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Your Environment. Your Health.

Cynthia Rider, Ph.D.

General Toxicology and Cancer Group

Cynthia Rider, Ph.D.
Cynthia V. Rider, Ph.D.
Toxicologist
Tel 984-287-3175
cynthia.rider@nih.gov
P.O. Box 12233
Mail Drop K2-12
Durham, N.C. 27709

Cynthia Rider, Ph.D., is a toxicologist in the Toxicology Branch of the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS). As a study scientist, she designs and evaluates results from toxicological studies of chemicals selected for investigation by the NTP. She is particularly interested in developing and refining methods for evaluating the toxicity of mixtures to inform risk assessment. Currently, she is the project leader for polycyclic aromatic compounds, which are being used as a case study to evaluate the joint action of chemicals with component-based approaches (e.g., dose addition models). She is also leading an effort to inform the safety evaluation of complex mixtures. Toward this goal, she is using botanical dietary supplements, such as Ginkgo biloba extract, to develop methods for determining sufficient similarity of complex mixtures. Rider serves as co-chair with Danielle Carlin, Ph.D., of the NIEHS Combined Exposure/Mixtures working group, which aims to advance mixtures research throughout the Institute.

Rider received her B.S. from Tulane University, New Orleans, LA in Environmental Studies and Biology and her Ph.D. from North Carolina State University, Raleigh, NC in Environmental Toxicology. She completed post doctoral training in the Reproductive Toxicology Branch of the National Health and Environmental Effects Research Laboratory, U. S. Environmental Protection Agency and the Nicholas School of the Environment at Duke University. She joined the NTP in 2010.

Selected Publications

  1. Rider, C.V., Simmons, J.E. (Eds.). (2018) Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk. Springer. 
  2. Catlin, N.R., Collins, B.J., Auerbach, S.S., Ferguson, S.S., Harnly, J.M., Gennings, C., Waidyanatha, S., Rice, G.E., Smith-Roe, S.L., Witt, K.L., Rider CV. (2018). How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract. Food Chem. Toxicol. 118:328-339. 
  3. Waidyanatha, S., Ryan, K.R., Roe, A.L., Jia, W., Paine, M., Ferguson, S., Gurley, B.J., Welch, K., Chow, M.S.S., Devito, M., Rider, C.V. (2018). Follow that botanical: Challenges and recommendations for assessing absorption, distribution, metabolism and excretion of botanical dietary supplements. Food Chem. Toxicol. 121:194-202. 
  4. Shipkowski, K.A., Betz, J.M., Birnbaum, L.S., Bucher, J.R., Coates, P.M., Hopp, D.C., MacKay, D., Oketch-Rabah H., Walker, N.J., Welch, C., Rider, C.V. (2018). Naturally complex: Perspectives and challenges associated with botanical dietary supplement safety assessment. Food Chem. Toxicol. 118:963-971. 
  5. Wolf, C.J., Rider, C.V., Lau, C., Abbott, B.D. (2014) Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation. Toxicology. 316:43-54. [Abstract Wolf, C.J., Rider, C.V., Lau, C., Abbott, B.D. (2014) Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation. Toxicology. 316:43-54.]
  6. Rider CV, Nyska AN, Cora MC, Kissling GE, Smith C, Travlos GS, Hejtmancik MR, Kooistra L, Morrison JP, Chan PC. (2014). Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets. Toxicologic pathology 2014 42(5):830-843. [Abstract Rider CV, Nyska AN, Cora MC, Kissling GE, Smith C, Travlos GS, Hejtmancik MR, Kooistra L, Morrison JP, Chan PC. (2014). Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets. Toxicologic pathology 2014 42(5):830-843.]
  7. Rider, C.V., Janardhan, K.S., Rao, D., Morrison, J.P., McPherson, C.A., Harry, G.J. (2012). Evaluation of N-butylbenzenesulfonamide (NBBS) neurotoxicity in Sprague-Dawley male rats following 27-day oral exposure. Neurotoxicology 33(6):1528-1535.   [Abstract Rider, C.V., Janardhan, K.S., Rao, D., Morrison, J.P., McPherson, C.A., Harry, G.J. (2012). Evaluation of N-butylbenzenesulfonamide (NBBS) neurotoxicity in Sprague-Dawley male rats following 27-day oral exposure. Neurotoxicology 33(6):1528-1535.  ]
  8. Rider, C.V., Furr, J., Wilson, V.S., Gray, L.E. (2010). Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. Int. J. Androl. 33(2):443-462. [Abstract Rider, C.V., Furr, J., Wilson, V.S., Gray, L.E. (2010). Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. Int. J. Androl. 33(2):443-462.]
  9. Rider, C.V., Wilson, V.S., Howdeshell, K.L., Hotchkiss, A.K., Furr, J., Lambright, C.R., Gray, L.E. (2009). Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development. Toxicol. Pathol. 37:100-113. [Abstract Rider, C.V., Wilson, V.S., Howdeshell, K.L., Hotchkiss, A.K., Furr, J., Lambright, C.R., Gray, L.E. (2009). Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development. Toxicol. Pathol. 37:100-113.]
  10. Rider, C.V., Furr, J., Wilson, V.S., Gray, L.E. (2008). A mixture of seven antiandrogens induces reproductive malformations in rats. Int. J. Androl. 31:249-262. [Abstract Rider, C.V., Furr, J., Wilson, V.S., Gray, L.E. (2008). A mixture of seven antiandrogens induces reproductive malformations in rats. Int. J. Androl. 31:249-262.]
  11. Rider, C.V. and LeBlanc, G.A. (2005). An integrated addition and interaction model for assessing toxicity of chemical mixtures. Toxicol. Sci. 87:520-528. [Abstract Rider, C.V. and LeBlanc, G.A. (2005). An integrated addition and interaction model for assessing toxicity of chemical mixtures. Toxicol. Sci. 87:520-528.]
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