Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Selected Publications

Chromosome Stability Group

  1. Menendez D, Nguyen T, Snipe J, Resnick MA. The Cytidine Deaminase APOBEC3 Family is Subject to Transcriptional Regulation by p53. Molecular cancer research: MCR 2017 ():-. [Abstract Menendez D, Nguyen T, Snipe J, Resnick MA. The Cytidine Deaminase APOBEC3 Family is Subject to Transcriptional Regulation by p53. Molecular cancer research: MCR 2017 ():-.]
  2. Menendez D, Lowe J, Snipe J, Resnick MA. Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells. Oncotarget 2016 Aug 11. doi: 10.18632/oncotarget.11210 [Abstract Menendez D, Lowe J, Snipe J, Resnick MA. Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells. Oncotarget 2016 Aug 11. doi: 10.18632/oncotarget.11210]
  3. Andres SN, Appel CD, Westmoreland JW, Williams JS, Nguyen Y, Robertson PD, Resnick MA, Williams RS. Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair. Nature structural & molecular biology 2015 22(2):158-166. [Abstract Andres SN, Appel CD, Westmoreland JW, Williams JS, Nguyen Y, Robertson PD, Resnick MA, Williams RS. Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair. Nature structural & molecular biology 2015 22(2):158-166.]
  4. Lowe JM, Menendez D, Bushel PR, Shatz M, Kirk EL, Troester MA, Garantziotis S, Fessler MB, Resnick MA. p53 and NF-kappaB coregulate proinflammatory gene responses in human macrophages. Cancer Res 2014 74(8):2182-2192.   [Abstract Lowe JM, Menendez D, Bushel PR, Shatz M, Kirk EL, Troester MA, Garantziotis S, Fessler MB, Resnick MA. p53 and NF-kappaB coregulate proinflammatory gene responses in human macrophages. Cancer Res 2014 74(8):2182-2192.  ]
  5. Nguyen TA, Menendez D, Resnick MA, Anderson CW. Mutant TP53 posttranslational modifications: challenges and opportunities. Human mutation 2014 35(6):738-755. [Abstract Nguyen TA, Menendez D, Resnick MA, Anderson CW. Mutant TP53 posttranslational modifications: challenges and opportunities. Human mutation 2014 35(6):738-755.]
  6. Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A. Break-induced replication is a source of mutation clusters underlying kataegis. Cell reports 2014 7(5):1640-1648. [Abstract Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A. Break-induced replication is a source of mutation clusters underlying kataegis. Cell reports 2014 7(5):1640-1648.]
  7. Chan K, Resnick MA, Gordenin DA. The choice of nucleotide inserted opposite random abasic sites formed within chromosomal DNA is indicative of the polymerases participating in translesion DNA synthesis. DNA repair 2013 12(11):878-889. [Abstract Chan K, Resnick MA, Gordenin DA. The choice of nucleotide inserted opposite random abasic sites formed within chromosomal DNA is indicative of the polymerases participating in translesion DNA synthesis. DNA repair 2013 12(11):878-889.]
  8. Ma, W., Westmoreland, J., and Resnick, M.A. Homologous recombination rescues single strand DNA gaps generated by NER and reduced translesion DNA synthesis in yeast G2 cells.  Proc. Nat. Acad Sci. 2013 110(31):E2895-E2904. [Abstract Ma, W., Westmoreland, J., and Resnick, M.A. Homologous recombination rescues single strand DNA gaps generated by NER and reduced translesion DNA synthesis in yeast G2 cells.  Proc. Nat. Acad Sci. 2013 110(31):E2895-E2904.]
  9. Menendez, D., Nguyen, T-A., Freudenberg, Mathew, V. J., Anderson, C.W., Jothi, R., and Resnick, M.A. Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells. Nucl. Acid Res. 2013 41(15):7286-7301. [Abstract Menendez, D., Nguyen, T-A., Freudenberg, Mathew, V. J., Anderson, C.W., Jothi, R., and Resnick, M.A. Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells. Nucl. Acid Res. 2013 41(15):7286-7301.]
  10. Roberts, SA, Lawrence, MS, Klimczak, LJ, Frage, D, Stojanov, P, Kiezun, A, Kryukov, GV, Carter, SL, Saksena, G, Harris, S, Shah, R, Resnick, MA, Getz, G, Gordenin, DA.  An apobec cytidine deaminase mutagenesis pattern is ubiquitous in human cancers.  Nature Genetics 45: 970-976, 2013. [Abstract Roberts, SA, Lawrence, MS, Klimczak, LJ, Frage, D, Stojanov, P, Kiezun, A, Kryukov, GV, Carter, SL, Saksena, G, Harris, S, Shah, R, Resnick, MA, Getz, G, Gordenin, DA.  An apobec cytidine deaminase mutagenesis pattern is ubiquitous in human cancers.  Nature Genetics 45: 970-976, 2013.]
  11. Westmoreland JW, Resnick MA. Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease. PLoS Genetics 2013 9(3):e1003420. [Abstract Westmoreland JW, Resnick MA. Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN), Sae2 (Ctp1), and Mre11-nuclease. PLoS Genetics 2013 9(3):e1003420.]
  12. Madenspacher, J., Azzam, K., Gowdy, K., Malcolm, K., Nick, J., Aloor, D. J., Draper, D., Guardiola, J., Shatz, M., Menendez, D., Lowe, J., Lu, J., Bushel, P., Li, Leping, Merrick, A., Resnick, M.A. and Fessler, M. p53 Integrates host defense and cell fate during bacterial pneumonia. J. Experimental Medicine:  891-904, 2013.   [Abstract Madenspacher, J., Azzam, K., Gowdy, K., Malcolm, K., Nick, J., Aloor, D. J., Draper, D., Guardiola, J., Shatz, M., Menendez, D., Lowe, J., Lu, J., Bushel, P., Li, Leping, Merrick, A., Resnick, M.A. and Fessler, M. p53 Integrates host defense and cell fate during bacterial pneumonia. J. Experimental Medicine:  891-904, 2013.  ]
  13. Ma, W., Halweg, C. J., Menendez, D., Resnick, M.A. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc. Nat. Acad. Sci. 109: 6590-5, 2012. [Abstract Ma, W., Halweg, C. J., Menendez, D., Resnick, M.A. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc. Nat. Acad. Sci. 109: 6590-5, 2012.]
  14. Roberts, S.A., Sterling, J., Thompson, C., Yang, Y., Harris, S., Mav, D., Shah, R., Klimczak, L., Kryukov, G. V., Malc, E., Mieczkowski, P., Resnick, M.A., and Gordenin, D. A.  Clustered simultaneous mutations in yeast and human cancers are caused by damage to long regions of single-strand DNA. Molec. Cell 25: 424-435. 2012. [Abstract Roberts, S.A., Sterling, J., Thompson, C., Yang, Y., Harris, S., Mav, D., Shah, R., Klimczak, L., Kryukov, G. V., Malc, E., Mieczkowski, P., Resnick, M.A., and Gordenin, D. A.  Clustered simultaneous mutations in yeast and human cancers are caused by damage to long regions of single-strand DNA. Molec. Cell 25: 424-435. 2012.]
  15. Shatz, M., Menendez, D., Resnick, M.A.  The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells. Cancer Research 72: 3948-57, 2012. [Abstract Shatz, M., Menendez, D., Resnick, M.A.  The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells. Cancer Research 72: 3948-57, 2012.]
  16. Jordan, J.J., Menendez, D., Sharav, J., Beno, I., Resnick, M.A.* and  Haran, T.E.*  Low-level expression of p53 changes the rules of transactivation and reveals super-activating sequences. Proc. Nat. Acad. Sci. 109:  14387-92, 2012. *Equal contributions [Abstract Jordan, J.J., Menendez, D., Sharav, J., Beno, I., Resnick, M.A.* and  Haran, T.E.*  Low-level expression of p53 changes the rules of transactivation and reveals super-activating sequences. Proc. Nat. Acad. Sci. 109:  14387-92, 2012. *Equal contributions]
  17. Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA. Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS genetics 2012 8(12):e1003149.  [Abstract Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA. Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS genetics 2012 8(12):e1003149. ]
  18. Menendez, D., Shatz, M., Garantziotis, S., Fessler, M., and Resnick, M.A.  The human Toll-like receptor family is integrated into human DNA damage and p53 network. Mar;7(3):e1001360. Epub 2011 Mar 31   [Abstract Menendez, D., Shatz, M., Garantziotis, S., Fessler, M., and Resnick, M.A.  The human Toll-like receptor family is integrated into human DNA damage and p53 network. Mar;7(3):e1001360. Epub 2011 Mar 31  ]
  19. Ma, W., Westmoreland,  J.W., Gordenin, D.A. and Resnick, M.A.  Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease. PLoS Genetics Apr;7(4):e1002059. Apr 28, Epub 2011 [Abstract Ma, W., Westmoreland,  J.W., Gordenin, D.A. and Resnick, M.A.  Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease. PLoS Genetics Apr;7(4):e1002059. Apr 28, Epub 2011]
  20. Menendez, D., Inga, A., and Resnick, M.A. Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences. Proc. Nat. Acad. Sci. 107: 1500-1505, 2010. [Abstract Menendez, D., Inga, A., and Resnick, M.A. Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences. Proc. Nat. Acad. Sci. 107: 1500-1505, 2010.]
  21. Covo, S., Westmoreland, J.W., Gordenin, D.A., Resnick, M.A. Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes. PLoS Genetics 6(7):e1001006, 2010. [Abstract Covo, S., Westmoreland, J.W., Gordenin, D.A., Resnick, M.A. Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes. PLoS Genetics 6(7):e1001006, 2010.]
  22. Ma, W., Panduri, V., Sterling, J.F., Van Houten, B., Gordenin, D.A., and Resnick, M.A. The transition of closely-opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1. Molec. Cell. Biol. 29: 1212-1221, 2009. [Abstract Ma, W., Panduri, V., Sterling, J.F., Van Houten, B., Gordenin, D.A., and Resnick, M.A. The transition of closely-opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1. Molec. Cell. Biol. 29: 1212-1221, 2009.]
  23. Menendez, D., Inga, A., and Resnick, M.A. The expanding universe of p53 targets. Invited review. Nature Reviews Cancer 9: 724-733, 2009. [Abstract Menendez, D., Inga, A., and Resnick, M.A. The expanding universe of p53 targets. Invited review. Nature Reviews Cancer 9: 724-733, 2009.]
  24. Westmoreland, J., Ma, W., Yan, Y., van Hulle, K., Malkova, A., and Resnick, M.A. RAD50 (MRX) is required for efficient initiation of resection and recombinational repair at random, g-induced double-strand break ends. PLoS Genetics 5 (9): e1000656, 2009. [Abstract Westmoreland, J., Ma, W., Yan, Y., van Hulle, K., Malkova, A., and Resnick, M.A. RAD50 (MRX) is required for efficient initiation of resection and recombinational repair at random, g-induced double-strand break ends. PLoS Genetics 5 (9): e1000656, 2009.]
  25. Larrea, A.A., Lujan, S.A., McElhinny, S. A. Mieczkowski, P.A., Resnick, M.A., Gordenin, D. A. and Kunkel, T. A.  Genome wide model for the normal eukaryotic DNA replication fork. Proc. Nat. Acad. Sci. 107: 17674-9, 2010.   [Abstract Larrea, A.A., Lujan, S.A., McElhinny, S. A. Mieczkowski, P.A., Resnick, M.A., Gordenin, D. A. and Kunkel, T. A.  Genome wide model for the normal eukaryotic DNA replication fork. Proc. Nat. Acad. Sci. 107: 17674-9, 2010.  ]
  26. Jegga, A., Menendez, D., Inga, A., Aronow, B., and Resnick, M.A. Functional evolution of the p53 regulatory network through its target response elements. Proc. Nat. Acad. Sci. 105: 944-949, 2008. [Abstract Jegga, A., Menendez, D., Inga, A., Aronow, B., and Resnick, M.A. Functional evolution of the p53 regulatory network through its target response elements. Proc. Nat. Acad. Sci. 105: 944-949, 2008.]
  27. Jordan, J.J., Menendez, D., Inga, A., Nourredine, M., Bell, D., and Resnick, M.A. Noncanonical DNA motifs as transactivation targets by wild type and mutant p53. PLoS Genetics 4(6): e1000104, 2008. [Abstract Jordan, J.J., Menendez, D., Inga, A., Nourredine, M., Bell, D., and Resnick, M.A. Noncanonical DNA motifs as transactivation targets by wild type and mutant p53. PLoS Genetics 4(6): e1000104, 2008.]
  28. Argueso, J.L., Westmoreland, J., Mieczkowski, P., Gawel, M., Petes, T.D. and Resnick, M.A. Double strand breaks associated with repetitive DNA unlock genome plasticity. Proc. Nat. Acad. Sci. 105: 11845-50, 2008. (Also see PNAS commentary.) [Abstract Argueso, J.L., Westmoreland, J., Mieczkowski, P., Gawel, M., Petes, T.D. and Resnick, M.A. Double strand breaks associated with repetitive DNA unlock genome plasticity. Proc. Nat. Acad. Sci. 105: 11845-50, 2008. (Also see PNAS commentary.)]
  29. Yang Y, Sterling J, Storici F, Resnick MA, Gordenin DA. 2008. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet 4(11): e1000264. [Abstract Yang Y, Sterling J, Storici F, Resnick MA, Gordenin DA. 2008. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet 4(11): e1000264.]
  30. Menendez, D., Inga, A., Snipe, J., Krysiak, O., Schönfelder, G., and Resnick, M.A. A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1. Mol. Cell. Biol. 27: 2590-2560, 2007. [Abstract Menendez, D., Inga, A., Snipe, J., Krysiak, O., Schönfelder, G., and Resnick, M.A. A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1. Mol. Cell. Biol. 27: 2590-2560, 2007.]
  31. Storici, F., Bebenek, K., Kunkel, T. A., Gordenin, D., and Resnick, M.A. RNA-templated DNA repair. Nature 447: 338-341, 2007. [Abstract Storici, F., Bebenek, K., Kunkel, T. A., Gordenin, D., and Resnick, M.A. RNA-templated DNA repair. Nature 447: 338-341, 2007.]
  32. Menendez, D., Krysiak, O., Inga, A., Gehrandt, B., Resnick, M.A.*, and Schönfelder, G.* *Equal contributors. A SNP in the FLT1 promoter integrates the VEGF system into the p53 transcriptional network. Proc. Nat. Acad. Sci. 103: 1406-1411, 2006. [Abstract Menendez, D., Krysiak, O., Inga, A., Gehrandt, B., Resnick, M.A.*, and Schönfelder, G.* *Equal contributors. A SNP in the FLT1 promoter integrates the VEGF system into the p53 transcriptional network. Proc. Nat. Acad. Sci. 103: 1406-1411, 2006.]
  33. Storici, F., Snipe, J.R., Chan, G.K., Gordenin, D.*, and Resnick, M.A.* *Equal contributors. Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing. Mol. Cell. Biol. 26: 7645-7657, 2006. [Abstract Storici, F., Snipe, J.R., Chan, G.K., Gordenin, D.*, and Resnick, M.A.* *Equal contributors. Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing. Mol. Cell. Biol. 26: 7645-7657, 2006.]
Back
to Top