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Selected Publications

Molecular Endocrinology Group

  1. Oakley RH, Busillo JM, Cidlowski JA. Cross-talk between the Glucocorticoid Receptor and MyoD Family Inhibitor Domain Containing Protein Provides a New Mechanism for Generating Tissue-Specific Responses to Glucocorticoids. The Journal of biological chemistry 2017 ():-. [Abstract]
  2. Kadmiel M, Janoshazi A, Cidlowski JA. Glucocorticoid action in human corneal epithelial cells establishes roles for corticosteroids in wound healing and barrier function of the eye. Experimental Eye Research 2016 152():10-33. [Abstract]
  3. Cruz-Topete D, He B, Chang J, Xu X, Cidlowski JA. Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death. The Journal of biological chemistry 2016 291(37):19374-19386. [Abstract]
  4. Cruz-Topete, D, Myers, P, Foley, J , Willis, M, Cidlowski, J. Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice. Endocrinology 2016 157(7):2759-2771. [Abstract]
  5. Quinn MA, Cidlowski JA. Endogenous hepatic glucocorticoid receptor signaling coordinates sex-biased inflammatory gene expression. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 2016 30(2):971-982. [Abstract]
  6. Bortner CD, Scoltock AB, Cain DW, Cidlowski JA. T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways. Cell death and differentiation 2016 23(5):889-902. [Abstract]
  7. He B, Cruz-Topete D, Oakley RH, Xiao X, Cidlowski JA. Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver. Molecular and cellular biology 2015 36(5):714-730. [Abstract]
  8. Whirledge SD, Oakley RH, Myers PH, Lydon JP, DeMayo F, Cidlowski JA. Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization. Proceedings of the National Academy of Sciences of the United States of America 2015 112(49):15166-15171. [Abstract]
  9. Cruz-Topete D, Cidlowski JA. One hormone, two actions: anti- and pro-inflammatory effects of glucocorticoids. Neuroimmunomodulation 2015 22(1-2):20-32. [Abstract]
  10. Bortner CD, Cidlowski JA. Ion channels and apoptosis in cancer. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2014 369(1638):20130104-. [Abstract]
  11. Gruver-Yates AL, Quinn MA, Cidlowski JA. Analysis of glucocorticoid receptors and their apoptotic response to dexamethasone in male murine B cells during development. Endocrinology 155(2):463-474, 2014. [Abstract]
  12. Franco R, Bortner CD, Schmitz I, Cidlowski JA. Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1. Apoptosis: an international journal on programmed cell death 19(1):117-134, 2014. [Abstract]
  13. Kadmiel M, Cidlowski JA. Glucocorticoid Receptor Signaling in Health and Disease. Trends in Pharmacological Sciences 2013 34(9):518-530. [Abstract]
  14. Gruver-Yates AL, Cidlowski JA. Tissue-specific actions of glucocorticoids on apoptosis: a double-edged sword. Cells 2013 2(2):202-223. [Abstract]
  15. Oakley RH, Cidlowski JA. The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. Journal of Allergy and Clinical Immunology 2013 132(5):1033-1044. [Abstract]
  16. Whirledge S, Cidlowski JA. A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary. Endocrinology 154(12):4450-4468, 2013. [Abstract]
  17. Revollo JR, Oakley RH, Lu NZ, Kadmiel M, Gandhavadi M, Cidlowski JA. HES1 Is a Master Regulator of Glucocorticoid Receptor–Dependent Gene Expression. Science Signaling 6(304):ra103-, 2013. [Abstract]
  18. Whirledge S, Xu X, Cidlowski JA. Global gene expression analysis in human uterine epithelial cells defines new targets of glucocorticoid and estradiol antagonism. Biology of Reproduction 89(3):66, 2013. [Abstract]
  19. Oakley RH, Ren R, Cruz-Topete D, Bird GS, Myers PH, Boyle MC, Schneider MD, Willis MS, Cidlowski JA. Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease. Proceedings of the National Academy of Sciences of the United States of America 110(42):17035-40, 2013. [Abstract]
  20. Oakley RH, Revollo J, Cidlowski JA. Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America 109(43):17591-6, 2012. [Abstract]
  21. Ren R, Oakley RH, Cruz-Topete D, Cidlowski JA. Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosis. Endocrinology  153(11):5346-60, 2012. [Abstract]
  22. Jewell CM, Scoltock AB, Hamel BL, Yudt MR, Cidlowski JA. Complex human glucocorticoid receptor dim mutations define glucocorticoid induced apoptotic resistance in bone cells. Endocrinology 26(2):244-56, 2012. [Abstract]
  23. Bortner CD, Scoltock AB, Sifre MI, Cidlowski JA. Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes.. The Journal of biological chemistry 287(9):6284-95, 2012.  [Abstract]
  24. Gross KL, Oakley RH, Scoltock AB, Jewel CM, Cidlowski JA. Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. Molecular Endocrinology 25(7):1087-1099, 2011. [Abstract]
  25. Busillo JM, Azzam KM, Cidlowski JA. Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome. The Journal of biological chemistry 286(44):38703-13, 2011. [Abstract]
  26. Smith LK, Shah RR, Cidlowski JA. Glucocorticoids modulate microRNA expression and processing during lymphocyte apoptosis. The Journal of biological chemistry 285(47):36698-36708, 2010. [Abstract]
  27. Ajiro K, Scoltock A , Smith LK, Ashasima M, Cidlowski JA. Reciprocal Epigenetic Modification of Histone H2B occurs in Chromatin during Apoptosis in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America 17(6):984-993, 2010. [Abstract]
  28. Gross KL, Lu NZ, Cidlowski JA. Molecular mechanisms regulating glucocorticoid sensitivity and resistance. Molecular and cellular endocrinology 2009 300(1-2):7-16. [Abstract]
  29. Franco R, Dehaven WI, Sifre MI, Bortner CD, Cidlowski JA. Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis. J Biol Chem 283(52):36071-36087, 2008. [Abstract]
  30. Galliher-Beckley AJ, Williams JG, Collins JB, Cidlowski JA. Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles. Molecular and cellular biology 28(24):7309-7322, 2008. [Abstract]
  31. Gross KL, Cidlowski JA. Tissue-specific glucocorticoid action: A family affair. Trends in endocrinology and metabolism: TEM   19(9):331-339, 2008. [Abstract]
  32. Bortner CD, Sifre MI, Cidlowski JA. Cationic gradient reversal and cytoskeleton-independent volume fegulatory pathways define an early stage of apoptosis. The Journal of Biological Chemistry 283(11):7219-7229, 2008. [Abstract]
  33. Lu NZ, Collins JB, Grissom SF, Cidlowski JA. Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. Molecular and Cellular Biology 27(20):7143-7160, 2007. [Abstract]
  34. Franco R, Panayiotidis MI, Cidlowski JA. Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. Journal of Biological Chemistry 282(42):30452-30465, 2007. [Abstract]
  35. Lewis-Tuffin LJ, Jewell CM, Bienstock RJ, Collins JB and Cidlowski JA. Human glucocorticoid receptor ? binds RU-486 and is transcriptionally active.  Molecular and Cellular Biology p. 2266-2282, Mar 2007. [Abstract]
  36. Lu NZ and Cidlowski JA.  Glucocorticoid receptor isoforms generate transcription specificity.  Trends in Cell Biology 16(6):301-307, 2006. [Abstract]
  37. Franco R, Bortner CD and Cidlowski JA.  Potential roles of electrogenic ion transport and plasma membrane depolarization in apoptosis. J. of  Membrane Biology 209: 43-58, 2006. [Abstract]
  38. Franco R and Cidlowski JA.  SLCO/OATP-like transport of glutathione in FasL-induced apoptosis.  Journal of Biological Chemistry 281 (40):29542-29557, 2006. [Abstract]
  39. Smoak K and Cidlowski JA.  Glucocorticoids regulate tristetetraprolin synthesis and posttrancriptionally regulate tumor necrosis factor alpha inflammatory signaling.  Molecular and Celullar Biology 26(23):9126-9135, 2006. [Abstract]
  40. G. Heimlich and Cidlowski JA. Selective role of intracellular chloride in the regulation of the intrinsic but not extrinsic pathway of apoptosis in Jurkat T-cells. J. Biol. Chem. 281: 2232-2241, 2006. [Abstract]
  41. Schaaf MJM, Lewis-Tuffin LJ and Cidlowski JA. Ligand-Selective Targeting of the Glucocorticoid Receptor to Nuclear Subdomains is associated with Decreased Receptor Mobility. Molecular Endocrinology 19(6): 1501-1515, 2005. [Abstract]
  42. Lu NZ and Cidlowski JA. Translational Regulatory Mechanisms Generate N-terminal Glucocorticoid Receptor Isoforms with Unique Transcriptional Target Genes. Molecular Cell. Vol.18, 331-342 April 29, 2005. [Abstract]
  43. Hermoso MA, Matsuguchi T, Smoak K and Cidlowski JA. Glucocorticoids and Tumor Necrosis Factor Alpha Cooperatively Regulate Toll-Like Receptor 2 Gene Expression. Molecular and Cellular Biology, p.4743-4756, June 2004. [Abstract]