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Your Environment. Your Health.

Esra Mutlu, Ph.D.

Esra Mutlu
Esra Mutlu, Ph.D.
Chemist
Tel 984-287-3165
esra.mutlu@nih.gov
P.O. Box 12233
Mail Drop K2-07
Durham, N.C. 27709

Esra Mutlu, Ph.D., is a chemist in the Chemistry and ADME (absorption, distribution, metabolism and excretion) Resources Group in the Program Operations Branch (POB) in the Division of the National Toxicology Program (NTP). Mutlu provides NTP with expertise in organic chemistry, analytical chemistry, and interpretation and application of mass spectrometry and serves on NTP study design teams to provide technical assistance in these areas of chemistry.

As a chemist, Mutlu is involved in the design, conduct, interpretation and reporting of NTP research and testing activities that investigate the toxicology of a variety of chemicals and complex mixtures including botanicals, polycyclic aromatic hydrocarbons, sunscreen ingredients, and phenolic benzotriazoles. Mutlu’s research interests include using state-of-the-art mass spectrometric techniques to quantitate products of reactive metabolites of xenobiotics with DNA and other macromolecules. She is also interested in understanding the mode of action of chemicals and their metabolites in vivo.

Mutlu received her BSc (Honors) in Chemistry from Yildiz Technical University, Istanbul, Turkey in 2001 and her Ph.D. in Organic Chemistry from University of Newcastle upon Tyne, UK in 2004. She joined University of North Carolina at Chapel Hill as a Goldberg postdoctoral fellow in Curriculum of Toxicology, where she developed assays to quantitate DNA adducts of xenobiotics and/or their metabolites by mass spectrometric techniques which were applied to samples from in vivo and in vitro exposures. In 2011, she joined the U.S. Environmental Protection Agency as a postdoctoral fellow and was actively involved in research on chemistry, mutagenicity and mutagenic emission factors of particulate matters of diesel, biodiesel, and wood stove emissions. She worked as a research associate at University of North Carolina Gillings School of Global Public Health briefly prior to joining NTP in 2014 as a chemist.

Selected Publications

  1. Mutlu E, Cristy T, Graves SW, Hooth MJ, Waidyanatha S. 2016 Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies. Environmental Science and Pollution Research. [Abstract]
  2. Mutlu E, Warren SH, Ebersviller SM, Kooter IM, Schmid JE, Dye JA, Linak WP, Gilmour MI, Jetter JJ, Higuchi M, DeMarini DM. 2016. Mutagenicity and Pollutant Emission Factors of Solid-Fuel Cookstoves: Comparison with Other Combustion Sources. Environ Health Prospect. 124(7):974-82. Pub 2016 Feb 19. [Abstract]
  3. Mutlu E, Gao L, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA. 2016. Polychlorinated Biphenyls Induce Oxidative DNA Adducts in Female Sprague-Dawley Rats. Chem Res Toxicol. 29(8):1335-44. [Abstract]
  4. Mutlu E, Warren SH, Matthews PP, Schmid JE, Kooter IM, Linak WP, Ian Gilmour M, DeMarini DM. 2016. Health effects of soy-biodiesel emissions:bioassay-directed fractionation for mutagenicity. Inhal Toxicol. 27(11):597-612. [Abstract]
  5. Mutlu E, Warren SH, Matthews PP, King C, Walsh L, Kligerman AD, Schmid JE, Janek D, Kooter IM, Linak WP, Gilmour MI, DeMarini DM. 2015. Health effects of soy-biodiesel emissions: mutagenicity-emission factors. Inhal Toxicol. 27(11):585-96. [Abstract]
  6. Mutlu E, Nash DG, King C, Krantz TQ, Preston WT, Kooter IM, Higuchi M, DeMarini D, Linak WP, Gilmour MI. 2015. Generation and characterization of diesel engine combustion emissions from petroleum diesel and soybean biodiesel fuels and application for inhalation exposure studies. Inhal Toxicol. 27(11):515-32. [Abstract]
  7. Nakamura J, Mutlu E, Sharma V, Collins L, Bodnar W, Yu R,  Lai Y, Moeller B, Lu L, Swenberg J. 2014. The endogenous exposome. DNA Repair 19:3-13.  [Epub ahead of print]. [Abstract]
  8. Mutlu E, Warren SH, Matthews P, King C, Linak WP, Kooter IM, Schmid JE, Ross JE, Gilmour MI, DeMarini DD. 2013. Bioassay–directed fractionation and subfractionation for mutagenicity and chemical analysis of diesel exhaust particles. Environ Mol Mutagen 54(9):719-736. Pub 2013 Sep 16. [Abstract]
  9. Mutlu E, Jeong YC, Collins LB, Ham AJ, Upton PB, Winsett D, Hatch G, and Swenberg JA. 2012. A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-Oxoethyl)guanine in sprague-dawley rats. Chem Res Toxicol 20;25(2):391-9. Pub 2012 Jan 24. [Abstract]
  10. Mutlu E, Collins LB,  Stout MD, Upton PB, Dave LR,  Winsett D, Hatch G, Evansky P, Swenberg JA. 2010. Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N(2),3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC. Chem Res Toxicol 23(9): 1485-1491. [Abstract]
  11. Golding BT, Barnes ML, Bleasdale C, Henderson AP, Jiang D., Li X, Mutlu E, Petty HJ, Sadeghi MM. 2010. Modeling the formation and reactions of benzene metabolites. Chem Biol Interact. 19;184(1-2):196-200. [Abstract]
  12. Baskerville-Abraham IM, Boysen G, Troutman JM, Mutlu E, Collins L, DeKrafft KE,  Lin W, King C, Chaney SG, Swenberg JA. 2009. Development of an ultraperformance liquid chromatography/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts. Chem Res Toxicol 22(5):905-12. [Abstract]
  13. Craven E, Mutlu E, Lundberg D, Temizdemir S, Dechert S,  Brombacher H, Janiak C. 2002. Thallium(I) complexes with modified poly(pyrazolyl)borate ligands-metal-ligand coordination and crystal packing. Polyhedron 21:553-562. [Abstract]
  14. Henderson AP, Mutlu E, Leclercq A, Bleasdale C, Clegg W, Henderson RA, Golding BT. 2002. Trapping of benzene oxide-oxepin and methyl-substituted derivatives with 4-Phenyl-1,2,4-triazoline-3,5-dione. Chem. Comm 7 (17): 1956-1957. [Abstract]
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