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Your Environment. Your Health.

Selected Publications

Molecular Pathogenesis Group

  1. Jackson-Humbles DN, Seely JC, Herbert R, Malarkey D, McIntyre B, Foster P, Dixon D. Uterine Paramesonepric cysts in Harlan Sprague Dawley Rats from the National Toxicology Program Studies. Toxilogic Pathology, 2018 Jun;46(4):421-430. doi: 10.1177/0192623318772487. Epub 2018 Apr 29 [Abstract] [Full Text]
  2. Flake GP, Moore AB, Sutton D, Flagler N, Clayton N, Kissling GE, Wicker Hall B, Horton J, Walmer D, Robboy SJ, Dixon D. The Life Cycle of the Uterine Fibroid Myocyte. Current Obstetrics and Gynecology Reports, 2018 7(2):97-105 doi: 10.1007/s1366. [Abstract]
  3. Vicetti Miguel RD, Quispe Calla NE, Dixon D, Foster RA, Gambotto A, Pavelko SD, Hall-Stoodley L, Cherpes TL. IL-4–secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage. PNAS, 2017 Aug 15;114(33):E6892-E6901. doi: 10.1073/pnas.1621253114. Epub 2017 Aug 1. [Abstract] [Full Text]
  4. Jokinen MP, Morgan DL, Price HC, Herbert RA, Saddler T, Dixon D. Immunohistochemical Characterization of Sarcomas in Trp53+ Haploinsufficient Mice. Toxicologic pathology, 2017 Aug;45(6):774-785. doi: 10.1177/0192623317730558. [Abstract] [Full Text]
  5. Irizarry AR, Gropp KE, Dixon D. A Brief Overview of the STP 35th Annual Symposium on the Basis and Relevance of Variation in Toxicologic Responses. Toxicologic pathology, 2017 Jan;45(1):52-56. doi: 10.1177/0192623316675765. Epub 2016 Nov 4. [Abstract] [Full Text]
  6. Hayes AW, Dixon D. Cornerstones of Toxicology. Toxicologic pathology, 2017 Jan;45(1):57-63. doi: 10.1177/0192623316675768. [Abstract] [Full Text]
  7. Yitang Yan , Deloris Sutton, Connie Cummings , Linda Yu , Lysandra Castro , Alicia B. Moore , Xiaohua Gao , Darlene Dixon. Immunogold electron microscopy and confocal analyses reveal distinctive patterns of histone H3 phosphorylation during mitosis in MCF-7 cells. Genes, chromosomes and cancer 2016 55(4):397-406. [Abstract]
  8. Elmore SA, Dixon D, Hailey JR, Harada T, Herbert RA, Maronpot RR, Nolte T, Regh J, Rittinghausen S, Rosol TJ, Satoh H, Vidal JD, Willard-Mack CL, Whitney K, Creasy D. Recommendations from the INHAND Apoptosis/Necrosis Working Group. Toxicologic pathology 2016 44(2):173-188. [Abstract]
  9. Mozzachio K, Moore AB, Kissling GE, Dixon D. Immunoexpression of Steroid Hormone Receptors and Proliferation Markers in Uterine Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa. Toxicologic pathology 2016 44(3):450-457. [Abstract]
  10. Castro L, Moore AB , Gao X, Yu L, Di X, Kissling GE , Dixon D. A High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy. Expert Opin Environ Biol, 2016;5(Suppl 1). doi: 10.4172/2325-9655.S1-003. [Abstract]
  11. Remick AK, Catlin NR, Quist EM, Steinbach TJ, Dixon D. Juvenile Toxicology: Relevance and Challenges for Toxicologists and Pathologists. Toxicologic pathology 2015 43(8):1166-1171. [Abstract]
  12. Keane, KA, Parker, GA, Regan, KS, Picut, C, Dixon, D, Creasy, D, Giri, D, Hukkanen, RR. Scientific and Regulatory Policy Committee (SRPC) Points to Consider: Histopathology Evaluation of the Pubertal Development and Thyroid Function Assay (OPPTS 890.1450, OPPTS 890.1500) in Rats to Screen for Endocrine Disruptors. Toxicologic pathology 2015 43(8):1047-1063. [Abstract]
  13. Picut CA, Dixon D, Simons ML, Stump DG, Remick AK. Postnatal ovary development in the rat: morphologic study and correlation of morphology to neuroendocrine parameters. Toxicologic pathology 2015 43(3):343-53-343-53. [Abstract]
  14. Gao X, Yu L , Moore AB, Kissling GE, Waalkes MP, Dixon D. Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways. Environmental health perspectives 2015 123(4):331-336. [Abstract]
  15. Dixon D , Alison R, Bach U, Colman K, Foley GL, Harleman JH , Haworth R, Herbert R, Heuser A, Long G, Mirsky M, Regan K, van Esch E, Westwood FR, Vidal J , Yoshida M. Nonproliferative and proliferative lesions of the rat and mouse female reproductive system. Journal of toxicologic pathology 2014 27(3-4 Suppl):1S-107S. [Abstract]
  16. Segars JH, Parrott EC, Nagel JD, Guo X, Gao X, Birnbaum LS, Pinn VW, Dixon D. Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations. Human reproduction update 2014 20(3):309-333. [Abstract]
  17. Flake GP, Moore AB, Flagler N, Wicker B, Clayton N, Kissling GE, Robboy SJ, Dixon D. The natural history of uterine leiomyomas: morphometric concordance with concepts of interstitial ischemia and inanosis. Obstetrics and gynecology international 2013 2013:285103-. [Abstract]
  18. Madenspacher JH, Azzam KM, Gowdy KM, Malcolm KC, Nick JA, Dixon D, Aloor JJ, Draper DW, Guardiola JJ, Shatz M, Menendez D, Lowe J, Lu J, Bushel P, Li L, Merrick BA, Resnick MA, Fessler MB. p53 Integrates host defense and cell fate during bacterial pneumonia.  Journal of Experimental Medicine 2013 210(5):891-904. [Abstract]
  19. Gao X , Yu L , Castro L, Tucker CJ, Moore AB, Xiao H , Dixon D. (2012) An essential role of p27 downregulation in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells. American journal of physiology. Endocrinology and Metabolism 303(8):E1025-E1035. [Abstract]
  20. Gao X, Wang Q , Wang J , Wang C , Lu L , Gao R , Huan F, Dixon D , Xiao H. (2012) Expression of calmodulin in germ cells is associated with fenvalerate-induced male reproductive toxicity. Archives of toxicology 86(9):1446-51. [Abstract]
  21. Yu L, Moore AB, Castro L, Gao X, Huynh HL, Klippel M, Flagler N, Lu Y, Kissling GE, Dixon D. (2012) Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells. Journal of signal transduction  2012:204236-. [Abstract]
  22. Di X, Andrews DM, Tucker CJ , Yu L, Moore AB, Zheng X, Castro L , Hermon T , Dixon D. (2012) A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. Experimental and Molecular Medicine 44(4):281-92. [Abstract]
  23. Annab LA, Bortner CD, Sifre MI, Collins JM, Shah RR, Dixon D, Karimi Kinyamu H, Archer TK. (2012) Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation; research in biological diversity 84(4):330-42. [Abstract]
  24. Gao X, Yu L, Castro L, Moore AB , Hermon T, Bortner C , Sifre M, Dixon D. (2010) An endocrine-disrupting chemical, fenvalerate, induces cell cycle progression and collagen type I expression in human uterine leiomyoma and myometrial cells. Toxicology letters 196(3):133-141. [Abstract]
  25. Draper DW, Madenspacher JH, Dixon D, King DH, Remaley AT, Fessler MB. (2010) ATP-binding cassette transporter G1 deficiency dysregulates host defense in the lung. American Journal of Respiratory and Critical Care Medicine 182(3):404-412. [Abstract]
  26. Yu L, Moore AB, Dixon D. (2010) Receptor Tyrosine Kinases and their Hormonal Regulation in Uterine Leiomyoma. Seminars in Reproductive Medicine 2010 28(3):250-259. [Abstract]
  27. Corn Minor RA, Limmon G, Miller-DeGraff L, Andrews D, Kaufman RJ, Dixon D, Imani F. (2010) Double-Stranded RNA-Activated Protein Kinase Regulates Early Innate Immune Responses During Respiratory Syncytial Virus Infection. J Interferon Cytokine Res 30(4):263-272. [Abstract]
  28. Yu L, Saile K, Swartz CD, He H, Zheng X, Kissling GE, Di X, Lucas S, Robboy SJ, and Dixon D. (2008). Differential Expression of Receptor Tyrosine Kinases (RTKs) and IGF-I Pathway Activation in Human Uterine Leiomyomas. Mol Med 14:264-275. [Abstract]
  29. Moore AB, Flake GP, Swartz CD, Heartwell G, Cousins D, Haseman JK, Kissling GE, Sidawy MK, and Dixon D. (2008). Association of Race, Age and Body Mass Index with Gross Pathology of Uterine Leiomyomas. J Reprod Med 53:90-96. [Abstract]
  30. Dixon D, Herbert R, Kissling GE, Brix A, Miller R, and Maronpot RR. (2008). Summary of Chemically Induced Pulmonary Lesions in the National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies. Toxicologic Pathol 36:428-39. [Abstract]
  31. Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, and Fessler MB. (2008). Effects of Liver X Receptor Agonist Treatment on Pulmonary Inflammation and Host Defense. J Immunol 180:3305-12. [Abstract]
  32. Veit AC, Painter JT, Miller R, Hardisty JF, and Dixon D. (2008). Characterization of Uterine Granular Cell Tumors in B6C3F1 Mice: A Histomorphological, Immunohistochemical, and Ultrastructural Study. Vet Pathol 45:654-62. [Abstract]
  33. Di X, Yu L, Moore AB, Castro L, Zheng X, Hermon T, and Dixon D. (2008). A Low Concentration of Genistein Induces Estrogen Receptor-Alpha and Insulin-like Growth Factor-I Receptor Interactions and Proliferation in Uterine LeiomyomaCells. Human Reprod 23:1873-1883. [Abstract]
  34. Hermon TL, Moore AB, Yu L, Kissling GE, Castora FJ, and Dixon D. (2008). Estrogen Receptor Alpha (ERalpha) Phospho-Serine-188 is Highly Expressed in Human Uterine Leiomyomas Compared to Matched Myometrium. Virchows Arch 453(6):557-569 [Abstract]
  35. Moore AB, Castro L, Yu L, Zheng X, Di X, Sifre M, Kissling GE, Newbold RR, Bortner CD, and Dixon D. (2007). Stimulatory and Inhibitory Effects of Genistein on Human Uterine Leiomyoma Cell Proliferation are Influenced by the Concentration. Hum Reprod 22(10):2623-2631. [Abstract]
  36. Tilley SL,  Stapleton C,  Jaradat M, Dixon D,  Hua X,  Erikson CJ, McCaskill JG, Chason KD, Liao, G,  Jania L, Koller BH, and Jetten AM. (2007). Retinoid-related Orphan Receptor (ROR) ? Controls Immunoglobulin Productio and Th1/Th2 Cytokine Balance in the Adaptive Immune Response to Allergen. J Immunol 178:3208-18. [Abstract]
  37. Jaradat M, Stapleton C, Dixon D, Tilley SL, Erikson CJ, McCaskill JG, Kang HS, Angers M, Liao G, Collins J, Grissom S, and  Jetten AM. (2006). Modulatory role for retinoid-related orphan receptor alpha (RORa) in allergen-induced lung inflammation. Am J Respir Crit Care Med 174(12):1299-1309. [Abstract]
  38. Varella-Garcia M, Chen L, Zheng X, Yu L, and Dixon D. (2006). Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction. Cancer Genet Cytogenet 170(1):71-5. [Abstract]
  39. Dixon D, Parrott EC, Segars JH, Olden K, and Pinn VW. (2006). The second National Institutes of Health International Congress on advances in uterine leiomyoma research: conference summary and future recommendations. Fertil Steril 86(4):800-6. [Abstract]
  40. Bauer AK, Dixon D, DeGraff LM, Cho HY, Walker CR, Malkinson AM, and Kleeberger SR. (2005). Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst 97(23):1778-81. [Abstract]
  41. Aoyama H, Couse JF, Hewitt, SC, Haseman, JK, He H, Zheng X, Majstoravich S, Korach KS, and Dixon, D. (2005). Upregulation of Estrogen Receptor Expression in the Uterus of Ovariectomized B6C3F1 Mice and Ishikawa Cells Treated with Bromoethane. Toxicol And Appl Pharmacol 209(3):226-235. [Abstract]
  42. Swartz CD, Afshari CA, Yu L, Hall KE, and Dixon D. (2005). Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines. Mol Hum Reprod. 11(6):441-50. [Abstract]
  43. Stapleton C, Jaradat M, Dixon D, Kim S-C, Liao G, Cristiano J, Moorman MP, and Jetten AM. (2005). Enhanced susceptibility of Staggerer (RORasg/sg) to lipopolysaccharide-induced airway inflammation. Am J Physiol Lung Cell Mol Physiol 289: L144-152. [Abstract]
  44. Hoffler U, Dixon D, Peddada S, and Ghanayem BI. (2005). Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice. Mutation Research 572: 58-72. [Abstract]
  45. Boorman G, Dixon D, Elwell M, Kerlin R, Morton D, Peters T, Regan K, and Sullivan J. (2004). STP Hyperplasia Working Group Society of toxicologic pathology position on assessment of hyperplastic lesions in rodent carcinogenicity. Toxicol Pathol 32(1): 124-125. [Abstract]
  46. Daniely Y, Liao G, Dixon D, Lionnoila RI, Oren M, and Jetten AM. (2004). Critical Role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol 287:C171-181. [Abstract]
  47. Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MT, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, and Jacks T. (2004). Boston Recommendations for Classification of Pulmonary Proliferative Lesions of the Mouse. Cancer Res 64:2307-2316. [Abstract]
  48. Mozzachio K, Linder K, and Dixon D. (2004). Uterine smooth muscle tumors in potbellied pigs (Sus scrofa) resemble human fibroids: a potential animal model. Toxicol Pathol 32(4):402-7. [Abstract]
  49. Vaidya VS, Shankar K, Dixon D, Lock EA, and Mehendale HM. (2003). Mechanisms of stimulated tissue repair in survival from acute renal tubular necrosis: Role of mapk pathway. Toxicol Sci 72(1): 45 Suppl. S.
  50. Boorman G, Dixon D, Elwell M, Kerlin R, Morton D, Peters T, Regan K, and Sullivan J. (2003). Assessment of hyperplastic lesions in rodent carcinogenicity studies. Toxicol Pathol 31(6): 709-710. [Abstract]
  51. Vaidya VS, Shankar K, Lock EA, Dixon D, and Mehendale HM. (2003). Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: Role of ERK1/2 pathway. Toxicol Pathol 31(6): 604-618. [Abstract]
  52. Picut CA, Aoyama H, Holder JW, Gold LS, Maronpot RR, and Dixon D. (2003). Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited. Exp Toxicol Pathol 55(1): 1-9. [Abstract]
  53. Flake GP, Andersen J, and Dixon D. (2003). Etiology and pathogenesis of uterine leiomyomas: A review. Environ Health Perspect 111(8): 1037-1054. [Abstract]
  54. Carney SA, Tahara H, Swartz CD, Risinger JI, He H, Moore AB, Haseman K, Barrett JC, and Dixon D. (2002). Immortalization of human uterine leiomyomas and myometrial cell lines after induction of telomerase activity: Molecular and phenotype characteristics. Lab Invest 82(6): 719-728. [Abstract]
  55. Mehta DV, Kim YS, Dixon D, and Jetten AM. (2002). Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblasts. Placenta 23(4): 281-287. [Abstract]
  56. Newbold RR, Moore AB, and Dixon D. (2002). Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES). Toxicol Pathol 30(5): 611-616. [Abstract]
  57. Dixon D, Flake GP, Moore AB, He H, Haseman JK, Risinger JI, Lancaster JM, Berchuck A, Barrett JC, and Robboy SJ. (2002). Cell proliferation and apoptosis in human uterine leiomyomas and myometria. Virchows Arch 441(1): 53-62. [Abstract]
  58. Couse JF, Dixon D, Yates M, Moore AB, Ma L, Maas R, and Korach KS. (2001). Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. Dev Biol 238(2): 224-238. [Abstract]
  59. Newbold RR, DiAugustine RP, Risinger JI, Everitt JI, Walmer DK, Parrott EC, and Dixon D. (2000). Advances in uterine leiomyoma research: Conference overview, summary, and future research recommendations. Environ Health Persp 108: 769-773 Suppl. 5. [Abstract]
  60. Dixon D, He H, and Haseman JK. (2000). Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium. Environ Health Persp 108: 795-802 Suppl. 5. [Abstract]
  61. Moore AB, He H, Yoshida A, Rico PJ, Haseman JK, and Dixon D. (2000). Transforming growth factor-alpha, epidermal growth factor receptor, and PCNA immunoexpression in uterine leiomyosarcomas and leiomyomas in B6C3F1 mice. Exp Toxicol Pathol 52(3): 195-200. [Abstract]
  62. Yoshida A, Newbold RA, and Dixon D. (2000). Abnormal cell differentiation and p21 expression of Endometrial Epithelial Cells following developmental exposure to Diethylstilbestrol (DES). Toxicol Pathol 28:237-245. [Abstract]
  63. Yoshida A, Newbold RA, and Dixon D. (1999). Effects of Neonatal Diethylstilbestrol (DES) Exposure on Morphology and Growth Patterns of Endometrial Epithelial Cells in CD-1 mice. Toxicol Pathol 27:325-333. [Abstract]
  64. Baird DD, Schectman JM, Dixon D, Sandler DP, and Hill MC. (1998). African Americans at higher risk than whites for uterine fibroids: Ultrasound evidence. Am J Epidemiol 147(11): 358 Suppl. S.
  65. Goelz MF, Dixon D, Myers PH, Clark JA, and Forsythe DB. (1998). Ganglioneuroma in the adrenal gland of a rat. Contemp Top Lab Anim 37(2): 75-77. [Abstract]
  66. Trukhanova LS, Hong HHL, Sills RC, Bowser AD, Gaul B, Boorman GA, Turusov VS, Devereux TR, and Dixon D. (1998). Predominant p53 G -> A transition mutation and enhanced cell proliferation in uterine sarcomas of CBA mice treated with 1,2-dimethylhydrazine. Toxicol Pathol 26(3): 367-374. [Abstract]
  67. Dixon D, Couse JF, and Korach KS. (1997). Disruption of the estrogen receptor gene in mice. Toxicol Pathol 25(5): 518-520. [Abstract]
  68. Packenham JP, duManoir S, Schrock E, Risinger JI, Dixon D, Denz DN, Evans JAC, Berchuck A, Barrett JC, Devereux TR, and Ried T. (1997). Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. Mol Carcinogen 19(4): 273-279. [Abstract]
  69. Aoyama H, Kato H, and Dixon D. (1997). Specificity of antibodies against rodent transforming growth factor-alpha protein. J Histochem Cytochem 45(5): 695-701. [Abstract]
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