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Your Environment. Your Health.

Xiaohua Gao, M.D., Ph.D

Xiaohua Gao, Ph.D.
Xiaohua Gao, M.D., Ph.D.
Fellow — Research
Tel 919-972-7983
xiaohua.gao@nih.gov
430 Davis Drive, Suite 410
Morrisville, NC 27560

Xiaohua Gao, M.D., Ph.D. is a Research Fellow in the National Toxicology Program Laboratory of the Division of the National Toxicology Program at the National Institute of Environmental Health Sciences. As a trainee under the supervision of Dr. Darlene Dixon in the Molecular Pathogenesis Group, Gao’s work focuses on the molecular basis of disease and understanding the pathogenesis of toxicant-induced changes in female reproductive tract tissues and in vitro assays in human cells, to assess the molecular mechanisms and signaling pathways of environmental substances that are of importance to the NTP testing program.

Gao received her M.D. and Ph.D. in Toxicology from Nanjing Medical University in Nanjing, China. Her doctoral research focused on the effects of pesticides and other endocrine disrupting chemicals (EDCs) on calmodulin signaling and T-type calcium channels of the reproductive tract using animal models and in vitro germ cells. Gao joined NIEHS as a visiting fellow in 2008.

Selected Publications

  1. Gao X, Yu L , Moore AB, Kissling GE, Waalkes MP, Dixon D. Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways. Environmental health perspectives 2015 123(4):331-336. [Abstract]
  2. Gao X, Yu L, Moore AB, Kissling GE, Dixon D. Cadmium potentiates cell proliferation in human uterine leiomyoma cells: A role for EGFR/MAPK pathway but not ER α or β. Environmental Health Perspectives. 2014 Oct 24. [Epub ahead of print]
  3. Segars JH, Parrott EC, Nagel JD, Guo XC, Gao X, Birnbaum LS, Pinn VW, Dixon D. Proceedings from the Third National Institutes of Health International Congress on advances in uterine leiomyoma research: Comprehensive review, conference summary, and future recommendations. Human Reproduction Update. 2014 May-Jun;20(3):309-33. [Abstract]
  4. Gao X, Yu L, Castro L, Tucker CJ, Moore AB, Xiao H, Dixon D. An essential role of p27 down-regulation in Fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells. American Journal of Physiology - Endocrinology and Metabolism. 2012 Oct;303(8):E1025-35. (Featured as cover image). [Abstract]
  5. Gao X, Wang Q, Wang J, Wang C, Lu L, Gao R, Huan F, Dixon D, Xiao H. Expression of calmodulin in germ cells is associated with Fenvalerate-induced male reproductive toxicity. Archives of Toxicology. 2012 Sep;86(9):1443-51. [Abstract]
  6. Gao X, Yu L, Castro L, Moore AB, Hermon T, Bortner C, Sifre M and Dixon D. An endocrine-disrupting chemical, fenvalerate, induces cell cycle progression and collagen type I expression in human uterine leiomyoma and myometrial cells. Toxicology Letters. 2010, 15;196(3):133-41. [Abstract]
  7. Yu L, Moore AB, Castro L, Gao X, Huynh HC, Klippel M, Flagler ND, Lu Y, Kissling GE, Dixon D. Estrogen regulates mapk-related genes through genomic and nongenomic interactions between igf-i receptor tyrosine kinase and estrogen receptor-alpha signaling pathways in human uterine leiomyoma cells. Journal of Signal Transduction. 2012;2012:204236. [Abstract]
  8. Wang Q, Lu L, Gao X, Wang C, Wang J, Cheng J, Gao R, Xiao H. Effects of raloxifene on voltage-dependent T-type Ca2+ channels in mouse spermatogenic cells. Pharmacology. 2011; 87(1-2):70-80. [Abstract]
  9. Wang J, Jiang L, Gao X, Ding H, Wang Q, Cheng J, Gao R, Xiao H. Fenvalerate-induced Ca2+ transients via both intracellular and extracellular way in mouse GC-2spd (ts) cells. Toxicology. 2009 May 17;259(3):122-32. [Abstract]
  10. Lu L, Wang C, Gao X, Xu P, Wang J, Wang Q, Cheng J, Xiao H. Effects of copper on T-type Ca2+ channels in mouse spermatogenic cells. J Membr Biol. 2009 227(2):87-94. [Abstract]
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