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Program Operations Branch

The three workgroups within the Program Operations Branch provide advice, services and oversight to accomplish NTP programmatic goals.

Chemistry and ADME Resources Group

The Chemistry and ADME (absorption, distribution, metabolism, excretion) Resources Group (CARG) provides resources for chemistry, ADME, and toxicokinetics in support of the mission of the National Toxicology Program.

The group, comprised of Suramya Waidyanatha, Ph.D., Brad Collins, and Esra Mutlu, Ph.D, directs the work of contracted resources to conduct chemistry activities, ADME and toxicokinetic studies and monitors them for technical and fiscal performance.

CARG coordinates with other Division of National Toxicology Program organizations so that the timelines for chemistry, ADME, and toxicokinetic activities efficiently augment other DNTP activities to ensure that the needs of the program are met, the best available methods and techniques are used, and that the results are appropriately and accurately described and reported.

Toxicology Study Management

The Toxicology Study Management Workgroup (TSMW) directs, implements, and oversees carcinogenicity, mechanistic and reproductive toxicology testing performed by contract laboratories on substances nominated to NTP for study. Studies are conducted according to rigorous NTP specifications, scientific guidelines and good laboratory practices. Its members include Helen Cunny, Ph.D. and Matthew Stout, Ph.D. The TSMW works with other NTP scientists to develop and implement research projects to accomplish the NTP mission. Responsibilities of the TSMW include direct oversight of project execution, data acquisition, presentation of results, and budget oversight. Additional responsibilities include scientific input to NTP management regarding annual reports and inclusion of new technologies in study designs.

In addition, Stout directs the activities of contracted quality assessment resources to audit records on the conduct and reporting of NTP studies, updates that result from NTP pathology peer review process and the preparation of NTP technical reports. This contract also assesses the accuracy of data on the NTP website and aids in the evaluation of quality programs in place at contract laboratories that conduct studies for NTP.

Information and Data Management

Information and Data Management Workgroup (IDMW) supports NTP efforts in the collection, management, reporting and storing of experimental data. These efforts are achieved through the design, use and maintenance of software customized for NTP and through the Chemical Effects in Biological Systems (CEBS) database. The CEBS database is designed for use by NTP as well as the public at large. The IDMW also facilitates the flow of information and comments to NTP through the website and by email, as well as disseminates data and information to the general public and scientific community. The workgroup is comprised of Beth Bowden, Jennifer Fostel, Ph.D., Laura Hall, and Shawn Jeter along with onsite contracted support from Sharon Einloth, Audrey Foster, Razvan Pataca, Robbie Robinson, Jacki Vandervoort, and Cori Vella.

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