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Anika Dzierlenga, Ph.D.

Developmental and Reproductive Toxicology Group

Anika L. Dzierlenga, Ph.D.
Anika L. Dzierlenga, Ph.D.
Fellow — IRTA
Tel 919-541-3696
anika.dzierlenga@nih.gov
530 Davis Dr
Keystone Building 2069
Durham, NC 27713

Anika Dzierlenga, Ph.D. is an Intramural Research Training Award (IRTA) Fellow in the Toxicology Branch of the Division of the National Toxicology Program (DNTP) at the National Institute of Environmental Health Sciences. As a study scientist, Dzierlenga works in interdisciplinary teams to evaluate the toxicity of various therapeutic and environmental chemicals. Her responsibilities include designing and implementing toxicity studies, preparing technical reports, and writing manuscripts for publication. Dzierlenga is specifically interested in toxicokinetics and PBPK modeling, hepatotoxicity, and developmental and reproductive toxicity.

Dzierlenga obtained her Bachelor of Science degree in Biochemistry from Trinity University in San Antonio, Texas, and completed her Ph.D. in Pharmacology & Toxicology at the University of Arizona College of Pharmacy in Tucson, Arizona in 2016. Her doctoral work focused on understanding the mechanisms and functional consequences of drug transporter misregulation in nonalcoholic steatohepatitis (NASH).

Selected Publications

  1. Dzierlenga AL, Clarke JD, Cherrington N. Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval and Insertion Processes. Drug Metab Dispos. 2016 Sep. [Epub ahead of print] [Abstract]
  2. Laho T, Clarke JD, Dzierlenga AL, Li H, Klein DM, Goedken M, Micuda S, Cherrington NJ. Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir. Biochem Pharmacol. 2016 Sep. 115:144-51. Epub 2016 Jul 2. [Abstract]
  3. Dzierlenga AL, Clarke JD, Klein DM, Anumol T, Snyder SA, Li H, Cherrington NJ. Biliary Elimination of Pemetrexed Is Dependent on Mrp2 in Rats: Potential Mechanism of Variable Response in Nonalcoholic Steatohepatitis. J Pharmacol Exp Ther. 2016 Aug. 358(2):246-53. Epub 2016 May 27. [Abstract]
  4. Clarke JD, Dzierlenga AL, Nelson NR, Li H, Werts S, Goedken MJ, Cherrington NJ. Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis. Diabetes. 2015 Sep. 64(9):3305-13. Epub 2015 May 27. [Abstract]
  5. Dzierlenga AL, Clarke JD, Hargraves TL, Ainslie GR, Vanderah TW, Paine MF, Cherrington NJ. Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis. J Pharmacol Exp Ther. 2015 Mar. 352(3):462-70. Epub 2014 Dec 15. [Abstract]