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Your Environment. Your Health.

Troy Hubbard, Ph.D.

General Toxicology and Cancer Group

Troy Hubbard
Troy D. Hubbard, Ph.D.
Fellow — IRTA
Tel 984-287-3143
530 Davis Dr
Keystone Building
Durham, NC 27713

Troy Hubbard, Ph.D. is an Intramural Research Training Award (IRTA) Fellow in the Toxicology Branch of the Division of the National Toxicology Program (DNTP) at the National Institute of Environmental Health Sciences. As a study scientist, Hubbard works in cross-functional teams to evaluate the potential toxicity and carcinogenicity of chemical agents nominated to the NTP testing program, such as pharmaceuticals, botanicals, and environmental contaminants. Hubbard is responsible for design and implementation of toxicity studies and communicating study results by preparation of NTP technical reports and writing of manuscripts for publication. His primary research interests include hepatotoxicity, respiratory toxicology, and immunotoxicology.

Hubbard obtained his Bachelor of Arts degree in Biochemistry from Hood College in Frederick, Maryland in 2012, and a Ph.D. in Biochemistry, Microbiology, and Molecular Biology from The Pennsylvania State University under the mentorship of Dr. Gary Perdew in 2017. His dissertation research investigated the physiological and toxicological implications of the aryl hydrocarbon receptor (AHR), with a particular focus upon differential smoke toxicity between humans and Neanderthals as a result of evolutionary divergence of AHR ligand selectivity.

Selected Publications

  1. Hubbard, T. D., I. A. Murray, W. H. Bisson, A. P. Sullivan, A. Sebastian, G. H. Perry, N. G. Jablonski and G. H. Perdew (2016). "Divergent Ah Receptor Ligand Selectivity during Hominin Evolution." Molecular Biology and Evolution 33(10): 2648-2658. [Abstract] 
  2. Gutierrez, M. A., S. S. Davis, A. Rosko, S. M. Nguyen, K. P. Mitchell, S. Mateen, J. Neves, T. Y. Garcia, S. Mooney, G. H. Perdew, T. D. Hubbard, D. A. Lamba and A. Ramanathan (2016). "A novel AhR ligand, 2Al, protects the retina from environmental stress." Scientific Reports 6. [Abstract] 
  3. Zhang, L. M., R. G. Nichols, J. Correll, I. A. Murray, N. Tanaka, P. B. Smith, T. D. Hubbard, A. Sebastian, I. Albert, E. Hatzakis, F. J. Gonzalez, G. H. Perdew and A. D. Patterson (2015). "Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation." Environmental Health Perspectives 123(7): 679-688. [Abstract] 
  4. Hubbard, T. D., I. A. Murray and G. H. Perdew (2015). "Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation." Drug Metabolism and Disposition 43(10): 1522-1535. [Abstract] 
  5. Hubbard, T. D., I. A. Murray, W. H. Bisson, T. S. Lahoti, K. Gowda, S. G. Amin, A. D. Patterson and G. H. Perdew (2015). "Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles." Scientific Reports 5. [Abstract]