Dan Morgan, Ph.D.
General Toxicology and Cancer Group
- Dan Morgan, Ph.D.
- Tel 984-287-3163
- P.O. Box 12233Mail Drop K2-12Durham, N.C. 27709
Daniel Morgan, Ph.D., D.A.B.T., manages and participates in multidisciplinary teams of scientists from the National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences that are working to develop research programs to address a broad array of toxicological study needs for chemicals selected for study by the NTP. This includes the design, analysis, interpretation, and integration of carcinogenicity, reproductive and developmental, genetic, and general toxicology studies. These research programs serve to identify hazards associated with chemical exposure and increase our understanding of the interaction between chemical exposure and the development of disease. Study results are published as NTP Technical Reports and peer-reviewed research papers in scientific journals and provide critical data for use in risk assessment for human exposure.
Morgan also serves as the NTP's senior discipline expert in respiratory toxicology. His research interests focus on the biochemical and molecular mechanisms of inhaled environmental toxicants. Before joining the Toxicology Branch, Morgan was group leader of the Respiratory Toxicology group in the NTP Laboratory, and Project Officer for the NIEHS inhalation facility. His research focused on mechanisms of pulmonary toxicity of NTP chemicals at the tissue, cellular, and molecular levels.
Morgan received a B.S. in microbiology and biology in 1975, and a Ph.D. in Pharmacology and Toxicology in 1982 from the University of Kansas. He completed postdoctoral training in toxicology at the Comprehensive Cancer Center, Duke University Medical Center. Morgan worked as assistant director of the Laboratory of Environmental Toxicology and Pharmacology at Duke, and project leader in the cellular and molecular toxicology laboratory at Northrop Services prior to joining the NTP in 1988.
- Dunnick JK, Shockley KR, Morgan DL, et al. 2017. Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats. Archives of toxicology 91(4):1685-1696 [Abstract]
- Morgan DL, Jokinen MP, Johnson CL, Price HC, Gwinn WM, Bousquet RW, Flake GP. Chemical Reactivity and Respiratory Toxicity of the α-Diketone Flavoring Agents: 2,3-Butanedione, 2,3-Pentanedione, and 2,3-Hexanedione. Toxicologic pathology 2016 44(5):763-783. [Abstract]
- Dunnick JK, Merrick A, Brix A, Morgan DL, Gerrish K, Flake G, Foley J, Shockley KR. 2016. Molecular Changes in the Nasal Cavity after N, N-dimethyl-p-toluidine Exposure. Toxicologic pathology 2016 44(6):835-847. [Abstract]
- Fennell T , Morgan, DL, Watson SL, Dhungana S, Waidyanatha S. Systemic uptake, albumin and hemoglobin binding of [(14)C]2,3-butanedione administered by intratracheal instillation in male Harlan Sprague Dawley rats and oropharyngeal aspiration in male B6C3F1/N mice. Chemico-biological interactions 2015 227():112-119. [Abstract]
- Gwinn WM, Qu W, Bousquet RW, Price H, Shines CJ, Taylor GJ, Waalkes MP, Morgan DL. Macrophage solubilization and cytotoxicity of indium-containing particles in vivo. Toxicological sciences: an official journal of the Society of Toxicology 2015 144(1):17-26. [Abstract]
- Yildirim, E., Carey, M.A., Card, J.W., Dietrich, A., Flake, G.P., Bradbury, J.A., Rebolloso, Y., Germolec, D.R., Morgan, D.L., Zeldin, D.C., and Birnbaumer, L. (2012). Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. Am. J. Physiol.- Lung Cell. Molec. Physiol. 303 (6): L539-L549.
- Morgan, D.L., Jokinen, M.P., Price, H.C., Gwinn, W.M., Palmer, S.M., Flake, G.P. (2012). Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. Toxicol. Path. 40(3):448-65. [Abstract]
- Dackor R.T., Cheng, J., Voltz, J.W., Card, J.W., Ferguson, C.D., Garrett, R.C., Bradbury, J.A., DeGraff, L.M., Lih, F.B., Tomer, K.B., Flake, G.P., Travlos, G.S., Ramsey, R.W., Edin, M.L., Morgan, D.L. and Zeldin, D.C. (2011). Prostaglandin E(2) protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction. American Journal of Physiology-Lung Cellular and Molecular Physiology v. 301 (5): pp. L645-L655.
- Morgan D.L., Nyska A., Harbo S.J., Grumbein S.L., Dill J.A., Roycroft J.H., Kissling G.E., Cesta M.F. (2011). Multisite carcinogenicity and respiratory toxicity of inhaled 1-bromopropane in rats and mice. Toxicol. Path. 39(6):938-948. [Abstract]
- Palmer, S.M., Flake, G.P., Kelly, F.L., Zhang, H.L., Nugent, J.L., Price, H.C., Kirby, P.J., Foley, J.F., Gwinn, W.M., and Morgan, D.L. (2011). Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. PLOSone 6(3), e17644.
- Mathews, J.M., Watson, S.L., Snyder, R.W., Burgess, J.P., and Morgan, D.L. (2010). Reaction of the butter flavorant 2,3-butanedione with N-α-acetylarginine: a model for epitope formation with pulmonary proteins in the etiology of obliterative bronchiolitis. J. Agric. Food Chem. 58, 12761-8.
- Card, J.W., Carey, M.A., Voltz, J.W., Bradbury, J.A., Ferguson, C.D., Cohen, E.A., Schwartz, S., Flake, G.P., Morgan, D.L., Arbes Jr, S.J., Barrow, D.A., Barros, S.P., Offenbacher, S. and Zeldin, D.C. (2010). Modulation of allergic airway inflammation by the oral pathogen Porphyromonas gingivalis. Infection and Immunity 78(6): 2488-2496.
- Anderson, S.E., Munson, A.E., Butterworth, L.F., Germolec, D., Morgan, D.L., Roycroft, J.A., Dill, J. and Meade, B.J. (2010). Whole Body Inhalation Exposure to 1-Bromopropane suppresses the Igm response to sheep red blood cells in female B6C3F1 mice and Fisher 344/N rats. Inhal. Tox. 22, 125-132.
- Morrison, J.P., Ton, T-V., Collins, J.B., Switzer, R.C., Little, P.B., Morgan, D.L., and Sills, R.C. (2009). Gene expression studies reveal that DNA damage, vascular perturbation, and inflammation contribute to the pathogenesis of carbonyl sulfide neurotoxicity. Toxicol. Path. 37, 502-211.
- Garantziotis, S., Zhuowei, L., Potts, E.N., Kimata, K., Zhuo, L., Morgan, D.L., Savani, R.C., Noble, P.W., Foster, W.M., Schwartz, D.A., and Hollingsworth, J.W. (2009). Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. J. Biol. Chem. 284, 11309-11317.
- Kirby, P.K., Shines, C.J., Taylor, G.J., Bousquet, R.W., Price, H.C., Everitt, J.E., and Morgan, D.L. (2009). Pleural effects of indium phosphide in B6C3F1 mice: Nonfibrous particulate induced pleural fibrosis. Exp. Lung Res. 35, 858-882.