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Your Environment. Your Health.

Program Operations Branch

Michelle J. Hooth, Ph.D.
Michelle J. Hooth, Ph.D.
Toxicologist and Chief, Program Operations Branch
Tel (919) 316-4643
Fax (919) 541-4255
P.O. Box 12233
Mail Drop K2-07
Research Triangle Park, NC 27709

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Research Summary

The Program Operations Branch (POB) provides critical scientific and information technology expertise necessary to conduct and support the National Toxicology Program (NTP) research efforts. Staff members are responsible for the following general functions:

  • Acquiring and validating new methods and capabilities to address specific requirements for NTP studies.
  • Advising NTP staff and directing the work of NTP contract study laboratories conducting general toxicology, carcinogenicity, and developmental and reproductive toxicology studies.
  • Providing expertise, direction, and oversight for a number of NTP support functions including studies of absorption, distribution, metabolism and excretion (ADME) and toxicokinetics, analytical chemistry and quality assessment.
  • Conducting activities related to maintaining and developing databases for NTP studies as well as data capture and retrieval systems.
  • Receiving, tracking, maintaining, and disseminating NTP documents and data for both the NTP public and internal websites.


Program Operations Branch Logo NTP: Chemistry, ADME, Toxicology, Study Management, Information

To facilitate these activities, the Program Operations Branch is organized into the following:


  • Chemistry and ADME (Absorption, Distribution, Metabolism and Excretion) Resources Group (CARG)
  • Toxicology Study Management Workgroup (SMW)
  • Information and Data Management Workgroup (IDMW).

These groups work with a variety of NTP staff to accomplish program goals. Please see specific activities and interests of each section on the Organization ("/Rhythmyx/assembler/render?sys_contentid=52081&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="52081" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="52081" sys_siteid="" sys_folderid="") page.


Scientific Support Staff

Debbie McCarley
Debbie C. McCarley
Program Specialist

Tel (919) 541-2384
Fax (919) 541-0947
Anna Lee Mosley
Anna Lee S. Mosley

Tel (919) 541-9471
Fax (301) 480-2862