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Your Environment. Your Health.

Selected Publications

Pathology Support Group

  1. Hong HH, Hoenerhoff MJ, Ton TV, Herbert RA, Kissling GE, Hooth MJ, Behl M, Witt KL, Smith-Roe SL, Sills RC, Pandiri AR7. Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal. Toxicologic pathology 2015 43(6):872-882. [Abstract]
  2. Behl M, Stout MD, Herbert RA, Dill JA, Baker GL, Hayden BK, Roycroft JH, Bucher JR, Hooth MJ. Comparative toxicity and carcinogenicity of soluble and insoluble cobalt compounds. Toxicology 2015 33():195-. [Abstract]
  3. Quist EM, Filgo AJ, Cummings CA, Kissling G, Hoenerhoff MJ, Fenton SE. Hepatic mitochondrial alteration in CD-1 mice associated with prenatal exposures to low doses of perfluorooctanoic acid (PFOA): a PPAR-alpha independent mode of action. Toxicol Path 2014 Oct 42(1):12-44. [Abstract]
  4. Elmore SA, Boyle MC, Boyle MH, Cora MC, Crabbs TA, Cummings CA, Gruebbel MM, Johnson CL, McInnes EF, Nolte T, Shackelford CC, and Ward JM. Proceedings of the 2013 National Toxicology Program Satellite Symposium. Toxicol Pathol 2014 Jan 42(1):12-44. [Abstract]
  5. Dixon D , Alison R, Bach U, Colman K, Foley GL, Harleman JH , Haworth R, Herbert R, Heuser A, Long G, Mirsky M, Regan K, van Esch E, Westwood FR, Vidal J , Yoshida M. Nonproliferative and proliferative lesions of the rat and mouse female reproductive system. Journal of toxicologic pathology 2014 27(3-4 Suppl):1S-107S. [Abstract]
  6. Cesta MF, Malarkey DE, Herbert RA, Brix A, Hamlin MH 2nd, Singletary E, Sills RC, Bucher JR, Birnbaum LS. The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource. Toxicologic pathology 2014 42(2):458-460. [Abstract]
  7. Pratap SA, Cummings CA, Mishina Y, Archer TK. SOX8 Regulates Permeability of the Blood-Testes Barrier That Affects Adult Male Fertility in the Mouse. Biol Reprod 2013 May 88(5):133. [Abstract]
  8. Mercado-Feliciano M, Herbert RA, Wyde ME, Gerken DK, Hejtmancik MR, Hooth MJ. Pyrogallol-associated dermal toxicity and carcinogenicity in F344/N rats and B6C3F1/N mice.  Cutaneous and ocular toxicology (2013) 32(3):234-240. [Abstract]
  9. Witt KL, Stout MD, Herbert RA, Travlos GS, Kissling GE, Collins BJ, Hooth MJ. (2013) Mechanistic Insights from the NTP Studies of Chromium. Toxicologic pathology 41(2):326-342. [Abstract]
  10. Golomb E, Matza D, Cummings CA, Schwalb H, Kodavanti UP, Schneider A, Houminer E,  Korach A, Nyska A, and Shapira OM. Myocardial Mitochondrial Injury Induced by Pulmonary Exposure to Particulate Matter in Rats, Toxicol Path 2012 Jul 40(5):779-88. [Abstract]
  11. Cunningham ML, Collins BJ, Hejtmancik MR, Herbert RA, Travlos GS, Vallant MK, Stout MD. Effects of the PPAR[alpha] Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism. PPAR research 2012:681963, 2012. [Abstract]
  12. Rao DB, Little PB, Malarkey DE, Herbert RA, Sills RC. (2011) Histopathological Evaluation of the Nervous System in Routine National Toxicology Program Rodent Studies: A Modified Approach. Toxicologic Pathology 39(3):463-470. [Abstract]
  13. Painter JT, Clayton NP, Herbert RA. (2010) Useful immunohistochemical markers of tumor differentiation. Toxicologic Pathology 38(1):131-141. [Abstract]
  14. Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Malarkey DE, Hooth MJ. (2009) Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. Environmental health perspectives 117(5):716-722. [Abstract]
  15. Stout MD, Kissling GE, Suárez FA, Malarkey DE, Herbert RA, Bucher JR (2008) Influence of helicobacter hepaticus infection and diet on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice. Toxicologic pathology 36(6):783-794. [Abstract]
  16. Stout MD, Herbert RA, Kissling GE, Suarez F, Roycroft JH, Chhabra RS, Bucher JR. (2008) Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following two year inhalation exposure. Toxicology 244(2):209-219. [Abstract]
  17. Yong-Sik Kim, Hong Soon Kang, Ronald Herbert, Ju Youn Beak, Jennifer B. Collins, Sherry F. Grissom, Anton M. Jetten. (2008) Krüppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions Molecular and Cellular Biology, Vol. 28, No. 7, pg. 2358-2367. [Abstract]
  18. Yogeshkumar V. Murkunde, Ponnusamy Kalaiselvan, Subramaniyan Vijayakumar, Kuppusamy Hemalatha, Robert R. Maronpot, Ronald A. Herbert, Monique Y. Wells, (2008). Brain lesion in a Wistar rat: What’s Your Diagnosis. Lab Animal, Vol. 37, No. 9, 401 - 404.
  19. Wakamatsu N, Collins JB, Parker JS, Tessema M, Clayton NP, Ton TV, Hong HH, Belinsky S, Devereux TR, Sills RC, Lahousse SA (2008). Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors Toxicol Pathol.; 36(5):743-52. [Abstract]
  20. Hong HH, Ton TV, Kim Y, Wakamatsu N, Clayton NP, Chan PC, Sills RC, Lahousse SA. (2008) Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene. Toxicol Pathol.; 36(5):720-6. [Abstract]
  21. Voltz J, Card, Carey, DeGraff, Ferguson, Flake, Bonner, Korach, and Zeldin. (2008) Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis.Am J Respir Cell Mol Biol 39:45-52. [Abstract]
  22. Moore A, Flake, Swartz, Heartwell, Cousins, Haseman, Kissling, Sidawy, and Dixon. (2008) Association of race, age and body mass index with gross pathology of uterine fibroids. J Repro Med 53:90-96. [Abstract]
  23. Carey M, Card, Bradbury, Moorman, Haykal-Coates, Gavett, Graves, Walker, Flake, Voltz, Zhu, Jacobs, Dakhama, Larsen, Loader, Gelfand, Germolec, Korach, and Zeldin. (2007) Spontaneous airway hyperresponsiveness in estrogen receptor-a deficient mice. Am J Respir Crit Care Med 175:126-135. [Abstract]
  24. Flake G, Rivera, Funkhouser, Maygarden, Meadows, Long, Stockton, Jones, Yim, Slebos, and Taylor. (2007) Detection of pre-invasive lung cancer: technical aspects of the LIFE project. Tox Path 35:65-74. [Abstract]
  25. Card J, Voltz, Carey, Bradbury, DeGraff, Lih, Bonner, Morgan, Flake, and Zeldin. (2007) Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis. Am J Respir Cell Mol Biol 37:300-308. [Abstract]
  26. Jiang C, Foley J, Clayton N, Kissling G, Jokinen M, Herbert R, Diaz M. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice (2007). J Immunol.; 178(11):7422-31. [Abstract]
  27. Clayton NP, Yoshizawa K, Kissling GE, Burka LT, Chan PC, Nyska A. Immunohistochemical Analysis of Expression of Hepatic Cytochrome P450. (2007) Exp Toxicol Pathol.; 58(4):223-36. [Abstract]
  28. Kissling GE, Malarkey DE, Vallant MK, Johnson JD, Hejtmancik MR, Herbert RA, Boorman GA. Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice. Experimental and toxicologic pathology : Official journal of the Gesellschaft fur Toxikologische Pathologie 2006; 2-3: 89-99. [Abstract]
  29. Houle CD, Ton TV, Clayton N, Huff J, Hong HH, Sills RC (2006). Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice. Toxicol Pathol.; 34(6):752-62. [Abstract]
  30. Card J, Carey, Bradbury, DeGraff, Morgan, Moorman, Flake, and Zeldin. (2006) Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation. J Immunol 177:621-630. [Abstract]
  31. Yoshizawa K, Kissling GE, Johnson JA, Clayton NP, Flagler ND, Nyska A. (2005) Chemical-induced atrial thrombosis in NTP rodent studies. Toxicol Pathol.; 33(5):517-32. [Abstract]
  32. Lambertini L, Surin K, Ton TV, Clayton N, Dunnick JK, Kim Y, Hong HH, Devereux TR, Sills RC. (2005) Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy). Toxicol Pathol.; 33(2):292-9. [Abstract]
  33. Kim Y, Hong HH, Lachat Y, Clayton NP, Devereux TR, Melnick RL, Hegi ME, Sills RC. (2005) Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice. Toxicol Pathol.; 33(3):307-12. [Abstract]
  34. Tani Y, Suttie, Flake, Nyska, and Maronpot. (2005) Epithelial-stromal tumor of the seminal vesicles in the transgenic adenocarcinoma mouse prostate model. Vet Pathol 42:306-314. [Abstract]
  35. Nyska A, Cummings CA, Vainshtein A, Nadler Y, Ezov N, Gileadi O, Behar V. Electron Microscopy of Wet Tissues: New Imaging Capabilities for Renal Pathology. Toxicol Pathol 2004 32:357-363. [Abstract]
  36. Long PH, Herbert RA, Nyska A. Hexachlorobenzene-induced incisor degeneration in sprague-dawley rats. Toxicol Pathol. 2004 Jan-Feb;32(1):35-40. [Abstract]
  37. Rhodes, M.C, C.D. Hébert, R.A. Herbert, E.J. Morinello, J.H. Roycroft, G.S. Travlos, K.M. Abdo. (2004) Absence of Toxic Effects in F344/N Rats and B6C3F1 Mice Following Subchronic Administration of Chromium Picolinate Monohydrate. Food and Chemical Tox, Volume 43/ No. 1. 21-29. [Abstract]
  38. Maronpot R, Flake, and Huff. (2004) Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicologic Pathology 32(Suppl. 1): 40-48. [Abstract]
  39. Sills R, Hong, Flake, Moomaw, Clayton, Boorman, Dunnick, and Devereux. (2004) o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis. Carcinogenesis 25(4): 605-612. [Abstract]
  40. Nyska A, Jokinen, Brix, Sells, Wyde, Orzech, Haseman, Flake, and Walker. (2004) Exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds. Environ Health Perspect 112: 903-909. [Abstract]
  41. Ahmed F, James, Lysle, Dobbs, Johnke, Flake, Stockton, Sinar, Naziri, Evans, Kovacs, and Allison. (2004) Improved methods for extracting RNA from exfoliated human colonocytes in stool and RT-PCR analysis. Digestive Diseases and Sciences 49(11/12):1889-1898. [Abstract]
  42. Long PH, Herbert RA, Peckham JC, Grumbein SL, Shackelford CC, Abdo K. Morphology of nasal lesions in F344/N rats following chronic inhalation exposure to naphthalene vapors. Toxicol Pathol. 2003 Nov-Dec;31(6):655-64. [Abstract]
  43. Herbert RA, K. Abdo. Gastric neuroendocrine tumors: Methyleugenol. In: “Predictive Value of Rodent Forestomach and Gastric Neuroendocrine Tumors in Evaluating Carcinogenic Risks to Humans”: Views and Expert Opinions of an IARC Working Group. IARC Technical Publication No. 39, Lyon, 2003.
  44. Carey M, Germolec, Bradbury, Gooch, Moorman, Flake, Langenbach, and Zeldin. (2003) Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice. Am. J. Respir. Crit. Care Med. 167: 1509-1515. [Abstract]
  45. Flake G, Andersen, and Dixon. (2003) Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect 111: 1037-1054. [Abstract]
  46. Nyska A, Moomaw CR, Foley JF, Maronpot RR, Malarkey DE, Cummings CA, Peddada S, Moyer CF, Allen DG, Travlos G, Chan PC. The hepatic endothelial carcinogen Riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial-growth factor expression after short-term exposure. Toxicol Appl Pharmacol. 2002 184:153-164. [Abstract]
  47. Long PH, Herbert RA. (2002) Epithelial-induced intrapulpal denticles in B6C3F1 mice. Toxicol Pathol. Nov-Dec;30(6):744-8. [Abstract]
  48. Dixon, D, Flake, Moore, He, Haseman, Risinger, Lancaster, Berchuck, Barrett, and Robboy. (2002) Cell proliferation and apoptosis in human uterine leiomyomas and myometria. Virchows Arch 441(1): 53-62. [Abstract]
  49. Kim K-S, Baek, Flake, Loftin, Calvo, and Eling. (2002) Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue. Gastroenterology 122: 1388-1398. [Abstract]
  50. Herbert RA, Hailey JR.; Wolf JC, Jokinen MP, Travlos GS, C.C. Shackelford. Nomenclature. In: The Handbook of Toxicological Pathology (W . Haschek-Hock ed) pp 157-167, 2001.  
  51. Tsao CC, Coulter SJ, Chien A, Luo G, Clayton NP, Maronpot R, Goldstein JA, Zeldin DC. (2001) Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products. J Pharmacol Exp Ther.; 299(1):39-47. [Abstract]  
  52. Devereux, TR., Stern, Flake, Yu, Zhang, London, and Taylor. (2001) CTNNB1 Mutations and b-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1. Molecular Carcinogenesis 31: 68-73.  
  53. Ma, M, Devereux, Sills, Stockton, Sun, Clayton, Portier, and Flake. (2001) Loss of E-cadherin expression in gastric intestinal metaplasia and later stage p53 altered expression in gastric carcinogenesis. Exp Toxic Pathol 53: 237-246. [Abstract]
  54. Slebos, R, Hoppin, Tolbert, Holly, Brock, Zhang, Bracci, Foley, Stockton, McGregor, Flake, and Taylor. (2000) K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study. Cancer Epidemiology, Biomarkers, & Prevention 9: 1223-1232. [Abstract]
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