Skip Navigation

Your Environment. Your Health.

CaREFREE Study: Calorie Restriction, Environment, and Fitness: Reproductive Effects Evaluation

Open for Recruitment

Study Background

The CaREFREE Study: Calorie Restriction, Environment, and Fitness: Reproductive Effects Evaluation

Open for Recruitment

Additional Information

Many women develop irregular menstrual cycles which may make it difficult to become pregnant and increase the risk of osteoporosis. Why do exercise and diet have this effect in some women but not others? This study will help us understand how nutrition, exercise, and the environment affect women's reproductive cycles.

Participants will be asked to track three consecutive menstrual cycles and come in for 9-10 visits on specific days. Participants will undergo two 5-day exercise and diet regimens provided by the study. Procedures include a physical exam, fitness testing, measurement of body fat and bone density, blood sampling, and daily at home blood & urine tests.

Participants will be compensated for their time.

For more information on this study, please visit the Clinical Trials Study page

This content is available to use on your website.
Please visit NIEHS Syndication to get started.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Healthy woman between the ages of 18-28 living in the Raleigh-Durham-Chapel Hill area
  • Regular menstrual cycles for the past three months
  • Not using hormonal birth control
  • Never given birth
  • Not pregnant, breastfeeding, or planning on becoming pregnant for the duration of the study
  • Not dieting or actively trying to lose weight during the past three months

What will you do?

  • Participate in 9-10 study visits over a period of three to four months
  • Participate in physical exams and blood, urine, and ovulation tests
  • Complete physical fitness and body composition assessments
  • Follow a meal and exercise plan; nutritional shakes, bars, and cookies provided
  • Keep track of your menstrual cycle
  • Provide your own transportation to the NIEHS Clinical Research Unit in Research Triangle Park, North Carolina and the University of North Carolina at Chapel Hill
  • Participants will receive up to $1,300 for completing all study steps

Study Location

The study will take place at NIEHS Clinical Research Unit in Research Triangle Park, North Carolina and the University of North Carolina at Chapel Hill. Participants will be responsible for providing their own transportation. Only one visit to UNC is necessary. Parking will be provided free of charge.

Protocol Number: 16-E-0157

Contact Information

For more information about this research study, call 1-855-MYNIEHS or email carefree@mail.nih.gov.

Principal Investigator

Janet E. Hall, M.D., M.S.
Janet E. Hall, M.D., M.S.
NIEHS Clinical Director and Principal Investigator
Tel 919-316-4525
janet.hall@nih.gov
P.O. Box 12233
Mail Drop A2-03
Durham, N.C. 27709
Abbie Smith-Ryan
Abbie Smith-Ryan, Ph.D.
Associate Researcher
Department of Exercise & Sport Science
University of North Carolina at Chapel Hill