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Your Environment. Your Health.

Blood Vessel Study

Closed for Recruitment

Study Background

Additional Information

The endothelium is the inner lining of blood vessels. The cells in this lining help regulate blood flow and immune system function. Problems with endothelial cells can contribute to heart disease, high blood pressure, and diabetes. Certain genes or parts of genes may be related to problems with endothelial function. Researchers want to study healthy adults who have genes that may affect their endothelial function. More information on these genes may provide more information on genetic risk for certain diseases.

Participants will have a single study visit that will take place at the NIEHS Clinical Research Unit (CRU) in Research Triangle Park, North Carolina, and volunteers will be compensated for their time.

Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. Participants will have an ultrasound of the artery in the arm and will be given a short-acting medication called nitroglycerin to study blood flow and blood pressure.

For more information on this study, please visit the Clinical Trials Study page.


Enrolling by invitation only.

You may be eligible for this study if you are a current participant of the Environmental Polymorphisms Registry and:

  • Age 18-65 years
  • Willing and able to provide informed consent
  • Able to comply with all protocol procedures

What will you do?

  • Participate in one study visit.
  • Visit will take place at the National Institute of Environmental Health Sciences Clinical Research Unit (CRU) in Research Triangle Park, NC.
  • Provide medical history, have a physical exam and electrocardiogram, provide urine and blood samples, have an ultrasound of the artery in the arm and will be given a short-acting dose of nitroglycerin.
  • Participants will receive compensation upon completion of all study procedures.

Why Participate?

  • Be part of a research study to help scientists at NIEHS understand how certain genes affect the inner lining of blood vessels and arteries.
  • Receive compensation for your time and effort.

Study Location

Sample collections are conducted at the NIEHS Clinical Research Unit located in Research Triangle Park, North Carolina.

Protocol Number: 12-E-0061

Enrollment and Contact Information

For more information and to enroll in this study, please contact Grace Isshiki at (919) 541-4973.

Principal Investigator

Darryl Zeldin, M.D.
Darryl C. Zeldin, M.D.
Scientific Director and Principal Investigator
Tel 984-287-3641
Fax 919-541-4214
P.O. Box 12233
Mail Drop A2-05
Durham, N.C. 27709
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