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Your Environment. Your Health.

Inhaled Nanosilver Study

Closed for Recruitment

Study Background

The goal of the Inhaled Nanosilver Study is to assess the impact of inhaled silver nanoparticles on immune responses in the lung. Due to its antimicrobial properties, there are many consumer products which contain nanosilver, such as cleaning supplies and clothing fabrics. There are also several products on the market that people use to inhale nanosilver dissolved in water, which the manufacturers claim help to boost the immune system. This research study will investigate whether nanosilver affects the function of the lung.

Participants of the Nanosilver Study will have 1 screening visit and 3 study visits. All of the visits will take place at the Clinical Research Unit (CRU) on the National Institute of Environmental Health Sciences (NIEHS) campus in Research Triangle Park.

During the visits, team members will talk to you about your medical history and any medications you take, record vital signs, conduct breathing tests and a physical exam, and collect blood and urine samples from you.  The treatment visit will involve breathing in a solution of nanosilver using a nebulizer, which is a machine that creates a fine mist. Two of the visits will involve a procedure called a bronchoscopy during which cells may be collected from areas of the lung.  

For more information on this study, please visit the Clinical Trials Study page.


You may be eligible for this study if you meet the following criteria:

  • 18-60 years old
  • Non-smoking
  • Non-pregnant or breastfeeding
  • Cannot have any lung or cardiovascular conditions
  • No allergies to metals

What will you do?

  • Participate in 1 screening visit and 3 study visits.
  • All visits will take place at the National Institute of Environmental Health Sciences Clinical Research Unit (CRU) in Research Triangle Park, NC.
  • Visits include providing medical information, physical exams, lung function testing, collection of biological samples (blood and urine), completing bronchoscopy procedures, and inhalation of nanosilver solution.
  • Qualified participants may be compensated up to $1190 for completion of all screening and study visits.

Why Participate?

  • Be part of a research study to help scientists at NIEHS understand how inhaled nanosilver affects lung function and the immune system of the lung.  
  • Receive compensation for your time and effort.

Study Location

Sample collections are conducted at the NIEHS Clinical Research Unit located in Research Triangle Park, North Carolina.

Protocol Number: 15-E-0104

Enrollment and Contact Information

For more information and to enroll in this study, please contact Grace Isshiki at (919) 541-4973.

Principal Investigator

Stavros Garantziotis, M.D.
Stavros Garantziotis, M.D.
Medical Director, NIEHS Clinical Research Unit and Principal Investigator
Tel 984-287-4412
Fax 919-541-9854
P.O. Box 12233
Mail Drop CU-01
Durham, N.C. 27709
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