Mechanistic Toxicology Branch
Julie Hall, Ph.D. is a postdoctoral fellow in the Biomolecular Screening Branch of the National Toxicology Program Division at the National Institute of Environmental Health Sciences (NIEHS). Her research focuses on understanding molecular mechanisms behind cellular responses to the heavy metal cadmium using the model organism Caenorhabditis elegans.
Since 2007, Hall has focused her research on understanding how the C. elegans metallothionein homology, mtl-1, is transcriptional regulated in response to cadmium. Utilizing the power of C. elegans genetics Hall has performed both reverse (candidate) and forward (mutagenesis) genetic screens. Several genes have been identified from the candidate screen and a pathway is emerging in the regulation of mtl-1. Additionally, several novel genes have recently been identified from the EMS mutagenesis screen and are being confirmed using various genetic techniques and whole genome NextGen sequencing techniques.
Hall received a B.S. degree in Biotechnology from Elizabethtown College in Elizabethtown, PA in 2001 and a Ph.D. in Biology from the University of North Carolina at Chapel Hill, NC in 2007. Her graduate worked focused on using C. elegans genetics to identify genes involved in both DNA damage response and telomere maintenance. She joined NIEHS and the lab of Jonathan Freedman, Ph.D. in 2007 as a postdoctoral fellow.
- Hall J, Haas K and Freedman J. 2012. Role of MTL-1, MTL-2 and CDR-1 in mediating cadmium sensitivity in C. elegans. Toxicol Sci. 128(2):418-26.
- Bailly A, Freeman A, Hall J, Declais AC, Alpi A, Lilley D Ahmed S and Gartner A "The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair." PLoS Genetics Jul 15;6(7): e1001025. 2010.
- Greiss S, Hall J, Ahmed S and Gartner A "C. elegans SIR-2.1 translocation is linked to a pro-apoptotic pathway parallel to cep-1/p53-like during DNA damage-induced apoptosis." Genes and Development 22(20): 2831-42. 2008.
- Boerckel J, Walker D and Ahmed S "The RFC-like complex HPR-17 is required for telomere replication in C. elegans." Genetics 176:703-709. 2007.
- Clejan I, Boerckel J and Ahmed S "Developmental Modulation of nonhomologous end joining in Caenorhabditis elegans." Genetics 173(3):1301-17. 2006.