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Your Environment. Your Health.

Selected Publications

Inflammation & Autoimmunity

  1. Green DR, Oguin TH, Martinez J. The Clearance of Dying Cells: Table for Two. Cell death and differentiation 2016 23(6):915-926. [Abstract Green DR, Oguin TH, Martinez J. The Clearance of Dying Cells: Table for Two. Cell death and differentiation 2016 23(6):915-926.]
  2. Liu L*, Lu Y*, Martinez J*, Wang T, Wang J, Yang M, Liu G, Green DR, Wang R. Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent. Proceedings of the National Academy of Sciences of the United States of America 2016 113(6):1564-1569. [Abstract Liu L*, Lu Y*, Martinez J*, Wang T, Wang J, Yang M, Liu G, Green DR, Wang R. Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent. Proceedings of the National Academy of Sciences of the United States of America 2016 113(6):1564-1569.]
  3. Park S, Buck MD, Reese TA, Loginicheva E, Zhang X, Martinez J, Freeman ML, Blackman MA, Levine B, Green DR, Artyomov MN, Virgin HW. Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation. Cell host and microbe 2016 19(1):91-101. [Abstract Park S, Buck MD, Reese TA, Loginicheva E, Zhang X, Martinez J, Freeman ML, Blackman MA, Levine B, Green DR, Artyomov MN, Virgin HW. Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation. Cell host and microbe 2016 19(1):91-101.]
  4. Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagatikar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller B, Zhao H, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boom ACM, Zhang H, Randolph GJ, Artyomov MN, Virgin HW. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell host & microbe 2016 19(1):102-113. [Abstract Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagatikar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller B, Zhao H, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boom ACM, Zhang H, Randolph GJ, Artyomov MN, Virgin HW. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell host & microbe 2016 19(1):102-113.]
  5. Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC, Li S, Sharma P, Kaufman RJ, Martinez J, Pulendran B. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 2016 531(7595):523-527. [Abstract Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC, Li S, Sharma P, Kaufman RJ, Martinez J, Pulendran B. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 2016 531(7595):523-527.]
  6. Sanders MG, Parsons MJ, Howard A, Liu J, Fassio S, Martinez JA, Bouchier-Hayes L. Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes. Cell death & disease 2015 ():-. [Abstract Sanders MG, Parsons MJ, Howard A, Liu J, Fassio S, Martinez JA, Bouchier-Hayes L. Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes. Cell death & disease 2015 ():-.]
  7. Martinez J, Malireddi RK, Lu Q, Cunha LD, Pelletier S, Gingras S, Orchard R, Guan JL, Tan H, Peng J, Kanneganti TD, Virgin HW, Green DR. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nature cell biology 2015 17(7):893-906. [Abstract Martinez J, Malireddi RK, Lu Q, Cunha LD, Pelletier S, Gingras S, Orchard R, Guan JL, Tan H, Peng J, Kanneganti TD, Virgin HW, Green DR. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nature cell biology 2015 17(7):893-906.]
  8. Martinez J, Subbarao MRK, Lu Q, Cunha LD, Pelletier S, Gingras S, Orchard R, Tan H, Peng J, Kanneganti TD, Virgin HW, Green DR. Molecular characterization of LC3-associated phagocytosis (LAP) in the innate response to Aspergillus fumigatus infection. Nature Cell Biology 2015 (in revision).
  9. Xu X, Araki K, Li S, Han JH, Ye L, Tan WG, Konieczny BT, Bruinsma MW, Martinez J, Pearce EL, Green DR, Jones DP, Virgin HW, Ahmed R. Autophagy is essential for effector CD8(+) T cell survival and memory formation. Nature Immunology 15(12):1152-1161, 2014. [Abstract Xu X, Araki K, Li S, Han JH, Ye L, Tan WG, Konieczny BT, Bruinsma MW, Martinez J, Pearce EL, Green DR, Jones DP, Virgin HW, Ahmed R. Autophagy is essential for effector CD8(+) T cell survival and memory formation. Nature Immunology 15(12):1152-1161, 2014.]
  10. Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B, Neves-Costa A, Moita C, Pedroso D, Pinto A, Marques S, Faridi H, Costa P, Gozzelino R, Zhao J, Soares M, Gama-Carvalho M, Martinez J, Zhang Q, Doring G, Grompe M, Simas P, Huber T, Baltimore D, Gupta V, Green DR, Ferreira J, Moita L. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity 39(5):874-884, 2013. [Abstract Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B, Neves-Costa A, Moita C, Pedroso D, Pinto A, Marques S, Faridi H, Costa P, Gozzelino R, Zhao J, Soares M, Gama-Carvalho M, Martinez J, Zhang Q, Doring G, Grompe M, Simas P, Huber T, Baltimore D, Gupta V, Green DR, Ferreira J, Moita L. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity 39(5):874-884, 2013.]
  11. Kim J-Y*, Zhao H*, Martinez J, Doggett T, Kolesnikov A, Tang P, Ablonczy Z, Chan C, Zhou Z, Green D, Ferguson T. Non-canonical autophagy promotes the visual cycle. Cell 154(2): 365-376, 2013. *co-first authorship [Abstract Kim J-Y*, Zhao H*, Martinez J, Doggett T, Kolesnikov A, Tang P, Ablonczy Z, Chan C, Zhou Z, Green D, Ferguson T. Non-canonical autophagy promotes the visual cycle. Cell 154(2): 365-376, 2013. *co-first authorship]
  12. Martinez J, Verbist K, Wang R, Green D. The relationship between metabolism and the autophagy machinery during the innate immune response. Cell Metabolism 17(6):895-900, 2013. [Abstract Martinez J, Verbist K, Wang R, Green D. The relationship between metabolism and the autophagy machinery during the innate immune response. Cell Metabolism 17(6):895-900, 2013.]
  13. Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during influenza virus infection. Nature Immunology 14(5): 80-88, 2013. [Abstract Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during influenza virus infection. Nature Immunology 14(5): 80-88, 2013.]
  14. Henault J*, Martinez J*, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Coyle AJ, Kolbeck R, Green DR, Sanjuan MA. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity 37(6): 986-997, 2012. *co-first authorship [Abstract Henault J*, Martinez J*, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Coyle AJ, Kolbeck R, Green DR, Sanjuan MA. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity 37(6): 986-997, 2012. *co-first authorship]
  15. Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J, Tabas I. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metabolism 15(4):545-553, 2011. [Abstract Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J, Tabas I. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metabolism 15(4):545-553, 2011.]
  16. Miller C, Dillon C, Martinez J, Parsons M, Weinlich R, Melino G. Scientists contemplate unexplained death in Austrian Alps. EMBO Molecular Medicine 3(7):363-366, 2011. [Abstract Miller C, Dillon C, Martinez J, Parsons M, Weinlich R, Melino G. Scientists contemplate unexplained death in Austrian Alps. EMBO Molecular Medicine 3(7):363-366, 2011.]
  17. Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green D. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. PNAS 108(42):17396-17401, 2010. [Abstract Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green D. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. PNAS 108(42):17396-17401, 2010.]
  18. Martinez J, Huang X, Yang Y. Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA. PNAS 107(14): 6442- 6447, 2010. [Abstract Martinez J, Huang X, Yang Y. Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA. PNAS 107(14): 6442- 6447, 2010.]
  19. Martinez J, Huang X, Yang Y. Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection. PLoS Pathogens 6(3): e1000811, 2010. [Abstract Martinez J, Huang X, Yang Y. Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection. PLoS Pathogens 6(3): e1000811, 2010.]
  20. Quigley M, Martinez J, Huang X, Yang Y. A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood 113(10):2256-2264, 2009. [Abstract Quigley M, Martinez J, Huang X, Yang Y. A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood 113(10):2256-2264, 2009.]
  21. Martinez J, Huang X, Yang Y. Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. Journal of Immunology 180(3):1592-1597, 2008. [Abstract Martinez J, Huang X, Yang Y. Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. Journal of Immunology 180(3):1592-1597, 2008.]
  22. Zhu J, Martinez J, Huang X, Yang Y. Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta. Blood 109(2):619-625, 2007. [Abstract Zhu J, Martinez J, Huang X, Yang Y. Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta. Blood 109(2):619-625, 2007.]
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