief, Immunity, Inflammation, and Disease Laboratory and Principal Investigator
Tel 984-287-4081
P.O. Box 12233
Mail Drop D2-01
Durham, N.C. 27709
Stavros Garantziotis, M.D.
Stavros Garantziotis, M.D.
Medical Director, NIEHS Clinical Research Unit and Principal Investigator
Tel 984-287-4412
Fax 919-541-9854
P.O. Box 12233
Mail Drop CU-01
Durham, N.C. 27709
to Top