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Your Environment. Your Health.

Cox-2 Gene and the Immune System

Open for Recruitment

Study Background

The immune system contains several different types of cells in the blood and other parts of the body. The body can fight infections well with the right balance of these cell types. The wrong balance of cell types may cause diseases, such as allergies or asthma. The COX-2 gene may help decide the balance of cell types that the body makes as part of the immune system. It may also play a role in certain immune system diseases. Researchers want to see how COX-2 affects the cells in the immune system.

Participants will have one study visit that will take place at the NIEHS Clinical Research Unit (CRU) in Research Triangle Park, North Carolina, and volunteers will be compensated for their time.

Participants will collect a urine sample at home on the morning of the study visit that they will then give to researchers. During the study visit, participants will review their medical history, have a physical exam, and provide a blood sample. No treatment will be provided as part of the study.

For more information on this study, please visit the Clinical Trials Study webpage.


Enrolling by invitation only.

You may be eligible if you are a current participant of the Environmental Polymorphisms Registry and::

  • At least 18 years of age
  • Race self-identified as White or Black and Non-Hispanic ethnicity
  • Willing and able to provided informed consent
  • Able to comply with all protocol procedures

What will you do?

  • Participate in one study visit.
  • Visit will take place at the National Institute of Environmental Health Sciences Clinical Research Unit (CRU) in Research Triangle Park, NC.
  • Provide medical history, urine and blood samples.
  • Participants will receive $75 as compensation upon completion of all study procedures.

Why Participate?

  • Be part of a research study to help scientists at NIEHS understand the Cox-2 gene works in the body’s immune system.   
  • Receive compensation for your time and effort.

Study Location

Sample collections are conducted at the NIEHS Clinical Research Unit located in Research Triangle Park, North Carolina

Protocol Number: 12-E-0190

Enrollment and Contact Information

For more information and to enroll in this study, please contact Grace Isshiki at (919) 541-4973.

Principal Investigator

Darryl Zeldin, M.D.
Darryl C. Zeldin, M.D.
Scientific Director and Principal Investigator
Tel 984-287-3641
Fax 919-541-4214
P.O. Box 12233
Mail Drop A2-05
Durham, N.C. 27709
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