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Your Environment. Your Health.

B A. Merrick, Ph.D.

Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.

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B. Alex Merrick, Ph.D.
B A. Merrick, Ph.D.
Acting Chief, Mechanistic Toxicology Branch
Tel 984-287-3161
merrick@niehs.nih.gov
Curriculum Vitae B. Alex Merrick (403KB)
P.O. Box 12233
Mail Drop E1-05
Durham, N.C. 27709

B. Alex Merrick, Ph.D., is a Molecular Toxicologist who joined the NTP Biomolecular Screening Branch (BSB) in 2010. Merrick leads the Branch's Molecular Toxicology and Genomics Group. His responsibilities include identifying key signaling pathways and transcripts altered by environmental toxicants and participating in the Tox21 collaboration between the NTP, the NIH Chemical Genomics Center (NCGC), the Environmental Protection Agency's National Center for Computational Toxicology (NCCT) and the Food and Drug Administration (FDA). He is especially interested in performing molecular analysis in NTP archival tissues to discover gene expression and epigenetic signatures from chemical toxicology studies. Collaborative work with the Cellular and Molecular Pathology Branch aims to use NTP archival research to further pathological insight, better understand mechanisms of chemical toxicity and contribute to predictive models of toxicity and chemical prioritization as a complementary effort to the Tox21 high throughput screening program. In addition, NextGen sequencing projects will help NTP better evaluate chemically exposed tissues for differential transcript profiles that include splice variants, low copy transcripts and non-coding mRNA's.

Before joining the Biomolecular Screening Branch, Merrick was head of the Proteomics Group within the Division of Intramural Research's (DIR) National Center for Toxicogenomics. His group performed protein and gene expression profiling of hepatoxic agents to identify mechanisms of liver injury, with special interest in p53 biology.

Merrick received his Ph.D. in 1984 at the University of Nebraska Medical Center in Omaha, performing post-doctoral work in the Biology Division at Oak Ridge National Laboratory. He headed the Hepatotoxicology section at the US EPA in Cincinnati, OH from 1985 to 1988 before joining NIEHS in 1989. He currently serves as an adjunct Associate Professor in the Department of Environmental and Molecular Toxicology at NC State University.

Recent Publications

  1. Tandon A, Howard B, Ramaiahgari S, Maharana A, Ferguson S, Shah R, Merrick BA. 2022. Deep Learning Image Analysis of High-Throughput Toxicology Assay Images. SLAS Discov. 27(1):29-38. doi: 10.1016/j.slasd.2021.10.014. [Abstract Tandon A, Howard B, Ramaiahgari S, Maharana A, Ferguson S, Shah R, Merrick BA. 2022. Deep Learning Image Analysis of High-Throughput Toxicology Assay Images. SLAS Discov. 27(1):29-38. doi: 10.1016/j.slasd.2021.10.014.]
  2. Wei Z, Zhao J, Niebler J, Hao JJ, Merrick BA, Xia M. 2020. Quantitative Proteomic Profiling of Mitochondrial Toxicants in a Human Cardiomyocyte Cell Line. Front Genet; doi: 10.3389/fgene.2020.00719 [Online 7 July 2020]. [Abstract Wei Z, Zhao J, Niebler J, Hao JJ, Merrick BA, Xia M. 2020. Quantitative Proteomic Profiling of Mitochondrial Toxicants in a Human Cardiomyocyte Cell Line. Front Genet; doi: 10.3389/fgene.2020.00719 [Online 7 July 2020].]
  3. Merrick BA, Phadke DP, Bostrom MA, Shah RR, Wright GM, Wang X, Gordon O, Pelch KE, Auerbach SS, Paules RS, DeVito MJ, Waalkes MP, Tokar EJ. KRAS-retroviral fusion transcripts and gene amplification in arsenic-transformed, human prostate CAsE-PE cancer cells. Toxicol Appl Pharmacol 2020. doi: 10.1016/j.taap.2020.115017 [Online 25 April 2020]. [Abstract Merrick BA, Phadke DP, Bostrom MA, Shah RR, Wright GM, Wang X, Gordon O, Pelch KE, Auerbach SS, Paules RS, DeVito MJ, Waalkes MP, Tokar EJ. KRAS-retroviral fusion transcripts and gene amplification in arsenic-transformed, human prostate CAsE-PE cancer cells. Toxicol Appl Pharmacol 2020. doi: 10.1016/j.taap.2020.115017 [Online 25 April 2020].]
  4. Grimm SA, Shimbo T, Takaku M, Thomas JW, Auerbach SS, Bennett B, Bucher JR, Burkholder A, Day F, Du Y, Due Y, French JE, Li J, Merrick BA, Tice RR, Wang T, Xu X, Bushel P, Fargo DC, Mullikin JC and Wade PA. (2019). Genetics, sex and life experience-based influences on DNA methylation in mice. Nature Comm. 10(1):305. [Abstract Grimm SA, Shimbo T, Takaku M, Thomas JW, Auerbach SS, Bennett B, Bucher JR, Burkholder A, Day F, Du Y, Due Y, French JE, Li J, Merrick BA, Tice RR, Wang T, Xu X, Bushel P, Fargo DC, Mullikin JC and Wade PA. (2019). Genetics, sex and life experience-based influences on DNA methylation in mice. Nature Comm. 10(1):305.]
  5. Aloor J, Azzam K, Guardiola J, Gowdy K, Madenspacher J, Gabor K, Mueller G, Lin W-C, Lowe J, Gruzdev A, Henderson M, Draper D, Merrick B, and Fessler M. (2019). Leucine-Rich Repeats and Calponin Homology containing 4 regulates the innate immune response. J. Biol. Chem. 294(6):1996-2018. [Abstract Aloor J, Azzam K, Guardiola J, Gowdy K, Madenspacher J, Gabor K, Mueller G, Lin W-C, Lowe J, Gruzdev A, Henderson M, Draper D, Merrick B, and Fessler M. (2019). Leucine-Rich Repeats and Calponin Homology containing 4 regulates the innate immune response. J. Biol. Chem. 294(6):1996-2018.]
  6. Panzacchi S, Gnudi F, Madrioli D, Montella R, Strollo V, Merrick BA, Belpoggi F, Tibaldi E. Effects of short and long-term alcohol-based fixation on Sprague-Dawley rat tissue morphology, protein and nucleic acid preservation. Acta Histochemica 2019 121(6):750-760. [Abstract Panzacchi S, Gnudi F, Madrioli D, Montella R, Strollo V, Merrick BA, Belpoggi F, Tibaldi E. Effects of short and long-term alcohol-based fixation on Sprague-Dawley rat tissue morphology, protein and nucleic acid preservation. Acta Histochemica 2019 121(6):750-760.] 
  7. Balik-Meisner MR, Phadke D, Mav D, Everett LJ, Shah RR, Shepard PJ, Tal T, Merrick BA, Paules RS. Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics. Zebrafish 2019 ():-. [Abstract Balik-Meisner MR, Phadke D, Mav D, Everett LJ, Shah RR, Shepard PJ, Tal T, Merrick BA, Paules RS. Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics. Zebrafish 2019 ():-.]
  8. Merrick BA. Next-generation sequencing data for use in risk assessment. Current opinion in toxicology 2019 18:18-26.  [Abstract Merrick BA. Next-generation sequencing data for use in risk assessment. Current opinion in toxicology 2019 18:18-26. ]
  9. Merrick BA, Phadke DP, Bostrom MA, Shah RR, Wright GM, Wang X, Pelch KE, Waalkes MP, Auerbach SS, Paules RS, DeVito MJ, Tokar EJ. Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS. PLoS One 2019 14(4):e0215504. [Abstract Merrick BA, Phadke DP, Bostrom MA, Shah RR, Wright GM, Wang X, Pelch KE, Waalkes MP, Auerbach SS, Paules RS, DeVito MJ, Tokar EJ. Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS. PLoS One 2019 14(4):e0215504.]
  10. Foley JF, Phadke DP, Hardy O, Hardy S, Miller V, Madan A, Howard K, Kruse K, Lord C, Ramaiahgari S, Solomon GG, Shah RR, Pandiri AR, Herbert RA, Sills RC and Merrick BA. (2018). Whole exome sequencing in the rat. BMC Genomics. 13:e0190992, 1-14. [Abstract Foley JF, Phadke DP, Hardy O, Hardy S, Miller V, Madan A, Howard K, Kruse K, Lord C, Ramaiahgari S, Solomon GG, Shah RR, Pandiri AR, Herbert RA, Sills RC and Merrick BA. (2018). Whole exome sequencing in the rat. BMC Genomics. 13:e0190992, 1-14.]
  11. Merrick BA, Chang JS, Bostrom MA, Phadke DP, Shah RR, Wang X, Gordon O and Wright, GM. (2018). HAfTs are novel lncRNA transcripts from aflatoxin exposure. PLoS One. 13(1): e0190992, 1-25. [Abstract Merrick BA, Chang JS, Bostrom MA, Phadke DP, Shah RR, Wang X, Gordon O and Wright, GM. (2018). HAfTs are novel lncRNA transcripts from aflatoxin exposure. PLoS One. 13(1): e0190992, 1-25.]
  12. Mav D, Shah RR, Howard BE, Auerbach SS, Bushel PR, Collins JB, Gerhold D, Judson RS, Karmaus AL, Maull E, Mendrick DL, Merrick BA, Sipes NS, Svoboda D and Paules RS. (2018). A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics. PLoS One 13(2):e0191105, 1-19. [Abstract Mav D, Shah RR, Howard BE, Auerbach SS, Bushel PR, Collins JB, Gerhold D, Judson RS, Karmaus AL, Maull E, Mendrick DL, Merrick BA, Sipes NS, Svoboda D and Paules RS. (2018). A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics. PLoS One 13(2):e0191105, 1-19.]
  13. Li R, Grimm SA, Mav D, Gu H, Djukovic D, Shah R, Merrick BA, Raftery D and Wade PA. (2018). Epigenetic memory of obesity predisposes to colorectal cancer. Cell Reports. 22(3): 624-637. [Abstract Li R, Grimm SA, Mav D, Gu H, Djukovic D, Shah R, Merrick BA, Raftery D and Wade PA. (2018). Epigenetic memory of obesity predisposes to colorectal cancer. Cell Reports. 22(3): 624-637.]
  14. Duncan CG, Kondilis-Mangum HD, Grimm SA, Bushel P, Chrysovergis K, Roberts JD, Tyson F, Merrick BA and Wade P. (2018). Base-resolution analysis of DNA methylation patterns downstream of Dnmt3a in mouse naïve B cells. 3G: Genes|Genomes|Genetics. [Abstract Duncan CG, Kondilis-Mangum HD, Grimm SA, Bushel P, Chrysovergis K, Roberts JD, Tyson F, Merrick BA and Wade P. (2018). Base-resolution analysis of DNA methylation patterns downstream of Dnmt3a in mouse naïve B cells. 3G: Genes|Genomes|Genetics.]
  15. Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT and Xia M. (2017). Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library. Endocrinology. 159(2):744-753. [Abstract Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT and Xia M. (2017). Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library. Endocrinology. 159(2):744-753.]
  16. Teng CT, Hsieh J-H, Zhao J, Huang R, Xia M, Martin N, Gao X, Dixon D, Auerbach SS, Witt KL Merrick BA. (2017). Development of novel cell lines for high throughput screening to detect estrogen- related receptor alpha modulators. SLAS Discovery. 22:720-731. [Abstract Teng CT, Hsieh J-H, Zhao J, Huang R, Xia M, Martin N, Gao X, Dixon D, Auerbach SS, Witt KL Merrick BA. (2017). Development of novel cell lines for high throughput screening to detect estrogen- related receptor alpha modulators. SLAS Discovery. 22:720-731.]
  17. Dunnick, J.K., Merrick, B.A., Brix, A., Morgan, D.L., Gerrish, K., Wang, Y., Flake, G., Foley, J., Shockley, K.R. Molecular changes in the nasal cavity after N,N-Dimethyl-p-toluidine exposure. Toxicol. Path. 44(6), 835-847, 2016. [Abstract Dunnick, J.K., Merrick, B.A., Brix, A., Morgan, D.L., Gerrish, K., Wang, Y., Flake, G., Foley, J., Shockley, K.R. Molecular changes in the nasal cavity after N,N-Dimethyl-p-toluidine exposure. Toxicol. Path. 44(6), 835-847, 2016.]
  18. Pelch KE, Tokar EJ, Merrick BA, and Waalkes MP. (2015). Differential DNA methylation profile of key genes in malignant prostate epithelial cells transformed by inorganic arsenic or cadmium. Toxicol Appl Pharmacol. 286:159-167. [Abstract Pelch KE, Tokar EJ, Merrick BA, and Waalkes MP. (2015). Differential DNA methylation profile of key genes in malignant prostate epithelial cells transformed by inorganic arsenic or cadmium. Toxicol Appl Pharmacol. 286:159-167.]
  19. Morgan D, Merrick BA, Gerrish KE, Stockton PS, Foley JF, Wang Y, Gwinn WM, Kelly FF, Palmer SM, Ton T-V T, Hoenerhoff JJ and Flake GP. (2015). Gene expression of obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats. PLoS One. 10(2):e0118459. [Abstract Morgan D, Merrick BA, Gerrish KE, Stockton PS, Foley JF, Wang Y, Gwinn WM, Kelly FF, Palmer SM, Ton T-V T, Hoenerhoff JJ and Flake GP. (2015). Gene expression of obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats. PLoS One. 10(2):e0118459.]
  20. Auerbach SS, Phadke D, Mav D, Gao Y, Xie B, Shin JH, Shah RR, Merrick BA, Tice RR. (2015). RNA-Seq-based Toxicogenomic Assessment of Fresh Frozen and Formalin Fixed Tissues Yields Similar Mechanistic Insights. J Appl Toxicol. 35:766-780. [Abstract Auerbach SS, Phadke D, Mav D, Gao Y, Xie B, Shin JH, Shah RR, Merrick BA, Tice RR. (2015). RNA-Seq-based Toxicogenomic Assessment of Fresh Frozen and Formalin Fixed Tissues Yields Similar Mechanistic Insights. J Appl Toxicol. 35:766-780.]
  21. Merrick BA, Paules RS, Tice RR. Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective. International journal of biotechnology 2015 14(1):7-27. [Abstract Merrick BA, Paules RS, Tice RR. Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective. International journal of biotechnology 2015 14(1):7-27.]
  22. Chen S, Hsieh JH, Huang R, Sakamuru S , Hsin LY, Xia M, Shockley KR, Auerbach S, Kanaya N, Lu H, Svoboda D, Witt KL, Merrick BA, Teng CT, Tice RR. Cell-based high-throughput screening for aromatase inhibitors in the Tox21 10K library. Toxicological sciences: an official journal of the Society of Toxicology 2015 147(2):446-457. [Abstract Chen S, Hsieh JH, Huang R, Sakamuru S , Hsin LY, Xia M, Shockley KR, Auerbach S, Kanaya N, Lu H, Svoboda D, Witt KL, Merrick BA, Teng CT, Tice RR. Cell-based high-throughput screening for aromatase inhibitors in the Tox21 10K library. Toxicological sciences: an official journal of the Society of Toxicology 2015 147(2):446-457.]
  23. Morgan DL, Merrick BA, Gerrish KE, Stockton PS, Wang Y, Foley JF, Gwinn WM, Kelly FL, Palmer SM, Ton TV, Flake GP. Gene expression in obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats. PloS one 2015 10(2):e0118459. [Abstract Morgan DL, Merrick BA, Gerrish KE, Stockton PS, Wang Y, Foley JF, Gwinn WM, Kelly FL, Palmer SM, Ton TV, Flake GP. Gene expression in obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats. PloS one 2015 10(2):e0118459.]
  24. Teng CT, Beams B, Alex Merrick B, Martin N, Romeo C, Jetten AM. Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals. Biochemical and biophysical research communications 2014 444(2):177-181. [Abstract Teng CT, Beams B, Alex Merrick B, Martin N, Romeo C, Jetten AM. Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals. Biochemical and biophysical research communications 2014 444(2):177-181.]
  25. Madenspacher JH, Azzam KM, Gowdy KM, Malcolm KC, Nick JA, Dixon D, Aloor JJ, Draper DW, Guardiola JJ, Shatz M, Menendez D, Lowe J, Lu J, Bushel P, Li L, Merrick BA, Resnick MA, Fessler MB. p53 Integrates host defense and cell fate during bacterial pneumonia.  Journal of Experimental Medicine 2013 210(5):891-904. [Abstract Madenspacher JH, Azzam KM, Gowdy KM, Malcolm KC, Nick JA, Dixon D, Aloor JJ, Draper DW, Guardiola JJ, Shatz M, Menendez D, Lowe J, Lu J, Bushel P, Li L, Merrick BA, Resnick MA, Fessler MB. p53 Integrates host defense and cell fate during bacterial pneumonia.  Journal of Experimental Medicine 2013 210(5):891-904.]
  26. Dhungana S, Merrick BA, Tomer KB, Fessler MB. Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide. Molecular & Cellular Proteomics: MCP 2013, 8(1):201-213. [Abstract Dhungana S, Merrick BA, Tomer KB, Fessler MB. Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide. Molecular & Cellular Proteomics: MCP 2013, 8(1):201-213.]
  27. Merrick BA, Phadke DP, Auerbach SS, Mav D, Stiegelmeyer SM, Shah RR, Tice RR. RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats. PLOS ONE 2013 8(4):e61768-. [Abstract Merrick BA, Phadke DP, Auerbach SS, Mav D, Stiegelmeyer SM, Shah RR, Tice RR. RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats. PLOS ONE 2013 8(4):e61768-.]
  28. Teng CT, Goodwin B, Shockley K, Xia M, Huang R, Norris J, Merrick BA, Jetten AM, Austin CP, Tice RR. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-Biological Interactions 2013 203(3): 556-564. [Abstract Teng CT, Goodwin B, Shockley K, Xia M, Huang R, Norris J, Merrick BA, Jetten AM, Austin CP, Tice RR. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-Biological Interactions 2013 203(3): 556-564.]
  29. Li Y, Luh CJ, Burn KA, Arao Y, Jiang Z, Teng CT, Tice EE, Korach KS. Endocrine-disrupting chemicals (EDCs): in vitro mechanism of estrogenic activation and differential effects on ER target genes. Environ Health Perspect 2013; 121(4): 459-466. [Abstract Li Y, Luh CJ, Burn KA, Arao Y, Jiang Z, Teng CT, Tice EE, Korach KS. Endocrine-disrupting chemicals (EDCs): in vitro mechanism of estrogenic activation and differential effects on ER target genes. Environ Health Perspect 2013; 121(4): 459-466.]
  30. Thomas R, Thomas RS, Auerbach SS, Portier CJ. Biological networks for predicting chemical hepatocarcinogenicity using gene expression data from treated mice and relevance across human and rat species. PLoS One 2013. 30;8(5):e63308. [Abstract Thomas R, Thomas RS, Auerbach SS, Portier CJ. Biological networks for predicting chemical hepatocarcinogenicity using gene expression data from treated mice and relevance across human and rat species. PLoS One 2013. 30;8(5):e63308.]
  31. Thomas RS, Philbert MA, Auerbach SS, Wetmore BA, Devito MJ, Cote I, Rowlands JC, Whelan MP, Hays SM, Andersen ME, Meek ME, Reiter LW, Lambert JC, Clewell HJ 3rd, Stephens ML, Zhao QJ, Wesselkamper SC, Flowers L, Carney EW, Pastoor TP, Petersen DD, Yauk CL, Nong A. Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework. Toxicol Sci 2013. Sep 19. [Epub ahead of print]. [Abstract Thomas RS, Philbert MA, Auerbach SS, Wetmore BA, Devito MJ, Cote I, Rowlands JC, Whelan MP, Hays SM, Andersen ME, Meek ME, Reiter LW, Lambert JC, Clewell HJ 3rd, Stephens ML, Zhao QJ, Wesselkamper SC, Flowers L, Carney EW, Pastoor TP, Petersen DD, Yauk CL, Nong A. Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework. Toxicol Sci 2013. Sep 19. [Epub ahead of print].]
  32. Wetmore BA, Wambaugh JF, Ferguson SS, Li L, Clewell HJ 3rd, Judson RS, Freeman K, Bao W, Sochaski MA, Chu TM, Black MB, Healy E, Allen B, Andersen ME, Wolfinger RD, Thomas RS. Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays. Toxicol Sci 2013. 132(2):327-46. [Abstract Wetmore BA, Wambaugh JF, Ferguson SS, Li L, Clewell HJ 3rd, Judson RS, Freeman K, Bao W, Sochaski MA, Chu TM, Black MB, Healy E, Allen B, Andersen ME, Wolfinger RD, Thomas RS. Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays. Toxicol Sci 2013. 132(2):327-46.]
  33. Merrick BA, Auerbach SS, Stockton PS, Foley JF, Malarkey DE, Sills RC, Irwin RD, Tice RR. Testing an aflatoxin B1 gene signature in rat archival tissues. Chemical research in toxicology. 2012 25(5):1132-44. [Abstract Merrick BA, Auerbach SS, Stockton PS, Foley JF, Malarkey DE, Sills RC, Irwin RD, Tice RR. Testing an aflatoxin B1 gene signature in rat archival tissues. Chemical research in toxicology. 2012 25(5):1132-44.]
  34. Smith CM, Nolan CK, Edwards MA, Hatfield JB, Stewart TW, Ferguson SS, Lecluyse EL, Sahi J. J. 2012. A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes. Pharm Sci. 101(10):3989-4002. [Abstract Smith CM, Nolan CK, Edwards MA, Hatfield JB, Stewart TW, Ferguson SS, Lecluyse EL, Sahi J. J. 2012. A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes. Pharm Sci. 101(10):3989-4002.]
  35. Zhang SY, Surapureddi S, Coulter S, Ferguson SS, Goldstein JA. 2012. Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver. Mol Pharmacol. 2012 Jun 20 82(3):529-40. [Abstract Zhang SY, Surapureddi S, Coulter S, Ferguson SS, Goldstein JA. 2012. Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver. Mol Pharmacol. 2012 Jun 20 82(3):529-40.]
  36. Wise A, Parham F, Axelrad DA, Guyton KZ, Portier C, Zeise L, Zoeller RT, Woodruff TJ. Upstream adverse effects in risk assessment: A model of polychlorinated biphenyls, thyroid hormone disruption and neurological outcomes in humans. Environmental Research 2012; 117:90-99. [Abstract Wise A, Parham F, Axelrad DA, Guyton KZ, Portier C, Zeise L, Zoeller RT, Woodruff TJ. Upstream adverse effects in risk assessment: A model of polychlorinated biphenyls, thyroid hormone disruption and neurological outcomes in humans. Environmental Research 2012; 117:90-99.]
  37. Parham F, Wise A, Axelrad DA, Guyton KZ, Portier C, Zeise L, Zoeller RT, Woodruff TJ. Adverse effects in risk assessment: Modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans. Environmental Research 2012; 116:74-84. [Abstract Parham F, Wise A, Axelrad DA, Guyton KZ, Portier C, Zeise L, Zoeller RT, Woodruff TJ. Adverse effects in risk assessment: Modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans. Environmental Research 2012; 116:74-84.]
  38. Hao Tang, Xiang S. Wang, Jui-Hua Hsieh, Alexander Tropsha. In press. Do crystal structures obviate the need for theoretical models of GPCRs for structure based virtual screening? Proteins 2012. 80(6):1503-21 [Abstract Hao Tang, Xiang S. Wang, Jui-Hua Hsieh, Alexander Tropsha. In press. Do crystal structures obviate the need for theoretical models of GPCRs for structure based virtual screening? Proteins 2012. 80(6):1503-21]
  39. Hsieh JH, Yin S, Wang XS, Liu S, Dokholyan NV, Tropsha A. Cheminformatics meets molecular mechanics: a combined application of knowledge-based pose scoring and physical force field-based hit scoring functions improves the accuracy of structure-based virtual screening. J Chem Inf Model 2012. 52(1):16-28. [Abstract Hsieh JH, Yin S, Wang XS, Liu S, Dokholyan NV, Tropsha A. Cheminformatics meets molecular mechanics: a combined application of knowledge-based pose scoring and physical force field-based hit scoring functions improves the accuracy of structure-based virtual screening. J Chem Inf Model 2012. 52(1):16-28.]
  40. Merrick BA, Dhungana S, Williams JG, Aloor JJ, Peddada S, Tomer KB and Fessler MB. Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3. Mol Cell Proteomics. 2011 Oct;10(10):M110.006007 [Abstract Merrick BA, Dhungana S, Williams JG, Aloor JJ, Peddada S, Tomer KB and Fessler MB. Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3. Mol Cell Proteomics. 2011 Oct;10(10):M110.006007]  
  41. Teng CT, Li Y, Stockton P, Foley J. Fasting induces the expression of PGC-1a and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney. PloS one 2011 6(11):e26961-.  [Abstract Teng CT, Li Y, Stockton P, Foley J. Fasting induces the expression of PGC-1a and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney. PloS one 2011 6(11):e26961-. ]
  42. Jui-Hua Hsieh, Shuangye Yin, Alexander Sedykh, Nikolay Dokholyan and Alexander Tropsha
    Combined application of cheminformatics- and physical force field-based scoring functions improves binding affinity prediction for CSAR data sets. Chem. Inf. Model. 2011, 51(9), 2027-35 [Abstract Jui-Hua Hsieh, Shuangye Yin, Alexander Sedykh, Nikolay Dokholyan and Alexander Tropsha
    Combined application of cheminformatics- and physical force field-based scoring functions improves binding affinity prediction for CSAR data sets. Chem. Inf. Model. 2011, 51(9), 2027-35    ]
  43. Smoak KA, Aloor JJ, Madenspacher J, Merrick BA, Collins JB, Zhu X, Cavigiolio G, Oda MN, Parks JS and Fessler MB. Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation. Cell Metabol. 2010, 11:493-502. [Abstract Smoak KA, Aloor JJ, Madenspacher J, Merrick BA, Collins JB, Zhu X, Cavigiolio G, Oda MN, Parks JS and Fessler MB. Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation. Cell Metabol. 2010, 11:493-502.]  
  44. Auerbach, S. S., Shah, R. R., Mav, D., Smith, C. S., Walker, N. J., Vallant, M. K., Boorman, G. A. and Irwin, R. D. (2010). Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning. Toxicol Appl Pharmacol 243, 300-14. [Abstract Auerbach, S. S., Shah, R. R., Mav, D., Smith, C. S., Walker, N. J., Vallant, M. K., Boorman, G. A. and Irwin, R. D. (2010). Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning. Toxicol Appl Pharmacol 243, 300-14.]
  45. Merrick BA and Witzmann FA. The role of toxicoproteomics in assessing organ specific toxicity. EXS. 2009, 99:367-400. [Abstract Merrick BA and Witzmann FA. The role of toxicoproteomics in assessing organ specific toxicity. EXS. 2009, 99:367-400.]  
  46. Dhungana S, Merrick BA, Tomer KB and Fessler MB. Quantitative proteomic analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide. Mol Cell Proteomics. 2009, 8:201-213. [Abstract Dhungana S, Merrick BA, Tomer KB and Fessler MB. Quantitative proteomic analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide. Mol Cell Proteomics. 2009, 8:201-213.]  
  47. Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. Dose-response modeling of high-throughput screening data. Journal of Biomolecular Screening 2009; 14:1216-1227. [Abstract Parham F, Austin C, Southall N, Huang R, Tice R, Portier C. Dose-response modeling of high-throughput screening data. Journal of Biomolecular Screening 2009; 14:1216-1227.]
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