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Your Environment. Your Health.

Selected Publications

Immunogenetics

  1. Thomas SY, Whitehead GS, Takaku M, Ward JM, Xu X, Nakano K, Lyons-Cohen MR, Nakano H, Gowdy KM, Wade PA, Cook DN. MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens. Mucosal Immunol. 2017 Oct 25. doi: 10.1038/mi.2017.84. [Epub ahead of print] [Abstract]
  2. Whitehead GS, Thomas SY, Shalaby KH, Nakano K, Moran TP, Ward JM, Flake GP, Nakano H and Cook DN. TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation. J Clin Invest. 2017 Sep 1;127(9):3313-3326. doi: 10.1172/JCI90890. Epub 2017 Jul 31. PMID: 28758900 [Abstract]
  3. Lyons-Cohen MR, Thomas SY, Cook DN, and Nakano H. Precision Cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells. Journal of Visualized Experiments. 2017 Apr. 5;(122) [Abstract]
  4. Nakano H, Lyons-Cohen MR, Whitehead GS, Nakano K, Cook DN. Distinct functions of CXCR4, CCR2, and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung. Journal of leukocyte biology 2017 ():-. [Abstract]
  5. McAlees JW , Whitehead GS , Harley I , Cappelletti M, Rewerts CL , Holdcroft AM , Divanovic S , Wills-Karp M , Finkelman F , Karp1 CL , Cook DN. Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation. Mucosal immunology 2015 8(4):863-873 [Abstract]
  6. Nakano H, Moran TP, Nakano K, Gerrish KE, Bortner CD, Cook DN. Complement Receptor C5aR1/CD88 and Dipeptidyl Peptidase-4/CD26 Define Distinct Hematopoietic Lineages of Dendritic Cells. Journal of Immunology 2015 194(8):3808-3819. [Abstract]
  7. Hsia BJ, Whitehead GS, Thomas SY, Nakano K, Gowdy KM, Aloor JJ, Nakano H, Cook DN. Trif-dependent induction of Th17 immunity by lung dendritic cells. Mucosal immunology 2015 8(1):186-197. [Abstract]
  8. Moran TP, Nakano H, Kondilis-Mangum HD, Wade PA, and Cook DN. Epigenetic control of ccr7 expression in distinct lineages of lung dendritic cells. Journal of immunology (Baltimore, Md.: 1950) 2014 193(10):4904-4913. [Abstract] 
  9. Whitehead GS, Thomas SY, Cook DN. Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products. Environmental health perspectives 122(1):34-42, 2014. [Abstract]
  10. Nakano H, Burgents J, Nakano K, Whitehead G, Cheong C, Bortner C, Cook D. Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunology 6(4):678-691, 2013. [Abstract]
  11. Wilson RH, Maruoka S, Whitehead GS, Foley JF, Flake GP, Sever ML, Zeldin DC, Kraft M, Garantziotis S, Nakano H, Cook DN. The TLR5 ligand, bacterial flagellin, promotes asthma by priming allergic responses to indoor allergens. Nat Med. Nov;18(11):1705-10, 2012. [Abstract]
  12. Nakano H, Free ME, Wilson RH, Maruoka S, Whitehead GS, Cook DN. Lung resident CD103+ dendritic cells selectively prime Th2 responses to inhaled antigens. Mucosal Immunol. 2012 Jan;5(1):53-65, 2012. [Abstract]
  13. Whitehead GS, Wilson RH, Nakano K, Burch LH, Nakano H, Cook DN. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. Journal of Allergy and Clinical Immunology 2012 129(1):207-15. [Abstract]
  14. Hollingsworth, JW, Free, ME, Li, Z, Andrews, LN, Nakano, H, Cook, DN. Ozone activates pulmonary dendritic cells and promotes allergic sensitization through a Toll-like receptor 4-dependent mechanism. Journal of Allergy and Clinical Immunology 125(5):1167-1170, 2010. [Abstract]
  15. Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009 Oct 15;180(8):720-30. Epub 2009 Aug 6. [Abstract]
  16. Cook DN, Bottomly K. Innate immune control of pulmonary dendritic cell signaling. Proceedings of the American Thoracic Society 4(3):234-239, 2007. [Abstract]
  17. Hollingsworth JW, Whitehead GS, Lin KL, Nakano H, Gunn MD, Schwartz DA, Cook DN. TLR4 signaling attenuates ongoing allergic inflammation. J Immunol. 176(10):5856-62, May 15, 2006. [Abstract]
  18. Whitehead GS, Wang T, Degraff LM, Card JW, Lira SA, Graham GJ, and Cook DN. (2006) The chemokine receptor D6 has opposing affects on allergic inflammation and airway reactivity. American Journal of Respiratory and Critical Care Medicine. 2006 Nov 9; [Epub ahead of print], PMID: 17095748 [PubMed - as supplied by publisher]. [Abstract] 
  19. Jamison T*, Cook DN*, Nibbs RJ, Rot A, Noxon C, McLean P, Alcam A, Lira SA, Wiekowski M, and Graham GJ. The chemokine receptor D6 limits the inflammatory response in vivo. *Equal Contributions. Nature Immunology 6:403-11, 2005. [Abstract] [Full Text] [PDF]
  20. Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors and the pathogenesis of human disease. Nature Immunology 5:975-9, 2004. [Abstract] [Full Text] [PDF]
  21. Lukacs NW, Prosser DM, Wiekowski M, Lira SA and Cook DN (2001). Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation. Journal of Experimental Medicine 194:551-6, 2001. [Abstract] [Full Text] [PDF]
  22. Cook DN, Prosser DM, Forster R, Zhang J, Kuklin NA, Abbondanzo SJ, Xiao-Da N, Chen S, Manfra DJ, Wiekowski MT, Sullivan LM, Smith SR, Greenberg HB, Narula SK, Lipp M, Lira SA. CCR6 mediates dendritic cell localization, lymphocyte homeostasis and immune responses in mucosal tissue. Immunity 12:495-503, 2000. [Abstract]
  23. Cook DN, Beck MA, Coffman TM, Kirby SL, Sheridan JH, Pragnell IB and Smithies O. Requirement of MIP-1alpha for an inflammatory response to viral infection. Science 269:1583-1585, 1995. [Abstract]
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