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Your Environment. Your Health.

Systems Toxicology Group

Dori Germolec, Ph.D.
Dori Germolec, Ph.D.
Group Leader, Systems Toxicology
Tel (919) 541-3230
P.O. Box 12233
Mail Drop K2-15
Research Triangle Park, NC 27709

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Systems Toxicology Group

Research Summary

The Systems Toxicology Group, headed by Dori Germolec, Ph.D., designs research and/or testing protocols to characterize the biologic, toxicologic and/or physiologic effects of chemicals and/or agents on specific targets such as the immune, respiratory and nervous systems. Group members serve as project leaders for the toxicologic and carcinogenic assessments of agents of interest to the National Toxicology Program (NTP) as well as subject matter experts in multidisciplinary review teams comprised of in-house and external scientists evaluating studies on selected chemicals. The Systems Toxicology Group also serves as a resource for regulatory and research agencies, and the public who are looking for information on the toxicity of chemicals and how they affect function and burden of disease.

Major Areas of Research

  • Initiate and develop research projects or programs to investigate the mechanisms underlying the targeted toxicity of chemicals.
  • Immunotoxicology Testing Program - Develops and establishes methods with predictive value to evaluate potentially immunotoxic chemicals and drugs; examines selected agents for immunotoxicity in adult and developing animals employing a suite of well-established tests to identify specific targets and effects; and conducts mechanistic studies to define the cellular and molecular events associated with immunotoxicity.
  • Neurotoxicity Testing Program – Develop guidelines for the comprehensive assessment of developmental and adult neurotoxicity testing to include end-points such as observational batteries, behavior, pathology and genomics.

Current Projects

  • Toxicologic and Carcinogenic assessments of:
    • Mold
    • Herbal products/Dietary supplements
    • Aromatic Phosphate Flame Retardants
    • Metals
  • Immunotoxicological Evaluation of:
    • Brominated Dioxins
    • Herbal products/Dietary supplements
    • Metals
    • Flame retardants
  • Neurotoxicology assessments of:
    • Flame retardants
    • Dioxin-like compounds
    • Metals
    • Plasticizers


Dori Germolec, Ph.D. is a biologist who joined the National Institute of Environmental Health Sciences (NIEHS) in 1985. She specializes in the effects of chemicals on the immune system and is an adjunct assistant professor in the department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University.


Her scientific investigations have resulted in over 100 publications in various areas of toxicology, resulting in the receipt of an NIH Merit Award and The Society of Toxicology Best Publication Award in 1995. In 2004 she received the Outstanding Young Investigator Award from the Immunotoxicology Specialty Section of the SOT. Germolec is active in the Society of Toxicology (SOT), and was elected SOT Councilor for 2011 – 2013. She also served as past president of the Immunotoxicology Specialty Section and as a member of the Program Committee (2003-2006). Germolec also plays a key role in fostering an atmosphere of professional excellence and scientific endeavor among scientists at NIEHS. She has served as a member of the NIEHS Assembly of Scientists (AOS) Council since 2000, most recently as the AoS president in 2011.


Germolec received an M.A. in physical anthropology from Duke University in 1983 and a Ph.D. in toxicology from North Carolina State University in 1995.