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Your Environment. Your Health.

Selected Publications

Inositol Signaling Group

  1. Puhl-Rubio AC, Stashko MA, Wang H, Hardy PB, Tyagi V, Li B, Wang X, Kireev D, Jessen HJ, Frye SV, Shears SB, Pearce KH. Use of protein kinase-focused compound libraries for the discovery of new inositol phosphate kinase inhibitors. SLAS Discov. 2018 May 1:2472555218775323. doi: 10.1177/2472555218775323 [Abstract]
  2. Yousaf R, Gu C, Ahmed ZM, Khan SN, Friedman TB, Riazuddin S, Shears SB, Riazuddin S. Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse. PLoS Genet. 2018 Mar 28;14(3):e1007297. doi: 10.1371/journal.pgen.1007297 [Abstract] 
  3. Wang H, Gu C, Rolfes RJ, Jessen HJ, Shears SB. Structural and biochemical characterization of Siw14: a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates. 2018 J.Biol.Chem. Mar 14. pii: jbc.RA117.001670. doi: 10.1074/jbc.RA117.001670 [Abstract] 
  4. Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, Ferreira SS, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO. Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells. 2018 Cell Signal. 2018 46:120-128. doi: 10.1016/j.cellsig.2018.03.001. [Abstract] 
  5. Nair VS, Gu C, Janoshazi AK, Jessen HJ, Wang H, Shears SB. Inositol Pyrophosphate Synthesis by Diphosphoinositol Pentakisphosphate Kinase-1 is Regulated by Phosphatidylinositol(4,5)bisphosphate. Biosci Rep. 2018 Feb 19. pii: BSR20171549. doi: 10.1042/BSR20171549. [Abstract]
  6. Shears SB, Hayakawa Y. The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?  Cytokine. 2018 Feb 15. pii: S1043-4666(18)30056-5. doi: 10.1016/j.cyto.2018.02.016. [Abstract]
  7. Rajasekaran SS, Illies C, Shears SB, Wang H, Ayala TS, Martins JO, Daré E, Berggren PO, Barker CJ. Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity. Cell Signal. 2018 42: 127-133. [Abstract] 
  8. Sung EJ, Ryuda M, Matsumoto H, Uryu O, Ochiai M, Cook ME, Yi NY, Wang H, Putney JW, Bird GS, Shears SB, Hayakawa Y. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13786-13791. [Abstract]
  9. Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB. KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype. Proc Natl Acad Sci U S A. 2017 114: 11968-11973. [Abstract] 
  10. Wang H, Shears SB. Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities. J Biol Chem. 2017 292 (44) 18192-18202. [Abstract] 
  11. Shears, SB. Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling. J Cell Physiol 2018 233: 1897-1912 [Abstract]
  12. Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB. The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis. J Biol Chem 2017; 292(11):4544-4555. [Abstract]
  13. Gu C, Wilson MSC, Jessen HJ, Saiardi A, Shears SB. Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels. PloS One 2016 11(10):-. [Abstract]
  14. Hager A, Wu M, Wang H, Brown NW, Shears SB, Veiga N, Fiedler D. Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues. Chemistry (Weinheim an der Bergstrasse, Germany) 2016 22(35):12406-12414. [Abstract]
  15. Shears SB. Towards pharmacological intervention in inositol pyrophosphate signaling. Biochem Soc. Trans. 2016; 15:191-196. [Abstract]
  16. Riley AM, Wang H, Shears SB, L Potter BV. Synthetic tools for studying the chemical biology of InsP8. Chem Commun (Camb). 2015; 51(63):12605-12608. [Abstract]
  17. Shears SB. Inositol pyrophosphates: why so many phosphates? Adv Biol Regul. 2015; 57:203-216. [Abstract]
  18. Wang H, Nair VS, Holland AA, Capolicchio S, Jessen HJ, Johnson MK, Shears SB. Asp1 from Schizosaccharomyces pombe Binds a [2Fe-2S](2+) Cluster Which Inhibits Inositol Pyrophosphate 1-Phosphatase Activity. Biochemistry. 2015; 54(42):6462-6474. [Abstract]
  19. Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB. Identification of a functional nuclear translocation sequence in hPPIP5K2. BMC cell biology. 2015; 16(1):17-.  [Abstract]
  20. Tsuzuki S, Matsumoto H, Furihata S, Ryuda M, Tanaka H, Sung, EJ, Bird GS, Zhou Y, Shears SB, Hayakawa Y. Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP. Nat Commun. 2014; 5:4628. doi: 10.1038/ncomms5628. [Abstract]
  21. Capolicchio S, Wang H, Thakor DT, Shears SB, Jessen HJ. Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew Chem Int Ed Engl. 2014; 53(36):9508-9511.  [Abstract]
  22. Wang H, DeRose EF, London RE, Shears SB. IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. Nat Commun. 2014; 5:4178-. [Abstract]
  23. Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BV. Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 has a Surface-Mounted Substrate Capture Site that is a Target for Drug Discovery. Chemistry & Biology. 2014; 21(5):689-699. [Abstract]
  24. Stentz, R, Osborne, S, Horn, N, Li, AWH, Hautefort, I, Bongaerts, R, Rouyer, M, Bailey, P, Shears, SB, Hemmings, AM, Brearley, CA, Carding, SR. A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Reports. 2014; 6:646-656. [Abstract]
  25. Pulloor, NK, Nair, S, Kostic, AD, Bist, P, Weaver, JD, Riley, AM, Tyag, R, Uchil, PD, York, JD, Snyder, SH, Garcıa-Sastre, A, Potter, BVL, Lin, R, Shears, SB, Xavier, RJ, Krishnan, MN. Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response. PlOS Pathogens. 2014; 10(2): e1003981. doi:10.1371/journal.ppat.1003981 [Open Access]
  26. Wang, LD, Bi, X, Song, X, Pohl, NM, Cheng, Y, Zhou, Y, Shears, SB, Ansong, E, Xing, M, Wang, S, Xu, XC, Huang, P, Xu, L, Wang, L, Fan, Z, Zhao, X, Dong, H, Meltzer, SJ, Ding, I, Yang, W. A Sequence Variant in the Phospholipase C epsilon C2 Domain Is Associated with Esophageal Carcinoma and Esophagitis. Molecular Carcinogenesis. 2013; 52:80-86. [Abstract]
  27. Weaver JD, Wang H, Shears SB. The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Bioscience Reports. 2013; 33(2):229-241 [Abstract]
  28. Brehm, MA, Williams, J, Wunderberg, T, Mayr, GW, Shears, SB. A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 2013; 126(Pt 2):437-44. [Abstract]
  29. Kilari, RS, Weaver, JD, Shears, SB, Safrany, ST. Understanding inositol pyrophosphate metabolism and function: Kinetic characterization of the DIPPs. FEBS letters. 2013; 587(21):3464-3470. [Abstract]
  30. Gokhale N, Zaremba A, Janoshazi, AK, Weaver JD, Shears SB. PPIP5K1 Modulates Ligand Competition Between Diphosphoinositol Polyphosphates and PtdIns(3,4,5)P3 for Polyphosphoinositide-Binding Domains. The Biochemical journal. 2013; 453(3):413-426. [Abstract]
  31. Ganapathi, SB, Wei, SG, Zaremba, A, Lamb, FS, Shears, SB. Functional Regulation of ClC-3 in the Migration of Vascular Smooth Muscle Cells. Hypertension. 2013; 61(1):174-179. [Abstract]
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