Epigenetics & Stem Cell Biology Laboratory
Awards and Recognitions
Members of the Epigenetics and Stem Cell Biology Laboratory have been recognized for their outstanding science and contributions to the NIEHS and the NIH with a number of awards. A sample of recent recognitions include the following:
Dr. Amanda Conway
Dr. Amanda Conway, a Postdoctoral IRTA Fellow in Dr. Raja Jothi’s group, has won a prestigious NIGMS PRAT Fellowship (2014 - 2017).
Awards For Scientific Presentations
Several members of ESCBL have been recognized within NIEHS for their scientific presentations within NIEHS.
A number of post-doctoral fellows in ESCBL have earned the very competitive NIH Fellows Awards for Research Excellence (FARE) in the last few years:
- 2014 – Senthilkumar Cinghu, mentored by Raja Jothi, and George Fromm, mentored by Karen Adelman.
- 2015 – Andrew Oldfield, Penyi Yang, and Senthilkumar Cinghu, all mentored by Raja Jothi.
NIEHS Director's Awards of Merit
Several ESCBL members were recognized with NIEHS Director’s Awards of Merit for their participation in groups that provided sustained support of key research efforts.
Papers of the Month
Researchers from within NIEHS (Division of Intramural Research) publish many peer-reviewed articles in a variety of journals each year. The NIEHS highlights some of these publications and their importance to the advancement of science by choosing a select few each month as one of the Papers of the Month. Members of ESCBL were recognized in this way multiple times over the last few years, and are listed below.
For 2018 (through October):
- Kang HS, Kumar D, Liao G, Lichti-Kaiser K, Gerrish K, Liao XH, Refetoff S, Jothi R, Jetten AM. (2017) GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation. J Clin Invest 127:4326–4337.
- Qin Y, Roberts JD, Grimm SA, Lih FB, Deterding LJ, Li R, Chrysovergis K, Wade PA. (2018) An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. Genome Biol 19(1):7.
- Takaku M, Grimm SA, Roberts JD, Chrysovergis K, Bennett BD, Myers P, Perera L, Tucker CJ, Perou CM, Wade PA. (2018) GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network. Nat Commun 9(1):1059.
- Li Y, Hamilton KJ, Wang T, Coons LA, Jefferson WN, Li R, Wang Y, Grimm SA, Ramsey JT, Liu L, Gerrish KE, Williams CJ, Wade PA, Korach KS. (2018) DNA methylation and transcriptome aberrations mediated by ER alpha in mouse seminal vesicles following developmental DES exposure. Proc Natl Acad Sci U S A 115(18):E4189–E4198.
- Hoffman JA, Trotter KW, Ward JM, Archer TK. (2018) BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome. Elife 7:e35073.
- Zhang J, Gonzalez LE, Hall TM. (2017) Structural analysis reveals the flexible C-terminus of Nop15 undergoes rearrangement to recognize a pre-ribosomal RNA folding intermediate. Nucleic Acids Res 45(5): 2829-2837.
- Lavender CA, Shapiro AJ, Burkholder AB, Bennett BD, Adelman K, Fargo DC. (2017) ORIO (Online Resource for Integrative Omics): a web-based platform for rapid integration of next generation sequencing data. Nucleic Acids Res; doi: 10.1093/nar/gkx270.
- Zhou B, Liu J, Ren Z, Yao F, Ma J, Song J, Bennett B, Zhen Y, Wang L, Hu G, Hu S. (2017) Cnot3 enhances human embryonic cardiomyocyte proliferation by promoting cell cycle inhibitor mRNA degradation. Sci Rep 7(1):1500.
- Singh AP, Foley J, Tandon A, Phadke D, Kinyamu HK, Archer TK. (2017) A role for BRG1 in the regulation of genes required for development of the lymphatic system. Oncotarget 8:54925–54938.
- Cinghu S, Yang P, Kosak JP, Conway AE, Kumar D, Oldfield AJ, Adelman K, Jothi R. (2017) Intragenic enhancers attenuate host gene expression. Mol Cell 68(1):104−117.e6.
- Li P, Wang L, Bennett BD, Wang J, Li J, Qin Y, Takaku M, Wade PA, Wong J, Hu G. (2017) Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation. Nucleic Acids Res; doi: 10.1093/nar/gkx884.
- Zheng X, Yang P, Lackford B, Bennett BD, Wang L, Li H, Wang Y, Miao Y, Foley JF, Fargo DC, Jin Y, Williams CJ, Jothi R, Hu G. (2016) CNOT3-dependent mRNA deadenylation safeguards the pluripotent state. Stem Cell Reports 7(5):897−910.
- Zhang J, McCann KL, Qiu C, Gonzalez LE, Baserga SJ, Hall TM. (2016) Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA. Nat Commun 7:13085.
- Zhang S, Zhou B, Wang L, Li P, Bennett BD, Snyder R, Garantziotis S, Fargo DC, Cox AD, Chen L, Hu G. (2016) INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer. Oncogene 36(10):1430-1439.
- Harlid S, Adgent M, Jefferson WN, Panduri V, Umbach DM, Xu Z, Stallings VA, Williams CJ, Rogan WJ, Taylor JA. (2017) Soy formula and epigenetic modifications: analysis of vaginal epithelial cells from infant girls in the IFED Study. Environ Health Perspect 125(3):447-452.
- Lavender CA, Cannady KR, Hoffman JA, Trotter KW, Gilchrist DA, Bennett BD, Burkholder AB, Burd CJ, Fargo DC, Archer TK. (2016) Downstream antisense transcription predicts genomic features that define the specific chromatin environment at mammalian promoters. PLoS Genet 12(8):e1006224.
- Zhou B, Wang L, Zhang S, Bennett BD, He F, Zhang Y, Xiong C, Han L, Diao L, Li P, Fargo DC, Cox AD, Hu G. (2016) INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma. Genes Dev 30(12):1440-1453.
- Singh AP, Foley JF, Rubino M, Boyle MC, Tandon A, Shah R, Archer TK. (2016) Brg1 enables rapid growth of the early embryo by suppressing genes that regulate apoptosis and cell growth arrest. Mol Cell Biol 36(15):1990-2010.
- Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade PA. (2016) GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Genome Biol 17(1):36.
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