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Your Environment. Your Health.

Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease

Open for Recruitment

Study Background

NIEHS researchers theorize that changes in the surface proteins of cells called receptors may predispose people to diseases, such as heart disease, arthritis, and diabetes. This study needs volunteers to undergo tests to determine how these changes or variants lead to illness.

Glucocorticoids are primary stress response hormones released from the adrenal gland when an individual is under stress. Chronic or ongoing elevation of these hormones due to prolonged stress or medical treatments can have numerous harmful effects. Researchers are interested in learning more about how these hormones affect cell growth, development, and death. To study glucocorticoid hormones, researchers plan to use the medication dexamethasone, which affects the parts of cells that respond to glucocorticoid hormones.

For more information on this study, please visit the Clinical Trials Study page.

Eligibility

Enrolling by invitation only.

  • All participants must be currently enrolled in the Environmental Polymorphisms Registry
  • At least 18 years of age
  • Able to withhold glucocorticoid medications (such as Vitamin D & multivitamins) due to interference with study results

What will you do?

This study will require an initial screening visit and second study visit. The second visit must be completed within 14 days of the screening visit. During the first visit, we will review your medical and medication history, collect vital signs, and draw a blood sample. Additionally, a urine pregnancy test is performed for all women. You will be given a low dose of a tablet of dexamethasone to take at night before your second visit. Dexamethasone is a medicine that changes the levels of the stress hormone cortisol in the blood. This low dose test can tell how much cortisol your body is producing in response to the dexamethasone. Participants will return for a second visit for a blood draw. You will also need to fast for 12 hours overnight before both visits.

What will NIEHS do?

In the first part of the study, cells will be taken from your donated blood sample and tested for their response to glucocorticoid exposure in the laboratory. In the second part of the study, a dexamethasone test will be performed. Cortisol levels in the blood will be measured. We hope the results of this study will give us a better understanding of how the body responds to glucocorticoids and their role in human disease.

Study Location

Sample collections are conducted at the NIEHS Clinical Research Unit (CRU) located in Research Triangle Park (RTP), North Carolina.

Protocol Number: 10-E-0130

Enrollment and Contact Information

To volunteer or learn more, contact Grace Isshiki at (919) 541-4973

Principal Investigator

Stavros Garantziotis, M.D.
Stavros Garantziotis, M.D.
Medical Director, NIEHS Clinical Research Unit and Principal Investigator
Tel 919-541-9859
Fax 919-541-9854
garantziotis@niehs.nih.gov
P.O. Box 12233
Mail Drop CU-01
Durham, N.C. 27709